{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:43:21Z","timestamp":1792100601061,"version":"4.4.0"},"reference-count":180,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Life"],"abstract":"<jats:p>The present review explores the underlying mechanisms of phytophotodermatitis, a non-immunologic skin reaction triggered by certain plants followed by exposure to ultraviolet radiation emitted by sunlight. Recent research has advanced our understanding of the pathophysiology of phytophotodermatitis, highlighting the interaction between plant-derived photosensitizing compounds (e.g., furanocoumarins and psoralens) and ultraviolet light leading to skin damage (e.g., erythema, fluid blisters, edema, and hyperpigmentation), identifying these compounds as key contributors to the phototoxic reactions causing phytophotodermatitis. Progress in understanding the molecular pathways involved in the skin\u2019s response to these compounds has opened avenues for identifying potential therapeutic targets suitable for the management and prevention of this condition. The review emphasizes the importance of identifying the most common phototoxic plant families (e.g., Apiaceae, Rutaceae, and Moraceae) and plant species (e.g., Heracleum mantegazzianum, Ruta graveolens, Ficus carica, and Pastinaca sativa), as well as the specific phytochemical compounds responsible for inducing phytophototoxicity (e.g., limes containing furocoumarin have been linked to lime-induced photodermatitis), underscoring the significance of recognizing the dangerous plant sources. Moreover, the most used approaches and tests for accurate diagnosis such as patch testing, Wood\u2019s lamp examination, or skin biopsy are presented. Additionally, preventive measures such as adequate clothing (e.g., long-sleeved garments and gloves) and treatment strategies based on the current knowledge of phytophotodermatitis including topical and systemic therapies are discussed. Overall, the review consolidates recent findings in the field, covering a diverse array of phototoxic compounds in plants, the mechanisms by which they trigger skin reactions, and the implications for clinical management. By synthesizing these insights, we provide a comprehensive understanding of phytophotodermatitis, providing valuable information for both healthcare professionals and researchers working to address this condition.<\/jats:p>","DOI":"10.3390\/life14081019","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T04:29:57Z","timestamp":1723782597000},"page":"1019","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["New Insights Concerning Phytophotodermatitis Induced by Phototoxic Plants"],"prefix":"10.3390","volume":"14","author":[{"given":"Cristina","family":"Grosu (Dumitrescu)","sequence":"first","affiliation":[{"name":"Department of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-2484","authenticated-orcid":false,"given":"Alex-Robert","family":"J\u00eejie","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hora\u0163iu","family":"Manea","sequence":"additional","affiliation":[{"name":"University Clinic Clinical Skills, Department I Nursing, Faculty of Nursing, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Timisoara Municipal Emergency Clinical Hospital, 5 Take Ionescu Bv., 300062 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2631-7028","authenticated-orcid":false,"given":"Elena-Alina","family":"Moac\u0103","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Research Centre for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrada","family":"Iftode","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Research Centre for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7138-4908","authenticated-orcid":false,"given":"Daliana","family":"Minda","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Research and Processing Center for Medical and Aromatic Plants (Plant-Med), \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Chioiba\u015f","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"CBS Medcom Hospital, 12th Popa Sapca Street, 300047 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina-Adriana","family":"Dehelean","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Drug Industry, Management and Legislation, Faculty of Pharmacy, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"},{"name":"Research Centre for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Vlad","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Faculty of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 2nd Eftimie Murgu 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Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/phpp.12672","article-title":"Lime-Induced Phytophotodermatitis Occurred in Two Family Members Presented as Hyperpigmentation","volume":"37","author":"Wang","year":"2021","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.5021\/ad.2018.30.1.75","article-title":"Asymptomatic Hyperpigmentation without Preceding Inflammation as a Clinical Feature of Citrus Fruits-Induced Phytophotodermatitis","volume":"30","author":"Choi","year":"2018","journal-title":"Ann. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.5021\/ad.2017.29.1.86","article-title":"Five Cases of Phytophotodermatitis Caused by Fig Leaves and Relevant Literature Review","volume":"29","author":"Son","year":"2017","journal-title":"Ann. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/DER.0000000000000691","article-title":"Psoralen-Induced Phytophotodermatitis","volume":"32","author":"Ellis","year":"2021","journal-title":"Dermatitis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"25090","DOI":"10.3402\/jchimp.v4.25090","article-title":"Lime-Induced Phytophotodermatitis","volume":"4","author":"Hankinson","year":"2014","journal-title":"J. Community Hosp. Intern. Med. Perspect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jaad.2006.10.982","article-title":"An Outbreak of Paederus Dermatitis in a Suburban Hospital in South India: A Report of 123 Cases and Review of Literature","volume":"57","author":"Gnanaraj","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00431-006-0393-8","article-title":"Phytophotodermatitis Mimicking Non-Accidental Injury or Self-Harm","volume":"166","author":"Mehta","year":"2007","journal-title":"Eur. J. Pediatr."