{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:54:25Z","timestamp":1774511665996,"version":"3.50.1"},"reference-count":146,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Post-traumatic osteoporosis (PTO) presents a significant challenge in clinical practice, characterized by demineralization and decreased skeletal integrity following severe traumatic injuries. This literature review manuscript addresses the knowledge gaps surrounding PTO, encompassing its epidemiology, pathophysiology, risk factors, diagnosis, treatment, prognosis, and future directions. This review emphasizes the complexity of the etiology of PTO, highlighting the dysregulation of biomineralization processes, inflammatory cytokine involvement, hormonal imbalances, glucocorticoid effects, vitamin D deficiency, and disuse osteoporosis. Moreover, it underscores the importance of multidisciplinary approaches for risk mitigation and advocates for improved diagnostic strategies to differentiate PTO from other musculoskeletal pathologies. This manuscript discusses various treatment modalities, including pharmacotherapy, dietary management, and physical rehabilitation, while also acknowledging the limited evidence on their long-term effectiveness and outcomes in PTO patients. Future directions in research are outlined, emphasizing the need for a deeper understanding of the molecular mechanisms underlying PTO and the evaluation of treatment strategies\u2019 efficacy. Overall, this review provides a comprehensive overview of PTO and highlights avenues for future investigation to enhance clinical management and patient outcomes.<\/jats:p>","DOI":"10.3390\/life14050561","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T10:33:31Z","timestamp":1714559611000},"page":"561","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Navigating Post-Traumatic Osteoporosis: A Comprehensive Review of Epidemiology, Pathophysiology, Diagnosis, Treatment, and Future Directions"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6127-7626","authenticated-orcid":false,"given":"Matthew B.","family":"Weiss","sequence":"first","affiliation":[{"name":"School of Medicine, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0032-5310","authenticated-orcid":false,"given":"Shoaib A.","family":"Syed","sequence":"additional","affiliation":[{"name":"School of Medicine, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1670-4849","authenticated-orcid":false,"given":"Harris Z.","family":"Whiteson","sequence":"additional","affiliation":[{"name":"School of Medicine, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9304-9916","authenticated-orcid":false,"given":"Rahim","family":"Hirani","sequence":"additional","affiliation":[{"name":"School of Medicine, New York Medical College, Valhalla, NY 10595, USA"},{"name":"Graduate School of Biomedical Sciences, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-3986","authenticated-orcid":false,"given":"Mill","family":"Etienne","sequence":"additional","affiliation":[{"name":"School of Medicine, New York Medical College, Valhalla, NY 10595, USA"},{"name":"Department of Neurology, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj K.","family":"Tiwari","sequence":"additional","affiliation":[{"name":"School of Medicine, New York Medical College, Valhalla, NY 10595, USA"},{"name":"Graduate School of Biomedical Sciences, New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00000658-193301000-00004","article-title":"Post-Traumatic Painful Osteoporosis","volume":"97","author":"Fontaine","year":"1933","journal-title":"Ann. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00198-018-04818-2","article-title":"Risk of osteoporosis and fracture in victims with burn injury","volume":"30","author":"Kaewboonchoo","year":"2019","journal-title":"Osteoporos. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100743","DOI":"10.1016\/j.bonr.2020.100743","article-title":"Severe injury-induced osteoporosis and skeletal muscle mineralization: Are these related complications?","volume":"14","author":"Ihejirika","year":"2021","journal-title":"Bone Rep."},{"key":"ref_4","first-page":"437","article-title":"Principles of management of high-energy injuries of the leg","volume":"55","year":"2002","journal-title":"Med. Pregl."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00198-021-06208-7","article-title":"Determining the pharmacologic window of bisphosphonates that mitigates severe injury-induced osteoporosis and muscle calcification, while preserving fracture repair","volume":"33","author":"Saito","year":"2022","journal-title":"Osteoporos. