{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:26:36Z","timestamp":1790483196576,"version":"4.1.0"},"reference-count":42,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Double-blind randomized clinical trial comparing the efficacy of 52-week therapy with pirfenidone versus nintedanib versus standard therapy with mycophenolate mofetil in patients with interstitial lung disease associated with systemic connective tissue disease (CTD-ILD) and hypersensitivity disease (HP)","award":["2022\/ABM\/03\/00009"],"award-info":[{"award-number":["2022\/ABM\/03\/00009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease that affects more than 2 million people worldwide. It manifests through vasculopathy, an abnormal immunological response, and fibrosis leading to dysfunction of the multiple organs. The disease is categorized into two subtypes: limited cutaneous SSc and diffuse cutaneous SSc. Scleroderma can affect vital organs with respiratory, cardiac, renal, ocular, and dermatological complications. The ocular manifestations of the disease can occur in the anterior and posterior segments of the eye. Changes in the anterior segment related to the disease include eyelid skin remodeling, dry eye syndrome, and conjunctival abnormalities. The disease\u2019s impact on the posterior segment of the eye mostly causes pathologies in the retinal microcirculatory system and abnormalities in the optic nerve. This review provides detailed insights into ocular complications associated with scleroderma.<\/jats:p>","DOI":"10.3390\/life14050627","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T08:59:37Z","timestamp":1715677177000},"page":"627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ocular Manifestation in Systemic Sclerosis\u2014A Literature Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Katarzyna","family":"Paczwa","sequence":"first","affiliation":[{"name":"Opthalmology Department, Military Institute of Aviation Medicine, 01-755 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Rerych","sequence":"additional","affiliation":[{"name":"Opthalmology Department, Military Institute of Aviation Medicine, 01-755 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Romanowska-Pr\u00f3chnicka","sequence":"additional","affiliation":[{"name":"Department and Polyclinic of Systemic Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"R\u00f3\u017cycki","sequence":"additional","affiliation":[{"name":"Opthalmology Department, Military Institute of Aviation Medicine, 01-755 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Go\u0142\u0119biewska","sequence":"additional","affiliation":[{"name":"Opthalmology Department, Military Institute of Aviation Medicine, 01-755 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"744396","DOI":"10.3389\/fimmu.2021.744396","article-title":"Epidemiology of Ocular Manifestations in Autoimmune Disease","volume":"12","author":"Glover","year":"2021","journal-title":"Front. 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