{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:39:49Z","timestamp":1781188789208,"version":"3.54.1"},"reference-count":44,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>(1) Background: The recurrence of hemarthrosis in patients with hemophilia triggers a pathophysiological process of degenerative, progressive, and irreversible joint destruction. This hemophilic arthropathy is characterized by chronic pain, muscle atrophy, loss of mobility, and proprioceptive alterations. As the same joint undergoes repeated hemarthrosis, the function of the mechanical receptors deteriorates, causing a pathophysiological modulation and deterioration of the musculoskeletal system. The objective was to analyze the differences in stability and balance, as well as in ankle dorsal flexion, functionality, and muscle strength, between patients with bilateral hemophilic arthropathy and their healthy peers. (2) Methods: A cross-sectional descriptive case\u2013control study was performed. Twenty-two participants were recruited: 10 adult patients with bilateral hemophilic arthropathy of the knee and ankle and 12 healthy subjects. The variables were balance (Rs Scan pressure platform), ankle dorsiflexion range of motion (Leg Motion), functionality (2-Minute Walk Test), and ankle dorsal strength (dynamometry). (3) Results: Statistically significant differences (p &lt; 0.05) were found in the balance without visual support in the Max-Y variable (MD = 2.83; CI95%: 0.33;5.33; Effect size (d) = 0.67), ankle dorsiflexion (MD = 16.00; CI95%: 14.30; 20.0; d = 7.46), and strength of the ankle flexor muscles (MD = 128.50; CI95%: 92.50; 153.60; d = 2.76). (4) Conclusions: Ankle range of motion in dorsal flexion, functionality, and muscle strength in dorsal flexion is poorer in patients with bilateral lower limb hemophilic arthropathy than in their healthy peers. Patients with bilateral hemophilic ankle arthropathy have statistically poorer stability and balance without visual support than their healthy peers.<\/jats:p>","DOI":"10.3390\/life14081051","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T11:14:41Z","timestamp":1724325281000},"page":"1051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Stability, Balance, and Physical Variables in Patients with Bilateral Hemophilic Arthropathy of the Ankle versus Their Healthy Peers: A Case\u2013Control Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Carlos","family":"Truque-D\u00edaz","sequence":"first","affiliation":[{"name":"Faculty of Physiotherapy, Podiatry and Occupational Therapy, Catholic University San Antonio-UCAM, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8434-8308","authenticated-orcid":false,"given":"Javier","family":"Mero\u00f1o-Gallut","sequence":"additional","affiliation":[{"name":"T\u00fa. Bienestar 360\u00b0, Physiotherapy and Medical Center, 30730 San Javier, Spain"},{"name":"InHeFis Research Group, Instituto Asturiano de Investigaci\u00f3n Sanitaria (ISPA), 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4965-5721","authenticated-orcid":false,"given":"Cristina","family":"Molina-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy, Podiatry and Occupational Therapy, Catholic University San Antonio-UCAM, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4276-6982","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Cuesta-Barriuso","sequence":"additional","affiliation":[{"name":"InHeFis Research Group, Instituto Asturiano de Investigaci\u00f3n Sanitaria (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Surgery and Medical-Surgical Specialties, University of Oviedo, 33003 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"P\u00e9rez-Llanes","sequence":"additional","affiliation":[{"name":"InHeFis Research Group, Instituto Asturiano de Investigaci\u00f3n Sanitaria (ISPA), 33011 Oviedo, Spain"},{"name":"Department of Physiotherapy, University of Murcia, 30100 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41572-021-00278-x","article-title":"Haemophilia","volume":"7","author":"Berntorp","year":"2021","journal-title":"Nat. Rev. Dis. Primer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2516.2009.02128.x","article-title":"Malignancy in Patients with Haemophilia: A Review of the Literature","volume":"16","author":"Dunn","year":"2010","journal-title":"Haemophilia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3109\/09593985.2014.902148","article-title":"Manual Therapy in the Treatment of Ankle Hemophilic Arthropathy. A Randomized Pilot Study","volume":"30","year":"2014","journal-title":"Physiother. Theory Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/hae.13631","article-title":"Measurement of Joint Health in Persons with Haemophilia: A Systematic Review of the Measurement Properties of Haemophilia-specific Instruments","volume":"25","author":"Gouw","year":"2019","journal-title":"Haemophilia"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00264-020-04513-0","article-title":"Ankle Arthrodesis for End-Stage Haemophilic Ankle Arthropathy Using a Ilizarov Method","volume":"44","author":"Wang","year":"2020","journal-title":"Int. Orthop."