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2050313x221129782","DOI":"10.1177\/2050313X221129782","article-title":"Calcaneal reconstruction using a femoral head allograft and biologic adjuncts: A case report","volume":"10","author":"Weiss","year":"2022","journal-title":"SAGE Open Med. Case Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ecl.2012.04.006","article-title":"Pathophysiology of osteoporosis: New mechanistic insights","volume":"41","author":"Armas","year":"2012","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/21556660.2019.1677674","article-title":"Impact of fractures on quality of life in patients with osteoporosis: A US cross-sectional survey","volume":"8","author":"Gold","year":"2019","journal-title":"J. Drug Assess."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11657-021-00969-8","article-title":"Osteoporosis in Europe: A compendium of country-specific reports","volume":"17","author":"Willers","year":"2022","journal-title":"Arch. Osteoporos."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00198-020-05756-8","article-title":"Osteoporosis case ascertainment strategies in European and Asian countries: A comparative review","volume":"32","author":"Burden","year":"2021","journal-title":"Osteoporos. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"909153","DOI":"10.1155\/2014\/909153","article-title":"Treatment for Osteoporosis among Women in Japan: Associations with Patient Characteristics and Patient-Reported Outcomes in the 2008\u20132011 Japan National Health and Wellness Surveys","volume":"2014","author":"Sato","year":"2014","journal-title":"J. Osteoporos."},{"key":"ref_12","first-page":"797","article-title":"Epidemiology of osteoporosis in Japan","volume":"22","author":"Iki","year":"2012","journal-title":"Clin. Calcium"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.afos.2018.03.003","article-title":"An updated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study","volume":"4","author":"Cheung","year":"2018","journal-title":"Osteoporos. Sarcopenia"},{"key":"ref_14","unstructured":"Office of the Surgeon General (US) (2004). Bone Health and Osteoporosis: A Report of the Surgeon General, Reports of the Surgeon General; Office of the Surgeon General (US)."},{"key":"ref_15","first-page":"S125","article-title":"Mortality and osteoporotic fractures: Is the link causal, and is it modifiable?","volume":"26","author":"Teng","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/jamainternmed.2014.2362","article-title":"Survival and functional outcomes after hip fracture among nursing home residents","volume":"174","author":"Neuman","year":"2014","journal-title":"JAMA Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/0002-9610(62)90256-8","article-title":"Extremity fractures of patients with spinal cord injuries","volume":"103","author":"Comarr","year":"1962","journal-title":"Am. J. Surg."},{"key":"ref_18","first-page":"418","article-title":"Lower extremity fractures after spinal cord injury: A retrospective study","volume":"62","author":"Ragnarsson","year":"1981","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_19","first-page":"133","article-title":"Lower limb fractures in the chronic spinal cord injured patient","volume":"27","author":"Ingram","year":"1989","journal-title":"Paraplegia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.sc.3100648","article-title":"Fracture rates and risk factors for fractures in patients with spinal cord injury","volume":"36","author":"Vestergaard","year":"1998","journal-title":"Spinal Cord."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1365-2265.2006.02683.x","article-title":"Mechanisms of osteoporosis in spinal cord injury","volume":"65","author":"Jiang","year":"2006","journal-title":"Clin. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.5694\/j.1326-5377.2004.tb05908.x","article-title":"Osteoporosis: Underrated, underdiagnosed and undertreated","volume":"180","author":"Nguyen","year":"2004","journal-title":"Med. J. Aust."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.beem.2014.07.002","article-title":"Secondary osteoporosis: Pathophysiology & diagnosis","volume":"28","author":"Emkey","year":"2014","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.molmed.2016.06.002","article-title":"Osteoporosis: The Result of an \u2018Aged\u2019 Bone Microenvironment","volume":"22","author":"Yu","year":"2016","journal-title":"Trends Mol. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cjtee.2017.05.003","article-title":"Interleukin-6 and interleukin-10 plasma levels and mRNA expression in polytrauma patients","volume":"20","author":"Sapan","year":"2017","journal-title":"Chin. J. Traumatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"528","DOI":"10.4103\/ijccm.IJCCM_442_17","article-title":"CD14+ Monocytic Cytokines: Impact on Outcome in Severely Injured Patients","volume":"22","author":"Bhardwaj","year":"2018","journal-title":"Indian. J. Crit. Care Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S8756-3282(03)00086-3","article-title":"Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease","volume":"33","author":"Bendre","year":"2003","journal-title":"Bone"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1172\/JCI200523394","article-title":"IL-1 mediates TNF-induced osteoclastogenesis","volume":"115","author":"Wei","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1242\/bio.20148128","article-title":"Autocrine signaling is a key regulatory element during osteoclastogenesis","volume":"3","author":"Kopesky","year":"2014","journal-title":"Biol. Open"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1136\/annrheumdis-2016-eular.5380","article-title":"AB0078 Role of IL-8 and Its Receptor in Anti-Citrullinated Protein Antibody Mediated Osteoclastogenesis in RA","volume":"75","author":"Liu","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.4110\/in.2018.18.e8","article-title":"Regulation of Osteoclast Differentiation by Cytokine Networks","volume":"18","author":"Amarasekara","year":"2018","journal-title":"Immune Netw."},{"key":"ref_32","first-page":"213","article-title":"TNF-\u03b1 and IL-6: The Link between Immune and Bone System","volume":"21","author":"Wang","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"ref_33","unstructured":"Feingold, K.R., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., Dungan, K., and Hofland, J. (2000). Endotext, MDText.com, Inc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000082360","article-title":"Glucocorticoid-induced osteoporosis: From basic mechanisms to clinical aspects","volume":"12","author":"Alesci","year":"2005","journal-title":"Neuroimmunomodulation"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"111036","DOI":"10.1016\/j.mce.2020.111036","article-title":"Characterization of the cortisol response to traumatic hemorrhage and intra-abdominal contamination models in Cynomologus Macaques","volume":"518","author":"Atwood","year":"2020","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_36","first-page":"3046","article-title":"Glucocorticoid receptor\u03b2 isoform exhibits a disproportionate increase over the \u03b1 isoform in the lungs of a polytrauma rat model","volume":"11","author":"Cheng","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1054\/ghir.1999.0133","article-title":"Protein metabolism and the use of growth hormone and insulin-like growth factor-I in the critically ill patient","volume":"9","author":"Carroll","year":"1999","journal-title":"Growth Horm. IGF Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ccc.2005.09.003","article-title":"Treatment with GH and IGF-1 in critical illness","volume":"22","author":"Hinds","year":"2006","journal-title":"Crit. Care Clin."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1210\/endo.137.1.8536635","article-title":"Stimulatory effect of growth hormone on bone resorption and osteoclast differentiation","volume":"137","author":"Nishiyama","year":"1996","journal-title":"Endocrinology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1017\/S0714980816000696","article-title":"Effects of Recombinant Human Growth Hormone for Osteoporosis: Systematic Review and Meta-Analysis","volume":"36","author":"Atkinson","year":"2017","journal-title":"Can. J. Aging"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/nm.2793","article-title":"Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells","volume":"18","author":"Xian","year":"2012","journal-title":"Nat. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/03008207.2017.1290085","article-title":"Osteoblast-osteoclast interactions","volume":"59","author":"Chen","year":"2018","journal-title":"Connect. Tissue Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2302\/kjm.38.262","article-title":"Endocrine changes after burn trauma\u2014A review","volume":"38","author":"Dolecek","year":"1989","journal-title":"Keio J. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/archsurg.133.11.1200","article-title":"Gender differences in human sepsis","volume":"133","author":"Kahlke","year":"1998","journal-title":"Arch. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.alcohol.2004.05.005","article-title":"Ethanol and burn injury: Estrogen modulation of immunity","volume":"33","author":"Kovacs","year":"2004","journal-title":"Alcohol"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1677\/joe.0.1640129","article-title":"Estrogen mediates the sex difference in post-burn immunosuppression","volume":"164","author":"Gregory","year":"2000","journal-title":"J. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1210\/jcem-64-4-842","article-title":"Effect of burn trauma on adrenal and testicular steroid hormone production","volume":"64","author":"Lephart","year":"1987","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1365-2265.1991.tb03771.x","article-title":"Serum androgens in intensive-care patients: Correlations with clinical findings","volume":"34","author":"Luppa","year":"1991","journal-title":"Clin. Endocrinol."},{"key":"ref_49","first-page":"171","article-title":"Sex steroid hormones in circulatory shock, sepsis syndrome, and septic shock","volume":"43","author":"Fourrier","year":"1994","journal-title":"Circ. Shock"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/00024382-199608000-00011","article-title":"Steroid hormone alterations following induction of chronic intraperitoneal sepsis in male rats","volume":"6","author":"Sharma","year":"1996","journal-title":"Shock"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1210\/endo-124-3-1576","article-title":"Androgens directly stimulate proliferation of bone cells in vitro","volume":"124","author":"Kasperk","year":"1989","journal-title":"Endocrinology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1359\/jbmr.1997.12.3.464","article-title":"Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro","volume":"12","author":"Kasperk","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/(SICI)1097-4644(19981001)71:1<96::AID-JCB10>3.0.CO;2-G","article-title":"Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line","volume":"71","author":"Hofbauer","year":"1998","journal-title":"J. Cell Biochem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3109\/13685538.2014.954995","article-title":"The effects of orchidectomy and supraphysiological testosterone administration on trabecular bone structure and gene expression in rats","volume":"18","author":"Chin","year":"2015","journal-title":"Aging Male"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2147\/CIA.S115472","article-title":"A concise review of testosterone and bone health","volume":"11","author":"Mohamad","year":"2016","journal-title":"Clin. Interv. Aging"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1159\/000371845","article-title":"The RANKL-RANK Story","volume":"61","author":"Nagy","year":"2015","journal-title":"Gerontology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"a031237","DOI":"10.1101\/cshperspect.a031237","article-title":"Regulation of Bone Remodeling by Parathyroid Hormone","volume":"8","author":"Wein","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_58","first-page":"100137","article-title":"High Rates of Vitamin D Deficiency in Acute Rehabilitation Patients","volume":"3","author":"Wu","year":"2021","journal-title":"Arch. Rehabil. Res. Clin. Transl."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/cphy.c140071","article-title":"PTH and Vitamin D","volume":"6","author":"Khundmiri","year":"2016","journal-title":"Compr. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00223-021-00836-1","article-title":"Disuse Osteoporosis: Clinical and Mechanistic Insights","volume":"110","author":"Rolvien","year":"2022","journal-title":"Calcif. Tissue Int."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1359\/jbmr.090411","article-title":"Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt\/beta-catenin signaling","volume":"24","author":"Lin","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: From human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1479164117738442","article-title":"Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases","volume":"15","author":"Ackers","year":"2018","journal-title":"Diab Vasc. Dis. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"eaau7137","DOI":"10.1126\/scitranslmed.aau7137","article-title":"Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand","volume":"10","author":"Luther","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e49631","DOI":"10.7554\/eLife.49631","article-title":"Stimulation of Piezo1 by mechanical signals promotes bone anabolism","volume":"8","author":"Li","year":"2019","journal-title":"Elife"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1359\/jbmr.060107","article-title":"Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss","volume":"21","author":"Aguirre","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/jbmr.2807","article-title":"Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs","volume":"31","author":"Majeska","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00198-006-0229-4","article-title":"Effects of spinal cord injury on osteoblastogenesis, osteoclastogenesis and gene expression profiling in osteoblasts in young rats","volume":"18","author":"Jiang","year":"2007","journal-title":"Osteoporos. Int."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/SLA.0b013e3181856241","article-title":"Pathophysiologic response to severe burn injury","volume":"248","author":"Jeschke","year":"2008","journal-title":"Ann. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e009395","DOI":"10.1136\/bmjopen-2015-009395","article-title":"Long-term musculoskeletal morbidity after adult burn injury: A population-based cohort study","volume":"5","author":"Randall","year":"2015","journal-title":"BMJ Open"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.burns.2015.09.009","article-title":"Autonomic dysfunction and osteoporosis after electrical burn","volume":"42","author":"Roshanzamir","year":"2016","journal-title":"Burns"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/MCC.0000000000000734","article-title":"Bone metabolism and fracture risk during and after critical illness","volume":"26","author":"Rousseau","year":"2020","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.metabol.2019.06.001","article-title":"The role of the musculoskeletal system in post-burn hypermetabolism","volume":"97","author":"Klein","year":"2019","journal-title":"Metabolism"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1111\/j.1582-4934.2010.01127.x","article-title":"Endogenous toll-like receptor ligands and their biological significance","volume":"14","author":"Yu","year":"2010","journal-title":"J. Cell Mol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"E436","DOI":"10.1152\/ajpendo.00535.2015","article-title":"Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma","volume":"311","author":"Ogunbileje","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jbm4.10011","article-title":"Interactions of Phosphate Metabolism With Serious Injury, Including Burns","volume":"1","author":"Porter","year":"2017","journal-title":"JBMR Plus"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13018-019-1082-4","article-title":"Burn and thoracic trauma alters fracture healing, systemic inflammation, and leukocyte kinetics in a rat model of polytrauma","volume":"14","author":"Mangum","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00198-011-1726-7","article-title":"Impact of a centralized osteoporosis coordinator on post-fracture osteoporosis management: A cluster randomized trial","volume":"23","author":"Jaglal","year":"2012","journal-title":"Osteoporos. Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1503\/cmaj.100771","article-title":"2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: Summary","volume":"182","author":"Papaioannou","year":"2010","journal-title":"CMAJ"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"0108021","DOI":"10.1115\/1.4029176","article-title":"Biomechanics and mechanobiology of trabecular bone: A review","volume":"137","author":"Oftadeh","year":"2015","journal-title":"J. Biomech. Eng."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"365","DOI":"10.22203\/eCM.v035a25","article-title":"Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover","volume":"35","author":"Fischer","year":"2018","journal-title":"Eur. Cell Mater."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/0269215513501905","article-title":"Incidence of skeletal fractures after traumatic spinal cord injury: A 10-year follow-up study","volume":"28","author":"Gifre","year":"2014","journal-title":"Clin. Rehabil."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/jamadermatol.2020.4968","article-title":"Association of Potent and Very Potent Topical Corticosteroids and the Risk of Osteoporosis and Major Osteoporotic Fractures","volume":"157","author":"Egeberg","year":"2021","journal-title":"JAMA Dermatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","article-title":"An overview and management of osteoporosis","volume":"4","year":"2017","journal-title":"Eur. J. Rheumatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00198-019-04852-8","article-title":"Risk of imminent fracture following a previous fracture in a Swedish database study","volume":"30","author":"Banefelt","year":"2019","journal-title":"Osteoporos. Int."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.beem.2011.05.002","article-title":"The effect of vitamin D on bone and osteoporosis","volume":"25","author":"Lips","year":"2011","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.3390\/ijms15046569","article-title":"Vitamin D: Link between osteoporosis, obesity, and diabetes?","volume":"15","author":"Bressan","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1038\/s41598-017-07511-2","article-title":"Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice","volume":"7","author":"Fischer","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_89","first-page":"57","article-title":"Mechanobiology of bone remodeling and fracture healing in the aged organism","volume":"1","author":"Liedert","year":"2016","journal-title":"Innov. Surg. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1210\/jc.2004-2364","article-title":"Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy","volume":"90","author":"Holick","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0140-6736(05)63013-9","article-title":"Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): A randomised placebo-controlled trial","volume":"365","author":"Grant","year":"2005","journal-title":"Lancet"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1001\/jama.2017.21640","article-title":"Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force","volume":"319","author":"Kahwati","year":"2018","journal-title":"JAMA"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bone.2004.03.024","article-title":"A meta-analysis of previous fracture and subsequent fracture risk","volume":"35","author":"Kanis","year":"2004","journal-title":"Bone"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s001980070064","article-title":"Long-term risk of osteoporotic fracture in Malm\u00f6","volume":"11","author":"Kanis","year":"2000","journal-title":"Osteoporos. Int."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00198-019-05219-9","article-title":"Rib fractures after blunt thoracic trauma in patients with normal versus diminished bone mineral density: A retrospective cohort study","volume":"31","author":"Prins","year":"2020","journal-title":"Osteoporos. Int."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/jbmr.3104","article-title":"Proximal Femur Volumetric Bone Mineral Density and Mortality. 13 Years of Follow-Up of the AGES-Reykjavik Study","volume":"32","author":"Marques","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/tri.13863","article-title":"A systematic review and meta-analysis on the incidence of osteoporosis and fractures after liver transplant","volume":"34","author":"Lim","year":"2021","journal-title":"Transpl. Int."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1359\/jbmr.070507","article-title":"Age-related changes in trabecular architecture differ in female and male C57BL\/6J mice","volume":"22","author":"Glatt","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1503\/cmaj.080672","article-title":"Our approach to osteoporosis screening and treatment needs to change","volume":"178","author":"Cooper","year":"2008","journal-title":"CMAJ"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2106\/JBJS.N.00648","article-title":"Sarcopenia and fragility fractures: Molecular and clinical evidence of the bone-muscle interaction","volume":"97","author":"Tarantino","year":"2015","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Ciuffi, S., Donati, S., Marini, F., Palmini, G., Luzi, E., and Brandi, M.L. (2020). Circulating MicroRNAs as Novel Biomarkers for Osteoporosis and Fragility Fracture Risk: Is There a Use in Assessment Risk?. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186927"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1089\/jwh.2017.6706","article-title":"Postmenopausal Osteoporosis: A Clinical Review","volume":"27","author":"Watts","year":"2018","journal-title":"J. Womens Health"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"BJGPO.2022.0142","DOI":"10.3399\/BJGPO.2022.0142","article-title":"Osteoporosis-related characteristics in care home residents in England: A retrospective cohort study","volume":"7","author":"Gerasimaviciute","year":"2023","journal-title":"BJGP Open"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2147\/CIA.S4965","article-title":"Diagnosis and management of osteoporosis in the older senior","volume":"4","author":"Vondracek","year":"2009","journal-title":"Clin. Interv. Aging"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"575936","DOI":"10.1155\/2013\/575936","article-title":"Postmenopausal osteoporosis: The role of immune system cells","volume":"2013","author":"Faienza","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jbmr.5650110802","article-title":"Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis","volume":"11","author":"Pacifici","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00198-019-05274-2","article-title":"Fracture risk following high-trauma versus low-trauma fracture: A registry-based cohort study","volume":"31","author":"Leslie","year":"2020","journal-title":"Osteoporos. Int."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1001\/jamainternmed.2021.2617","article-title":"Risk of Subsequent Fractures in Postmenopausal Women After Nontraumatic vs Traumatic Fractures","volume":"181","author":"Crandall","year":"2021","journal-title":"JAMA Intern. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12967-021-02836-z","article-title":"Cigarette smoke-associated inflammation impairs bone remodeling through NF\u03baB activation","volume":"19","author":"Lu","year":"2021","journal-title":"J. Transl. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3803\/EnM.2016.31.3.433","article-title":"Osteoporosis and Prevalent Fractures among Adult Filipino Men Screened for Bone Mineral Density in a Tertiary Hospital","volume":"31","author":"Mendoza","year":"2016","journal-title":"Endocrinol. Metab."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1055\/s-0039-1681114","article-title":"Avascular Necrosis with Cystic Changes in the Triquetrum after Trauma in Combination with Heavy Smoking and Local Corticosteroid Injections","volume":"12","author":"Ovadja","year":"2020","journal-title":"J. Hand Microsurg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1136\/bjsports-2021-104634","article-title":"Strong, steady and straight: UK consensus statement on physical activity and exercise for osteoporosis","volume":"56","author":"Skelton","year":"2022","journal-title":"Br. J. Sports Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1082413","DOI":"10.3389\/fendo.2023.1082413","article-title":"Bone health in childhood and adolescence: An overview on dual-energy X-ray absorptiometry scanning, fracture surveillance and bisphosphonate therapy for low-middle-income countries","volume":"14","author":"Madhuchani","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"E106","DOI":"10.1519\/JPT.0000000000000346","article-title":"Physical Therapist Management of Patients with Suspected or Confirmed Osteoporosis: A Clinical Practice Guideline From the Academy of Geriatric Physical Therapy","volume":"44","author":"Hartley","year":"2022","journal-title":"J. Geriatr. Phys. Ther."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2106\/JBJS.D.02289","article-title":"Interventions to improve osteoporosis treatment following hip fracture: A prospective, randomized trial","volume":"87","author":"Gardner","year":"2005","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/1759720X18785539","article-title":"Improving drug adherence in osteoporosis: An update on more recent studies","volume":"10","author":"Jaleel","year":"2018","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1007\/s00198-011-1661-7","article-title":"The impact of pharmacist interventions on osteoporosis management: A systematic review","volume":"22","author":"Elias","year":"2011","journal-title":"Osteoporos. Int."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11657-020-00871-9","article-title":"SCOPE 2021: A new scorecard for osteoporosis in Europe","volume":"16","author":"Kanis","year":"2021","journal-title":"Arch. Osteoporos."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0950-351X(97)80569-1","article-title":"Osteomalacia","volume":"11","author":"Francis","year":"1997","journal-title":"Baillieres Clin. Endocrinol. Metab."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/iju.13170","article-title":"Skeletal complications in cancer patients with bone metastases","volume":"23","author":"Tsuzuki","year":"2016","journal-title":"Int. J. Urol."},{"key":"ref_121","first-page":"321","article-title":"Bone Metastases: An Overview","volume":"11","author":"Macedo","year":"2017","journal-title":"Oncol. Rev."},{"key":"ref_122","first-page":"58","article-title":"Primary hyperparathyroidism","volume":"32","author":"Madkhali","year":"2016","journal-title":"Ulus. Cerrahi Derg."},{"key":"ref_123","first-page":"97","article-title":"Bone pain mechanism in osteoporosis: A narrative review","volume":"13","author":"Mattia","year":"2016","journal-title":"Clin. Cases Miner. Bone Metab."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jare.2022.08.019","article-title":"Pathophysiological mechanism of acute bone loss after fracture","volume":"49","author":"Zheng","year":"2023","journal-title":"J. Adv. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/MED.0000000000000087","article-title":"Weight loss and bone mineral density","volume":"21","author":"Hunter","year":"2014","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s11904-012-0119-7","article-title":"Osteoporosis and bone health in HIV","volume":"9","author":"Powderly","year":"2012","journal-title":"Curr. HIV\/AIDS Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"12s","DOI":"10.1097\/00007632-199712151-00003","article-title":"Osteoporosis: Definition and clinical presentation","volume":"22","author":"Glaser","year":"1997","journal-title":"Spine"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Aibar-Almaz\u00e1n, A., Voltes-Mart\u00ednez, A., Castellote-Caballero, Y., Afanador-Restrepo, D.F., Carcel\u00e9n-Fraile, M.D.C., and L\u00f3pez-Ruiz, E. (2022). Current Status of the Diagnosis and Management of Osteoporosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169465"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1055\/s-0038-1677483","article-title":"Urinary N-telopeptide: The New Diagnostic Test for Osteoporosis","volume":"5","author":"Ganesan","year":"2019","journal-title":"Surg. J."