{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:17:19Z","timestamp":1783480639869,"version":"3.55.0"},"reference-count":52,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>SARS-CoV-2 is responsible for the global coronavirus disease 2019 (COVID-19) pandemic. While the cardiovascular effects of COVID-19 have been thoroughly described, there are limited published studies in the literature establishing a connection between spontaneous coronary artery dissection (SCAD) and COVID-19. Cardiovascular manifestations include, among others, myocarditis, acute myocardial infraction, and thrombosis. In general, SCAD is an uncommon and underdiagnosed cause of acute myocardial infarction (AMI), particularly in younger women and in patients with underlying fibromuscular dysplasia (FMD). Many patients with SCAD often report significant emotional stress, especially in relation with job loss, during the week preceding their cardiac event. Moreover, the COVID-19 pandemic has led to societal stress and increased unemployment, factors that have been associated with cardiovascular morbidity. SCAD emerges as a rare manifestation of coronary artery disease, which a few recent case reports link to COVID-19. The aim of this article is to summarize the relevant data on the pathophysiology of COVID-19 and SCAD along with a review of the reported cases on acute coronary syndrome (ACS) following SARS-CoV2 infection and, thus, to provide insights about the relationship between COVID-19 and SCAD.<\/jats:p>","DOI":"10.3390\/life14030315","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T03:37:57Z","timestamp":1709091477000},"page":"315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spontaneous Coronary Artery Dissection and COVID-19: A Review of the Literature"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-0765","authenticated-orcid":false,"given":"Grigorios","family":"Tsigkas","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bozika","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassiani-Maria","family":"Nastouli","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-7952","authenticated-orcid":false,"given":"Anastasios","family":"Apostolos","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Hippocration General Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Routoula","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasia-Maria","family":"Georga","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Latta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-5468","authenticated-orcid":false,"given":"Angeliki","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-0378","authenticated-orcid":false,"given":"Michail I.","family":"Papafaklis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Leventopoulos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4560-7629","authenticated-orcid":false,"given":"Grigoris V.","family":"Karamasis","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periklis","family":"Davlouros","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Patras, 265 04 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"ref_1","unstructured":"(2024, February 12). COVID-19 Cases|WHO COVID-19 Dashboard. Available online: https:\/\/data.who.int\/dashboards\/covid19\/cases?n=c."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bpa.2021.02.003","article-title":"Impact of COVID-19 infection on the cardiovascular system: An evidence-based analysis of risk factors and outcomes","volume":"35","author":"Kaye","year":"2021","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pelle, M.C., Zaffina, I., Luc\u00e0, S., Forte, V., Trapanese, V., Melina, M., Giofr\u00e8, F., and Arturi, F. (2022). Endothelial Dysfunction in COVID-19: Potential Mechanisms and Possible Therapeutic Options. Life, 12.","DOI":"10.3390\/life12101605"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.hfc.2022.08.001","article-title":"The Cardiovascular Manifestations of COVID-19","volume":"19","author":"Louis","year":"2023","journal-title":"Heart Fail. Clin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41392-022-00907-1","article-title":"The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication","volume":"7","author":"Ning","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s44161-023-00336-5","article-title":"SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels","volume":"2","author":"Eberhardt","year":"2023","journal-title":"Nat. Cardiovasc. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.4103\/0366-6999.208245","article-title":"Spontaneous coronary artery dissection as a cause of acute myocardial infarction in young female population: A single-center study","volume":"130","author":"Meng","year":"2017","journal-title":"Chin. Med. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jacc.2017.06.053","article-title":"Spontaneous Coronary Artery Dissection: Clinical Outcomes and Risk of Recurrence","volume":"70","author":"Saw","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41579-022-00713-0","article-title":"SARS-CoV-2 pathogenesis","volume":"20","author":"Lamers","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jama.2020.12839","article-title":"Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review","volume":"324","author":"Wiersinga","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li","year":"2003","journal-title":"Nature"},{"key":"ref_13","unstructured":"Fountain, J.H., Kaur, J., and Lappin, S.L. (2024, February 12). Physiology, Renin Angiotensin System, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470410\/."