{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:47:02Z","timestamp":1775616422415,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cV Babe\u0219\u201d University of Medicine and Pharmacy, from Timisoara, Romania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Sinusoidal obstruction syndrome\/veno-occlusive disease (SOS\/VOD) is a rare liver vascular condition, potentially life-threatening, with clinical signs of portal hypertension, frequently reported in relation to bone marrow transplantation and possibly in non-transplantation-related chemotherapy. We report the case of a 65-year-old female patient who insidiously developed fatigue, mild tenderness of the right upper abdominal quadrant, hepato-splenomegaly and slight weight gain consecutive to ascites development, as well as persistent elevation of transaminases and mild thrombocytopenia. To note, she had a previous history of colorectal cancer (CRC) with liver metastases and several courses of chemotherapy. Abdominal duplex and elastography measurements made the diagnosis of cirrhosis improbable. A lot of lab work-ups were performed in order to rule out several diseases and conditions. Further, transjugular access was used to perform the measurement of the hepatic venous pressure gradient and liver biopsy that confirmed SOS\/VOD. In late 2023, she was diagnosed with endometrial adenocarcinoma, requiring chemotherapy again. At present, the liver condition is stationary, but the prognosis is, however, uncertain. In conclusion, we presented the atypical case of a female patient who developed portal hypertension syndrome associated with the late onset of SOS\/VOD, after 5-fluorouracil and oxaliplatin chemotherapy for CRC and liver metastases, subsequently diagnosed with endometrial adenocarcinoma, which posed many diagnostic and therapeutic challenges. Given the potentially bad outcome, an early diagnosis of SOS\/VOD in patients receiving drugs of risk is important not only to stratify further risk, but also to initiate an appropriate therapy in order to improve the prognosis.<\/jats:p>","DOI":"10.3390\/life14070845","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T03:52:58Z","timestamp":1720065178000},"page":"845","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatic Veno-Occlusive Disease and Colorectal Cancer: Expect the Unexpected"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-6618","authenticated-orcid":false,"given":"Doina","family":"Georgescu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Florin","family":"Lighezan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Lascu","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7476-6584","authenticated-orcid":false,"given":"Roxana","family":"Buzas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Faur","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Embriology, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Ionita","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8619-0479","authenticated-orcid":false,"given":"Ciprian Ilie","family":"Rosca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Suceava","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Despina","family":"Calamar-Popovici","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Ionita","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-7664","authenticated-orcid":false,"given":"Oana Elena","family":"Ancusa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, \u201cV Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1007\/s12072-017-9827-9","article-title":"The portal hypertension syndrome: Etiology, classification, relevance, and animal models","volume":"12","author":"Bosch","year":"2018","journal-title":"Hepatol. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e00552","DOI":"10.14309\/crj.0000000000000552","article-title":"An Anomalous Cause of Portal Hypertension","volume":"8","author":"Brown","year":"2021","journal-title":"ACG Case Rep. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4254\/wjh.v7.i4.688","article-title":"Cirrhosis and portal hypertension: The importance of risk stratification, the role of hepatic venous pressure gradient measurement","volume":"7","author":"Nicolini","year":"2015","journal-title":"World J. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Berzigotti, A. (2017). Advances and challenges in cirrhosis and portal hypertension. BMC Med., 15.","DOI":"10.1186\/s12916-017-0966-6"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.37358\/RC.19.6.7301","article-title":"Portal vein thrombosis and gut microbiota: Understanding the burden","volume":"70","author":"Georgescu","year":"2019","journal-title":"Rev. Chim."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100316","DOI":"10.1016\/j.jhepr.2021.100316","article-title":"Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy","volume":"3","author":"Iwakiri","year":"2021","journal-title":"JHEP Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41409-023-01992-8","article-title":"Diagnosis and severity criteria for sinusoidal obstruction syndrome\/veno-occlusive disease in adult patients: A refined classification from the European society for blood and marrow transplantation (EBMT)","volume":"58","author":"Mohty","year":"2023","journal-title":"Bone Marrow Transplant."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.bbmt.2015.09.024","article-title":"Hepatic Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation: Risk Factors and Stratification, Prophylaxis, and Treatment","volume":"22","author":"Dalle","year":"2016","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3904\/kjim.2021.082","article-title":"Hepatic sinusoidal obstruction syndrome\/veno-occlusive disease after hematopoietic cell transplantation: Historical and current considerations in Korea","volume":"36","author":"Yoon","year":"2021","journal-title":"Korean J. Int. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/bmt.2015.52","article-title":"Sinusoidal obstruction syndrome\/veno-occlusive disease: Current situation and perspectives-a position statement from the European society for blood and marrow transplantation (EBMT)","volume":"50","author":"Mohty","year":"2015","journal-title":"Bone Marrow Transplant."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"152882","DOI":"10.1016\/j.tox.2021.152882","article-title":"Oxaliplatin-induced hepatic sinusoidal obstruction syndrome","volume":"460","author":"Zhu","year":"2021","journal-title":"Toxicology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"7866","DOI":"10.3748\/wjg.v27.i46.7866","article-title":"Imaging of the chemotherapy-induced hepatic damage: Yellow liver, blue liver, and pseudocirrhosis","volume":"27","author":"Calistri","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.suronc.2016.05.030","article-title":"The influence of chemotherapy-associated sinusoidal dilatation on short-term outcome after partial hepatectomy for colorectal liver metastases: A systematic review with meta-analysis","volume":"25","author":"Zhao","year":"2016","journal-title":"Surg. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bonifazi, F., Barbato, F., Ravaioli, F., Sessa, M., Defrancesco, I., Arpinati, M., Cavo, M., and Colecchia, A. (2020). Diagnosis and Treatment of VOD\/SOS After Allogeneic Hematopoietic Stem Cell Transplantation. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00489"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/bjh.13215","article-title":"How I manage sinusoidal obstruction syndrome after haematopoietic cell transplantation","volume":"168","author":"Carreras","year":"2015","journal-title":"Br. J. Haematol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41409-019-0705-z","article-title":"Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome\/veno-occlusive disease in adult patients: A position statement from an international expert group","volume":"55","author":"Mohty","year":"2020","journal-title":"Bone Marrow Transplant."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00247-021-05174-w","article-title":"Imaging features of hepatic sinusoidal obstruction syndrome or veno-occlusive disease in children","volume":"52","author":"Bohte","year":"2022","journal-title":"Pediatr. Radiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.bbmt.2019.10.024","article-title":"Incidence, Predictors, and Outcomes of Veno-Occlusive Disease\/Sinusoidal Obstruction Syndrome after Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation","volume":"26","author":"Lewis","year":"2020","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_19","first-page":"130","article-title":"Manifestations and Management of Veno-occlusive Disease\/Sinusoidal Obstruction Syndrome in the Era of Contemporary Therapies","volume":"15","author":"Tewari","year":"2017","journal-title":"Clin. Adv. Hematol. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jceh.2014.10.002","article-title":"Sinusoidal obstruction syndrome (hepatic veno-occlusive disease)","volume":"4","author":"Fan","year":"2014","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/s41409-020-01135-3","article-title":"Underdiagnosed veno-occlusive disease\/sinusoidal obstruction syndrome (VOD\/SOS) as a major cause of multi-organ failure in acute leukemia transplant patients: An analysis from the EBMT Acute Leukemia Working Party","volume":"5","author":"Bazarbachi","year":"2021","journal-title":"Bone Marrow Transplant."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e2018001","DOI":"10.4084\/mjhid.2018.001","article-title":"Late-Onset Hepatic Veno-Occlusive Disease after Allografting: Report of Two Cases with Atypical Clinical Features Successfully Treated with Defibrotide","volume":"10","author":"Castellino","year":"2018","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/ajt.16345","article-title":"Early and late-onset veno-occlusive disease\/sinusoidal syndrome post allogeneic stem cell transplantation\u2014A real-world UK experience","volume":"21","author":"Mehra","year":"2021","journal-title":"Am. J. Transplant."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"21797","DOI":"10.18632\/oncotarget.25021","article-title":"Bevacizumab exacerbates sinusoidal obstruction syndrome (SOS) in the animal model and increases MMP 9 production","volume":"9","author":"Jafari","year":"2018","journal-title":"Oncotarget"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wang, Y., Qiao, D., Li, Y., and Xu, F. (2018). Risk factors for hepatic veno-occlusive disease caused by Gynura segetum: A retrospective study. BMC Gastroenterol., 18.","DOI":"10.1186\/s12876-018-0879-7"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e359","DOI":"10.1038\/emm.2017.85","article-title":"Radiation-induced liver disease: Current understanding and future perspectives","volume":"49","author":"Kim","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.bbmt.2019.11.026","article-title":"Genetic Susceptibility to Hepatic Sinusoidal Obstruction Syndrome in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation","volume":"26","author":"Ansari","year":"2020","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_28","first-page":"446","article-title":"Predicting sinusoidal obstruction syndrome after allogeneic stem cell transplantation with the EASIX biomarker panel","volume":"6","author":"Jiang","year":"2021","journal-title":"Haematologica"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.bbmt.2016.07.011","article-title":"High variability in the reported management of hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation","volume":"22","author":"Skeens","year":"2016","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1182\/blood-2014-03-551630","article-title":"How I treat sinusoidal obstruction syndrome","volume":"123","author":"Chao","year":"2014","journal-title":"Blood"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/bmt.2017.161","article-title":"Diagnosis and severity criteria for sinusoidal obstruction syndrome\/veno-occlusive disease in pediatric patients: A new classification from the European society for blood and marrow transplantation","volume":"53","author":"Corbacioglu","year":"2018","journal-title":"Bone Marrow Transplant."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1038\/s41409-021-01233-w","article-title":"Hepatic veno-occlusive disease\/sinusoidal obstruction syndrome after hematopoietic stem cell transplantation for thalassemia major: Incidence, management, and outcome","volume":"56","author":"Lai","year":"2021","journal-title":"Bone Marrow Transplant."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"100558","DOI":"10.1016\/j.jhepr.2022.100558","article-title":"Hepatic venous pressure gradient in sinusoidal obstruction syndrome: Diagnostic value and link with histological lesions","volume":"4","author":"Gressens","year":"2022","journal-title":"JHEP Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/HMER.S79243","article-title":"Defibrotide in the treatment of hepatic veno-occlusive disease","volume":"8","author":"Fulgenzi","year":"2016","journal-title":"Hepat. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.bbmt.2018.06.013","article-title":"Risk Score for the development of veno-occlusive disease after allogeneic hematopoietic cell transplant","volume":"24","author":"Strouse","year":"2018","journal-title":"Biol. Blood Marrow Transplant."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/7\/845\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:09:57Z","timestamp":1760108997000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/7\/845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":35,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["life14070845"],"URL":"https:\/\/doi.org\/10.3390\/life14070845","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,4]]}}}