{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:24:22Z","timestamp":1790267062711,"version":"4.1.0"},"reference-count":122,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Gender Medicine has had an enormous expansion over the last ten years. Autoimmune liver diseases include several conditions, i.e., autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and conditions involving the liver or biliary tree overlapping with AIH, as well as IgG4-related disease. However, little is known about the impact of sex in the pathogenesis and natural history of these conditions. The purpose of this review is to provide an update of the gender disparities among the autoimmune liver diseases by reviewing the data published from 1999 to 2023. The epidemiology of these diseases has been changing over the last years, due to the amelioration of knowledge in their diagnosis, pathogenesis, and treatment. The clinical data collected so far support the existence of sex differences in the natural history of autoimmune liver diseases. Notably, their history could be longer than that which is now known, with problems being initiated even at a pediatric age. Moreover, gender disparity has been observed during the onset of complications related to end-stage liver disease, including cancer incidence. However, there is still an important debate among researchers about the impact of sex and the pathogenesis of these conditions. With this review, we would like to emphasize the urgency of basic science and clinical research to increase our understanding of the sex differences in autoimmune liver diseases.<\/jats:p>","DOI":"10.3390\/life14040500","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T11:09:20Z","timestamp":1712920160000},"page":"500","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Are Gender Differences Important for Autoimmune Liver Diseases?"],"prefix":"10.3390","volume":"14","author":[{"given":"Annarosa","family":"Floreani","sequence":"first","affiliation":[{"name":"Scientific Consultant IRCCS Negrar, 37024 Verona, Italy"},{"name":"University of Padova, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2247-8227","authenticated-orcid":false,"given":"Daniela","family":"Gabbia","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6398-8237","authenticated-orcid":false,"given":"Sara","family":"De Martin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/hep.32743","article-title":"Health disparities in chronic liver disease","volume":"77","author":"Kardashian","year":"2023","journal-title":"Hepatology"},{"key":"ref_2","first-page":"25","article-title":"Meeting Individual Social Needs Falls Short of Addressing Social Determinants of Health","volume":"77","author":"Castrucci","year":"2019","journal-title":"Health Aff. Forefr."},{"key":"ref_3","first-page":"146","article-title":"A sex and gender perspective in medicine: A new mandatory challenge for human health. Preface","volume":"52","author":"Ortona","year":"2016","journal-title":"Ann. Ist. Super. Sanita"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41467-019-08475-9","article-title":"Population-wide analysis of differences in disease progression patterns in men and women","volume":"10","author":"Westergaard","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sayaf, K., Gabbia, D., Russo, F.P., and De Martin, S. (2022). The Role of Sex in Acute and Chronic Liver Damage. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810654"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sayaf, K., Zanotto, I., Gabbia, D., Alberti, D., Pasqual, G., Zaramella, A., Fantin, A., De Martin, S., and Russo, F.P. (2023). Sex Drives Functional Changes in the Progression and Regression of Liver Fibrosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216452"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1515\/cclm-2012-0849","article-title":"Gender medicine: A task for the third millennium","volume":"51","author":"Baggio","year":"2013","journal-title":"Clin. Chem. Lab. Med. CCLM"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.jhep.2015.03.005","article-title":"Autoimmune hepatitis\u2014Update 2015","volume":"62","author":"Manns","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jhep.2013.10.020","article-title":"Autoimmune hepatitis in Denmark: Incidence, prevalence, prognosis, and causes of death. A nationwide registry-based cohort study","volume":"60","author":"Vilstrup","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/hep.32653","article-title":"Sociodemographic and geographic differences in the US epidemiology of autoimmune hepatitis with and without cirrhosis","volume":"77","author":"Bittermann","year":"2023","journal-title":"Hepatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cld.2023.06.003","article-title":"Autoimmune Hepatitis","volume":"28","author":"Yuming","year":"2024","journal-title":"Clin. Liver Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4254\/wjh.v6.i4.160","article-title":"Drug-induced autoimmune liver disease: A diagnostic dilemma of an increasingly reported disease","volume":"6","author":"Castiella","year":"2014","journal-title":"World J. Hepatol."},{"key":"ref_13","first-page":"59174","article-title":"Induction of Drug-Induced, Autoimmune Hepatitis in BALB\/c Mice for the Study of Its Pathogenic Mechanisms","volume":"159","author":"Thomas","year":"2020","journal-title":"J. Vis. Exp."