},{"key":"ref_14","unstructured":"Evans, P.C., Rainger, G.E., Mason, J.C., Guzik, T.J., Osto, E., Stamataki, Z., Neil, D., Hoefer, I.E., Fragiadaki, M., and Waltenberger, J. (2024, February 18). Endothelial Dysfunction in COVID-19: A Position Paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science. Available online: https:\/\/academic.oup.com\/cardiovascres\/article-abstract\/doi\/10.1093\/cvr\/cvaa230\/5880580."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"E0178","DOI":"10.1097\/CCE.0000000000000178","article-title":"Role for Anti-Cytokine Therapies in Severe Coronavirus Disease 2019","volume":"2","author":"Buckley","year":"2020","journal-title":"Crit. Care Explor."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41591-020-0901-9","article-title":"Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19","volume":"26","author":"Liao","year":"2020","journal-title":"Nat. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41577-021-00536-9","article-title":"Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19","volume":"21","author":"Bonaventura","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e019650","DOI":"10.1161\/JAHA.120.019650","article-title":"Coronavirus disease 2019\u2014Associated thrombosis and coagulopathy: Review of the pathophysiological characteristics and implications for antithrombotic management","volume":"10","author":"Capodanno","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41569-020-0413-9","article-title":"COVID-19 and cardiovascular disease: From basic mechanisms to clinical perspectives","volume":"17","author":"Nishiga","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_20","first-page":"37","article-title":"Spontaneous coronary artery dissection\u2014A review","volume":"5","author":"Yip","year":"2015","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.jacc.2020.05.084","article-title":"Spontaneous Coronary Artery Dissection: JACC State-of-the-Art Review","volume":"76","author":"Hayes","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/cvr\/cvab183","article-title":"Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: Pathophysiological and clinical implications","volume":"118","author":"Margaritis","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"110410","DOI":"10.1016\/j.mehy.2020.110410","article-title":"COVID-19: A double threat to takotsubo cardiomyopathy and spontaneous coronary artery dissection?","volume":"146","author":"Shojaei","year":"2021","journal-title":"Med. Hypotheses"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mehy.2018.09.039","article-title":"Eosinophilic inflammation in spontaneous coronary artery dissection: A potential therapeutic target?","volume":"121","author":"Pitliya","year":"2018","journal-title":"Med. Hypotheses"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2045894020966547","DOI":"10.1177\/2045894020966547","article-title":"Circulating markers of angiogenesis and endotheliopathy in COVID-19","volume":"10","author":"Pine","year":"2020","journal-title":"Pulm. Circ."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2050313X2097598","DOI":"10.1177\/2050313X20975989","article-title":"Multivessel spontaneous coronary artery dissection in a patient after mild COVID-19: A case report","volume":"8","author":"Kireev","year":"2020","journal-title":"SAGE Open Med. Case Rep."},{"key":"ref_27","first-page":"100551","article-title":"\u201cSpontaneous\u201d Coronary Artery Dissection After SARS-CoV-2 Messenger RNA Vaccination","volume":"2","author":"Mohammed","year":"2023","journal-title":"J. Soc. Cardiovasc. Angiogr. Interv."},{"key":"ref_28","first-page":"141","article-title":"COVID-19 and spontaneous coronary artery dissection: Causality?","volume":"3","author":"Aparisi","year":"2021","journal-title":"REC Interv. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"334","DOI":"10.5543\/tkda.2021.34846","article-title":"Spontaneous right coronary artery dissection in a patient with COVID-19 infection: A case report and review of the literature","volume":"49","author":"Emren","year":"2021","journal-title":"Turk. Kardiyol. Dern. Arsivi"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"A94","DOI":"10.1016\/j.chest.2021.07.121","article-title":"Spontaneous Coronary Artery Dissection: A Rare Sequela of COVID-19","volume":"160","author":"Ahmad","year":"2021","journal-title":"Chest"},{"key":"ref_31","first-page":"e26479","article-title":"Spontaneous Coronary Artery Dissection Following SARS-CoV-2-Associated Multisystem Inflammatory Syndrome","volume":"14","author":"Pettinato","year":"2022","journal-title":"Cureus"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/j.jcin.2020.04.006","article-title":"Spontaneous Coronary Artery Dissection in a Patient with COVID-19","volume":"13","author":"Courand","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1093\/eurheartj\/ehaa813","article-title":"Spontaneous coronary artery dissection after COVID-19 infection presenting with ST segment elevation","volume":"41","author":"Cannata","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjcr\/ytaa133","article-title":"Atherosclerotic spontaneous coronary artery dissection (A-SCAD) in a patient with COVID-19: Case report and possible mechanisms","volume":"4","author":"Albiero","year":"2020","journal-title":"Eur. Heart J. Case Rep."