{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:19:29Z","timestamp":1785007169397,"version":"3.55.0"},"reference-count":55,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Purpose or Objective\u2014The aim of the study is to evaluate the efficacy and safety of SBRT on detectable prostate bed recurrence in RT-na\u00efve prostate cancer patients. Materials and methods: Eighty-six patients who underwent SBRT for macroscopic bed recurrence after prostatectomy were retrospectively included. Patients were treated based on mpMRI or choline\/PSMA PET. Results: The median time to biochemical relapse (BCR) after RP was 46 months, with a median PSA at restaging of 1.04 ng\/mL. Forty-six patients were staged with mpMRI and choline\/PSMA PET, while ten and thirty were treated based on PET and MRI only, respectively. Only one late G \u2265 2 GI toxicity was observed. With a median BCR follow-up of 14 months, twenty-nine patients experienced a BCR with a median PSA at recurrence of 1.66 ng\/mL and a median survival free from the event of 40.1 months. The median time to BCR was 17.9 months. Twenty-seven patients had clinical relapse (CR), with a median CR follow-up of 16.27 months and a median time to CR of 23.0 months. Biochemical recurrence-free survival at one and two years was 88% and 66%, respectively, while clinical recurrence-free survival at one and two years was 92% and 82%, respectively. Regarding local relapses, seven were in the field of treatment, while eight of them were outside the field of treatment. Conclusions: Data showed that SBRT targeting only the macroscopic bed recurrence instead of the whole prostate bed is safe and effective. Additional data and longer follow-ups will provide a clearer indication of the appropriate treatment and staging methodology for these patients.<\/jats:p>","DOI":"10.3390\/life14070870","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T14:04:35Z","timestamp":1720793075000},"page":"870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Image-Guided Stereotactic Body Radiotherapy on Detectable Prostate Bed Recurrence after Prostatectomy in RT-Na\u00efve Patients"],"prefix":"10.3390","volume":"14","author":[{"given":"Riccardo","family":"Santamaria","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, IEO European Institute of Oncology IRCCS, 20139 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4655-4634","authenticated-orcid":false,"given":"Mattia","family":"Zaffaroni","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, IEO European Institute of Oncology IRCCS, 20139 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7830-3149","authenticated-orcid":false,"given":"Maria Giulia","family":"Vincini","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, IEO European Institute of Oncology IRCCS, 20139 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Colombi","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, IEO European Institute of Oncology IRCCS, 20139 Milan, Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4944-7685","authenticated-orcid":false,"given":"Aurora","family":"Gaeta","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, European Institute of Oncology IRCCS, 20139 Milan, Italy"},{"name":"Department of Statistics and Quantitative Methods, University of Milan-Bicocca, 20126 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6580-6767","authenticated-orcid":false,"given":"Federico","family":"Mastroleo","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, IEO European Institute of Oncology IRCCS, 20139 Milan, Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, 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