{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:05:31Z","timestamp":1789520731639,"version":"build-2803163510"},"reference-count":141,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundacion Universidad Alfonso X El Sabio","award":["2024_4\/260"],"award-info":[{"award-number":["2024_4\/260"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The detrimental effects of ultraviolet radiation (UVR) on human skin are well-documented, encompassing DNA damage, oxidative stress, and an increased risk of carcinogenesis. Conventional photoprotective measures predominantly rely on filters, which scatter or absorb UV radiation, yet fail to address the cellular damage incurred post-exposure. To fill this gap, antioxidant molecules and DNA\u2013repair enzymes have been extensively researched, offering a paradigm shift towards active photoprotection capable of both preventing and reversing UV\u2013induced damage. In the current review, we focused on \u201cactive photoprotection\u201d, assessing the state-of-the-art, latest advancements and scientific data from clinical trials and in vivo models concerning the use of DNA-repair enzymes and naturally occurring antioxidant molecules.<\/jats:p>","DOI":"10.3390\/life14070822","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T05:22:38Z","timestamp":1719552158000},"page":"822","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Understanding Active Photoprotection: DNA-Repair Enzymes and Antioxidants"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9457-8361","authenticated-orcid":false,"given":"Emilio","family":"Garcia-Mouronte","sequence":"first","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, Carretera M-607 km 9.1, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-9441","authenticated-orcid":false,"given":"Luis Alfonso","family":"P\u00e9rez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, Carretera M-607 km 9.1, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-9032","authenticated-orcid":false,"given":"Jorge","family":"Naharro-Rodriguez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, Carretera M-607 km 9.1, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-0730","authenticated-orcid":false,"given":"Montserrat","family":"Fern\u00e1ndez Guarino","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, Carretera M-607 km 9.1, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.jaad.2020.11.074","article-title":"Visible Light. Part II: Photoprotection against Visible and Ultraviolet Light","volume":"84","author":"Geisler","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.0303-6987.2005.00281.x","article-title":"Ultraviolet Radiation and Skin Cancer: Molecular Mechanisms","volume":"32","author":"Hussein","year":"2005","journal-title":"J. Cutan. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Loureiro, J.B., Abrantes, M., Oliveira, P.A., and Saraiva, L. (2020). P53 in Skin Cancer: From a Master Player to a Privileged Target for Prevention and Therapy. Biochim. Biophys. Acta Rev. Cancer, 1874.","DOI":"10.1016\/j.bbcan.2020.188438"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/php.13703","article-title":"Ultraviolet Radiation Exposure and Its Impacts on Cutaneous Phosphorylation Signaling in Carcinogenesis: Focusing on Protein Tyrosine Phosphatases","volume":"99","author":"Asare","year":"2023","journal-title":"Photochem. Photobiol."},{"key":"ref_5","first-page":"201","article-title":"Recent Information on Photoaging Mechanisms and the Preventive Role of Topical Sunscreen Products","volume":"29","author":"Pondeljak","year":"2020","journal-title":"Acta Dermatovenerol. Alp. Pannonica Adriat."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.jaad.2021.02.048","article-title":"Visible Light. Part I: Properties and Cutaneous Effects of Visible Light","volume":"84","author":"Austin","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/jocd.15576","article-title":"The Impact of Blue Light and Digital Screens on the Skin","volume":"22","author":"Kumari","year":"2023","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_8","first-page":"305","article-title":"Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature","volume":"35","author":"Suitthimeathegorn","year":"2022","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Uzunbajakava, N.E., Tobin, D.J., Botchkareva, N.V., Dierickx, C., Bjerring, P., and Town, G. (2023). Highlighting Nuances of Blue Light Phototherapy: Mechanisms and Safety Considerations. J. Biophotonics, 16.","DOI":"10.1002\/jbio.202200257"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jaad.2020.04.079","article-title":"Photoprotection beyond Ultraviolet Radiation: A Review of Tinted Sunscreens","volume":"84","author":"Lyons","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/abd1806-4841.20143971","article-title":"Brazilian Consensus on Photoprotection","volume":"89","author":"Schalka","year":"2014","journal-title":"An. Bras. Dermatol."