{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:37:33Z","timestamp":1778243853213,"version":"3.51.4"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Direct skin contact with items containing lanolin can induce sensitization and development of contact dermatitis (CD). This multi-centric study investigated prevalence of lanolin sensitization among 30,269 outpatients from North-Eastern Italy patch tested during 1997\u20132021. Methods: European baseline and extended Triveneto series were applied on the upper part of patients\u2019 back and removed after 48 h. Risk factors for lanolin sensitization were investigated by multiple logistic regression analysis, reporting adjusted odds ratios (aOR) with 95% confidence interval (95%CI). Results. Overall lanolin patch test positive ratio (PTPR) was 1.64% (=501\/30,629), with variability over time and by research center. The body area most frequently affected by CD were hands (36.32%), followed by face (19.52%) and legs (8.09%), with a lanolin PTPR of 1.68%, 1.37% and 3.07%, respectively. Prevalence of occupational CD was 8.24%, and 1.83% patients with occupational CD patch tested positive against lanolin. Lanolin sensitization was significantly higher in males (aOR = 1.34; 95%CI: 1.08; 1.65) and among patients with leg CD aged 49\u201360 years (aOR = 2.34; 95%CI: 1.20; 4.57) or older than 60 (aOR = 4.21; 95%CI: 2.59; 6.85). Sub-group analysis confirmed the significantly higher sensitization rate of older patients with leg CD, with much stronger effect size in females 61+ years old (aOR = 5.33; 95%CI 2.87; 9.89) than males in the same age group (aOR = 2.92; 95%CI: 1.34; 6.39). Moreover, female house painters were more likely to test positive to lanolin. Conclusions: The variability of lanolin PTPR over time and by research center endorsed the ongoing debate on the relevance of the respective skin reaction. Clinicians assessing patients with dermatitis should collect information on potential risk factors for lanolin sensitization, particularly use of skin care products containing the hapten. Occupational exposure to lanolin-containing varnishes should also be considered.<\/jats:p>","DOI":"10.3390\/life14080916","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T14:26:50Z","timestamp":1721744810000},"page":"916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sensitization to Lanolin in North-Eastern Italy, 1997\u20132021: Prevalence, Risk Factors and the Impact of Occupation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6285-7355","authenticated-orcid":false,"given":"Luca","family":"Cegolon","sequence":"first","affiliation":[{"name":"Department of Medical, Surgical & Health Sciences, University of Trieste, 34128 Trieste, Italy"},{"name":"Public Health Department, University Health Agency Giuliano-Isontina (ASUGI), 34148 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-0417","authenticated-orcid":false,"given":"Francesca","family":"Larese Filon","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical & Health Sciences, University of Trieste, 34128 Trieste, Italy"},{"name":"Occupational Medicine Unit, University Health Agency Giuliano-Isontina (ASUGI), 34148 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the North-East Research Group on Contact Dermatitis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"ref_1","first-page":"243","article-title":"Analysis of ointments, oils and waxes. XX. The chemical composition of lanolin wax. 2. Alcohols","volume":"33","author":"Chemtob","year":"1975","journal-title":"Ann. Pharm. Fran\u00e7aises"},{"key":"ref_2","first-page":"63","article-title":"Analysis of ointments, oils and waxes. XII. Study of the chemical composition of lanolin. I. Preliminary examination and fractionation of the sample studies","volume":"31","author":"Fawaz","year":"1973","journal-title":"Ann. Pharm. Fran\u00e7aises"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0536.1979.tb04801.x","article-title":"Lanolin and derivatives chemistry: Relationship to allergic contact dermatitis","volume":"5","author":"Schlossman","year":"1979","journal-title":"Contact Dermat."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1089\/derm.2022.0002","article-title":"Lanolin","volume":"34","author":"Jenkins","year":"2023","journal-title":"Dermatitis"},{"key":"ref_5","unstructured":"National Center for Biotechnology Information (2024, July 14). PubChem Compound Summary Lanolin, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Lanolin."},{"key":"ref_6","unstructured":"National Center for Biotechnology Information (2024, July 14). PubChem Annotation Record for Lanolin, Source: Hazardous Substances Data Bank (HSDB), Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/source\/hsdb\/1817."