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Lovell, C., Paulsen, E., and Lepoittevin, J.-P. (2020). Adverse Skin Reactions to Plants and Plant Products. Contact Dermatitis, Springer International Publishing.","DOI":"10.1007\/978-3-319-72451-5_88-2"},{"key":"ref_11","first-page":"187","article-title":"Botanical Briefs: Phytophotodermatitis Is an Occupational and Recreational Dermatosis in the Limelight","volume":"107","author":"Janusz","year":"2021","journal-title":"Cutis"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Trevino, J., and Chen, A.Y.-Y. (2020). Dermatological Manual of Outdoor Hazards, Springer International Publishing.","DOI":"10.1007\/978-3-030-37782-3"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/bjd.13405","article-title":"Photodermatology over the Past 125 Years","volume":"171","author":"Roelandts","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/pde.15556","article-title":"Dermatitis versus Nonaccidental Trauma: A Systematic Review of Initial Pediatric Misdiagnoses","volume":"41","author":"King","year":"2024","journal-title":"Pediatr. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1600-0536.2008.01451.x","article-title":"Phytophotodermatitis Due to Homemade Ointment for Pediculosis Capitis","volume":"59","author":"Morais","year":"2008","journal-title":"Contact Dermat."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.26452\/ijrps.v11i4.3239","article-title":"Phytophotodermatitis: A Case Report","volume":"11","author":"Saha","year":"2020","journal-title":"Int. J. Res. Pharm. Sci."},{"key":"ref_17","first-page":"51","article-title":"Phytophotodermatitis: A Review of Its Clinical and Pathogenic Aspects","volume":"1","author":"Jorge","year":"2016","journal-title":"J. Dermatol. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lozzi, F., Di Raimondo, C., Lanna, C., Diluvio, L., Mazzilli, S., Garofalo, V., Dika, E., Dellambra, E., Coniglione, F., and Bianchi, L. (2020). Latest Evidence Regarding the Effects of Photosensitive Drugs on the Skin: Pathogenetic Mechanisms and Clinical Manifestations. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12111104"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1396-0296.2004.04026.x","article-title":"Dermatologic Therapy Photocontact Dermatitis","volume":"17","author":"Eleo","year":"2004","journal-title":"Dermatol. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"271","DOI":"10.4082\/kjfm.21.0229","article-title":"Phytophotodermatitis Due to a Citrus-Based Hand Sanitizer: A Case Report","volume":"43","author":"Lee","year":"2022","journal-title":"Korean J. Fam. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/omcr\/omz113","article-title":"Lime-Induced Phytophotodermatitis","volume":"2019","author":"Abugroun","year":"2019","journal-title":"Oxf. Med. Case Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"D01110","DOI":"10.1029\/2009JD012442","article-title":"Low-Frequency Variations in Surface Atmospheric Humidity, Temperature, and Precipitation: Inferences from Reanalyses and Monthly Gridded Observational Data Sets","volume":"115","author":"Simmons","year":"2010","journal-title":"J. Geophys. Res. Atmos."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1016\/j.burns.2015.06.007","article-title":"Invasive Giant Hogweeds in Poland: Risk of Burns among Forestry Workers and Plant Distribution","volume":"41","author":"Rzymski","year":"2015","journal-title":"Burns"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Petit, R., Izambart, J., Guillou, M., da Silva Almeida, J.R.G., de Oliveira Junior, R.G., Sol, V., Ouk, T., Grougnet, R., Quintans-J\u00fanior, L.J., and Sitarek, P. (2023). A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers. Chem. Biodivers., 21.","DOI":"10.1002\/cbdv.202300494"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11882-024-01147-9","article-title":"The Role of the Environment in Allergic Skin Disease","volume":"24","author":"Faraz","year":"2024","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.12788\/cutis.0990","article-title":"Botanical Briefs: Fig Phytophotodermatitis (Ficus carica)","volume":"113","author":"Barker","year":"2024","journal-title":"Cutis"},{"key":"ref_27","first-page":"116","article-title":"Prolonged Hyperpigmentation Induced by Wild Parsnip","volume":"2","author":"Walling","year":"2020","journal-title":"Phytophotodermatitis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.det.2020.02.010","article-title":"Plant Associated Irritant & Allergic Contact Dermatitis (Phytodermatitis)","volume":"38","author":"Sheehan","year":"2020","journal-title":"Dermatol. Clin."},{"key":"ref_29","first-page":"e41888","article-title":"Fig Tree-Induced Phytophotodermatitis: A Case Report on the Perils of a Hobby","volume":"15","author":"Pinto","year":"2023","journal-title":"Cureus"},{"key":"ref_30","first-page":"E31","article-title":"Case Letter Phytophotodermatitis in a Butterfly Enthusiast Induced by Common Rue","volume":"105","author":"Conner","year":"2020","journal-title":"Cutis"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.12788\/cutis.0389","article-title":"Botanical Briefs: Phytophotodermatitis Caused by Giant Hogweed (Heracleum mantegazzianum)","volume":"108","author":"Flanagan","year":"2021","journal-title":"Cutis"},{"key":"ref_32","first-page":"938","article-title":"Phytophotodermatitis: Rash with many faces","volume":"63","author":"Harshman","year":"2017","journal-title":"Can. Fam. Physician."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1469-8137.1992.tb00068.x","article-title":"Light-activated plant defense","volume":"122","author":"Downum","year":"1992","journal-title":"New Phytol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/cod.12122","article-title":"Systemic Allergic Dermatitis Caused by Apiaceae Root Vegetables","volume":"70","author":"Paulsen","year":"2014","journal-title":"Contact Dermat."