{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:52:10Z","timestamp":1776412330702,"version":"3.51.2"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Roxana Elena Axente"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The cutaneous microbiome represents a topic of high interest nowadays. Multiple studies have suggested the importance of the skin microbiome in different dermatological pathologies, highlighting the possible implications of cutaneous microorganisms in either the pathogenesis or prognosis of skin maladies. Psoriasis represents a common inflammatory skin disease, with a high prevalence in the worldwide population. The role of the cutaneous microbiome in psoriasis could explain a number of pathogenic theories and treatment objectives of this incurable skin disease. Our interest in the characteristics of the cutaneous microbiome, especially in psoriatic patients who attended a tertiary dermatological centre in Galati, Romania, is reflected in our current study, of which the preliminary results are discussed in this article. Using three types of skin sampling techniques (swabs, adhesive tape, and punch biopsies), we tried to characterise the microorganisms harboured in the skin of psoriatic patients and healthy individuals. This study was performed using culture-based probes, which were analysed using MALDI-TOF mass spectrometer equipment. Our preliminary results suggested that the greatest diversity was observed in the perilesional areas of psoriatic patients. The lowest cutaneous diversity was obtained from sampling psoriatic plaques. These results are similar to other studies of the cutaneous microbiome in psoriasis. The most frequent microorganisms found in all groups studied were of the Staphylococcus species: Staphylococcus epidermidis, Staphylococcus hominis, and Staphylococcus aureus. Analysing the living environment of each individual from this study, our preliminary results suggested different results from other studies, as higher diversity and heterogenicity was observed in urban environments than in rural living areas. Regarding the differences between sexes, our preliminary results showed higher quantitative and qualitative changes in the skin microbiome of male participants than female participants, opposite to the results found in other studies of the cutaneous microbiome in psoriasis. Given these preliminary results, we can conclude that we have found important differences by studying the cutaneous microbiome of psoriatic patients and healthy control individuals from a population that, to our knowledge, has not been yet studied from this point of view. Our results showed important characteristics of the skin microbiome in an Eastern European population, where cultural and environmental living habits could influence the cutaneous microbiome.<\/jats:p>","DOI":"10.3390\/life14060678","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T11:17:52Z","timestamp":1716549472000},"page":"678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Eastern County from an European Eastern Country\u2014The Characteristics of Cutaneous Microbiome in Psoriasis Patients\u2014Preliminary Results"],"prefix":"10.3390","volume":"14","author":[{"given":"Diana Sabina","family":"Radaschin","sequence":"first","affiliation":[{"name":"Department of Dermatology, \u201cSaint Parascheva\u201d Infectious Disease Clinical Hospital, 800179 Galati, Romania"},{"name":"Department of Clinical Medical, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-0818","authenticated-orcid":false,"given":"Alina Viorica","family":"Iancu","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra Mariana","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Environment, \u201cDunarea de Jos\u201d University, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8327-1364","authenticated-orcid":false,"given":"Gabriela","family":"Gurau","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Niculet","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florin Ciprian","family":"Bujoreanu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \u201cSaint Parascheva\u201d Infectious Disease Clinical Hospital, 800179 Galati, Romania"},{"name":"Department of Clinical Medical, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentina","family":"Nastase","sequence":"additional","affiliation":[{"name":"Department of Neuropsychomotor Rehabilitation, \u201cSf. Ioan\u201d Clinical Hospital for Children, 800487 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodora","family":"Radaschin","sequence":"additional","affiliation":[{"name":"Radiology Department, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana Gabriela","family":"Popa","sequence":"additional","affiliation":[{"name":"Dermatology Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1452-6615","authenticated-orcid":false,"given":"Roxana Elena","family":"Axente","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-7068","authenticated-orcid":false,"given":"Alin Laurentiu","family":"Tatu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \u201cSaint Parascheva\u201d Infectious Disease Clinical Hospital, 800179 Galati, Romania"},{"name":"Department of Clinical Medical, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3889\/oamjms.2018.055","article-title":"Use of Curcumin in Psoriasis","volume":"6","author":"Nardo","year":"2018","journal-title":"Maced. 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