{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:40:22Z","timestamp":1791441622082,"version":"4.3.3"},"reference-count":191,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Haut.AI O\u00dc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Autofluorescence is a remarkable property of human skin. It can be excited by UV and observed in the dark using special detection systems. The method of fluorescence photography (FP) is an effective non-invasive tool for skin assessment. It involves image capturing by a camera the emission of light quanta from fluorophore molecules in the skin. It serves as a useful tool for cosmetic and skincare research, especially for the detection of pathological skin states, like acne, psoriasis, etc. To the best of our knowledge, there is currently no comprehensive review that fully describes the application and physical principles of FP over the past five years. The current review covers various aspects of the skin FP method from its biophysical basis and the main fluorescent molecules of the skin to its potential applications and the principles of FP recording and analysis. We pay particular attention to recently reported works on the automatic analysis of FP based on artificial intelligence (AI). Thus, we argue that FP is a rapidly evolving technology with a wide range of potential applications. We propose potential directions of the development of this method, including new AI algorithms for the analysis and expanding the range of applications.<\/jats:p>","DOI":"10.3390\/life14101271","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T06:23:18Z","timestamp":1728282198000},"page":"1271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["State-of-the-Art in Skin Fluorescent Photography for Cosmetic and Skincare Research: From Molecular Spectra to AI Image Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2699-6761","authenticated-orcid":false,"given":"Konstantin","family":"Chekanov","sequence":"first","affiliation":[{"name":"Haut.AI O\u00dc, Telliskivi 60a\/8, 10412 Tallinn, Harjumaa, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-0626","authenticated-orcid":false,"given":"Daniil","family":"Danko","sequence":"additional","affiliation":[{"name":"Haut.AI O\u00dc, Telliskivi 60a\/8, 10412 Tallinn, Harjumaa, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-5455","authenticated-orcid":false,"given":"Timur","family":"Tlyachev","sequence":"additional","affiliation":[{"name":"Haut.AI O\u00dc, Telliskivi 60a\/8, 10412 Tallinn, Harjumaa, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5391-0294","authenticated-orcid":false,"given":"Konstantin","family":"Kiselev","sequence":"additional","affiliation":[{"name":"Haut.AI O\u00dc, Telliskivi 60a\/8, 10412 Tallinn, Harjumaa, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Hagens","sequence":"additional","affiliation":[{"name":"Beiersdorf AG, Beiersdorfstra\u00dfe 1-9, 22529 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8946-2724","authenticated-orcid":false,"given":"Anastasia","family":"Georgievskaya","sequence":"additional","affiliation":[{"name":"Haut.AI O\u00dc, Telliskivi 60a\/8, 10412 Tallinn, Harjumaa, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.patbio.2011.09.002","article-title":"Physico-biological foundation of skin fluorescence\u2014Review","volume":"60","author":"Szepetiuk","year":"2012","journal-title":"Pathol. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1117\/1.429876","article-title":"In vivo fluorescence spectroscopy of the human skin: Experiments and models","volume":"3","author":"Sinichkin","year":"1998","journal-title":"J. Biomed. Opt."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1751-1097.1995.tb09881.x","article-title":"Spectroscopic and microscopic characteristics of human skin autofluorescence emission","volume":"61","author":"Zeng","year":"1995","journal-title":"Photochem. Photobiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1600-0846.2007.00237.x","article-title":"Laser induced autofluorescence studies of animal skin used in modeling of human cutaneous tissue spectroscopic measurements","volume":"13","author":"Drakaki","year":"2007","journal-title":"Skin Res. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.archoralbio.2019.07.001","article-title":"Which are the main fluorophores in skin and oral mucosa? A review with emphasis on clinical applications of tissue autofluorescence","volume":"105","author":"Giovannacci","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01876650","article-title":"Laser-induced autofluorescence for medical diagnosis","volume":"4","author":"Koenig","year":"1994","journal-title":"J. Fluoresc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1117\/12.57700","article-title":"Fluorescence detection and photodynamic activity of endogenous protoporphyrin in human skin","volume":"31","author":"Rueck","year":"1992","journal-title":"Opt. Eng."},{"key":"ref_8","first-page":"109","article-title":"Autofluorescence Excitation Imaging of Nonmelanoma Skin Cancer for Margin Assessment Before Mohs Micrographic Surgery: A Pilot Study","volume":"10","author":"Ortiz","year":"2024","journal-title":"Dermatol. Surg."},{"key":"ref_9","first-page":"63","article-title":"Biophotonic Technologies for Non-Invasive Assessment of Skin Condition and Blood Microcirculation","volume":"49","author":"Spigulis","year":"2012","journal-title":"Latv. J. Phys. Tech. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Spigulis, J., Lihachev, A., Gailite, L., and Erts, R. (2008, January 5). Novel Laser Technologies for Human Skin In-Vivo Assessment. Proceedings of the Advanced Laser Technologies 2007, Siofok, Hungary.","DOI":"10.1117\/12.803940"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"D163","DOI":"10.1364\/AO.48.00D163","article-title":"Imaging of Laser-Excited Tissue Autofluorescence Bleaching Rates","volume":"48","author":"Spigulis","year":"2009","journal-title":"Appl. Opt."