{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:56:25Z","timestamp":1792439785097,"version":"4.5.0"},"reference-count":74,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>There is evidence for a particular relationship between low-grade inflammation (LGI) and intermittent hypoxia (IH) related to obstructive sleep apnoea syndrome (OSAS). However, despite the potential deleterious cardiovascular consequences associated with this LGI in hypertensive patients, few studies have investigated the impact of IH related to OSAS on CRP levels in this subpopulation. In total, 1404 hypertensive patients were selected retrospectively from the Sleep Laboratory database. CRP levels \u22653 mg\/L but &lt;10 mg\/L were used as cut-offs to identify hypertensive patients with LGI. Logistic regressions were conducted to examine the risk of LGI associated with IH related to OSAS in hypertensive patients. LGI was frequent (33.8%) in hypertensive patients. After adjustment for confounders, multivariate logistic regressions revealed that only moderate to severe OSAS (apnoea\u2013hypopnoea index \u2265 15\/h) with high IH (oxygen desaturation index \u2265 15\/h) [OR 1.51 (95% CI 1.06\u20132.14)] was significantly associated with LGI in hypertensive patients (p-value = 0.045). Consistent with our hypothesis, our results demonstrated the existence of a particular subtype of hypertensive patients at high cardiovascular risk characterised by the presence of LGI induced by IH hypoxia related to moderate to severe OSAS, which justifies the establishment of adequate management of this pathology to allow better cardiovascular prevention in this subpopulation.<\/jats:p>","DOI":"10.3390\/life14050592","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T15:05:01Z","timestamp":1715007901000},"page":"592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Intermittent Hypoxia Related to Obstructive Sleep Apnoea Syndrome on Low-Grade Inflammation in Hypertensive Patients: Potential Implications for Cardiovascular Risk"],"prefix":"10.3390","volume":"14","author":[{"given":"Matthieu","family":"Hein","sequence":"first","affiliation":[{"name":"H\u00f4pital Universitaire de Bruxelles, Service de Psychiatrie et Laboratoire du Sommeil, Universit\u00e9 Libre de Bruxelles, ULB, 1070 Brussels, Belgium"},{"name":"Laboratoire de Psychologie M\u00e9dicale et Addictologie (ULB312), Universit\u00e9 Libre de Bruxelles, ULB, 1020 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5603-4600","authenticated-orcid":false,"given":"Benjamin","family":"Wacquier","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire de Bruxelles, Service de Psychiatrie et Laboratoire du Sommeil, Universit\u00e9 Libre de Bruxelles, ULB, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Conenna","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire de Bruxelles, Service de Psychiatrie et Laboratoire du Sommeil, Universit\u00e9 Libre de Bruxelles, ULB, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pol","family":"Lanquart","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire de Bruxelles, Service de Psychiatrie et Laboratoire du Sommeil, Universit\u00e9 Libre de Bruxelles, ULB, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Point","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire de Bruxelles, Service de Psychiatrie et Laboratoire du Sommeil, Universit\u00e9 Libre de Bruxelles, ULB, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cjca.2020.01.013","article-title":"Inflammation in Hypertension","volume":"36","author":"Xiao","year":"2020","journal-title":"Can. 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