},{"key":"ref_12","first-page":"302","article-title":"\u201cActive\u201d Photoprotection: Sunscreens with DNA Repair Enzymes","volume":"152","author":"Megna","year":"2017","journal-title":"G. Ital. Dermatol. Venereol. Organo Uff. Soc. Ital. Dermatol. Sifilogr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/ics.12316","article-title":"Plant-Based Active Photoprotectants for Sunscreens","volume":"38","author":"Cefali","year":"2016","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Parrado, C., Philips, N., Gilaberte, Y., Juarranz, A., and Gonz\u00e1lez, S. (2018). Oral Photoprotection: Effective Agents and Potential Candidates. Front. Med., 5.","DOI":"10.3389\/fmed.2018.00188"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/1523-1747.ep12873312","article-title":"Repair of Pyrimidine(6-4)Pyrimidone Photoproducts in Mouse Skin","volume":"95","author":"Mitchell","year":"1990","journal-title":"J. Investig. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100194","DOI":"10.1016\/j.plgene.2019.100194","article-title":"UV-Induced DNA Damage and Repair: A Cyanobacterial Perspective","volume":"19","author":"Pathak","year":"2019","journal-title":"Plant Gene"},{"key":"ref_17","first-page":"3864","article-title":"Green Tea Polyphenol Treatment to Human Skin Prevents Formation of Ultraviolet Light B-Induced Pyrimidine Dimers in DNA","volume":"6","author":"Katiyar","year":"2000","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1093\/emboj\/cdf456","article-title":"Enhanced Repair of Cyclobutane Pyrimidine Dimers and Improved UV Resistance in Photolyase Transgenic Mice","volume":"21","author":"Schul","year":"2002","journal-title":"EMBO J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-Gamboa, D., D\u00edaz-Zamorano, A.L., Mel\u00e9ndez-S\u00e1nchez, E.R., Reyes-Pardo, H., Villase\u00f1or-Zepeda, K.R., L\u00f3pez-Arellanes, M.E., Sosa-Hern\u00e1ndez, J.E., Coronado-Apodaca, K.G., G\u00e1mez-M\u00e9ndez, A., and Afewerki, S. (2022). Photolyase Production and Current Applications: A Review. Molecules, 27.","DOI":"10.3390\/molecules27185998"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome Maintenance Mechanisms for Preventing Cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0092-8674(85)90150-3","article-title":"DNA Repair in an Active Gene: Removal of Pyrimidine Dimers from the DHFR Gene of CHO Cells Is Much More Efficient than in the Genome Overall","volume":"40","author":"Bohr","year":"1985","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ng1102-338","article-title":"Shining a Light on Photolyases","volume":"32","author":"Menck","year":"2002","journal-title":"Nat. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1073\/pnas.35.2.73","article-title":"Effect of Visible Light on the Recovery of Streptomyces Griseus Conidia from Ultra-Violet Irradiation Injury","volume":"35","author":"Kelner","year":"1949","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1128\/jb.58.4.511-522.1949","article-title":"Photoreactivation of Ultraviolet-Irradiated Escherichia Coli with Special Reference to the Dose-Reduction Principle and to Ultraviolet-Induced Mutation","volume":"58","author":"Kelner","year":"1949","journal-title":"J. Bacteriol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/molbev\/msp029","article-title":"Evolution of Mutation Rates: Phylogenomic Analysis of the Photolyase\/Cryptochrome Family","volume":"26","author":"Lynch","year":"2009","journal-title":"Mol. Biol. Evol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1021\/cr0204348","article-title":"Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors","volume":"103","author":"Sancar","year":"2003","journal-title":"Chem. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"7302","DOI":"10.1038\/ncomms8302","article-title":"The Molecular Origin of High DNA-Repair Efficiency by Photolyase","volume":"6","author":"Tan","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.1002\/j.1460-2075.1994.tb06961.x","article-title":"A New Class of DNA Photolyases Present in Various Organisms Including Aplacental Mammals","volume":"13","author":"Yasui","year":"1994","journal-title":"EMBO J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"17696","DOI":"10.1073\/pnas.0607993103","article-title":"A Cryptochrome\/Photolyase Class of Enzymes with Single-Stranded DNA-Specific Photolyase Activity","volume":"103","author":"Selby","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1590\/S0100-879X1997000300003","article-title":"Evolution of Circadian Organization in Vertebrates","volume":"30","author":"Menaker","year":"1997","journal-title":"Braz. J. Med. Biol. Res. Rev. Bras. Pesqui. Medicas Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/00005053-194409000-00057","article-title":"The Vertebrate Eye and its Adaptive Radiation","volume":"100","author":"Walls","year":"1944","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Gerkema, M.P., Davies, W.I.L., Foster, R.G., Menaker, M., and