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Lihachev, A., Rozniece, K., Lesins, J., and Spigulis, J. (2011, January 22\u201327). Photobleaching Measurements of Pigmented and Vascular Skin Lesions: Results of a Clinical Trial. Proceedings of the European Conference on Biomedical Optics, Munich, Germany.","DOI":"10.1364\/ECBO.2011.80872F"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASW.0000792932.01773.d5","article-title":"Skin Autofluorescence as a Novel and Noninvasive Technology for Advanced Glycation End Products in Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis","volume":"34","author":"Varikasuvu","year":"2021","journal-title":"Adv. Skin Wound Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1007\/s00125-004-1451-2","article-title":"Simple Non-Invasive Assessment of Advanced Glycation Endproduct Accumulation","volume":"47","author":"Meerwaldt","year":"2004","journal-title":"Diabetologia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13098-017-0241-1","article-title":"Skin Autofluorescence, a Non-Invasive Biomarker for Advanced Glycation End Products, Is Associated with the Metabolic Syndrome and Its Individual Components","volume":"9","author":"Slagter","year":"2017","journal-title":"Diabetol. Metabol. Syndr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/ATVBAHA.112.300016","article-title":"Skin Autofluorescence as a Measure of Advanced Glycation End Products Deposition Is Elevated in Peripheral Artery Disease","volume":"33","author":"Noordzij","year":"2013","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ymeth.2021.02.016","article-title":"The AGE Reader: A Non-Invasive Method to Assess Long-Term Tissue Damage","volume":"203","author":"Atzeni","year":"2022","journal-title":"Methods"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1364\/OPEX.12.004496","article-title":"Noninvasive, Optical Detection of Diabetes: Model Studies with Porcine Skin","volume":"12","author":"Hull","year":"2004","journal-title":"Opt. Express"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12933-016-0343-3","article-title":"Skin Collagen Fluorophore LW-1 Versus Skin Fluorescence as Markers for the Long-term Progression of Subclinical Macrovascular Disease in Type 1 Diabetes","volume":"15","author":"Sell","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"den Dekker, M.A.M., Zwiers, M., van den Heuvel, E.R., de Vos, L.C., Smit, A.J., Zeebregts, C.J., Oudkerk, M., Vliegenthart, R., Lefrandt, J.D., and Mulder, D.J. (2013). Skin Autofluorescence, a Non-invasive Marker for AGE Accumulation, Is Associated with the Degree of Atherosclerosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083084"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1007\/BF01726474","article-title":"Hautuntersuchungen im gefilterten Quarzlicht","volume":"6","author":"Bommer","year":"1927","journal-title":"Klin. Wochenschr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0924-2031(01)00142-4","article-title":"Fluorescence spectroscopy of skin","volume":"28","author":"Kollias","year":"2002","journal-title":"Vib. Spectrosc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1046\/j.1523-1747.2002.19635.x","article-title":"Optical Non-invasive Approaches to Diagnosis of Skin Diseases","volume":"7","author":"Kollias","year":"2002","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zouboulis, C., Katsambas, A., and Kligman, A. (2014). Modern Technology for Imaging and Evaluation of Acne Lesions. Pathogenesis and Treatment of Acne and Rosacea, Springer. Chapter 45.","DOI":"10.1007\/978-3-540-69375-8"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1440-0960.2003.00632.x","article-title":"Imaging the skin","volume":"44","author":"Aspres","year":"2003","journal-title":"Aust. J. Dermatol."},{"key":"ref_26","first-page":"566","article-title":"Fluorescent diagnostics in dermatology (review)","volume":"9","author":"Galkina","year":"2013","journal-title":"Saratov J. Med. Sci. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Datta, R., Heaster, T.M., Heaster, T.M., Sharick, J.T., Gillette, A.A., Gillette, A.A., Skala, M.C., and Skala, M.C. (2020). Fluorescence Lifetime Imaging Microscopy: Fundamentals and Advances in Instrumentation, Analysis, and Applications. J. Biomed. Opt., 25.","DOI":"10.1117\/1.JBO.25.7.071203"},{"key":"ref_28","first-page":"305","article-title":"Clinical study on the effects of a cosmetic product on dermal extracellular matrix components using a high-resolution multiphoton tomograph","volume":"16","author":"Bazin","year":"2010","journal-title":"Ski. Res. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wizenty, J., Schumann, T., Theil, D., Stockmann, M., Pratschke, J., Tacke, F., Aigner, F., and Wuensch, T. (2020). Recent advances and the potential for clinical use of autofluorescence detection of extra-ophthalmic tissues. Molecules, 25.","DOI":"10.3390\/molecules25092095"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/jid.1967.150","article-title":"Red fluorescence of comedones: Production of porphyrins by Corynebacterium acnes","volume":"49","author":"Cornelius","year":"1967","journal-title":"J. Investig. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0531-5565(70)90029-X","article-title":"A fluorescent compound in collagen and its relation to the age of the animal","volume":"5","author":"Deyl","year":"1970","journal-title":"Exp. Gerontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(69)80328-5","article-title":"Fluorescence of collagen\u2014Properties of tyrosine residues and another fluorescent element in calf skin collagen","volume":"5","author":"Deyl","year":"1969","journal-title":"FEBS Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0531-5565(74)90041-2","article-title":"Disappearance of tyrosine residues in collagen with age. Suggestion of a possible reaction mechanism","volume":"9","author":"Deyl","year":"1974","journal-title":"Exp. Gerontol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1684\/ejd.2008.0612","article-title":"Skin and mucosal fluorescence diagnosis with different light sources","volume":"19","author":"Mordas","year":"2009","journal-title":"Eur. J. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.0926-9959.2001.00007.x","article-title":"New photographic techniques for clinical evaluation of acne","volume":"15","author":"Rizova","year":"2001","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/exd.13330","article-title":"The Kollias legacy: Skin autofluorescence and beyond","volume":"26","author":"Bargo","year":"2017","journal-title":"Exp. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0190-9622(96)90497-1","article-title":"Fluorescence photography in the evaluation of acne","volume":"35","author":"Lucchina","year":"1996","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0190-9622(97)70285-8","article-title":"Fluorescence photography in the evaluation of hyperpigmentation in photodamaged skin","volume":"36","author":"Kollias","year":"1997","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1039\/b705461k","article-title":"Milestones in the development of photodynamic therapy and fluorescence diagnosis","volume":"6","author":"Juzeniene","year":"2007","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s13555-024-01104-4","article-title":"Applications of Ultraviolet and Sub-ultraviolet Dermatoscopy in Neoplastic and Non-neoplastic Dermatoses: A Systematic Review","volume":"14","author":"Pietkiewicz","year":"2024","journal-title":"Dermatol. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0190-9622(99)70005-8","article-title":"Digital fluorescence photography can assess the suppressive effect of benzoyl peroxide on Propionibacterium acnes","volume":"41","author":"Pagnoni","year":"1999","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_42","first-page":"61","article-title":"Potential of Trachyspermum ammi (ajwain) gel for treatment of facial acne vulgaris: A pilot study with skin biophysical profile assessment and red fluorescence photography","volume":"7","author":"Talebi","year":"2020","journal-title":"Res. J. Pharmacogn."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1930004","DOI":"10.1142\/S1793545819300040","article-title":"Fluorescence lifetime imaging microscopy and its applications in skin cancer diagnosis","volume":"12","author":"Liu","year":"2019","journal-title":"J. Innov. Opt. Health Sci."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Hollands, G.J., Usher-Smith, J.A., Hasan, R., Alexander, F., Clarke, N., and Griffin, S.J. (2022). Visualising health risks with medical imaging for changing recipients\u2019 health behaviours and risk factors: Systematic review with meta-analysis. PLoS Med., 19.","DOI":"10.1371\/journal.pmed.1003920"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clindermatol.2022.10.001","article-title":"Digital photography for the dermatologist","volume":"41","author":"Baig","year":"2023","journal-title":"Clin. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"101743","DOI":"10.1016\/j.pdpdt.2020.101743","article-title":"Ultraviolet imaging in dermatology","volume":"30","author":"Mojeski","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Gorbunova, I.A., Danilova, M.K., Sasin, M.E., Belik, V.P., Golyshev, D.P., and Vasyutinskii, O.S. (2023). Determination of fluorescence quantum yields and decay times of NADH and FAD in water\u2013alcohol mixtures: The analysis of radiative and nonradiative relaxation pathways. J. Photochem. Photobiol. A: Chem., 436.","DOI":"10.1016\/j.jphotochem.2022.114388"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1523-1747.2000.00091.x","article-title":"Fluorescence excitation spectroscopy provides information about human skin in vivo","volume":"115","author":"Gillies","year":"2000","journal-title":"J. Investig. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Liu, Y., Zhu, G., Wang, Q., Ni, J., Liu, L., Zhang, J., Zhang, T., Li, Z., and Wang, X. (2023). Noninvasive detection of diabetes mellitus based on skin fluorescence and diffuse reflectance spectroscopy. J. Biophotonics, 17.","DOI":"10.1002\/jbio.202300098"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sun, Y., Pu, Y., Yang, Y., and Alfano, R.R. (2012). Biomarkers spectral subspace for cancer detection. J. Biomed. Opt., 17.","DOI":"10.1117\/1.JBO.17.10.107005"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3390\/photonics1040530","article-title":"Time-resolved fluorescence in photodynamic therapy","volume":"1","author":"Yeh","year":"2014","journal-title":"Photonics"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.talanta.2010.07.034","article-title":"Rapid simultaneous determination of protoporphyrin IX, uroporphyrin III and coproporphyrin III in human whole blood by non-linear variable-angle synchronous fluorescence technique coupled with partial least squares","volume":"82","author":"Huang","year":"2010","journal-title":"Talanta"},{"key":"ref_53","first-page":"1","article-title":"Natural dye sensitizer for Gr\u00e4tzel cells: Sepia melanin","volume":"3","author":"Mbonyiryivuze","year":"2015","journal-title":"Phys. Mater. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Dervieux, E., Bodinier, Q., Uhring, W., and Th\u00e9ron, M. (2020). Measuring hemoglobin spectra: Searching for carbamino-hemoglobin. J. Biomed. Opt., 25.","DOI":"10.1117\/1.JBO.25.10.105001"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1038\/ncomms4936","article-title":"Separating NADH and NADPH fluorescence in live cells and tissues using FLIM","volume":"5","author":"Blacker","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1751-1097.1981.tb04293.x","article-title":"The fluorescence decay of reduced nicotinamides in aqueous solution after excitation with a UV-mode locked Ar ion laser","volume":"33","author":"Visser","year":"1981","journal-title":"Photochem. Photobiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/lapl.200810132","article-title":"Multi-wavelength fluorescence lifetime spectroscopy: A new approach to the study of endogenous fluorescence in living cells and tissues","volume":"6","author":"Chorvat","year":"2009","journal-title":"Laser Phys. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.3390\/ijms14011952","article-title":"pH dependence of the fluorescence lifetime of FAD in solution and in cells","volume":"14","author":"Islam","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Mienaltowski, M.J., and Birk, D.E. (2014). Structure, Physiology, and Biochemistry of Collagens. Progress in Heritable Soft Connective Tissue Diseases, Springer.","DOI":"10.1007\/978-94-007-7893-1_2"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0065-3233(05)70013-9","article-title":"Elastin","volume":"70","author":"Mithieux","year":"2005","journal-title":"Adv. Protein Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1126\/science.180.4086.561","article-title":"Cross-Linking of Collagen: Endogenous aldehydes in collagen react in several ways to form a variety of unique covalent cross-links","volume":"180","author":"Tanzer","year":"1973","journal-title":"Science"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1042\/BST0350849","article-title":"Biochemistry and functional significance of collagen cross-linking","volume":"35","author":"Robins","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref_63","unstructured":"La Bella, F., and Thornhill, D.P. (1965, January 25\u201327). Effects of UV irradiation in Human and Bovine Collagen and Elastin. Proceedings of the Third Canadian Conference on Research in the Rheumatic Disorders, Toronto, ON, Canada."