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3831\/KPI.2021.24.1.14","article-title":"Review of Pharmacological Properties and Chemical Constituents of Pastinaca Sativa","volume":"24","author":"Kenari","year":"2021","journal-title":"J. Pharmacopunct."},{"key":"ref_36","first-page":"15","article-title":"Phototoxic activity of selected Thai Rutaceous and Umbelliferous plant extracts","volume":"26","author":"Phachasupap","year":"2012","journal-title":"J. Health Res."},{"key":"ref_37","first-page":"213","article-title":"Phototoxicity of Herbal Plants and Herbal Products","volume":"31","author":"Fu","year":"2013","journal-title":"J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/cod.14162","article-title":"Allergic Contact Dermatitis to Compositae: An Australian Case Series","volume":"87","author":"Punchihewa","year":"2022","journal-title":"Contact Dermat."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1600-0536.1992.tb00888.x","article-title":"Compositae Dermatitis: A Survey","volume":"26","author":"Paulsen","year":"1992","journal-title":"Contact Dermat."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.phytochem.2018.05.003","article-title":"Phytochemical Profiles, Phototoxic and Antioxidant Properties of Eleven Hypericum Species\u2014A Comparative Study","volume":"152","author":"Napoli","year":"2018","journal-title":"Phytochemistry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3897\/phytokeys.102.24380","article-title":"The Medicinal Plants of Myanmar","volume":"102","author":"DeFilipps","year":"2018","journal-title":"PhytoKeys"},{"key":"ref_42","first-page":"1254","article-title":"Patterns of Furanocoumarin Distribution and Insect Herbivory in the Umbelliferae","volume":"62","author":"Berenbaum","year":"1981","journal-title":"Plant Chem. Community Struct."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1046\/j.1365-2745.1999.00403.x","article-title":"Slug Herbivory as a Limiting Factor for the Geographical Range of Arnica Montana","volume":"87","author":"Bruelheide","year":"1999","journal-title":"J. Ecol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2699.2010.02407.x","article-title":"Topographically Controlled Thermal-Habitat Differentiation Buffers Alpine Plant Diversity against Climate Warming","volume":"38","author":"Scherrer","year":"2011","journal-title":"J. Biogeogr."},{"key":"ref_45","first-page":"208747","article-title":"Plant Phenotypic Plasticity in Response to Environmental Factors","volume":"2014","author":"Gratani","year":"2014","journal-title":"Adv. Bot."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1539-6924.2009.01343.x","article-title":"Ensemble Habitat Mapping of Invasive Plant Species","volume":"30","author":"Stohlgren","year":"2010","journal-title":"Risk Anal."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Kowalska, J., Rok, J., Rzepka, Z., and Wrze\u015bniok, D. (2021). Drug-Induced Photosensitivity\u2014From Light and Chemistry to Biological Reactions and Clinical Symptoms. Pharmaceuticals, 14.","DOI":"10.3390\/ph14080723"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10530-021-02645-x","article-title":"Risks of Giant Hogweed (Heracleum mantegazzianum) Range Increase in North America","volume":"24","author":"Cuddington","year":"2022","journal-title":"Biol. Invasions"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hussain, S.Z., Naseer, B., Qadri, T., Fatima, T., and Bhat, T.A. (2021). Fig (Ficus carica)\u2014Morphology, Taxonomy, Composition and Health Benefits. Fruits Grown in Highland Regions of the Himalayas, Springer International Publishing.","DOI":"10.1007\/978-3-030-75502-7_6"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3417\/2010034","article-title":"New Subfamily Classification for the Rutaceae","volume":"99","author":"Morton","year":"2014","journal-title":"Ann. Mo. Bot. Gard."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1002\/jsfa.2979","article-title":"Analysis of Furanocoumarins in Vegetables (Apiaceae) and Citrus Fruits (Rutaceae)","volume":"87","author":"Peroutka","year":"2007","journal-title":"J. Sci. Food Agric."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"10677","DOI":"10.1021\/jf402763t","article-title":"Coumarin and Furanocoumarin Quantitation in Citrus Peel via Ultraperformance Liquid Chromatography Coupled with Mass Spectrometry (UPLC-MS)","volume":"61","author":"Dugrand","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1039\/c1pp05191a","article-title":"A Review of UVA-Mediated Photosensitivity Disorders","volume":"11","author":"Smith","year":"2012","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jpeds.2021.08.029","article-title":"Fig Tree Leaves Phytophotodermatitis","volume":"239","author":"Papazoglou","year":"2021","journal-title":"J. Pediatr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.burns.2016.10.018","article-title":"Keeping Pace with the Media; Giant Hogweed Burns\u2014A Case Series and Comprehensive Review","volume":"43","author":"Baker","year":"2017","journal-title":"Burns"},{"key":"ref_56","first-page":"e54286","article-title":"Phytophotodermatitis Due to Fig Tree Sap Activated by Ultraviolet Light: A Case Report","volume":"16","author":"Vilela","year":"2024","journal-title":"Cureus"},{"key":"ref_57","first-page":"e59674","article-title":"Phytophotodermatitis From Lime Margaritas on a Mexico Vacation","volume":"16","author":"Cochran","year":"2024","journal-title":"Cureus"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Tine, Y., Renucci, F., Costa, J., W\u00e9l\u00e9, A., and Paolini, J. (2017). A Method for LC-MS\/MS Profiling of Coumarins in Zanthoxylum zanthoxyloides (Lam.) B. Zepernich and Timler Extracts and Essential Oils. Molecules, 22.","DOI":"10.3390\/molecules22010174"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"21526567221074944","DOI":"10.1177\/21526567221074944","article-title":"Recurrent Bilateral Lime Disease in a Young Female-Case Report","volume":"13","author":"Nagireddi","year":"2022","journal-title":"Allergy Rhinol."