Hut, R.A. (2013). The Nocturnal Bottleneck and the Evolution of Activity Patterns in Mammals. Proc. Biol. Sci., 280.","DOI":"10.1098\/rspb.2013.0508"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1073\/pnas.030528897","article-title":"Enzyme plus Light Therapy to Repair DNA Damage in Ultraviolet-B-Irradiated Human Skin","volume":"97","author":"Stege","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","first-page":"570","article-title":"Reduced Ultraviolet-Induced DNA Damage and Apoptosis in Human Skin with Topical Application of a Photolyase-Containing DNA Repair Enzyme Cream: Clues to Skin Cancer Prevention","volume":"5","author":"Berardesca","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"ref_35","first-page":"1118","article-title":"Topical Liposomal DNA-Repair Enzymes in Polymorphic Light Eruption","volume":"10","author":"Hofer","year":"2011","journal-title":"Photochem. Photobiol. Sci. Off. J. Eur. Photochem. Assoc. Eur. Soc. Photobiol."},{"key":"ref_36","first-page":"693","article-title":"Efficacy of a Photolyase-Based Device in the Treatment of Cancerization Field in Patients with Actinic Keratosis and Non-Melanoma Skin Cancer","volume":"148","author":"Puviani","year":"2013","journal-title":"G. Ital. Dermatol. Venereol. Organo Uff. Soc. Ital. Dermatol. Sifilogr."},{"key":"ref_37","first-page":"2","article-title":"A Pilot, Prospective, Open-Label Study on the Effects of a Topical Photorepair and Photoprotection Film-Forming Medical Device in Patients with Actinic Keratoses Evaluated by Means of Skin Analysis Camera Antera 3D","volume":"6","author":"Milani","year":"2015","journal-title":"J. Clin. Exp. Dermatol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/exd.12177","article-title":"Role of CPI-17 in Restoring Skin Homoeostasis in Cutaneous Field of Cancerization: Effects of Topical Application of a Film-Forming Medical Device Containing Photolyase and UV Filters","volume":"22","author":"Malvehy","year":"2013","journal-title":"Exp. Dermatol."},{"key":"ref_39","first-page":"220","article-title":"Field Cancerisation Improvement with Topical Application of a Film-Forming Medical Device Containing Photolyase and UV Filters in Patients with Actinic Keratosis, a Pilot Study","volume":"5","author":"Puig","year":"2014","journal-title":"J. Clin. Exp. Dermatol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000368182","article-title":"Preventive Long-Term Effects of a Topical Film-Forming Medical Device with Ultra-High UV Protection Filters and DNA Repair Enzyme in Xeroderma Pigmentosum: A Retrospective Study of Eight Cases","volume":"6","author":"Giustini","year":"2014","journal-title":"Case Rep. Dermatol."},{"key":"ref_41","first-page":"226","article-title":"Evaluation of the Effects of a Cream Containing Liposomeencapsulated Photolyase and SPF 100 Sunscreen on Facial Actinic Keratosis: Clinical, Dermoscopic, and Confocal Microscopy Based Analysis","volume":"6","author":"Rstom","year":"2014","journal-title":"Surg. Cosmet. Dermatol."},{"key":"ref_42","first-page":"986","article-title":"Comparative Effects of Sunscreens Alone vs Sunscreens Plus DNA Repair Enzymes in Patients With Actinic Keratosis: Clinical and Molecular Findings from a 6-Month, Randomized, Clinical Study","volume":"14","author":"Carducci","year":"2015","journal-title":"J. Drugs Dermatol. JDD"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13046-015-0203-0","article-title":"The Efficacy of a Photolyase-Based Device on the Cancerization Field: A Clinical and Thermographic Study","volume":"34","author":"Laino","year":"2015","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/bjd.14721","article-title":"A 9-Month, Randomized, Assessor-Blinded, Parallel-Group Study to Evaluate Clinical Effects of Film-Forming Medical Devices Containing Photolyase and Sun Filters in the Treatment of Field Cancerization Compared with Sunscreen in Patients after Successful Photodynamic Therapy for Actinic Keratosis","volume":"175","author":"Eibenschutz","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e401","DOI":"10.1111\/jdv.14209","article-title":"Management of Cancerization Field with a Medical Device Containing Photolyase: A Randomized, Double-Blind, Parallel-Group Pilot Study","volume":"31","author":"Moscarella","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"ref_46","first-page":"13030\/qt5zc6085s","article-title":"The Use of a Sunscreen Containing DNA-Photolyase in the Treatment of Patients with Field Cancerization and Multiple Actinic Keratoses: A Case-Series","volume":"23","year":"2017","journal-title":"Dermatol. Online J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.abd.2021.06.005","article-title":"Efficacy of Sunscreen with Photolyase or Regular Sunscreen Associated with Topical Antioxidants in Treating Advanced Photodamage and Cutaneous Field Cancerization: A Randomized Clinical Trial","volume":"97","author":"Alvares","year":"2022","journal-title":"An. Bras. Dermatol."