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Cho, J., Kim, L., Li, Z., Rose, N.R., Talor, M.V., and Njoku, D.B. (2013). Sex bias in experimental immune-mediated, drug-induced liver injury in BALB\/c mice: Suggested roles for Tregs, estrogen, and IL-6. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061186"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1572-0241.2006.00479.x","article-title":"Pregnancy in Autoimmune Hepatitis: Outcome and Risk Factors","volume":"101","author":"Schramm","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1111\/j.1572-0241.2002.07124.x","article-title":"Improvement of Autoimmune Hepatitis During Pregnancy Followed by Flare-Up After Delivery","volume":"97","author":"Buchel","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/gut.48.1.97","article-title":"Management and outcome of pregnancy in autoimmune hepatitis","volume":"48","author":"Heneghan","year":"2001","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1365-2796.2002.01047.x","article-title":"Development of liver dysfunction after delivery is possibly due to postpartum autoimmune hepatitis. A report of three cases","volume":"252","author":"Izumi","year":"2002","journal-title":"J. Intern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"J239","DOI":"10.1016\/j.jaut.2011.12.002","article-title":"Outcomes of pregnancy in women with autoimmune hepatitis","volume":"38","author":"Westbrook","year":"2012","journal-title":"J. Autoimmun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.4049\/jimmunol.175.8.5050","article-title":"Estrogen Enhances Susceptibility to Experimental Autoimmune Myasthenia Gravis by Promoting Type 1-Polarized Immune Responses","volume":"175","author":"Delpy","year":"2005","journal-title":"J. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5459","DOI":"10.4049\/jimmunol.1203312","article-title":"Estradiol Promotes Functional Responses in Inflammatory and Steady-State Dendritic Cells through Differential Requirement for Activation Function-1 of Estrogen Receptor \u03b1","volume":"190","author":"Seillet","year":"2013","journal-title":"J. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.4049\/jimmunol.180.3.1423","article-title":"17\u03b2-Estradiol Alters the Activity of Conventional and IFN-Producing Killer Dendritic Cells","volume":"180","author":"Siracusa","year":"2008","journal-title":"J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/jnr.10409","article-title":"Estrogen inhibition of EAE involves effects on dendritic cell function","volume":"70","author":"Liu","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.4049\/jimmunol.1001322","article-title":"Estriol Generates Tolerogenic Dendritic Cells In Vivo That Protect against Autoimmunity","volume":"186","author":"Papenfuss","year":"2011","journal-title":"J. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4049\/jimmunol.162.1.35","article-title":"Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells","volume":"162","author":"Bebo","year":"1999","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.4049\/jimmunol.1400076","article-title":"Testosterone Suppresses Hepatic Inflammation by the Downregulation of IL-17, CXCL-9, and CXCL-10 in a Mouse Model of Experimental Acute Cholangitis","volume":"194","author":"Schwinge","year":"2015","journal-title":"J. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.4049\/jimmunol.167.4.2060","article-title":"Testosterone Acts Directly on CD4+ T Lymphocytes to Increase IL-10 Production","volume":"167","author":"Liva","year":"2001","journal-title":"J. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.3389\/fimmu.2020.01567","article-title":"The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases?","volume":"11","author":"Henze","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Meester, I., Manilla-Mu\u00f1oz, E., Le\u00f3n-Cach\u00f3n, R.B.R., Paniagua-Frausto, G.A., Carri\u00f3n-Alvarez, D., Ruiz-Rodr\u00edguez, C.O., Rodr\u00edguez-Rangel, X., and Garc\u00eda-Mart\u00ednez, J.M. (2020). SeXY chromosomes and the immune system: Reflections after a comparative study. Biol. Sex Differ., 11.","DOI":"10.1186\/s13293-019-0278-y"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jaut.2012.11.002","article-title":"Autoimmune hepatitis: A comprehensive review","volume":"41","author":"Liberal","year":"2013","journal-title":"J. Autoimmun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jhep.2007.08.013","article-title":"Impact of gender on the long-term outcome and survival of patients with autoimmune hepatitis","volume":"48","author":"Underhill","year":"2008","journal-title":"J. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1111\/j.1572-0241.2002.05921.x","article-title":"Gender effects and synergisms with histocompatibility leukocyte antigens in type 1 autoimmune hepatitis","volume":"97","author":"Czaja","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cgh.2007.12.048","article-title":"Genetic Factors Affecting the Occurrence, Clinical Phenotype, and Outcome of Autoimmune Hepatitis","volume":"6","author":"Czaja","year":"2008","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3748\/wjg.15.1025","article-title":"Influence of genes, sex, age and environment on the onset of autoimmune hepatitis","volume":"15","author":"Lapierre","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0140-6736(95)91438-2","article-title":"Epstein-Barr virus as a trigger for autoimmune hepatitis in susceptible individuals","volume":"346","author":"Vento","year":"1995","journal-title":"Lancet"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/01.gme.0000142914.55849.6a","article-title":"Autoimmune hepatitis associated with the use of black cohosh: A case study","volume":"11","author":"Cohen","year":"2004","journal-title":"Menopause"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/00004836-200609000-00018","article-title":"Autoimmune Hepatitis Triggered by Statins","volume":"40","author":"Alla","year":"2006","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1007\/s10620-023-07967-5","article-title":"Incorporating the Molecular Mimicry of Environmental Antigens into the Causality of Autoimmune Hepatitis","volume":"68","author":"Czaja","year":"2023","journal-title":"Dig. Dis. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.molmed.2020.04.001","article-title":"The Gut Microbiota: Emerging Evidence in Autoimmune Diseases","volume":"26","author":"Zhang","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"910561","DOI":"10.3389\/fmed.2022.910561","article-title":"Mini-Review: Gut-Microbiota and the Sex-Bias in Autoimmunity\u2014Lessons Learnt From Animal Models","volume":"9","author":"Rosser","year":"2022","journal-title":"Front. Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Cheng, Z., Yang, L., and Chu, H. (2022). The Gut Microbiota: A Novel Player in Autoimmune Hepatitis. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.947382"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1002\/hep.27998","article-title":"A novel \u201chumanized mouse\u201d model for autoimmune hepatitis and the association of gut microbiota with liver inflammation","volume":"62","author":"Yuksel","year":"2015","journal-title":"Hepatology"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhu, N., Su, X., Gao, Y., and Yang, R. (2023). Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis. Cells, 12.","DOI":"10.3390\/cells12050793"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"980768","DOI":"10.3389\/fimmu.2022.980768","article-title":"HLA, gut microbiome and hepatic autoimmunity","volume":"13","author":"Vergani","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Fu, Y., Li, J., Zhu, Y., Chen, C., Liu, J., Gu, S., Zheng, Y., and Li, Y. (2023). Causal effects of gut microbiome on autoimmune liver disease: A two-sample Mendelian randomization study. BMC Med. Genom., 16.","DOI":"10.1186\/s12920-023-01670-0"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1111\/liv.15382","article-title":"Extrahepatic autoimmune diseases in autoimmune hepatitis: Effect on mortality","volume":"42","author":"Jensen","year":"2022","journal-title":"Liver Int."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/flgastro-2022-102113","article-title":"Clinical implications of gender and race in patients admitted with autoimmune hepatitis: Updated analysis of US hospitals","volume":"14","author":"Lee","year":"2023","journal-title":"Frontline Gastroenterol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.14309\/ajg.0000000000001525","article-title":"Increased Cancer Risk in Autoimmune Hepatitis: A Danish Nationwide Cohort Study","volume":"117","author":"Jensen","year":"2022","journal-title":"Am. J. Gastroenterol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s12072-021-10249-9","article-title":"Sex and regional disparities in incidence of hepatocellular carcinoma in autoimmune hepatitis: A systematic review and meta-analysis","volume":"15","author":"Yan","year":"2021","journal-title":"Hepatol. Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2125.2009.03587.x","article-title":"Fluvoxamine pharmacokinetics in healthy elderly subjects and elderly patients with chronic heart failure","volume":"69","author":"Orlando","year":"2010","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.3748\/wjg.v22.i3.1260","article-title":"Pharmacokinetic drug interactions in liver disease: An update","volume":"22","author":"Palatini","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"100094","DOI":"10.1016\/j.jhepr.2020.100094","article-title":"Features and outcome of AIH patients without elevation of IgG","volume":"2","author":"Hartl","year":"2020","journal-title":"JHEP Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7519","DOI":"10.3748\/wjg.v23.i42.7519","article-title":"Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis","volume":"23","author":"Gabbia","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.cgh.2023.02.005","article-title":"New Treatment Paradigms in Primary Biliary Cholangitis","volume":"21","author":"Levy","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Floreani, A., Gabbia, D., and De Martin, S. (2024). Current Perspectives on the Molecular and Clinical Relationships between Primary Biliary Cholangitis and Hepatocellular Carcinoma. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042194"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1080\/17474124.2023.2242771","article-title":"Primary biliary cholangitis: Primary autoimmune disease or primary secretory defect","volume":"17","author":"Floreani","year":"2023","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_58","first-page":"266","article-title":"Increased cancer risk in a large population-based cohort of patients with primary biliary cirrhosis: Follow-up for up to 36 years","volume":"8","author":"Boonstra","year":"2014","journal-title":"Hepatol. Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.cgh.2017.10.018","article-title":"Factors Associated with Prevalence and Treatment of Primary Biliary Cholangitis in United States Health Systems","volume":"16","author":"Lu","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhep.2017.03.022","article-title":"EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis","volume":"67","author":"Hirschfield","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"J109","DOI":"10.1016\/j.jaut.2011.10.003","article-title":"Autoimmune disease and gender: Plausible mechanisms for the female predominance of autoimmunity","volume":"38","author":"Quintero","year":"2012","journal-title":"J. Autoimmun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.3389\/fimmu.2019.02815","article-title":"Abnormal Expression of ER\u03b1 in Cholangiocytes of Patients with Primary Biliary Cholangitis Mediated Intrahepatic Bile Duct Inflammation","volume":"10","author":"Cao","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.3748\/wjg.v12.i22.3537","article-title":"Estrogens and the pathophysiology of the biliary tree","volume":"12","author":"Alvaro","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"ref_64","first-page":"185","article-title":"The effect of estradiol, but not progesterone, on the production of cytokines in stimulated whole blood, is concentration-dependent","volume":"24","author":"Matalka","year":"2003","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/hep.28641","article-title":"Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance","volume":"64","author":"Bae","year":"2016","journal-title":"Hepatology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/hep.29524","article-title":"The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity","volume":"67","author":"Bae","year":"2018","journal-title":"Hepatology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/hep.29625","article-title":"Female preponderance of primary biliary cholangitis is all about our understanding of its autoimmune nature","volume":"67","author":"Carbone","year":"2018","journal-title":"Hepatology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jhep.2004.08.022","article-title":"Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis","volume":"41","author":"Alvaro","year":"2004","journal-title":"J. Hepatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"G981","DOI":"10.1152\/ajpgi.00061.2011","article-title":"Castration inhibits biliary proliferation induced by bile duct obstruction: Novel role for the autocrine trophic effect of testosterone","volume":"301","author":"Yang","year":"2011","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fmed.2020.00117","article-title":"New Therapeutic Targets in Autoimmune Cholangiopathies","volume":"7","author":"Gerussi","year":"2020","journal-title":"Front. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1053\/j.gastro.2021.02.061","article-title":"X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis","volume":"160","author":"Asselta","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/cei.13288","article-title":"The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases","volume":"197","author":"Mohr","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s10620-020-06402-3","article-title":"Gender and Racial Differences in Hospitalizations for Primary Biliary Cholangitis in the USA","volume":"66","author":"Adejumo","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"ref_74","first-page":"896","article-title":"New insights into sex differences in primary biliary cholangitis. Gender difference in primary biliary cholangitis","volume":"72","author":"Wu","year":"2022","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.cld.2022.06.011","article-title":"Hepatocellular Carcinoma in Primary Biliary Cholangitis","volume":"26","author":"Sy","year":"2022","journal-title":"Clin. Liver Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/gutjnl-2014-308351","article-title":"Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: A multicentre international study","volume":"65","author":"Trivedi","year":"2016","journal-title":"Gut"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Floreani, A., Gabbia, D., and De Martin, S. (2022). Obeticholic Acid for Primary Biliary Cholangitis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10102464"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1053\/j.gastro.2018.08.065","article-title":"Epidemiology and Management of Hepatocellular Carcinoma","volume":"156","author":"Kulik","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000315247","article-title":"Gender disparity of hepatocellular carcinoma: The roles of sex hormones","volume":"78","author":"Yeh","year":"2010","journal-title":"Oncology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/21678707.2020.1865917","article-title":"Gut microbial profiling as a therapeutic and diagnostic target for managing primary biliary cholangitis","volume":"8","author":"Floreani","year":"2020","journal-title":"Expert Opin. Orphan Drugs"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"100286","DOI":"10.1016\/j.jhepr.2021.100286","article-title":"Cholangiocyte senescence in primary sclerosing cholangitis is associated with disease severity and prognosis","volume":"3","author":"Cazzagon","year":"2021","journal-title":"JHEP Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0140-6736(13)60096-3","article-title":"Primary sclerosing