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00003086-199607000-00009","article-title":"Hemophilic Ankle Arthropathy","volume":"328","author":"Ribbans","year":"1996","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1302\/0301-620X.76B6.7983125","article-title":"Supramalleolar Tibial Osteotomy for Haemophilic Arthropathy of the Ankle","volume":"76","author":"Pearce","year":"1994","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/hae.13925","article-title":"Clinical Gait Features Are Associated with MRI Findings in Patients with Haemophilic Ankle Arthropathy","volume":"26","author":"Eerdekens","year":"2020","journal-title":"Haemophilia"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-2516.2007.01613.x","article-title":"Posturographic Analysis of Balance Control in Patients with Haemophilic Arthropathy","volume":"14","author":"Gallach","year":"2008","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature25453","article-title":"Structure of the Mechanically Activated Ion Channel Piezo1","volume":"554","author":"Saotome","year":"2018","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1177\/1545968315573055","article-title":"Assessing Proprioception: A Systematic Review of Possibilities","volume":"29","author":"Hillier","year":"2015","journal-title":"Neurorehabil. Neural Repair"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/jnnp.73.5.473","article-title":"Joint Position Sense and Vibration Sense: Anatomical Organisation and Assessment","volume":"73","author":"Gilman","year":"2002","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1152\/jn.00417.2016","article-title":"The Cerebellum Contributes to Proprioception during Motion","volume":"118","author":"Weeks","year":"2017","journal-title":"J. Neurophysiol."},{"key":"ref_14","first-page":"e212","article-title":"The Effects of Repetitive Haemarthrosis on Postural Balance in Children with Haemophilia","volume":"19","author":"Souza","year":"2013","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/hae.13484","article-title":"Postural Control during a Transition Task in Haemophilic Children, Adolescents and Young Adults with Haemophilic Ankle Arthropathy","volume":"24","author":"Deschamps","year":"2018","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jht.2018.05.001","article-title":"The Interaction between Pain and Movement","volume":"33","author":"Merkle","year":"2020","journal-title":"J. Hand Ther. Off. J. Am. Soc. Hand Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2478\/raon-2022-0040","article-title":"Reliability of haemophilia early arthropathy detection with ultrasound (HEAD-US) in children: A comparative magnetic resonance imaging (MRI) study","volume":"56","author":"Plut","year":"2022","journal-title":"Radiol. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"W336","DOI":"10.2214\/AJR.14.12501","article-title":"Diagnostic Accuracy of Ultrasound for Assessment of Hemophilic Arthropathy: MRI Correlation","volume":"204","author":"Doria","year":"2015","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/hae.12197","article-title":"Using the Haemophilia Joint Health Score for Assessment of Teenagers and Young Adults: Exploring Reliability and Validity","volume":"19","author":"Fischer","year":"2013","journal-title":"Haemophilia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1365-2516.2006.01312.x","article-title":"Hemophilia Joint Health Score Reliability Study","volume":"12","author":"Hilliard","year":"2006","journal-title":"Haemophilia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.ijsu.2014.07.013","article-title":"STROBE Initiative The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies","volume":"12","author":"Altman","year":"2014","journal-title":"Int. J. Surg. Lond. Engl."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/hae.14128","article-title":"Paediatric Patients with Blood-Induced Ankle Joint Arthritis Demonstrate Physiological Foot Joint Mechanics and Energetics during Walking","volume":"26","author":"Tijskens","year":"2020","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_23","first-page":"197","article-title":"The Validity and Reliability of a New Instrumented Device for Measuring Ankle Dorsiflexion Range of Motion","volume":"10","author":"Calatayud","year":"2015","journal-title":"Int. J. Sports Phys. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhang, J., Chen, X., Huang, S., Wang, Y., Lin, W., Zhou, R., and Zou, H. (2018). Two-Minute Walk Test: Reference Equations for Healthy Adults in China. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0201988"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Karle, V., Hartung, V., Ivanovska, K., M\u00e4urer, M., Flachenecker, P., Pfeifer, K., and Tallner, A. (2020). The Two-Minute Walk Test in Persons with Multiple Sclerosis: Correlations of Cadence with Free-Living Walking Do Not Support Ecological Validity. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17239044"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1037\/a0028086","article-title":"On Effect Size","volume":"17","author":"Kelley","year":"2012","journal-title":"Psychol. Methods"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00167-015-3660-2","article-title":"The Improvement of Postural Control in Patients with Mechanical Ankle Instability after Lateral Ankle Ligaments Reconstruction","volume":"24","author":"Li","year":"2016","journal-title":"Knee Surg. Sports Traumatol. Arthrosc. Off. J. ESSKA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00042752-200605000-00003","article-title":"Postural Control Deficits in Participants with Functional Ankle Instability as Measured by the Balance Error Scoring System","volume":"16","author":"Docherty","year":"2006","journal-title":"Clin. J. Sport Med. Off. J. Can. Acad. Sport Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00167-010-1097-1","article-title":"Difference in Balance Measures between Patients with Chronic Ankle Instability and Patients after an Acute Ankle Inversion Trauma","volume":"18","author":"Kingma","year":"2010","journal-title":"Knee Surg. Sports Traumatol. Arthrosc. Off. J. ESSKA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.3113\/FAI.2008.1069","article-title":"Proprioception after Total Ankle Arthroplasty","volume":"29","author":"Conti","year":"2008","journal-title":"Foot Ankle Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.arth.2014.08.031","article-title":"Unipedal Balance Is Affected by Lower Extremity Joint Arthroplasty Procedure 1 Year Following Surgery","volume":"30","author":"Butler","year":"2015","journal-title":"J. Arthroplasty"},{"key":"ref_32","unstructured":"Dyck, P.J., and Thomas, P.K. (2005). Peripheral Neuropathy, Saunders. [4th ed.]."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Catan, L., Amaricai, E., Onofrei, R.R., Popoiu, C.M., Iacob, E.R., Stanciulescu, C.M., Cerbu, S., Horhat, D.I., and Suciu, O. (2020). The Impact of Overweight and Obesity on Plantar Pressure in Children and Adolescents: A Systematic Review. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17186600"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Mueller, S., Carlsohn, A., Mueller, J., Baur, H., and Mayer, F. (2016). Influence of Obesity on Foot Loading Characteristics in Gait for Children Aged 1 to 12 Years. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0149924"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10865-006-9085-0","article-title":"The Fear-Avoidance Model of Musculoskeletal Pain: Current State of Scientific Evidence","volume":"30","author":"Leeuw","year":"2007","journal-title":"J. Behav. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ucero-Lozano, R., L\u00f3pez-Pina, J.A., Ortiz-P\u00e9rez, A., and Cuesta-Barriuso, R. (2021). Quality of Life and Its Predictors among Adult Patients with Haemophilic Arthropathy. An Observational Study. BMC Musculoskelet. Disord., 22.","DOI":"10.1186\/s12891-021-04319-0"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1365-2516.2010.02312.x","article-title":"Comprehensive Elements of a Physiotherapy Exercise Programme in Haemophilia\u2014A Global Perspective","volume":"16","author":"Blamey","year":"2010","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_38","first-page":"e245","article-title":"Static Postural Balance Evaluation and an Investigation of the Relationship with Joint Health in Children with Severe Haemophilia: A Controlled Cross-Sectional Study","volume":"27","author":"Tat","year":"2021","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Scaturro, D., Vitagliani, F., Tomasello, S., Mangano, M.S., Signa, G., and Letizia Mauro, G. (2022). Postural Assessment Systems in the Prevention of Haemophilic Arthropathy: A Narrative Review. J. Funct. Morphol. Kinesiol., 7.","DOI":"10.3390\/jfmk7030068"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1302\/2058-5241.4.180068","article-title":"Musculoskeletal Treatment in Haemophilia","volume":"4","author":"Atilla","year":"2019","journal-title":"EFORT Open Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1365-2516.2010.02309_4.x","article-title":"The Ankle Joint","volume":"16","year":"2010","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2516.2008.01732.x","article-title":"Physiopathology of Haemophilic Arthropathy","volume":"14","author":"Lafeber","year":"2008","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/hae.14556","article-title":"Effectiveness of Physical Exercise on Postural Balance in Patients with Haemophilia: A Systematic Review","volume":"28","author":"Carrasco","year":"2022","journal-title":"Haemoph. Off. J. World Fed. Hemoph."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13047-017-0209-2","article-title":"Normal Foot Loading Parameters and Repeatability of the Footscan\u00ae Platform System","volume":"10","author":"Xu","year":"2017","journal-title":"J. Foot Ankle Res."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/8\/1051\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:41:49Z","timestamp":1760110909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/8\/1051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":44,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["life14081051"],"URL":"https:\/\/doi.org\/10.3390\/life14081051","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]}}}