},{"key":"ref_48","first-page":"532","article-title":"Estudio observacional sobre la efectividad y tolerabilidad de un producto t\u00f3pico con fotoliasa y filtros solares en pacientes con queratosis act\u00ednicas tratados con crioterapia en condiciones de uso habitual","volume":"31","author":"Grillo","year":"2016","journal-title":"Piel Form. Contin. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jaad.2007.01.047","article-title":"Vehicle-Controlled, Double-Blind, Randomized Study of Imiquimod 5% Cream Applied 3 Days per Week in One or Two Courses of Treatment for Actinic Keratoses on the Head","volume":"57","author":"Jorizzo","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1016\/j.jaad.2021.02.082","article-title":"Guidelines of Care for the Management of Actinic Keratosis","volume":"85","author":"Eisen","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/jdv.14682","article-title":"Actinic Keratosis Area and Severity Index (AKASI) Is Associated with the Incidence of Squamous Cell Carcinoma","volume":"32","author":"Schmitz","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/jdv.15580","article-title":"Evaluation of Two Histological Classifications for Actinic Keratoses\u2014PRO Classification Scored Highest Inter-Rater Reliability","volume":"33","author":"Schmitz","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/jdv.13626","article-title":"Actinic Keratosis: Correlation between Clinical and Histological Classification Systems","volume":"30","author":"Schmitz","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/ajd.13447","article-title":"A Review of Actinic Keratosis, Skin Field Cancerisation and the Efficacy of Topical Therapies","volume":"62","author":"Sinclair","year":"2021","journal-title":"Australas. J. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2340\/00015555-2854","article-title":"Incidence of Actinic Keratosis and Risk of Skin Cancer in Subjects with Actinic Keratosis: A Population-Based Cohort Study","volume":"98","author":"Lee","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"ref_56","first-page":"4","article-title":"Xeroderma Pigmentosum","volume":"13","author":"Norgauer","year":"2003","journal-title":"Eur. J. Dermatol. EJD"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/1346-8138.12310","article-title":"Comparative Study for the Effect of Photodynamic Therapy, Imiquimod Immunotherapy and Combination of Both Therapies on 40 Lesions of Actinic Keratosis in Japanese Patients","volume":"40","author":"Tanaka","year":"2013","journal-title":"J. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1073\/pnas.72.10.4071","article-title":"Restoration of Ultraviolet-Induced Unscheduled DNA Synthesis of Xeroderma Pigmentosum Cells by the Concomitant Treatment with Bacteriophage T4 Endonuclease V and HVJ (Sendai Virus)","volume":"72","author":"Tanaka","year":"1975","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1517\/14712598.8.6.829","article-title":"T4 Endonuclease V: Review and Application to Dermatology","volume":"8","author":"Cafardi","year":"2008","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1073\/pnas.67.4.1839","article-title":"T4 Endonuclease Involved in Repair of DNA","volume":"67","author":"Yasuda","year":"1970","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0027-5107(02)00215-4","article-title":"Enhanced DNA Repair of Cyclobutane Pyrimidine Dimers Changes the Biological Response to UV-B Radiation","volume":"509","author":"Yarosh","year":"2002","journal-title":"Mutat. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/1523-1747.ep12395551","article-title":"Localization of Liposomes Containing a DNA Repair Enzyme in Murine Skin","volume":"103","author":"Yarosh","year":"1994","journal-title":"J. Investig. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/phpp.12597","article-title":"DNA Repair Enzymes in Sunscreens and Their Impact on Photoageing-A Systematic Review","volume":"36","author":"Luze","year":"2020","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Eckstein, F., and Lilley, D.M.J. (1994). Structure and Function of T4 Endonuclease V. Nucleic Acids and Molecular Biology, Springer.","DOI":"10.1007\/978-3-642-78666-2"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1074\/jbc.270.8.3765","article-title":"T4 Endonuclease V Protects the DNA Strand Opposite a Thymine Dimer from Cleavage by the Footprinting Reagents DNase I and 1,10-Phenanthroline-Copper","volume":"270","author":"Latham","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1111\/j.1600-0625.2008.00747.x","article-title":"UV-Induced DNA Damage Initiates Release of MMP-1 in Human Skin","volume":"17","author":"Dong","year":"2008","journal-title":"Exp. Dermatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1523-1747.2000.00839.x","article-title":"Topical Treatment with Liposomes