{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:48:20Z","timestamp":1791726500149,"version":"4.3.4"},"reference-count":76,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dunarea de Jos University of Galati"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>(1) Background: Madelung\u2019s disease\u2014known also as Benign Symmetric Adenolipomatosis (BSA) or Multiple Symmetric Lipomatosis (MSL), is a rare subcutaneous tissue disease characterized by the proliferation of non-encapsulated fat tissue with mature adipocytes. Patients develop symmetrical fatty deposits of varying sizes, (located particularly around the neck, shoulders, upper and middle back, arms, abdomen, and thighs), having clinical, esthetic, and psychiatric repercussions. (2) Methods: We report a case diagnosed with BSA upon admission to the Neurological and Internal Medicine Departments of the Emergency Clinical Hospital of Galati. (3) Results: This patient developed compressive phenomena and liposarcoma with liver metastasis, followed by death shortly after hospital presentation. The histopathology examination confirmed right latero-cervical liposarcoma and round cell hepatic metastasis. The specific metabolic ethiopathogenic mechanism has not been elucidated, but the adipocytes of BSA are different from normal cells in proliferation, hormonal regulation, and mitochondrial activity; a rare mitochondrial gene mutation, together with other interacting genetic or non-genetic factors, have been considered in recent studies. A thorough literature search identified only three cases reporting malignant tumors in BSA patients. (4) Conclusions: The goal of our paper is to present this rare case in the oncogenic synergism of two tumors. In the management of this BSA disorder, possible malignant transformation should be considered, although only scarce evidence was found supporting this.<\/jats:p>","DOI":"10.3390\/life14040521","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T08:22:44Z","timestamp":1713342164000},"page":"521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Madelung\u2019s Disease Evolving to Liposarcoma: An Uncommon Encounter"],"prefix":"10.3390","volume":"14","author":[{"given":"Mihaiela","family":"Lungu","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"\u201cSt. Ap. Andrei\u201d Clinical County Emergency Hospital, 800579 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0871-1339","authenticated-orcid":false,"given":"Violeta Diana","family":"Oprea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"\u201cSt. Ap. Andrei\u201d Clinical County Emergency Hospital, 800579 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8211-505X","authenticated-orcid":false,"given":"Gabriela","family":"Stoleriu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"\u201cSt. Spiridon\u201d Clinical Emergency County Hospital Iasi, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Maria","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Ovidius University of Constan\u021ba, 900470 Constan\u021ba, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0986-8056","authenticated-orcid":false,"given":"Andrei Lucian","family":"Zaharia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"\u201cSt. Ap. Andrei\u201d Clinical County Emergency Hospital, 800579 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3944-7263","authenticated-orcid":false,"given":"Ana","family":"Croitoru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"\u201cSt. Ap. Andrei\u201d Clinical County Emergency Hospital, 800579 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Stan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"\u201cSt. Ap. Andrei\u201d Clinical County Emergency Hospital, 800579 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9249-5247","authenticated-orcid":false,"given":"Elena","family":"Niculet","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800008 Galati, Romania"},{"name":"\u201cSt. Ap. Andrei\u201d Clinical County Emergency Hospital, 800579 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00266-012-9874-5","article-title":"Madelung\u2019s disease: Comorbidities, fatty mass distribution, and response to treatment of 22 patients","volume":"37","year":"2013","journal-title":"Aesthetic Plast. 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