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/978-3-030-91979-5_2","article-title":"Quantitative Ultrasound (QUS) in the Management of Osteoporosis and Assessment of Fracture Risk: An Update","volume":"1364","author":"Hans","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13018-017-0585-0","article-title":"Investigation and management of osteoporosis in aged trauma patients: A treatment algorithm adapted to the German guidelines for osteoporosis","volume":"12","author":"Neuerburg","year":"2017","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/0009-9236(95)90245-7","article-title":"Studies of the oral bioavailability of alendronate","volume":"58","author":"Gertz","year":"1995","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1359\/jbmr.090209","article-title":"Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture","volume":"24","author":"Eriksen","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bone.2018.10.001","article-title":"Denosumab effects on bone density and turnover in postmenopausal women with low bone mass with or without previous treatment","volume":"120","author":"Tsourdi","year":"2019","journal-title":"Bone"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0165-3806(87)90084-8","article-title":"Glutamine synthetase and energy metabolism enzymes in cultivated chick neurons and astrocytes: Modulation by serum and hydrocortisone","volume":"428","author":"Tholey","year":"1987","journal-title":"Brain Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s00068-020-01304-5","article-title":"Malnutrition and its effects in severely injured trauma patients","volume":"46","author":"Dijkink","year":"2020","journal-title":"Eur. J. Trauma. Emerg. Surg."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00198-015-3440-3","article-title":"The National Osteoporosis Foundation\u2019s position statement on peak bone mass development and lifestyle factors: A systematic review and implementation recommendations","volume":"27","author":"Weaver","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1007\/s00198-020-05541-7","article-title":"Core principles for fracture prevention: North American Consensus from the National Osteoporosis Foundation, Osteoporosis Canada, and Academia Nacional de Medicina de Mexico","volume":"31","author":"Lewiecki","year":"2020","journal-title":"Osteoporos. Int."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"185","DOI":"10.5694\/mja16.00568","article-title":"Osteoporosis treatment: A missed opportunity","volume":"205","author":"Milat","year":"2016","journal-title":"Med. J. Aust."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"491976","DOI":"10.1155\/2015\/491976","article-title":"Immediate weight-bearing after ankle fracture fixation","volume":"2015","author":"Firoozabadi","year":"2015","journal-title":"Adv. Orthop."},{"key":"ref_141","first-page":"92","article-title":"Osteoporosis: A Review of Treatment Options","volume":"43","author":"Tu","year":"2018","journal-title":"Pharm. Ther."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/jbmr.2478","article-title":"Life Expectancy in Patients Treated for Osteoporosis: Observational Cohort Study Using National Danish Prescription Data","volume":"30","author":"Abrahamsen","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4137\/CMAMD.S14077","article-title":"Modern rehabilitation in osteoporosis, falls, and fractures","volume":"7","author":"Dionyssiotis","year":"2014","journal-title":"Clin. Med. Insights Arthritis Musculoskelet. Disord."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1359\/JBMR.040507","article-title":"Musculoskeletal rehabilitation in osteoporosis: A review","volume":"19","author":"Pfeifer","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"ref_145","first-page":"193","article-title":"Diagnosis and treatment of osteoporosis","volume":"79","author":"Sweet","year":"2009","journal-title":"Am. Fam. Physician"},{"key":"ref_146","unstructured":"Paul, K., Cohen, A., Nelson, S., Becker, B., Cho, M., Gibert, J., Janson, E., Kaur, H., Kavanagh, M., and Kintner, J. (2022). Osteoporosis Screening, Diagnosis, and Treatment Guideline, Kaiser Foundation Health Plan of Washington."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/5\/561\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:34:22Z","timestamp":1760106862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/5\/561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":146,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["life14050561"],"URL":"https:\/\/doi.org\/10.3390\/life14050561","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]}}}