Containing T4 Endonuclease V Protects Human Skin in Vivo from Ultraviolet-Induced Upregulation of Interleukin-10 and Tumor Necrosis Factor-Alpha","volume":"114","author":"Wolf","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0140-6736(00)04214-8","article-title":"Effect of Topically Applied T4 Endonuclease V in Liposomes on Skin Cancer in Xeroderma Pigmentosum: A Randomised Study","volume":"357","author":"Yarosh","year":"2001","journal-title":"Lancet"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/1523-1747.ep12612828","article-title":"Sunscreens and T4N5 Liposomes Differ in Their Ability to Protect against Ultraviolet-Induced Sunburn Cell Formation, Alterations of Dendritic Epidermal Cells, and Local Suppression of Contact Hypersensitivity","volume":"104","author":"Wolf","year":"1995","journal-title":"J. Investig. Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"De Rosa, M., Johnson, S.A., and Opresko, P.L. (2021). Roles for the 8-Oxoguanine DNA Repair System in Protecting Telomeres From Oxidative Stress. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.758402"},{"key":"ref_71","first-page":"21","article-title":"Generation, Repair and Replication of Guanine Oxidation Products","volume":"39","author":"Kino","year":"2017","journal-title":"Genes Environ. Off. J. Jpn. Environ. Mutagen Soc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cell.2017.01.002","article-title":"Endogenous DNA Damage as a Source of Genomic Instability in Cancer","volume":"168","author":"Tubbs","year":"2017","journal-title":"Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-biochem-013118-111315","article-title":"Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism","volume":"88","author":"Beard","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"102921","DOI":"10.1016\/j.dnarep.2020.102921","article-title":"Mammalian DNA Base Excision Repair: Dancing in the Moonlight","volume":"93","author":"Caldecott","year":"2020","journal-title":"DNA Repair"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"7022","DOI":"10.1073\/pnas.89.15.7022","article-title":"Evidence That MutY and MutM Combine to Prevent Mutations by an Oxidatively Damaged Form of Guanine in DNA","volume":"89","author":"Michaels","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.freeradbiomed.2017.01.008","article-title":"Repair of 8-oxoG:A Mismatches by the MUTYH Glycosylase: Mechanism, Metals and Medicine","volume":"107","author":"Banda","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_77","first-page":"297","article-title":"DNA Repair Enzymes: An Important Role in Skin Cancer Prevention and Reversal of Photodamage--a Review of the Literature","volume":"14","author":"Kabir","year":"2015","journal-title":"J. Drugs Dermatol. JDD"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ymgme.2012.02.017","article-title":"Human 8-Oxoguanine-DNA Glycosylase-1 Is Downregulated in Human Basal Cell Carcinoma","volume":"106","author":"Huang","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1751-1097.2007.00257.x","article-title":"Topical Treatment with OGG1 Enzyme Affects UVB-Induced Skin Carcinogenesis","volume":"84","author":"Wulff","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"ref_80","first-page":"309","article-title":"An Experimental Double-Blind Irradiation Study of a Novel Topical Product (TPF 50) Compared to Other Topical Products with DNA Repair Enzymes, Antioxidants, and Growth Factors with Sunscreens: Implications for Preventing Skin Aging and Cancer","volume":"13","author":"Emanuele","year":"2014","journal-title":"J. Drugs Dermatol. JDD"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Michalak, M. (2022). Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23020585"},{"key":"ref_82","first-page":"164","article-title":"Oxidative Stress and Antioxidant Strategies in Dermatology","volume":"21","author":"Baek","year":"2016","journal-title":"Redox Rep. Commun. Free Radic. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1098-2744(199811)23:3<175::AID-MC6>3.0.CO;2-B","article-title":"The Effect of Vitamin E Acetate on Ultraviolet-Induced Mouse Skin Carcinogenesis","volume":"23","author":"Berton","year":"1998","journal-title":"Mol. Carcinog."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1098-2744(199903)24:3<169::AID-MC3>3.0.CO;2-A","article-title":"Prevention of DNA Photodamage by Vitamin E Compounds and Sunscreens: Roles of Ultraviolet Absorbance and Cellular Uptake","volume":"24","author":"McVean","year":"1999","journal-title":"Mol. Carcinog."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/mc.10055","article-title":"Protective Effect of Vitamin E on Ultraviolet B Light-Induced Damage in Keratinocytes","volume":"34","author":"Maalouf","year":"2002","journal-title":"Mol. Carcinog."