},{"key":"ref_7","first-page":"63","article-title":"Final report of the safety assessment for acetylated lanolin alcohol and related compounds","volume":"4","author":"Elder","year":"1980","journal-title":"J. Environ. Pathol. Toxicol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"E06071","DOI":"10.1016\/j.heliyon.2021.e06071","article-title":"Hydrogel or ointment? comparison of five different galenics regarding tissue breathability and transepidermal water loss","volume":"7","author":"Voss","year":"2021","journal-title":"Heliyon"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.12788\/cutis.0825","article-title":"Lanolin: The 2023 American Contact Dermatitis Society Allergen of the Year","volume":"112","author":"Johnson","year":"2023","journal-title":"Cutis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/DER.0000000000000871","article-title":"Lanolin allergic reactions: North American contact dermatitis group experience, 2001 to 2018","volume":"33","author":"Silverberg","year":"2022","journal-title":"Dermatitis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/jnu.12010","article-title":"A systematic review of the interventions for nipple trauma in breastfeeding mothers","volume":"45","author":"Vieira","year":"2013","journal-title":"J. Nurs. Sch."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2133.1966.tb12196.x","article-title":"Lanolin dermatitis","volume":"78","author":"Cronin","year":"1966","journal-title":"Br. J. Derm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/cod.13689","article-title":"Clinical relevance of positive patch test reactions to lanolin: A ROAT study","volume":"84","author":"Uldahl","year":"2021","journal-title":"Contact Dermat."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2310\/6620.2008.07060","article-title":"Lanolin allergy: History, epidemiology, responsible allergens, and management","volume":"19","author":"Lee","year":"2008","journal-title":"Dermatitis"},{"key":"ref_15","first-page":"18","article-title":"Oil on paper: A collaborative conservation challenge","volume":"36","author":"Herro","year":"2017","journal-title":"Book Pap. Group Annu."},{"key":"ref_16","first-page":"1510","article-title":"Zum Kapitel der Hautkrankheiten auf \u201cnerv\u00f6ser\u201d Basis","volume":"69","author":"Marcus","year":"1922","journal-title":"M\u00fcnch Med. Wochenschr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0021-8707(30)90200-6","article-title":"The patch test in contact dermatitis (dermatitis venenata)","volume":"1","author":"Ramirez","year":"1929","journal-title":"J. Allergy."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1600-0536.1983.tb04448.x","article-title":"Comments on the allergenic activity of lanolin","volume":"9","author":"Giorgini","year":"1983","journal-title":"Contact Dermat."},{"key":"ref_19","first-page":"99","article-title":"Allergens of lanolin. Part 1. Isolation and identification of the allergens of hydrogenated lano- lin. Part 2. Allergenicity of synthetic alkane-alpha-beta-diols and alkanealpha, omega-diols","volume":"34","author":"Takano","year":"1983","journal-title":"J. Soc. Cosmet. Chem."},{"key":"ref_20","first-page":"127","article-title":"Skin reactions to ointment bases","volume":"49","author":"Hjorth","year":"1963","journal-title":"Trans. St. Johns. Hosp. Dermatol. Soc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0190-9622(82)70080-5","article-title":"Prospective study of cosmetic reactions: 1977\u20131980. North American Contact Dermatitis Group","volume":"6","author":"Eiermann","year":"1982","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-0536.1998.tb05856.x","article-title":"The myth of lanolin allergy","volume":"39","author":"Kligman","year":"1998","journal-title":"Contact Dermat."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1600-0536.1979.tb04824.x","article-title":"Allergy to lanolin","volume":"5","author":"Mortensen","year":"1979","journal-title":"Contact Dermat."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jaad.2009.11.033","article-title":"Results of patch testing to personal care product allergens in a standard series and a supplemental cosmetic series: An analysis of 945 patients from the Mayo Clinic Contact Dermatitis Group, 2000\u20132007","volume":"63","author":"Wetter","year":"2010","journal-title":"J. Am Acad. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2310\/6620.2009.08081","article-title":"Positive patch test reactions to lanolin: Cross-sectional data from the north American contact dermatitis group, 1994 to 2006","volume":"20","author":"Warshaw","year":"2009","journal-title":"Dermatitis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/DER.0b013e3182937aa4","article-title":"Diagnosis and Prevalence of Lanolin Allergy","volume":"24","author":"Miest","year":"2013","journal-title":"Dermatitis"},{"key":"ref_27","first-page":"176","article-title":"North American Contact Dermatitis Group patch-test results, 2001\u20132002 study period","volume":"15","author":"Pratt","year":"2004","journal-title":"Dermatitis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/cod.13210","article-title":"Diagnosing lanolin contact allergy with lanolin alcohol and Amerchol L101","volume":"80","author":"Knijp","year":"2019","journal-title":"Contact Dermat."