{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:17:22Z","timestamp":1760145442482,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["21K10437","24K13522"],"award-info":[{"award-number":["21K10437","24K13522"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Functional dyspepsia is distinguishable from Helicobacter pylori-associated dyspepsia. However, distinguishing H. pylori-associated dyspepsia from functional dyspepsia before H. pylori eradication is difficult. Therefore, in the present study, we aimed to investigate whether serum pepsinogen levels before H. pylori eradication are associated with the amelioration of dyspepsia after successful H. pylori eradication. Additionally, we examined the usefulness of serum pepsinogen levels and other factors in predicting dyspepsia outcomes. H. pylori eradication was effective in 14 patients (Responders) and ineffective in 19 patients (Non-responders). The pepsinogen I\/II ratio in Responders (3.4 \u00b1 1.2) and Non-responders (2.3 \u00b1 1.0) differed significantly (p = 0.006). The optimal cut-off pepsinogen I\/II value was 2.3. Multivariate logistic regression analysis showed that the adjusted odds ratio for Non-responders was 26.1 (95% confidence interval: 2.0\u2013338.0, p = 0.012) for a pepsinogen I\/II ratio \u2264 2.3 and 8.10 (95% confidence interval: 1.1\u201357.6, p = 0.037) for smoking habits. The pepsinogen I\/II ratio and smoking habits were associated with the effects of H. pylori eradication on dyspeptic symptoms. Thus, the pepsinogen I\/II ratio cut-off value can be used to identify patients likely to respond to H. pylori eradication after the resolution of dyspeptic symptoms.<\/jats:p>","DOI":"10.3390\/life14080935","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T14:31:07Z","timestamp":1721917867000},"page":"935","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Predicting Effectiveness of Eradication Therapy for Helicobacter pylori-Associated Dyspepsia Symptoms"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-5523","authenticated-orcid":false,"given":"Kohei","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1690-5923","authenticated-orcid":false,"given":"Daisuke","family":"Chinda","sequence":"additional","affiliation":[{"name":"Division of Endoscopy, Hirosaki University Hospital, Hirosaki 036-8563, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Aomori General Health Examination Center, Aomori 030-0962, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsu","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Akitaya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Nomiya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Sasaki Clinic of Gastroenterology and Internal Medicine, Aomori 030-0914, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Komai","sequence":"additional","affiliation":[{"name":"Komai Clinic of Gastroenterology and Internal Medicine, Aomori 030-0947, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Sawada","sequence":"additional","affiliation":[{"name":"Sawada Clinic of Internal Medicine, Hirosaki 036-8261, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"Saito","sequence":"additional","affiliation":[{"name":"Shinjo Clinic of Gastroenterology and Internal Medicine, Aomori 038-0042, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Chiba","sequence":"additional","affiliation":[{"name":"Chiba Clinic of Gastroenterology and Internal Medicine, Hirosaki 036-8316, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotake","family":"Sakuraba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsaku","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the RINGO Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","article-title":"Gastroduodenal disorders","volume":"150","author":"Stanghellini","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1440-1746.2010.06249.x","article-title":"Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life","volume":"25","author":"Kaji","year":"2010","journal-title":"J. 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