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cbi.2007.11.017","article-title":"Topically Applied Vitamin E Prevents Massive Cutaneous Inflammatory and Oxidative Stress Responses Induced by Double Application of 12-O-Tetradecanoylphorbol-13-Acetate (TPA) in Mice","volume":"172","author":"Rahman","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1440-0960.1998.tb01251.x","article-title":"Sunscreens and Vitamin E Provide Some Protection to the Skin Immune System from Solar-Simulated UV Radiation","volume":"39","author":"Halliday","year":"1998","journal-title":"Australas. J. Dermatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0003-9861(92)90613-2","article-title":"Topical Tocopherol Acetate Reduces Post-UVB, Sunburn-Associated Erythema, Edema, and Skin Sensitivity in Hairless Mice","volume":"296","author":"Trevithick","year":"1992","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_89","first-page":"56","article-title":"Photoprotective Effect of Superoxide-Scavenging Antioxidants against Ultraviolet Radiation-Induced Chronic Skin Damage in the Hairless Mouse","volume":"7","author":"Bissett","year":"1990","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0003-9861(83)90290-4","article-title":"Oxidation of Alpha-Tocopherol in Micelles and Liposomes by the Hydroxyl, Perhydroxyl, and Superoxide Free Radicals","volume":"226","author":"Fukuzawa","year":"1983","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-2133.1996.tb07843.x","article-title":"UVA-Induced Immune Suppression in Human Skin: Protective Effect of Vitamin E in Human Epidermal Cells in Vitro","volume":"134","author":"Michel","year":"1996","journal-title":"Br. J. Dermatol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/01635589109514117","article-title":"Topical Vitamin E Inhibition of Immunosuppression and Tumorigenesis Induced by Ultraviolet Irradiation","volume":"15","author":"Gensler","year":"1991","journal-title":"Nutr. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1139\/y93-109","article-title":"Partners in Defense, Vitamin E and Vitamin C","volume":"71","author":"Chan","year":"1993","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1745-7270.2007.00348.x","article-title":"Feruloyl Esterases as Biotechnological Tools: Current and Future Perspectives","volume":"39","author":"Fazary","year":"2007","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Burns, E.M., Tober, K.L., Riggenbach, J.A., Kusewitt, D.F., Young, G.S., and Oberyszyn, T.M. (2013). Differential Effects of Topical Vitamin E and C E Ferulic\u00ae Treatments on Ultraviolet Light B-Induced Cutaneous Tumor Development in Skh-1 Mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063809"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/01635589609514474","article-title":"Importance of the Form of Topical Vitamin E for Prevention of Photocarcinogenesis","volume":"26","author":"Gensler","year":"1996","journal-title":"Nutr. Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1468-3083.2011.04344.x","article-title":"Relationship between Food Intake and Cutaneous Solar Elastosis Adjacent to Basal Cell Carcinoma","volume":"27","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/01635589309514243","article-title":"Prevention of Photocarcinogenesis by Dietary Vitamin E","volume":"19","author":"Gerrish","year":"1993","journal-title":"Nutr. Cancer"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jdermsci.2012.03.010","article-title":"Changes in Photoinduced Cutaneous Erythema with Topical Application of a Combination of Vitamins C and E before and after UV Exposure","volume":"66","author":"Aguilera","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jaad.2008.05.004","article-title":"A Topical Antioxidant Solution Containing Vitamins C and E Stabilized by Ferulic Acid Provides Protection for Human Skin against Damage Caused by Ultraviolet Irradiation","volume":"59","author":"Murray","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_101","first-page":"464","article-title":"Protective Effects of a Topical Antioxidant Complex Containing Vitamins C and E and Ferulic Acid against Ultraviolet Irradiation-Induced Photodamage in Chinese Women","volume":"12","author":"Wu","year":"2013","journal-title":"J. Drugs Dermatol. JDD"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.0366-077X.2003.05634.x","article-title":"Expression of Fas-Receptor on Basal Cell Carcinomas after Treatment with Imiquimod 5% Cream or Vehicle","volume":"149","author":"Berman","year":"2003","journal-title":"Br. J. Dermatol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1358\/mf.2006.28.3.985227","article-title":"Phenolic Components and Antioxidant Activity of Fernblock, an Aqueous Extract of the Aerial Parts of the Fern Polypodium Leucotomos","volume":"28","author":"Garcia","year":"2006","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.jaad.2004.06.027","article-title":"Oral Polypodium Leucotomos Extract Decreases Ultraviolet-Induced Damage of Human Skin","volume":"51","author":"Pathak","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tiv.2005.09.008","article-title":"Polypodium leucotomos extract: Antioxidant activity and disposition","volume":"20","author":"Gombau","year":"2006","journal-title":"Toxicol. In Vitro"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0024-3205(02)01946-X","article-title":"Parameters Related to Oxygen Free Radicals in Erythrocytes, Plasma and Epidermis of the Hairless Rat","volume":"71","author":"Romeu","year":"2002","journal-title":"Life Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0378-5173(00)00358-6","article-title":"In Vitro and in Vivo Evaluation of Caffeic and Ferulic Acids as Topical Photoprotective Agents","volume":"199","author":"Saija","year":"2000","journal-title":"Int. J. Pharm."