{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:55:25Z","timestamp":1788263725785,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The aim of this study was to investigate the effectiveness of hesperidin (HES) on testicular histopathological changes, biochemical changes, and semen characteristics in rats exposed to glyphosate (GLP). The control group was given a normal diet devoid of GLP and HES, the HES group was given 100 mg\/kg\/day HES with the normal diet, the GLP group was given GLP at the LD50\/10 dose of normal feed, which was 787.85 mg\/kg\/day, and the GLP + HES group was given normal feed containing 787.85 mg\/kg\/day LD50\/10 dose of GLP in addition to 100 mg\/kg\/day HES. GLP administration reduced sperm motility, sperm plasma membrane integrity, glutathione levels, and total antioxidant levels in the testicular tissues of rats. Moreover, it caused an increase in right testis and left epididymis weights, abnormal sperm counts, malondialdehyde levels, total oxidant status, and DNA damage. The HES treatment showed curative effects on these parameters. Furthermore, HES was effective in lessening the histopathological damage that was caused by GLP. The results showedthat HES protects spermatological parameters and DNA integrity, improves antioxidant defenses, and lowers the damage and lipid peroxidation caused by GLP in testicular tissue.<\/jats:p>","DOI":"10.3390\/life14091190","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T07:38:57Z","timestamp":1726817937000},"page":"1190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Potential Protective Effect of Hesperidin (Vitamin P) against Glyphosate-Induced Spermatogenesis Damage in Male Rats: Biochemical and Histopathological Findings on Reproductive Parameters"],"prefix":"10.3390","volume":"14","author":[{"given":"\u015e\u00fckr\u00fc","family":"G\u00fcng\u00f6r","sequence":"first","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur 15030, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"K\u0131r\u0131kkulak","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, AfyonKocatepe University, Afyonkarahisar 03200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7586-0895","authenticated-orcid":false,"given":"Bar\u0131\u015f","family":"Denk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine, AfyonKocatepe University, Afyonkarahisar 03200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4838-1597","authenticated-orcid":false,"given":"Mehmet Fuat","family":"G\u00fclhan","sequence":"additional","affiliation":[{"name":"Department of Medicinal and Aromatic Plants, Technical Sciences Vocational School, Aksaray University, Aksaray 68100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-1706","authenticated-orcid":false,"given":"\u00d6zay","family":"G\u00fcle\u015f","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Veterinary Medicine, Ayd\u0131n Adnan Menderes University, Ayd\u0131n 09016, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Budak","sequence":"additional","affiliation":[{"name":"Department of Zootechnics and Animal Nutrition, Faculty of Veterinary Medicine, Aksaray University, Aksaray 68100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Enes","family":"\u0130nan\u00e7","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur 15030, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Avdatek","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, AfyonKocatepe University, Afyonkarahisar 03200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Yeni","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, AfyonKocatepe University, Afyonkarahisar 03200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umut","family":"Ta\u015fdemir","sequence":"additional","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Ankara University, Ankara 06110, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105291","DOI":"10.1016\/j.tiv.2021.105291","article-title":"Low concentrations of glyphosate alone affect the pubertal male rat meiotic step: An in vitro study","volume":"79","author":"Antonine","year":"2022","journal-title":"In Vitro Toxicol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3109\/15376516.2014.989349","article-title":"Combined effects of repeated administration of Bretmont Wipeout (glyphosate) and Ultrazin (atrazine) on testosterone, oxidative stress and sperm quality of Wistar rats","volume":"25","author":"Abarikwu","year":"2015","journal-title":"Toxicol. 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