},{"key":"ref_60","first-page":"793","article-title":"Polyphenols and Polyphenol-Derived Compounds and Contact Dermatitis","volume":"Volume 1","author":"Christensen","year":"2013","journal-title":"Polyphenols in Human Health and Disease"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3122\/jabfm.2021.02.200382","article-title":"Margarita Burn: Recognition and Treatment of Phytophotodermatitis","volume":"34","author":"Maniam","year":"2021","journal-title":"J. Am. Board Fam. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"168","DOI":"10.31083\/j.fbl2905168","article-title":"Plants-Occurring Anthraquinones as Photosensitive Compounds for Photodynamic Method: A Critical Overview","volume":"29","author":"Mantareva","year":"2024","journal-title":"Front. Biosci.\u2014Landmark"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.toxicon.2019.06.007","article-title":"Wild Parsnip (Pastinaca sativa)-Induced Photosensitization","volume":"167","author":"Stegelmeier","year":"2019","journal-title":"Toxicon"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Bonamonte, D., Foti, C., Gullo, G., and Angelini, G. (2021). Plant Contact Dermatitis. Clinical Contact Dermatitis, Springer International Publishing.","DOI":"10.1007\/978-3-030-49332-5_16"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.sajb.2014.12.006","article-title":"A Survey of Plants Responsible for Causing Allergic Contact Dermatitis in the Amathole District, Eastern Cape, South Africa","volume":"97","author":"Otang","year":"2015","journal-title":"S. Afr. J. Bot."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Veberic, R., and Mikulic-Petkovsek, M. (2015). Phytochemical Composition of Common Fig (Ficus carica L.) Cultivars. Nutritional Composition of Fruit Cultivars, Elsevier.","DOI":"10.1016\/B978-0-12-408117-8.00011-8"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2478\/s13382-014-0238-z","article-title":"Unusual Complications after Occupational Exposure to Giant Hogweed (Heracleum mantegazzianum): A Case Report","volume":"27","author":"Klimaszyk","year":"2014","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/jrnms-102-19","article-title":"An Unusual Rash for Royal: A Case Series","volume":"102","author":"Booth","year":"2016","journal-title":"J. R. Nav. Med. Serv."},{"key":"ref_69","first-page":"E118","article-title":"Lemons in the Arizona Sunshine: The Effects of Furocoumarins Leading to Phytophotodermatitis and Burn-like Injuries","volume":"29","author":"Matthews","year":"2017","journal-title":"Wounds"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"124","DOI":"10.12788\/cutis.0340","article-title":"Plant Dermatitis: More Than Just Poison Ivy","volume":"108","author":"Watchmaker","year":"2021","journal-title":"Cutis"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"13030\/qt0rc4v2qz","DOI":"10.5070\/D3242038189","article-title":"Phytophotodermatitis Induced by Wild Parsnip","volume":"24","author":"Walling","year":"2018","journal-title":"Dermatol. Online J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/JDN.0000000000000153","article-title":"Plant-Associated Dermatitis","volume":"7","author":"Iyer","year":"2015","journal-title":"J. Dermatol. Nurses Assoc."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/jbcr\/irx040","article-title":"A Phytophototoxic Injury at a Burns Unit: The Ungraceful After-Effects of the \u201cCommon Rue\u201d Plant","volume":"39","author":"Radotra","year":"2018","journal-title":"J. Burn Care Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jpag.2013.11.001","article-title":"Phytophotodermatitis","volume":"27","author":"Moreau","year":"2014","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/arch.940230204","article-title":"Food Utilization and Antioxidant Enzyme Activities of Black Swallowtail in Response to Plant Phototoxins","volume":"23","author":"Lee","year":"1993","journal-title":"Arch. Insect Biochem. Physiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1021\/ar0402863","article-title":"Light and Singlet Oxygen in Plant Defense against Pathogens: Phototoxic Phenalenone Phytoalexins","volume":"39","author":"Flors","year":"2006","journal-title":"Acc. Chem. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1111\/pde.12396","article-title":"Phototoxic Plant Burns: Report of a Case and Review of Topical Wound Treatment in Children","volume":"31","author":"Pfurtscheller","year":"2014","journal-title":"Pediatr. Dermatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/ps.6076","article-title":"Review: Allelochemicals as Multi-Kingdom Plant Defence Compounds: Towards an Integrated Approach","volume":"77","author":"Hickman","year":"2021","journal-title":"Pest. Manag. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.aca.2019.12.015","article-title":"Determination of Phototoxic Furanocoumarins in Natural Cosmetics Using SPE with LC-MS","volume":"1101","author":"Kreidl","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/B978-0-444-63430-6.00005-9","article-title":"Furanocoumarins: Biomolecules of Therapeutic Interest","volume":"Volume 43","author":"Blanquer","year":"2014","journal-title":"Studies in Natural Products Chemistry"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Souto, A.L., Sylvestre, M., T\u00f6lke, E.D., Tavares, J.F., Barbosa-Filho, J.M., and Cebri\u00e1n-Torrej\u00f3n, G. (2021). Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications, and Challenges. Molecules, 26.","DOI":"10.3390\/molecules26164835"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Muniyandi, K., George, B., Parimelazhagan, T., and Abrahamse, H. (2020). Role of Photoactive Phytocompounds in Photodynamic Therapy of Cancer. Molecules, 25.","DOI":"10.3390\/molecules25184102"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Acharya, R., Chacko, S., Bose, P., Lapenna, A., and Pattanayak, S.P. (2019). Structure Based Multitargeted Molecular Docking Analysis of Selected Furanocoumarins against Breast Cancer. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-52162-0"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Cuevas, J.M., Seoane-Rivero, R., Navarro, R., and Marcos-Fern\u00e1ndez, \u00c1. (2020). Coumarins into Polyurethanes for Smart and Functional Materials. Polymers, 12.","DOI":"10.3390\/polym12030630"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/157488509787081886","article-title":"Natural and Synthetic Furanocoumarins as Treatment for Vitiligo and Psoriasis","volume":"4","author":"Conforti","year":"2009","journal-title":"Curr. Drug Ther."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1002\/ange.201809984","article-title":"Mechanistische Studien in Der Photokatalyse","volume":"131","author":"Buzzetti","year":"2019","journal-title":"Angew. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/BJ20150942","article-title":"New Photosensitizers for Photodynamic Therapy","volume":"473","author":"Abrahamse","year":"2016","journal-title":"Biochem. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.1021\/acs.chemrev.0c01212","article-title":"Photoclick Chemistry: A Bright Idea","volume":"121","author":"Fairbanks","year":"2021","journal-title":"Chem. Rev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1039\/C7CS00594F","article-title":"Supramolecular Photosensitizers Rejuvenate Photodynamic Therapy","volume":"47","author":"Li","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4161\/viru.26475","article-title":"Can Biowarfare Agents Be Defeated with Light?","volume":"4","author":"Vatansever","year":"2013","journal-title":"Virulence"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"152985","DOI":"10.1016\/j.phymed.2019.152985","article-title":"The Photoactivity of Natural Products\u2014An Overlooked Potential of Phytomedicines?","volume":"60","author":"Siewert","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Dias, L.D., and Mfouo-Tynga, I.S. (2020). Learning from Nature: Bioinspired Chlorin-Based Photosensitizers Immobilized on Carbon Materials for Combined Photodynamic and Photothermal Therapy. Biomimetics, 5.","DOI":"10.3390\/biomimetics5040053"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Klimenko, A., Huber, R., Marcourt, L., Tabakaev, D., Koval, A., Dautov, S.S., Dautova, T.N., Wolfender, J.L., Thew, R., and Khotimchenko, Y. (2023). Shallow- and Deep-Water Ophiura Species Produce a Panel of Chlorin Compounds with Potent Photodynamic Anticancer Activities. Antioxidants, 12.","DOI":"10.3390\/antiox12020386"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1055\/s-1999-14049","article-title":"A Bioassay Using Artemia Salina for Detecting Phototoxicity of Plant Coumarins","volume":"65","author":"Ojala","year":"1999","journal-title":"Planta Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"100044","DOI":"10.1016\/j.phyplu.2021.100044","article-title":"Light-Activated Green Drugs: How We Can Use Them in Photodynamic Therapy and Mass-Produce Them with Biotechnological Tools","volume":"1","author":"Foresto","year":"2021","journal-title":"Phytomed. Plus"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alo, M. (2021). Phototoxic and Photoallergic Contact Reactions. Contact Dermatitis, Springer International Publishing.","DOI":"10.1007\/978-3-030-36335-2_18"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3109\/15569527.2011.584232","article-title":"Development of Phytophotodermatitis in Two Cases Related to Plantago Lanceolata","volume":"31","author":"Ozkol","year":"2012","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12948-021-00152-x","article-title":"A Spotlight on Lime: A Review about Adverse Reactions and Clinical Manifestations Due to Citrus Aurantiifolia","volume":"19","author":"Alessandrello","year":"2021","journal-title":"Clin. Mol. Allergy"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Dugrand-Judek, A., Olry, A., Hehn, A., Costantino, G., Ollitrault, P., Froelicher, Y., and Bourgaud, F. (2015). The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the Organization of Biosynthetic Pathways. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0142757"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.3390\/ijms15011441","article-title":"Secondary Plant Products Causing Photosensitization in Grazing Herbivores: Their Structure, Activity, and Regulation","volume":"15","author":"Quinn","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.lwt.2006.04.003","article-title":"Sterol and Vitamin D2 Concentrations in Cultivated and Wild Grown Mushrooms: Effects of UV Irradiation","volume":"40","author":"Teichmann","year":"2007","journal-title":"LWT"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"89","DOI":"10.33924\/amt-2022-02-08","article-title":"Analysis of the Harmful Effects of UV Radiation Generated During Welding","volume":"5","author":"Kafi","year":"2022","journal-title":"Acta Mater. Transylvanica"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Bj\u00f6rn, L.O., and Huovinen, P. (2015). Phototoxicity. Photobiology: The Science of Light and Life, Springer. [3rd ed.].","DOI":"10.1007\/978-1-4939-1468-5"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"E4106","DOI":"10.1097\/GOX.0000000000004106","article-title":"Tanning Beds, Rue, and Major Burns: An Alarming Association","volume":"10","author":"Barrios","year":"2022","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/jid.2011.476","article-title":"Irradiation of Skin with Visible Light Induces Reactive Oxygen Species and Matrix-Degrading Enzymes","volume":"132","author":"Liebel","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"22432","DOI":"10.1074\/jbc.C300048200","article-title":"UVB Light Stimulates Production of Reactive Oxygen Species: Unexpected Role for Catalase","volume":"278","author":"Heck","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1034\/j.1600-0625.2001.100407.x","article-title":"Solar Simulated Irradiation Modulates Gene Expression and Activity of Antioxidant Enzymes in Cultured Human Dermal Fibroblasts","volume":"10","author":"Leccia","year":"2001","journal-title":"Exp. Dermatol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1101\/gad.568810","article-title":"Nrf2 Establishes a Glutathione-Mediated Gradient of UVB Cytoprotection in the Epidermis","volume":"24","author":"Navid","year":"2010","journal-title":"Genes. Dev."