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/cod.12952","article-title":"IVDK Contact sensitization to lanolin alcohols and Amerchol\u00ae L101\u2014Analysis of IVDK data","volume":"78","author":"Uter","year":"2018","journal-title":"Contact Dermat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1600-0536.1997.tb00398.x","article-title":"Discrepancy in patch test results with wool wax alcohols and Amerchol L-101","volume":"36","author":"Matthieu","year":"1997","journal-title":"Contact Dermat."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/cod.12872","article-title":"Contact allergy to lanolin: Temporal changes in prevalence and association with atopic dermatitis","volume":"78","author":"Fransen","year":"2018","journal-title":"Contact Dermat."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/cod.14035","article-title":"Guidelines for diagnosis, prevention, and treatment of hand eczema","volume":"86","author":"Thyssen","year":"2022","journal-title":"Contact Dermat."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1600-0536.2007.01313.x","article-title":"Changes of the patch test population (MOAHLFA index) in long-term participants of the Information Network of Departments of Dermatology, 1999\u20132006","volume":"59","author":"Uter","year":"2008","journal-title":"Contact Dermat."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/pds.4064","article-title":"Contact allergy to ingredients of topical medications: Results of the European Surveillance System on Contact Allergies (ESSCA), 2009\u20132012","volume":"25","author":"Uter","year":"2016","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1365-2133.2001.04277.x","article-title":"A retrospective analysis of contact allergy to lanolin","volume":"145","author":"Wakelin","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1600-0536.1981.tb03984.x","article-title":"Lanolin of reduced sensitizing potential","volume":"7","author":"Clark","year":"1981","journal-title":"Contact Dermat."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.12968\/bjon.2000.9.1.6415","article-title":"Medilan: A hypoallergenic lanolin for emollient therapy","volume":"9","author":"Stone","year":"2000","journal-title":"Br. J. Nurs."},{"key":"ref_38","first-page":"830","article-title":"The paraben paradox","volume":"12","author":"Fisher","year":"1973","journal-title":"Cutis"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jaad.2018.07.017","article-title":"Allergic contact dermatitis to personal care products and topical medications in adults with atopic dermatitis","volume":"79","author":"Rastogi","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000063356","article-title":"The spectrum of contact allergy in elderly patients with and without lower leg dermatitis","volume":"204","author":"Uter","year":"2002","journal-title":"Dermatology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF03327387","article-title":"Allergic contact sensitivity in elderly patients","volume":"16","author":"Piaserico","year":"2004","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/j.1365-2133.2004.05917.x","article-title":"A high prevalence of sensitization still persists in leg ulcer patients: A retrospective series of 106 patients tested between 2001 and 2002 and a meta-analysis of 1975\u20132003 data","volume":"150","author":"Machet","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/cod.12307","article-title":"Contact sensitization to modern dressings: A multicentre study on 354 patients with chronic leg ulcers","volume":"72","author":"Valois","year":"2015","journal-title":"Contact Dermat."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1600-0536.2009.01541.x","article-title":"Contact allergy in chronic leg ulcers: Results of a multicentre study carried out in 423 patients and proposal for an updated series of patch tests","volume":"60","author":"Barbaud","year":"2009","journal-title":"Contact Dermat."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/cod.12763","article-title":"The current spectrum of contact sensitization in patients with chronic leg ulcers or stasis dermatitis\u2014New data from the Information Network of Departments of Dermatology (IVDK)","volume":"77","author":"Geier","year":"2017","journal-title":"Contact Dermat."},{"key":"ref_46","unstructured":"Rolex Lanolin (2024, June 10). Lanolin. Available online: www.rolexlanolin.com\/use-of-lanolin\/."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/8\/916\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:21:35Z","timestamp":1760109695000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/8\/916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["life14080916"],"URL":"https:\/\/doi.org\/10.3390\/life14080916","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,23]]}}}