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0846.2011.00549.x","article-title":"Impact of collagen crosslinking on the second harmonic generation signal and the fluorescence lifetime of collagen autofluorescence","volume":"18","author":"Lutz","year":"2012","journal-title":"Skin Res. Technol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"11058","DOI":"10.1021\/acs.jpcb.1c05001","article-title":"Collagen glycation detected by its intrinsic fluorescence","volume":"125","author":"Muir","year":"2021","journal-title":"J. Phys. Chem. B"},{"key":"ref_66","first-page":"2924","article-title":"Physical, biomechanical, and optical characterization of collagen and elastin blend hydrogels","volume":"48","author":"Liu","year":"2021","journal-title":"Ann. Biomed. Eng."},{"key":"ref_67","first-page":"562","article-title":"Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: Potential application to monitor human radiation risk","volume":"20","author":"Shu","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1021\/ac50017a041","article-title":"Evaluation of tetraphenylporphinatozinc (II) as a stable standard for porphyrin determinations by fluorescence spectrometry","volume":"49","author":"Lavallee","year":"1977","journal-title":"Anal. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1023\/A:1012342815215","article-title":"Coproporphyrins, uroporphyrins, and their metal Complexes: Biosynthesis and application to immune analysis and diagnostic methods","volume":"37","author":"Bykhovsky","year":"2001","journal-title":"Appl. Biochem. Microbiol."},{"key":"ref_70","first-page":"10","article-title":"Fluorescence Spectroscopy for Endogenous Porphyrins in Human Facial Skin","volume":"Volume 7161","author":"Seo","year":"2009","journal-title":"Photonic Therapeutics and Diagnostics V"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000489396","article-title":"Is human sebum the source of skin follicular ultraviolet-induced red fluorescence? A cellular to histological study","volume":"234","author":"Xu","year":"2018","journal-title":"Dermatology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF01808114","article-title":"Protoporphyrin IX as a possible ancient photosensitizer: Spectral and photochemical studies","volume":"20","author":"Lozovaya","year":"1990","journal-title":"Orig. Life Evol. Biosph."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1117\/12.431555","article-title":"Photobleaching of endogenous fluorochroms in tissues in vivo during laser irradiation","volume":"Volume 4241","author":"Stratonnikov","year":"2000","journal-title":"Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II"},{"key":"ref_74","first-page":"3927","article-title":"Hemoglobin research and the origins of molecular medicine","volume":"112","author":"Schechter","year":"2008","journal-title":"Blood. J. Am. Soc. Hematol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1096\/fasebj.5.14.1752358","article-title":"Enzymatic control of pigmentation in mammals","volume":"5","author":"Hearing","year":"1991","journal-title":"FASEB J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/php.12837","article-title":"Photodegradation of eumelanin and pheomelanin and its pathophysiological implications","volume":"94","author":"Ito","year":"2018","journal-title":"Photochem. Photobiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"429","DOI":"10.18388\/abp.2006_3314","article-title":"Melanin synthesis in microorganisms\u2014Biotechnological and medical aspects","volume":"53","author":"Grabacka","year":"2006","journal-title":"Acta Biochim. Pol."},{"key":"ref_78","first-page":"249","article-title":"Noninvasive computerized analysis of skin chromophores in vivo by reflectance spectroscopy","volume":"7","author":"Andersen","year":"1990","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1364\/JOT.83.000043","article-title":"How the melanin concentration in the skin affects the fluorescence-spectroscopy signal formation","volume":"83","author":"Dremin","year":"2016","journal-title":"J. Opt. Technol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Georgievskaya, A., Tlyachev, T., Danko, D., Chekanov, K., and Corstjens, H. (2023). How artificial intelligence adopts human biases: The case of cosmetic skincare industry. AI Ethics, 1\u201311.","DOI":"10.1007\/s43681-023-00378-2"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Chekanov, K. (2003). Diversity and distribution of carotenogenic algae in Europe: A review. Mar. Drugs, 21.","DOI":"10.3390\/md21020108"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Zaytseva, A., Chekanov, K., Zaytsev, P., Bakhareva, D., Gorelova, O., Kochkin, D., and Lobakova, E. (2021). Sunscreen effect exerted by secondary carotenoids and mycosporine-like amino acids in the aeroterrestrial chlorophyte Coelastrella rubescens under high light and UV-A irradiation. Plants, 10.","DOI":"10.3390\/plants10122601"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"102425","DOI":"10.1016\/j.algal.2021.102425","article-title":"Mycosporine-like amino acids: Algal metabolites shaping the safety and sustainability profiles of commercial sunscreens","volume":"58","author":"Sen","year":"2021","journal-title":"Algal Res."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Solovchenko, A., and Chekanov, K. (2014). Production of carotenoids using microalgae cultivated in photobioreactors. Production of Biomass and Bioactive Compounds Using Bioreactor Technology, Springer.","DOI":"10.1007\/978-94-017-9223-3_4"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-0846.1996.tb00072.x","article-title":"In vivo evaluation of sunscreens by spectroscopic methods","volume":"2","author":"Utz","year":"1996","journal-title":"Skin Res. Technol."