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4062\/biomolther.2014.130","article-title":"Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet b-Induced Oxidative Stress","volume":"23","author":"Susara","year":"2015","journal-title":"Biomol. Ther."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Fernando, P.D.S.M., Piao, M.J., Kang, K.A., Zhen, A.X., Herath, H.M.U.L., Kang, H.K., Choi, Y.H., and Hyun, J.W. (2022). Hesperidin Protects Human HaCaT Keratinocytes from Particulate Matter 2.5-Induced Apoptosis via the Inhibition of Oxidative Stress and Autophagy. Antioxidants, 11.","DOI":"10.3390\/antiox11071363"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kawashima, S., Funakoshi, T., Sato, Y., Saito, N., Ohsawa, H., Kurita, K., Nagata, K., Yoshida, M., and Ishigami, A. (2018). Protective Effect of Pre- and Post-Vitamin C Treatments on UVB-Irradiation-Induced Skin Damage. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-34530-4"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1021\/ar050151c","article-title":"Photophysics and Photochemistry of Pterins in Aqueous Solution","volume":"39","author":"Lorente","year":"2006","journal-title":"Acc. Chem. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1021\/acs.biochem.6b00420","article-title":"Photooxidation of Tryptophan and Tyrosine Residues in Human Serum Albumin Sensitized by Pterin: A Model for Globular Protein Photodamage in Skin","volume":"55","author":"Reid","year":"2016","journal-title":"Biochemistry"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1002\/cphc.201500219","article-title":"Unraveling the Degradation Mechanism of Purine Nucleotides Photosensitized by Pterins: The Role of Charge-Transfer Steps","volume":"16","author":"Serrano","year":"2015","journal-title":"ChemPhysChem"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/jid.2015.52","article-title":"FICZ: A Messenger of Light in Human Skin","volume":"135","author":"Syed","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1039\/b707312g","article-title":"Photosensitization of 2\u2032-Deoxyadenosine-5\u2032-Monophosphate by Pterin","volume":"5","author":"Petroselli","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1111\/php.12099","article-title":"Oxidation of Tyrosine Photoinduced by Pterin in Aqueous Solution","volume":"89","author":"Oliveros","year":"2013","journal-title":"Photochem. Photobiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/em.22087","article-title":"Mechanisms of DNA Damage, Repair, and Mutagenesis","volume":"58","author":"Chatterjee","year":"2017","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/carcin\/bgv109","article-title":"Citrus Consumption and Risk of Basal Cell Carcinoma and Squamous Cell Carcinoma of the Skin","volume":"36","author":"Wu","year":"2015","journal-title":"Carcinogenesis"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1021\/acs.jafc.7b01279","article-title":"Identification and Quantitation of Furocoumarins in Popularly Consumed Foods in the U.S. Using QuEChERS Extraction Coupled with UPLC-MS\/MS Analysis","volume":"65","author":"Melough","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Navarra, M., Mannucci, C., Delb\u00f2, M., and Calapai, G. (2015). Citrus Bergamia Essential Oil: From Basic Research to Clinical Application. Front. Pharmacol., 6.","DOI":"10.3389\/fphar.2015.00036"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"13765","DOI":"10.1073\/pnas.0604213103","article-title":"Cyclobutane Pyrimidine Dimers Are Predominant DNA Lesions in Whole Human Skin Exposed to UVA Radiation","volume":"103","author":"Mouret","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/php.12755","article-title":"The Phototoxic Potential of the Flavonoids, Taxifolin and Quercetin","volume":"93","author":"Kosina","year":"2017","journal-title":"Photochem. Photobiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.tibs.2012.01.001","article-title":"Noise in Cellular Signaling Pathways: Causes and Effects","volume":"37","author":"Ladbury","year":"2012","journal-title":"Trends Biochem. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11095-005-8497-9","article-title":"Analytical Studies on the Prediction of Photosensitive\/Phototoxic Potential of Pharmaceutical Substances","volume":"23","author":"Onoue","year":"2006","journal-title":"Pharm. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.jaad.2018.06.061","article-title":"Drug-Induced Phototoxicity: A Systematic Review","volume":"79","author":"Kim","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpra.2020.11.003","article-title":"Babchi Oil-Induced Phytophotodermatitis Mimicking Burn Injury","volume":"27","author":"Faulkner","year":"2021","journal-title":"JPRAS Open"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/acr2.11369","article-title":"Clinical Image: Phytophotodermatitis: A Butterfly-like Rash on the Face of a Young Woman","volume":"4","author":"He","year":"2022","journal-title":"ACR Open Rheumatol."},{"key":"ref_129","first-page":"227","article-title":"Phytophotodermatitis. Clinical and etiological aspects","volume":"XXII","author":"Bonta","year":"2014","journal-title":"Analele Univ. Din Oradea Fasc. Protec\u0163ia Mediu."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/cod.14103","article-title":"Paediatric Phytophotodermatitis \u2018by Proxy\u2019 from Parental Transfer of Lime","volume":"87","author":"Hamann","year":"2022","journal-title":"Contact Dermat."