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1600-0625.2007.00684.x","article-title":"Polypodium Leucotomos Extract Inhibits Glutathione Oxidation and Prevents Langerhans Cell Depletion Induced by UVB\/UVA Radiation in a Hairless Rat Model","volume":"17","author":"Mulero","year":"2008","journal-title":"Exp. Dermatol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1600-0781.1997.tb00108.x","article-title":"Topical or Oral Administration with an Extract of Polypodium Leucotomos Prevents Acute Sunburn and Psoralen-Induced Phototoxic Reactions as Well as Depletion of Langerhans Cells in Human Skin","volume":"13","author":"Pathak","year":"1997","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-0781.1996.tb00175.x","article-title":"Inhibition of Ultraviolet-Induced Formation of Reactive Oxygen Species, Lipid Peroxidation, Erythema and Skin Photosensitization by Polypodium Leucotomos","volume":"12","author":"Pathak","year":"1996","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00403-014-1535-x","article-title":"Current Knowledge in Polypodium Leucotomos Effect on Skin Protection","volume":"307","author":"Palomino","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1011-1344(01)00195-6","article-title":"Sunscreen Isn\u2019t Enough","volume":"64","author":"Diffey","year":"2001","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/2141256a0","article-title":"Metabolic Effects of Calagualine, an Antitumoral Saponine of Polypodium Leucotomos","volume":"214","author":"Horvath","year":"1967","journal-title":"Nature"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ad.2012.01.008","article-title":"Polypodium Leucotomos Extract in Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial","volume":"103","author":"Zapater","year":"2012","journal-title":"Actas Dermosifiliogr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1365-4362.1974.tb05081.x","article-title":"A New Agent (Hydrophilic Fraction of Polypodium Leucotomos) for Management of Psoriasis","volume":"13","author":"Padilla","year":"1974","journal-title":"Int. J. Dermatol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/j.1468-3083.2006.02132.x","article-title":"Treatment of Vitiligo Vulgaris with Narrow-Band UVB and Oral Polypodium Leucotomos Extract: A Randomized Double-Blind Placebo-Controlled Study","volume":"21","author":"Bos","year":"2007","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"e14776","DOI":"10.1111\/dth.14776","article-title":"NB-UVB plus Oral Polypodium Leucotomos Extract Display Higher Efficacy than NB-UVB Alone in Patients with Vitiligo","volume":"34","author":"Pacifico","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jdermsci.2005.12.006","article-title":"Systemic Immunomodulatory Effects of Polypodium Leucotomos as an Adjuvant to PUVA Therapy in Generalized Vitiligo: A Pilot Study","volume":"41","author":"Reyes","year":"2006","journal-title":"J. Dermatol. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jaad.2009.05.045","article-title":"Decrease of Ultraviolet A Light-Induced \u201cCommon Deletion\u201d in Healthy Volunteers after Oral Polypodium Leucotomos Extract Supplement in a Randomized Clinical Trial","volume":"62","author":"Villa","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1001\/jamadermatol.2013.4294","article-title":"A Randomized, Double-Blinded, Placebo-Controlled Trial of Oral Polypodium Leucotomos Extract as an Adjunct to Sunscreen in the Treatment of Melasma","volume":"149","author":"Ahmed","year":"2013","journal-title":"JAMA Dermatol."},{"key":"ref_121","first-page":"898","article-title":"Polypodium Leucotomos Supplementation in the Treatment of Scalp Actinic Keratosis: Could It Improve the Efficacy of Photodynamic Therapy?","volume":"41","author":"Auriemma","year":"2015","journal-title":"Dermatol. Surg. Off. Publ. Am. Soc. Dermatol. Surg. Al"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/phpp.12870","article-title":"The Combination of Oral and Topical Photoprotection with a Standardized Polypodium Leucotomos Extract Is Beneficial against Actinic Keratosis","volume":"39","author":"Pellacani","year":"2023","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e15326","DOI":"10.1111\/dth.15326","article-title":"Imiquimod-Side Effects in the Treatment of Periocular Skin Cancers: A Review of the Literature","volume":"35","author":"Avallone","year":"2022","journal-title":"Dermatol. Ther."