},{"key":"ref_35","first-page":"e37274","article-title":"The Coronavirus Double Threat: A Rare Presentation of Chest Pain in a Young Female","volume":"15","author":"Bashir","year":"2023","journal-title":"Cureus"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e6399","DOI":"10.1002\/ccr3.6399","article-title":"Spontaneous coronary artery dissection in a patient with recent COVID-19 infection: A case report","volume":"10","author":"Fakhrabadi","year":"2022","journal-title":"Clin. Case Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"E249","DOI":"10.1002\/ccd.28960","article-title":"Spontaneous coronary artery dissection of the left anterior descending artery in a patient with COVID-19 infection","volume":"97","author":"Kumar","year":"2021","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1093\/eurheartj\/ehaa400","article-title":"Multivessel spontaneous coronary artery dissection presenting in a patient with severe acute SARS-CoV-2 respiratory infection","volume":"41","author":"Gasso","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/MCA.0000000000000991","article-title":"Spontaneous coronary artery dissection in a patient with COVID-19","volume":"32","author":"Papanikolaou","year":"2021","journal-title":"Coron. Artery Dis."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Papageorgiou, A., Moulias, A., Papageorgiou, A., Karampitsakos, T., Apostolos, A., Tsigkas, G., and Davlouros, P. (2024, February 18). Spontaneous Coronary Artery Dissection as a Cause of Acute Myocardial Infarction in COVID-19 Patients: A Case Report and Review of the Literature. Available online: http:\/\/www.preprints.org.","DOI":"10.20944\/preprints202311.1941.v1"},{"key":"ref_41","first-page":"e40906","article-title":"Spontaneous Coronary Artery Dissection (SCAD) in an Atypical Patient without Risk Factors and Prior Asymptomatic COVID-19 Infection","volume":"25","author":"Shah","year":"2023","journal-title":"Cureus"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"A283","DOI":"10.1016\/j.chest.2022.08.215","article-title":"Case Report of Spontaneous Coronary Artery Dissection in a Patient Positive for COVID-19","volume":"162","author":"Lewars","year":"2022","journal-title":"Chest"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1016\/j.jcmg.2019.01.015","article-title":"Spontaneous Coronary Artery Dissection: Pathophysiological Insights from Optical Coherence Tomography","volume":"12","author":"Jackson","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11936-018-0622-2","article-title":"Spontaneous Coronary Artery Dissection: Diagnosis and Management","volume":"20","author":"Yeo","year":"2018","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1161\/CIRCULATIONAHA.112.105718","article-title":"Clinical features, management, and prognosis of spontaneous coronary artery dissection","volume":"126","author":"Tweet","year":"2012","journal-title":"Circulation"},{"key":"ref_46","first-page":"147","article-title":"Consensus of Chinese experts on diagnosis and treatment processes of acute myocardial infarction in the context of prevention and control of COVID-19 (first edition)","volume":"40","author":"Bu","year":"2020","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Qiu, L., Li, J., Yan, H., Guo, H., Song, D., and Su, X. (2022). Discussion on the causes of thrombolysis failure in a patient with STEMI: A case report. BMC Cardiovasc. Disord., 22.","DOI":"10.1186\/s12872-022-02922-0"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jacc.2020.04.039","article-title":"Management of Acute Myocardial Infarction during the COVID-19 Pandemic: A Position Statement from the Society for Cardiovascular Angiography and Interventions (SCAI), the American College of Cardiology (ACC), and the American College of Emergency Physicians (ACEP)","volume":"76","author":"Mahmud","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.jcin.2017.05.039","article-title":"Pulse on Spontaneous Coronary Artery Dissections: Experience Based Survey","volume":"10","author":"Buccheri","year":"2017","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1093\/eurheartj\/ehab372","article-title":"Antiplatelet therapy in patients with conservatively managed spontaneous coronary artery dissection from the multicentre DISCO registry","volume":"42","author":"Cerrato","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.thromres.2020.06.029","article-title":"The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management","volume":"194","author":"Diamond","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_52","first-page":"e23069","article-title":"Spontaneous Coronary Artery Dissection in the Setting of COVID-19 Pandemic-Related Stressors: A Case Report","volume":"14","author":"Roche","year":"2022","journal-title":"Cureus"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/3\/315\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:06:10Z","timestamp":1760105170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/3\/315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["life14030315"],"URL":"https:\/\/doi.org\/10.3390\/life14030315","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,28]]}}}