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1749-6632.2012.06510.x","article-title":"Plant Polyphenols and Human Skin: Friends or Foes","volume":"1259","author":"Korkina","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/15569527.2018.1561711","article-title":"Phytodermatitis in East and Southeast of Turkey: A Prospective Study","volume":"38","author":"An","year":"2019","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s13555-017-0194-1","article-title":"Melasma: An Up-to-Date Comprehensive Review","volume":"7","author":"Elbuluk","year":"2017","journal-title":"Dermatol. Ther."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Kartono, F., and Maibach, H.I. (2006). Irritants in Combination with a Synergistic or Additive Effect on the Skin Response: An Overview of Tandem Irritation Studies, Blackwell Munksgaard.","DOI":"10.1111\/j.0105-1873.2006.00792.x"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/all.12358","article-title":"The Multiple Factors Affecting the Association between Atopic Dermatitis and Contact Sensitization","volume":"69","author":"Thyssen","year":"2014","journal-title":"Allergy Eur. J. Allergy Clin. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1248\/bpb.35.612","article-title":"Lactobacillus Acidophilus Strain L-92 Induces CD4 CD25 Foxp3 Regulatory T Cells and Suppresses Allergic Contact Dermatitis","volume":"35","author":"Shah","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"916497","DOI":"10.1155\/2013\/916497","article-title":"Cytokines and Chemokines in Irritant Contact Dermatitis","volume":"2013","author":"Lee","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1046\/j.1523-1747.2000.00999.x","article-title":"Chemical Activation of Innate and Specific Immunity in Contact Dermatitis","volume":"115","author":"Zhang","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.wem.2012.11.005","article-title":"Dermatitis Linearis: Vesicating Dermatosis Caused by Paederus Species (Coleoptera: Staphylinidae). Case Series and Review","volume":"24","author":"Cressey","year":"2013","journal-title":"Wilderness Environ. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4103\/0378-6323.86511","article-title":"Phytophotodermatitis Due to Wild Carrot Decoction","volume":"77","author":"Zhang","year":"2011","journal-title":"Indian. J. Dermatol. Venereol. Leprol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1580\/PR31-05.1","article-title":"Toxicodendron Dermatitis: Poison Ivy, Oak, and Sumac","volume":"17","author":"Gladman","year":"2006","journal-title":"Wilderness Environ. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"13030\/qt2nv2d1n0","DOI":"10.5070\/D3241037971","article-title":"Phytophotodermatitis Related to Carrot Extract-Containing Sunscreen","volume":"24","author":"Bosanac","year":"2018","journal-title":"Dermatol. Online J."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1111\/ijd.12305","article-title":"Cutaneous Porphyrias Part I: Epidemiology, Pathogenesis, Presentation, Diagnosis, and Histopathology","volume":"52","author":"Horner","year":"2013","journal-title":"Int. J. Dermatol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"A6","DOI":"10.21276\/APALM.2200","article-title":"V A Histomorphological Study of Vesiculobullous Lesions of Skin","volume":"6","author":"Rokde","year":"2019","journal-title":"Ann. Pathol. Lab. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.4103\/jfmpc.jfmpc_2016_21","article-title":"Histopathology Spectrum of Skin Lesions in Teaching Institution","volume":"11","author":"Goswami","year":"2022","journal-title":"J. Family Med. Prim. Care"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/1346-8138.16222","article-title":"Detection Rate of Pustules in Palmoplantar Pustulosis with Dermoscopy","volume":"49","author":"Nakanishi","year":"2022","journal-title":"J. Dermatol."},{"key":"ref_147","first-page":"e15330","article-title":"Morphological Spectrum of Vesiculobullous Skin Lesions: An Institutional Perspective","volume":"3","author":"Ali","year":"2021","journal-title":"Cureus"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Ferguson, J. (2006). Phytophotodermatitis. Photodermatology, CRC Press.","DOI":"10.1201\/b15138"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"79","DOI":"10.12788\/cutis.0163","article-title":"Pink Patches with a Hyperpigmented Rim","volume":"107","author":"Hamid","year":"2021","journal-title":"Cutis"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/CM9.0000000000002838","article-title":"Good Efficacy and Safety Profile of Abrocitinib in Chinese Adult Patients with Atopic Dermatitis: A Case Series Study","volume":"137","author":"Hu","year":"2024","journal-title":"Chin. Med. J."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/09546634.2016.1174765","article-title":"Addressing Treatment Challenges in Atopic Dermatitis with Novel Topical Therapies","volume":"27","author":"Silverberg","year":"2016","journal-title":"J. Dermatol. Treat."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/dermato1010004","article-title":"A Case of Unilateral Hyperpigmentation","volume":"1","author":"Han","year":"2021","journal-title":"Dermato"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jpeds.2021.07.045","article-title":"Linear Hyperpigmentation in Chronic Phytophotodermatitis from Limes","volume":"239","author":"Dreher","year":"2021","journal-title":"J. Pediatr."