{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:46:14Z","timestamp":1790793974406,"version":"4.1.0"},"reference-count":122,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dr. Khuroo\u2019s Medical Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>A prospective study on 110 patients with echinococcosis at Dr. Khuroo\u2019s Medical Clinic, Srinagar, Kashmir, India, from March 2019 to April 2024 identified 12 cases (4 males, 8 females; mean age of 46.58 \u00b1 11.97 years) of Alveolar echinococcosis (AE). Two patients were detected through ultrasound examinations carried out for unrelated causes; one presented with features of liver abscess, and nine had pain in the right upper quadrant for a mean period of 2.2 \u00b1 1.79 years. All had the liver as the primary organ involved, with 15 tumor masses of a mean maximum diameter of 9.22 \u00b1 3.21 cm and volume of 426 \u00b1 374.61 cm3. Tumors placed centrally had invaded vessels and the biliary tract in eight patients, and those placed peripherally had invaded the liver capsule and adjacent organs in nine patients. Histologic examination of liver biopsies or resected organs revealed necrotic lesions, calcifications, and granulomatous inflammation with slender, thin-walled vesicles of bizarre configuration that stained strongly eosinophilic with periodic acid Schiff. Two patients had segmental liver resections; one was treated with liver aspiration, while the other nine with advanced disease received chemotherapy with albendazole along with praziquantel. Patients showed clinical improvement on a median follow-up of 12 months (range 1 to 60 months); however, MRI T2-weighted images and 18F-FDG-PET-CECT scans in two patients showed active disease on follow-up at one and five years, respectively. A systematic review detected 146 cases of AE in India from 1980 to April 2024. Twenty cases were from foreign countries, mostly from Central Asian republics, and 118 (93.65%) of the remaining 126 Indian patients were permanent residents of Kashmir Valley. The disease affected a population of 79,197 residing in 22 villages from 5 border districts of the valley. These villages were either high in or adjacent to the Himalayan mountain range. Disease prevalence in the affected population was 146.47\/105 (males 131.53\/105 and females 163.18\/105) and the incidence was 12.41\/105\/year (males 11.16\/105\/year and females 13.81\/105\/year). Possible causes of the emergence of AE are discussed, and future directions for research to face this challenge arebeen identified.<\/jats:p>","DOI":"10.3390\/life14070794","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:41:12Z","timestamp":1719225672000},"page":"794","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Case Series and Literature Review of Alveolar Echinococcosis in Kashmir, India: An Emerging Endemic Zone for Echinococcus multilocularis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2823-8814","authenticated-orcid":false,"given":"Mohammad Sultan","family":"Khuroo","sequence":"first","affiliation":[{"name":"Digestive Diseases Centre, Dr. Khuroo\u2019s Medical Clinic, Kashmir, Srinagar 190010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naira Sultan","family":"Khuroo","sequence":"additional","affiliation":[{"name":"Digestive Diseases Centre, Dr. Khuroo\u2019s Medical Clinic, Kashmir, Srinagar 190010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajaz Ahmad","family":"Rather","sequence":"additional","affiliation":[{"name":"Department of Surgery and Registrar Academics, Sher-I-Kashmir Institute of Medical Sciences Medical College and Hospital, Bemina, Kashmir, Srinagar 190010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5144\/0256-4947.2002.56","article-title":"Hydatid Disease: Current Status and Recent Advances","volume":"22","author":"Khuroo","year":"2002","journal-title":"Ann. 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