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1011-1344(01)00248-2","article-title":"Green Tea Polyphenols: DNA Photodamage and Photoimmunology","volume":"65","author":"Katiyar","year":"2001","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1600-0781.2007.00262.x","article-title":"Photoprotective Effects of Green Tea Polyphenols","volume":"23","author":"Yusuf","year":"2007","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/1523-1747.ep12371720","article-title":"Green Tea and Skin\u2014Anticarcinogenic Effects","volume":"102","author":"Mukhtar","year":"1994","journal-title":"J. Investig. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/jnci\/86.11.855","article-title":"Reduced Risk of Esophageal Cancer Associated with Green Tea Consumption","volume":"86","author":"Gao","year":"1994","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/carcin\/12.8.1527","article-title":"Protection against Ultraviolet B Radiation-Induced Photocarcinogenesis in Hairless Mice by Green Tea Polyphenols","volume":"12","author":"Wang","year":"1991","journal-title":"Carcinogenesis"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1067\/mjd.2001.112919","article-title":"Cutaneous Photoprotection from Ultraviolet Injury by Green Tea Polyphenols","volume":"44","author":"Elmets","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1600-0625.2008.00818.x","article-title":"Topical Application of Green and White Tea Extracts Provides Protection from Solar-Simulated Ultraviolet Light in Human Skin","volume":"18","author":"Camouse","year":"2009","journal-title":"Exp. Dermatol."},{"key":"ref_131","first-page":"699","article-title":"Photoprotective Herbal Extract Loaded Nanovesicular Creams Inhibiting Ultraviolet Radiations Induced Photoaging","volume":"3","author":"Kaur","year":"2011","journal-title":"Int. J. Drug Deliv."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"709628","DOI":"10.1155\/2015\/709628","article-title":"Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity","volume":"2015","author":"Jadoon","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_133","first-page":"1193","article-title":"Chemoprevention of Skin Cancer by Grape Constituent Resveratrol: Relevance to Human Disease?","volume":"19","author":"Aziz","year":"2005","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1751-1097.2007.00279.x","article-title":"Resveratrol Imparts Photoprotection of Normal Cells and Enhances the Efficacy of Radiation Therapy in Cancer Cells","volume":"84","author":"Mukhtar","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.275.5297.218","article-title":"Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes","volume":"275","author":"Jang","year":"1997","journal-title":"Science"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1751-1097.2004.tb00136.x","article-title":"Ultraviolet-B Radiation Causes an Upregulation of Survivin in Human Keratinocytes and Mouse Skin","volume":"80","author":"Aziz","year":"2004","journal-title":"Photochem. Photobiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.3390\/molecules19056202","article-title":"Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation","volume":"19","author":"Yan","year":"2014","journal-title":"Molecules"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1242\/jcs.02330","article-title":"Cyclic AMP Mediates Keratinocyte Directional Migration in an Electric Field","volume":"118","author":"Pullar","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref_139","first-page":"6831","article-title":"Protective Endogenous Cyclic Adenosine 5\u2032-Monophosphate Signaling Triggered by Pemphigus Autoantibodies","volume":"185","author":"Spindler","year":"2010","journal-title":"J. Immunol. Baltim. Md 1950"},{"key":"ref_140","first-page":"17","article-title":"The Effect of Vitamin E, L-Arginine, N-Nitro L-Arginine Methyl Ester and Forskolin on Endocrine and Metabolic Changes of Rats Exposed to Acute Cold Stress","volume":"27","author":"Korish","year":"2006","journal-title":"Saudi Med. J."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.freeradbiomed.2005.12.025","article-title":"Protective Effect of Cyclic AMP against Cisplatin-Induced Nephrotoxicity","volume":"40","author":"Mishima","year":"2006","journal-title":"Free Radic. Biol. Med."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/7\/822\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:06:47Z","timestamp":1760108807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/7\/822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":141,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["life14070822"],"URL":"https:\/\/doi.org\/10.3390\/life14070822","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,28]]}}}