{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:28:29Z","timestamp":1760146109797,"version":"build-2065373602"},"reference-count":130,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sapienza, University of Rome"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Prokineticins (PKs) are low molecular weight proteins that exert their effects by binding to two seven-transmembrane G-protein-coupled receptors (prokineticin receptors, PKRs). The prokineticin system is an important player in the development of various diseases. Several polymorphisms that are associated with infertility, neuroendocrine disorders, Hirschsprung\u2019s syndrome (HSCR), idiopathic central precocious puberty (CPP) and congenital disorders such as Kallmann syndrome (KS) have been described for both the PKs and PKR genes. The aim of this study is to summarize and describe the impact of PK\/PKR polymorphisms on the pathogenesis and outcome of the above diseases, highlighting the PK system as a therapeutic target and diagnostic biomarker in pathological conditions.<\/jats:p>","DOI":"10.3390\/life14101254","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T11:08:47Z","timestamp":1727780927000},"page":"1254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Polymorphisms of Prokineticins and Prokineticin Receptors Associated with Human Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Roberta","family":"Lattanzi","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cVittorio Erspamer\u201d, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d, CNR-Institute of Molecular Biology and Pathology, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19276","DOI":"10.1074\/jbc.M202139200","article-title":"Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins\/endocrine gland vascular endothelial growth factor","volume":"277","author":"Lin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0006-291X(02)00239-5","article-title":"Isolation and identification of EG-VEGF\/prokineticins as cognate ligands for two orphan G-protein-coupled receptors","volume":"293","author":"Masuda","year":"2002","journal-title":"Biochem. Biophys. Res. 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