},{"key":"ref_86","unstructured":"(2024, August 31). US Food & Drug Administration. Sun Protection Factor (SPF), Available online: https:\/\/www.fda.gov\/about-fda\/center-drug-evaluation-and-research-cder\/sun-protection-factor-spf."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0003-2670(98)00577-7","article-title":"In Vitro Measurement of Sun Protection Factor of Sunscreens by Diffuse Transmittance","volume":"380","author":"Springsteen","year":"1999","journal-title":"Anal. Chim. Acta"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1046\/j.1523-1747.1998.00345.x","article-title":"Psoriatic Plaques Exhibit Red Autofluorescence That Is Due to Protoporphyrin IX","volume":"111","author":"Bissonnette","year":"1998","journal-title":"J. Investig. Dermatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/srt.13011","article-title":"A novel UV-fluorescence approach to assess the long wear efficacy of foundations","volume":"27","author":"Messaraa","year":"2021","journal-title":"Skin Res. Technol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000018473","article-title":"Unravelling the patterns of subclinical pheomelanin-enriched facial hyperpigmentation: Effect of depigmenting agents","volume":"201","author":"Hermanns","year":"2000","journal-title":"Dermatology"},{"key":"ref_91","first-page":"1462","article-title":"Mechanisms of photoaging and chronological skin aging","volume":"138","author":"Fisher","year":"2022","journal-title":"Arch. Dermatol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0026-0495(92)90059-J","article-title":"Age-related increase of collagen fluorescence in human subcutaneous tissue","volume":"41","author":"Odetti","year":"1992","journal-title":"Metabolism"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1046\/j.1523-1747.2001.01361.x","article-title":"Aging and Effects of Ultraviolet A Exposure May Be Quantified by Fluorescence Excitation Spectroscopy In Vivo","volume":"116","author":"Tian","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_94","first-page":"324","article-title":"Wood\u2019s lamp in dermatology: Applications in the daily practice","volume":"9","author":"Veasey","year":"2017","journal-title":"Surg. Cosmet. Dermatol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Errichetti, E., Pietkiewicz, P., Bhat, Y.J., Salwowska, N., Szl\u0105zak, P., and Stinco, G. (2024). Diagnostic accuracy of ultravioletinduced fluorescence dermoscopy in non-neoplastic dermatoses (general dermatology): A multicentric retrospective comparative study. J. Eur. Acad. Dermatol. Venereol.","DOI":"10.1111\/jdv.19795"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Twarda-Clapa, A., Olczak, A., Bia\u0142kowska, A.M., and Kozio\u0142kiewicz, M. (2022). Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs. Cells, 11.","DOI":"10.3390\/cells11081312"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s001250051591","article-title":"Advanced Glycation End-Products: A Review","volume":"44","author":"Singh","year":"2001","journal-title":"Diabetologia"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Kuzan, A. (2021). Toxicity of advanced glycation end products (review). Biomed. Rep., 14.","DOI":"10.3892\/br.2021.1422"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/bbrc.1996.1308","article-title":"Formation of Crossline as a Fluorescent Advanced Glycation End Product in Vitro and in Vivo","volume":"226","author":"Obayashi","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.saa.2004.03.027","article-title":"Autofluorescence Characterization of Advanced Glycation End Products of Hemoglobin","volume":"61","author":"Vigneshwaran","year":"2005","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ab.2004.12.003","article-title":"Characterization of Advanced Glycation End Products for Biochemical Studies: Side Chain Modifications and Fluorescence Characteristics","volume":"338","author":"Schmitt","year":"2005","journal-title":"Anal. Biochem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1364\/BOE.6.001844","article-title":"Decrease in fluorescence lifetime by glycation of collagen and its application in determining advanced glycation end-products in human dentin","volume":"6","author":"Fukushima","year":"2015","journal-title":"Biomed. Opt. Express"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1089\/dia.2011.0108","article-title":"Two Fluorescent Wavelengths, 440ex\/520em nm and 370ex\/440em nm, Reflect Advanced Glycation and Oxidation End Products in Human Skin without Diabetes","volume":"14","author":"Beisswenger","year":"2012","journal-title":"Diabetes Technol. Ther."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ymeth.2020.12.003","article-title":"Minimal invasive fluorescence methods to quantify advanced glycation end products (AGEs) in skin and plasma of humans","volume":"203","author":"Alvarez","year":"2022","journal-title":"Methods"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.compbiomed.2016.04.005","article-title":"Assessment of advanced glycated end product accumulation in skin using auto fluorescence multispectral imaging","volume":"85","author":"Larsson","year":"2017","journal-title":"Comput. Biol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF02590223","article-title":"In vivo fluorescence spectroscopy and imaging of human skin tumours","volume":"9","author":"Sterenborg","year":"1994","journal-title":"Lasers Med. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.mrrev.2010.06.002","article-title":"Genetics of pigmentation in skin cancer\u2014A review","volume":"705","author":"Scherer","year":"2010","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"ref_108","first-page":"225","article-title":"In vivo skin fluorescence imaging in young Caucasian adults with early malignant melanomas","volume":"22","author":"Dewalque","year":"2014","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_109","unstructured":"Martens, G., and Gunzel, E.P. (1994). Method of detecting anomalies of the skin, more particularly melanomae, and apparatus for carrying out the method. (No. 5,363,854, November 15), U.S. Patent."