cholangitis","volume":"382","author":"Hirschfield","year":"2013","journal-title":"Lancet"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1053\/j.gastro.2021.08.032","article-title":"Prevalence of Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis","volume":"161","author":"Barberio","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1111\/liv.15339","article-title":"Prevalence of inflammatory bowel disease in patients with primary sclerosing cholangitis: A systematic review and meta-analysis","volume":"42","author":"Zhang","year":"2022","journal-title":"Liver Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/hep.24247","article-title":"Incidence of primary sclerosing cholangitis: A systematic review and meta-analysis","volume":"53","author":"Molodecky","year":"2011","journal-title":"Hepatology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.cgh.2021.08.039","article-title":"Epidemiology, Natural History, and Outcomes of Primary Sclerosing Cholangitis: A Systematic Review of Population-based Studies","volume":"20","author":"Trivedi","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3350\/cmh.2020.0028","article-title":"Current understanding of primary biliary cholangitis","volume":"27","author":"Tanaka","year":"2021","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1053\/j.gastro.2017.02.038","article-title":"Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate with Course of Primary Sclerosing Cholangitis","volume":"152","author":"Trivedi","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Friedrich, K., Rupp, C., Hov, J.R., Steinebrunner, N., Weiss, K.-H., Stiehl, A., Brune, M., Schaefer, P.K.Y., Schemmer, P., and Sauer, P. (2013). A Frequent PNPLA3 Variant Is a Sex Specific Disease Modifier in PSC Patients with Bile Duct Stenosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058734"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/apt.15375","article-title":"Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis","volume":"50","author":"Liwinski","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1136\/gutjnl-2015-311004","article-title":"Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD","volume":"65","author":"Sabino","year":"2016","journal-title":"Gut"},{"key":"ref_92","first-page":"E2","article-title":"The intestinal microbiota of patients with PSC are different from healthy controls and patients with ulcerative colitis across geographical regions","volume":"56","author":"Liwinski","year":"2018","journal-title":"Z. F\u00fcr Gastroenterol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hep.510280203","article-title":"Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome: Clinical features and response to therapy: Primary Biliary Cirrhosis-Autoimmune Hepatitis Overlap Syndrome: Clinical Features and Response to Therapy","volume":"28","author":"Wendum","year":"1998","journal-title":"Hepatology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/hep.25788","article-title":"Primary biliary cirrhosis and cancer risk: A systematic review and meta-analysis","volume":"56","author":"Liang","year":"2012","journal-title":"Hepatology"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Freedman, B.L., Danford, C.J., Patwardhan, V., and Bonder, A. (2020). Treatment of Overlap Syndromes in Autoimmune Liver Disease: A Systematic Review and Meta-Analysis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051449"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/hep.29204","article-title":"The natural history of primary sclerosing cholangitis in 781 children: A multicenter, international collaboration","volume":"66","author":"Deneau","year":"2017","journal-title":"Hepatology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2001.22131","article-title":"Autoimmune hepatitis\/sclerosing cholangitis overlap syndrome in childhood: A 16-year prospective study","volume":"33","author":"Gregorio","year":"2001","journal-title":"Hepatology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jhep.2023.02.030","article-title":"Primary sclerosing cholangitis and overlap features of autoimmune hepatitis: A coming of age or an age-ist problem?","volume":"79","author":"Ricciuto","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"m1067","DOI":"10.1136\/bmj.m1067","article-title":"Advances in the diagnosis and management of IgG4 related disease","volume":"369","author":"Lanzillotta","year":"2020","journal-title":"BMJ"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1093\/rheumatology\/key397","article-title":"Sex disparities in clinical characteristics and prognosis of immunoglobulin G4-related disease: A prospective study of 403 patients","volume":"58","author":"Wang","year":"2019","journal-title":"Rheumatol. Oxf. Engl."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12969-016-0079-3","article-title":"IgG4-related disease: A systematic review of this unrecognized disease in pediatrics","volume":"14","author":"Karim","year":"2016","journal-title":"Pediatr. Rheumatol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/RHU.0000000000001858","article-title":"Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype","volume":"28","author":"Baenas","year":"2022","journal-title":"JCR J. Clin. Rheumatol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.jhep.2023.08.005","article-title":"IgG4-related cholangitis\u2014A mimicker of fibrosing and malignant cholangiopathies","volume":"79","author":"Kersten","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jaut.2018.10.007","article-title":"Juvenile autoimmune hepatitis: A comprehensive review","volume":"95","author":"Sokollik","year":"2018","journal-title":"J. Autoimmun."