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1346-8138.2009.00706.x","article-title":"Guidelines for Management of Atopic Dermatitis","volume":"36","author":"Saeki","year":"2009","journal-title":"J. Dermatol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"420","DOI":"10.5021\/ad.2019.31.4.420","article-title":"Synergistic Effect of H1-Antihistamines on Topical Corticosteroids for Pruritus in Atopic Dermatitis: A Systematic Review and Meta-Analysis","volume":"31","author":"Hur","year":"2019","journal-title":"Ann. Dermatol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/ced.12104","article-title":"Use of Emollients in Dry-Skin Conditions: Consensus Statement","volume":"38","author":"Moncrieff","year":"2013","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000445955","article-title":"The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin","volume":"29","author":"Danby","year":"2016","journal-title":"Skin. Pharmacol. Physiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.anai.2022.01.012","article-title":"Optimizing Emollient Therapy for Skin Barrier Repair in Atopic Dermatitis","volume":"128","author":"Elias","year":"2022","journal-title":"Annals Allergy Asthma Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/jocd.13163","article-title":"Combined Effects of Glycerol and Petrolatum in an Emollient Cream: A Randomized, Double-Blind, Crossover Study in Healthy Volunteers with Dry Skin","volume":"19","author":"Vaillant","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"709152","DOI":"10.1155\/2014\/709152","article-title":"Zinc Therapy in Dermatology: A Review","volume":"2014","author":"Gupta","year":"2014","journal-title":"Dermatol. Res. Pract."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"121","DOI":"10.18203\/issn.2455-4529.IntJResDermatol20240969","article-title":"Expert Opinion on the Prescription Practice of Topical Calamine Lotion for Chronic Urticaria and Other Dermatologic Conditions in Indian Clinical Settings","volume":"10","author":"Manjula","year":"2024","journal-title":"Int. J. Res. Dermatol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/230949901302100222","article-title":"Calamine Lotion to Reduce Skin Irritation in Children with Cast Immobilisation","volume":"21","author":"Mak","year":"2013","journal-title":"J. Orthop. Surg."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.anai.2022.03.004","article-title":"Optimizing Topical Management of Atopic Dermatitis","volume":"128","author":"Butala","year":"2022","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1086\/644732","article-title":"Topical Antimicrobial Therapy for Treating Chronic Wounds","volume":"49","author":"Lipsky","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.2340\/00015555-3296","article-title":"Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions","volume":"99","author":"Yosipovitch","year":"2019","journal-title":"Acta Derm. Venereol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1742-481X.2012.01097.x","article-title":"Extending the TIME Concept: What Have We Learned in the Past 10 Years?","volume":"9","author":"Leaper","year":"2012","journal-title":"Int. Wound J."},{"key":"ref_167","first-page":"541","article-title":"Modern Wound Care\u2014Practical Aspects of Non-interventional Topical Treatment of Patients with Chronic Wounds","volume":"12","author":"Dissemond","year":"2014","journal-title":"J. Der Dtsch. Dermatol. Ges."},{"key":"ref_168","first-page":"e59199","article-title":"Unique Acute Phytophotodermatitis Reaction and a Visual Diagnostic Guide","volume":"16","author":"Agha","year":"2024","journal-title":"Cureus"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12016-018-8686-z","article-title":"Systemic Contact Dermatitis","volume":"56","author":"Aquino","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jaad.2017.12.077","article-title":"An Assessment of the Use of Antihistamines in the Management of Atopic Dermatitis","volume":"79","author":"He","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1097\/itx.0000000000000047","article-title":"Effectiveness of Antihistamines for Itch and Sleep Disturbance in Atopic Dermatitis: A Retrospective Cohort Study","volume":"6","author":"Tay","year":"2021","journal-title":"Itch"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s13671-019-00271-4","article-title":"Photoallergic Contact Dermatitis","volume":"8","author":"Cesur","year":"2019","journal-title":"Curr. Dermatol. Rep."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11882-017-0705-2","article-title":"Photodermatitis for the Allergist","volume":"17","author":"Coffin","year":"2017","journal-title":"Curr. Allergy Asthma Rep."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"i1010","DOI":"10.1136\/bmj.i1010","article-title":"Palliative Care in Patients with Heart Failure","volume":"353","author":"McIlvennan","year":"2016","journal-title":"BMJ"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12016-021-08875-0","article-title":"Contact Dermatitis: Classifications and Management","volume":"61","author":"Li","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/bjd.12256","article-title":"Standards of Care for Occupational Contact Dermatitis and Occupational Contact Urticaria","volume":"168","author":"Adisesh","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Cohen, D.E. (2019). Occupational Dermatoses. Handbook of Occupational Safety and Health, Wiley.","DOI":"10.1002\/9781119581482.ch7"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.jaad.2016.09.038","article-title":"Ultraviolet Radiation and the Skin: Photobiology and Sunscreen Photoprotection","volume":"76","author":"Young","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"e3212205","DOI":"10.17061\/phrp3212205","article-title":"Effectiveness, Compliance and Application of Sunscreen for Solar Ultraviolet Radiation Protection in Australia","volume":"32","author":"Henderson","year":"2022","journal-title":"Public Health Res. Pract."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"149","DOI":"10.5296\/ije.v12i3.16938","article-title":"Promotion of Safe Work Practices in the Agricultural Sector through Coaching as a Training Strategy in Australia","volume":"12","author":"Skiba","year":"2020","journal-title":"Int. J. Educ."}],"updated-by":[{"DOI":"10.3390\/life15030337","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000}}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/8\/1019\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T14:56:54Z","timestamp":1754233014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/8\/1019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":180,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["life14081019"],"URL":"https:\/\/doi.org\/10.3390\/life14081019","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,16]]}}}