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Streckfus, C.F. (2022). Exocrinology: A Textbook and Atlas of the Exocrine Cells, Glands, and Organs, Springer Nature.","DOI":"10.1007\/978-3-030-97552-4"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/cphy.c120006","article-title":"Porphyrin and Heme Metabolism and the Porphyrias","volume":"3","author":"Bonkovsky","year":"2013","journal-title":"Compr. Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.clindermatol.2004.03.004","article-title":"C. Acne and Sebaceous Gland Function","volume":"22","author":"Zouboulis","year":"2004","journal-title":"Clin. Dermatol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s004030000122","article-title":"High-Performance Liquid Chromatography Analysis of Porphyrins in Propionibacterium acnes","volume":"292","author":"Romiti","year":"2000","journal-title":"Arch. Dermatol. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/jdv.16789","article-title":"Is Cutibacterium (Previously Propionibacterium) acnes a Potential Pathogenic Factor in the Aetiology of the Skin Disease Progressive Macular Hypomelanosis?","volume":"35","author":"McDowell","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000250086","article-title":"In Vivo Porphyrin Fluorescence from Propionibacterium acnes: A Characterization of the Fluorescing Pigments","volume":"164","author":"Johnsson","year":"1982","journal-title":"Dermatology"},{"key":"ref_116","first-page":"316","article-title":"In Vivo Porphyrin Production by P","volume":"86","author":"Borelli","year":"2006","journal-title":"acnes in Untreated Acne Patients and Its Modulation by Acne Treatment. Acta Derm.-Venereol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00403-017-1718-3","article-title":"Measuring Acne Using Coproporphyrin III, Protoporphyrin IX, and Lesion-Specific Inflammation: An Exploratory Study","volume":"309","author":"Patwardhan","year":"2017","journal-title":"Arch. Dermatol. Res."},{"key":"ref_118","first-page":"369","article-title":"The Analysis of Facial Comedones by Porphyrin Fluorescence and Image Analysis","volume":"8","author":"Sauermann","year":"1990","journal-title":"J. Toxicol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/lsm.20469","article-title":"A Comparative Study of Intense Pulsed Light Alone and Its Combination with Photodynamic Therapy for the Treatment of Facial Acne in Asian Skin","volume":"39","author":"Yeung","year":"2007","journal-title":"Lasers Surg. Med."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Han, B., Jung, B., Nelson, J.S., and Choi, E.H. (2007). Analysis of Facial Sebum Distribution Using a Digital Fluorescent Imaging System. J. Biomed. Opt., 12.","DOI":"10.1117\/1.2435700"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/exd.14535","article-title":"Yin and Yang of Skin Microbiota in \u201cSwimmer Acne\u201d","volume":"31","author":"McGee","year":"2022","journal-title":"Exp. Dermatol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2133.1980.tb06557.x","article-title":"Facial Follicular Porphyrin Fluorescence: Correlation with Age and Density of Propionibacterium acnes","volume":"102","author":"McGinley","year":"1980","journal-title":"Br. J. Dermatol."},{"key":"ref_123","first-page":"889","article-title":"The Clinical Usefulness of Portable Digital Skin Fluorescence Equipment in Acne Patients","volume":"46","author":"Kim","year":"2008","journal-title":"Korean J. Dermatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/jb.133.2.811-815.1978","article-title":"Comparative Studies of Porphyrin Production in Propionibacterium acnes and Propionibacterium granulosum","volume":"133","author":"Lee","year":"1978","journal-title":"J. Bacteriol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1600-0846.2009.00360.x","article-title":"The Facial Red Fluorescence of Ultraviolet Photography: Is This Color Due to Propionibacterium acnes or the Unknown Content of Secreted Sebum?","volume":"15","author":"Youn","year":"2009","journal-title":"Skin Res. Technol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2133.2011.10598.x","article-title":"Ultraviolet-Induced Red Fluorescence of Patients with Acne Reflects Regional Casual Sebum Level and Acne Lesion Distribution: Qualitative and Quantitative Analyses of Facial Fluorescence","volume":"166","author":"Choi","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000439378","article-title":"Study of Facial Sebum Levels and Follicular Red Fluorescence in Patients with Acne Vulgaris in Nigeria","volume":"232","author":"Okoro","year":"2016","journal-title":"Dermatology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1600-0781.2010.00541.x","article-title":"Fluorescence Diagnostic Imaging in Patients with Acne","volume":"26","author":"Dobrev","year":"2010","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Brown, M.M., and Horswill, A.R. (2020). Staphylococcus epidermidis\u2014Skin Friend or Foe?. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1009026"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1159\/000499858","article-title":"Staphylococcus epidermidis: A Potential New Player in the Physiopathology of Acne?","volume":"235","author":"Claudel","year":"2019","journal-title":"Dermatology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"102388","DOI":"10.1016\/j.pdpdt.2021.102388","article-title":"Quantitative Assessment of Age-Dependent Changes in Porphyrins from Fluorescence Images of Ultraviolet Photography by Image Processing","volume":"35","author":"Wu","year":"2021","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/jocd.13453","article-title":"Variation of Biophysical Parameters of the Skin with Age, Gender, and Lifestyles","volume":"20","author":"Zhao","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"101928","DOI":"10.1016\/j.pdpdt.2020.101928","article-title":"Trends in Erythrocyte Protoporphyrin IX Concentration by Age, Sex and Season Among Patients with Erythropoietic Protoporphyria\u201420 Years of Follow-Up","volume":"32","author":"Heerfordt","year":"2020","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/clinchem\/34.4.757","article-title":"Factors influencing fluorescence spectra of free porphyrins","volume":"34","author":"Polo","year":"1988","journal-title":"Clin. Chem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-0846.2007.00279.x","article-title":"Fluorescent Image Analysis for Evaluating the Condition of Facial Sebaceous Follicles","volume":"14","author":"Son","year":"2008","journal-title":"Skin Res. Technol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Michalak, M. (2023). Plant Extracts as Skin Care and Therapeutic Agents. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242015444"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00425-010-1191-0","article-title":"Structural Implications on Color, Fluorescence, and Antiradical Activity in Betalains","volume":"232","author":"Escribano","year":"2010","journal-title":"Planta"},{"key":"ref_138","unstructured":"Herpens, A., Schagen, S., Scheede, S., and Kristof, B. (2007). Evaluation of Comedogenic Activity by Skin Fluorescence Imaging Analysis (Skin Analyzing Fluorescence Imaging Recorder). Bioengineering of the Skin, CRC Press."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.pdpdt.2017.05.016","article-title":"Protoporphyrin IX Fluorescence as Potential Indicator of Psoriasis Severity and Progression","volume":"19","author":"Wang","year":"2017","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e2023243","DOI":"10.5826\/dpc.1303a243","article-title":"Pink-Red Fluorescence Observed in Ultraviolet-Induced Fluorescence Dermoscopy of Psoriatic Plaques","volume":"13","author":"Pietkiewicz","year":"2023","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000083509","article-title":"The psoriasis area and severity index is the adequate criterion to define severity in chronic plaque-type psoriasis","volume":"210","author":"Schmitt","year":"2005","journal-title":"Dermatol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1346-8138.1983.tb01180.x","article-title":"Reflection Ultraviolet Photography as Surface Photography of the Skin","volume":"10","author":"Kikuchi","year":"1983","journal-title":"J. Dermatol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000081474","article-title":"The Conundrum of Skin Pores in Dermocosmetology","volume":"210","author":"Uhoda","year":"2004","journal-title":"Dermatology"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/srt.12865","article-title":"Segmentation Methods for Acne Vulgaris Images: Proposal of a New Methodology Applied to Fluorescence Images","volume":"26","year":"2020","journal-title":"Skin Res. Technol."},{"key":"ref_146","unstructured":"Cline, R.W., and Leduc, P. (2003). Portable system for detecting skin abnormalities based on characteristic autofluorescence. (No. 6,603,552, August 5), U.S. Patent."},{"key":"ref_147","unstructured":"Merola, K., Kollias, N., Pote, J.S., and Payonk, G. (2005). Method of promoting skin care products. (No. 6,961,517, November 1), US Patent."},{"key":"ref_148","unstructured":"Merola, K., Kollias, N., Pote, J.S., and Payonk, G. (2005). Method of promoting skin care products. (No. 6,922,523, July 26), US Patent."},{"key":"ref_149","unstructured":"Kollias, N., Merola, K., Pote, J., and Payonk, G. (2008). Imaging apparatus and methods for capturing and analyzing digital images of the skin. (Application No. 20,080,079,843, April 3), US Patent."},{"key":"ref_150","unstructured":"Kollias, N., Merola, K., Pote, J.S., and Payonk, G. (2010). Apparatus for and method of taking and viewing images of the skin. (No. 7,738,032, June 15), US Patent."},{"key":"ref_151","unstructured":"Demirli, R., and Hillebrand, G.G. (2012). Method and Apparatus for Simulation of Dacial Skin Aging and De-Aging. (No. 8,290,257), US Patent."},{"key":"ref_152","unstructured":"(2024, August 03). VISIA-CR User Guide. Available online: https:\/\/www.esthetec.fr\/wa_files\/VISIA-CR-User-Guide.pdf."},{"key":"ref_153","unstructured":"OBSERV 520 (2024, August 03). Sylton Diagnostic Systems. Available online: https:\/\/us.sylton.com\/product\/observ-520x-face-analysis\/."},{"key":"ref_154","unstructured":"(2024, August 03). Lumsail BS-3800 Built-In 20 Million Pixel 8 Different Spectrums 3D Skin Analyzer. Available online: https:\/\/www.lumsail.com\/product\/lumsail-bs-3800-built-in-20-million-pixel-8-different-spectrums-3d-skin-analyzer\/."},{"key":"ref_155","unstructured":"Van der Beek, N. (2017). From Practice to Theory: Computational Studies on Fluorescence Detection and Laser Therapy in Dermatology. [Ph.D. Thesis, University of Wales Trinity Saint David]."},{"key":"ref_156","unstructured":"(2024, August 03). Visiopor\u00ae PP 34N\u2014Monitoring Acne-Lesionsby Skin Fluorescence. Available online: https:\/\/www.courage-khazaka.com\/images\/Downloads\/Brochures\/Wissenschaftlich\/Brochure_Visiopor.pdf."},{"key":"ref_157","unstructured":"Information and Operating Instruction (2024, August 03). Visioscan\u00ae VC 98 and the Software SELS (Surface Evaluation of the Living Skin). Available online: https:\/\/www.cosmeticsonline.com.br\/produtos\/arquivos\/A42_instructions_vc98_sels_fw.pdf."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e13613","DOI":"10.1111\/srt.13613","article-title":"Skinly: A Novel Handheld IoT Device for Validating Biophysical Skin Characteristics","volume":"30","author":"Tobar","year":"2024","journal-title":"Skin Res. Technol."},{"key":"ref_159","unstructured":"(2024, August 03). Dermlte.com: Lumio 2. Available online: https:\/\/dermlite.com\/products\/lumio-2?_pos=1&_psq=lumio&_ss=e&_v=1.0."},{"key":"ref_160","unstructured":"Canfield VOSIOMED Dermoscopy (2024, August 03). Optima 3-in-1 Magnifier Brochure. Available online: https:\/\/www.canfieldsci.com\/common\/docs\/products\/47\/brochures\/OptimaBrochure.pdf."},{"key":"ref_161","unstructured":"(2024, August 03). DermLite. Available online: https:\/\/dermlite.com."},{"key":"ref_162","unstructured":"\u30d7\u30ed\u4ed5\u69d8\u306e\u808c\u30fb\u982d\u76ae\u30fb\u9aea\u6e2c\u5b9a\u30921\u53f0\u3067\u5b9f\u73fe (2024, August 03). Achieve professional-grade measurement of skin, scalp, and hair with a single device. Available online: https:\/\/www.sma-ski.com\/#shiyo."