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Afaa, T.J., Amegan-Aho, K.H., Dono, M.T., Odei, E., and Awuku, Y.A. (2020). Clinical characteristics of paediatric autoimmune hepatitis at a referral hospital in Sub Saharan Africa. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0239964"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"149","DOI":"10.47892\/rgp.2020.402.1083","article-title":"Clinical and laboratory data in pediatric autoimmune hepatitis: Study from referral center in Iran","volume":"40","author":"Haghighat","year":"2020","journal-title":"Rev. Gastroenterol. Peru Organo Of. Soc. Gastroenterol. Peru"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ajg.2021.05.009","article-title":"Paediatric autoimmune liver diseases: A descriptive study of patients from Saudi Arabia","volume":"22","author":"Saadah","year":"2021","journal-title":"Arab J. Gastroenterol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"205873842110732","DOI":"10.1177\/20587384211073265","article-title":"Autoimmune hepatitis in Egyptian children: A single center experience","volume":"36","author":"Mogahed","year":"2022","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e223","DOI":"10.1097\/PG9.0000000000000223","article-title":"The Epidemiology of Pediatric Autoimmune Hepatitis in Scotland: A National Cohort Study","volume":"3","author":"Sutton","year":"2022","journal-title":"JPGN Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"40102","DOI":"10.57187\/smw.2023.40102","article-title":"Epidemiology, clinical features and management of autoimmune hepatitis in Switzerland: A retrospective and prospective cohort study","volume":"153","author":"Ludz","year":"2023","journal-title":"Swiss Med. Wkly."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Altamimi, E., Al Omari, D., Obeidat, H., and Barham, K. (2024). Retrospective, single-center analysis of autoimmune hepatitis in Jordanian children: Clinical features, treatments, and outcomes. BMC Pediatr., 24.","DOI":"10.1186\/s12887-024-04590-9"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"100901","DOI":"10.1016\/j.jhepr.2023.100901","article-title":"Biliary disease progression in childhood onset autoimmune liver disease: A 30-year follow-up into adulthood","volume":"6","author":"Warner","year":"2024","journal-title":"JHEP Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jhep.2023.01.013","article-title":"Long-term outcomes of patients with type 1 or 2 autoimmune hepatitis presenting in childhood","volume":"78","author":"Maggiore","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.gastro.2003.08.022","article-title":"Pediatric-onset primary biliary cirrhosis","volume":"125","author":"Dahlan","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.dld.2006.03.001","article-title":"Primary biliary cirrhosis: When and why does the disease develop?","volume":"38","author":"Floreani","year":"2006","journal-title":"Dig. Liver Dis."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Invernizzi, P., Alessio, M.G., Smyk, D.S., Lleo, A., Sonzogni, A., Fabris, L., Candusso, M., Bogdanos, D.P., Iorio, R., and Torre, G. (2012). Autoimmune hepatitis type 2 associated with an unexpected and transient presence of primary biliary cirrhosis-specific antimitochondrial antibodies: A case study and review of the literature. BMC Gastroenterol., 12.","DOI":"10.1186\/1471-230X-12-92"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"106215","DOI":"10.1016\/j.ijscr.2021.106215","article-title":"Primary biliary cirrhosis in early childhood\u2014A rare case report","volume":"85","author":"Ullah","year":"2021","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/MOG.0b013e3283388f5b","article-title":"Unique features of primary sclerosing cholangitis in children","volume":"26","author":"Vergani","year":"2010","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cld.2015.08.008","article-title":"Sclerosing Cholangitis in Children and Adolescents","volume":"20","author":"Vergani","year":"2016","journal-title":"Clin. Liver Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.dld.2021.06.028","article-title":"Cutting edge issues in juvenile sclerosing cholangitis","volume":"54","author":"Vergani","year":"2022","journal-title":"Dig. Liver Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jaut.2018.10.008","article-title":"Autoimmune sclerosing cholangitis: Evidence and open questions","volume":"95","author":"Vergani","year":"2018","journal-title":"J. Autoimmun."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/j.1572-0241.1999.01229.x","article-title":"Genetic Heterogeneity in Susceptibility to Autoimmune Hepatitis Types 1 and 2","volume":"94","author":"Bittencourt","year":"1999","journal-title":"Am. J. Gastroenterol."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/4\/500\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:27:21Z","timestamp":1760106441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/4\/500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":122,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["life14040500"],"URL":"https:\/\/doi.org\/10.3390\/life14040500","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,12]]}}}