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Khongsuwan, M., Kiattisin, S., Wongseree, W., and Leelasantitham, A. (2012, January 29\u201331). Counting Number of Points for Acne Vulgaris Using UV Fluorescence and Image Processing. Proceedings of the 4th Biomedical Engineering International Conference, Chiang Mai, Thailand.","DOI":"10.1109\/BMEiCon.2012.6172038"},{"key":"ref_164","first-page":"1312","article-title":"VISIA System: A Possible Tool in the Cosmetic Practice","volume":"13","author":"Goldsberry","year":"2014","journal-title":"J. Drugs Dermatol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1111\/jocd.13846","article-title":"Recent Developments in Dermoscopy for Dermatology","volume":"20","author":"Chen","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41746-022-00587-9","article-title":"Dermoscopy Practice Guidelines for Use in Telemedicine","volume":"5","author":"Deda","year":"2022","journal-title":"NPJ Digit. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000538166","article-title":"Increasing the Distance between the Dermoscope and the Surgical Site during Intraoperative Dermoscopy","volume":"10","author":"Erdem","year":"2024","journal-title":"Skin Appendage Disor."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e2023135","DOI":"10.5826\/dpc.1302a135","article-title":"Scabies mite is bright green under UV dermatoscopy","volume":"13","author":"Pietkiewicz","year":"2023","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"104056","DOI":"10.1016\/j.pdpdt.2024.104056","article-title":"Assessing field cancerization and actinic keratosis using ultraviolet-induced fluorescence dermatoscopy after the application of 5-aminolevulinic acid\u2014An observational study","volume":"46","author":"Korecka","year":"2024","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Burger, W., and Burge, M.J. (2022). Digital Image Processing: An Algorithmic Introduction, Springer Nature.","DOI":"10.1007\/978-3-031-05744-1"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"May, A., Bhaumik, S., Gambhir, S.S., Zhan, C., and Yazdanfar, S. (2009). Whole-Body, Real-Time Preclinical Imaging of Quantum Dot Fluorescence with Time-Gated Detection. J. Biomed. Opt., 14.","DOI":"10.1117\/1.3269675"},{"key":"ref_172","first-page":"713","article-title":"A Fast Algorithm for Multilevel Thresholding","volume":"17","author":"Liao","year":"2001","journal-title":"J. Inf. Sci. Eng."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature14539","article-title":"Deep Learning","volume":"521","author":"LeCun","year":"2015","journal-title":"Nature"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"045001","DOI":"10.1063\/5.0188187","article-title":"Early Detection of Skin Cancer Using AI: Deciphering Dermatology Images for Melanoma Detection","volume":"14","author":"Deepa","year":"2024","journal-title":"AIP Adv."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.clindermatol.2023.12.022","article-title":"Artificial Intelligence in the Detection of Skin Cancer: State of the Art","volume":"42","author":"Strzelecki","year":"2024","journal-title":"Clin. Dermatol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Furriel, B.C., Oliveira, B.D., Pr\u00f4a, R., Paiva, J.Q., Loureiro, R.M., Calixto, W.P., and Giavina-Bianchi, M. (2024). Artificial Intelligence for Skin Cancer Detection and Classification in Clinical Environments: A Systematic Review. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1305954"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.eng.2019.08.015","article-title":"Artificial Intelligence in Healthcare: Review and Prediction Case Studies","volume":"6","author":"Rong","year":"2020","journal-title":"Engineering"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Georgievskaya, A., Danko, D., Baxter, R.A., Corstjens, H., and Tlyachev, T. (2023). Artificial Intelligence Approaches for Skin Anti-aging and Skin Resilience Research. Artificial Intelligence for Healthy Longevity, Springer International Publishing.","DOI":"10.1007\/978-3-031-35176-1_10"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"e15045","DOI":"10.1111\/exd.15045","article-title":"Predicting Human Chronological Age via AI Analysis of Dorsal Hand Versus Facial Images: A Study in a Cohort of Indian Females","volume":"33","author":"Georgievskaya","year":"2024","journal-title":"Exp. Dermatol."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Gohil, Z.M., and Desai, M.B. (2024). Revolutionizing Dermatology: A Comprehensive Survey of AI-Enhanced Early Skin Cancer Diagnosis. Arch. Comput. Methods Eng.","DOI":"10.1007\/s11831-024-10121-7"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Miyamoto, K., Dissanayake, B., Omotezako, T., Takemura, M., Tsuji, G., and Furue, M. (2021). Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula. J. Clin. Med., 10.","DOI":"10.3390\/jcm10112502"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Kim, M., and Song, M.H. (2023). High Performing Facial Skin Problem Diagnosis with Enhanced Mask R-CNN and Super Resolution GAN. Appl. Sci., 13.","DOI":"10.3390\/app13020989"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.18632\/aging.101629","article-title":"PhotoAgeClock: Deep Learning Algorithms for Development of Non-Invasive Visual Biomarkers of Aging","volume":"10","author":"Bobrov","year":"2018","journal-title":"Aging"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Alamdari, N., Tavakolian, K., Alhashim, M., and Fazel-Rezai, R. (2016, January 19\u201321). Detection and Classification of Acne Lesions in Acne Patients: A Mobile Application. Proceedings of the 2016 IEEE International Conference on Electro Information Technology (EIT), Grand Forks, ND, USA.","DOI":"10.1109\/EIT.2016.7535331"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Khan, J., Malik, A.S., Kamel, N., Dass, S.C., and Affandi, A.M. (2015, January 25\u201329). Segmentation of Acne Lesion Using Fuzzy C-Means Technique with Intelligent Selection of the Desired Cluster. Proceedings of the 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Milan, Italy.","DOI":"10.1109\/EMBC.2015.7319042"},{"key":"ref_186","first-page":"28","article-title":"Automatic Facial Spots and Acnes Detection System","volume":"3","author":"Chang","year":"2013","journal-title":"J. Cosmet. Dermatol. Sci. Appl."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/srt.12122","article-title":"Novel Techniques for Enhancement and Segmentation of Acne Vulgaris Lesions","volume":"20","author":"Malik","year":"2014","journal-title":"Skin Res. Technol."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Huynh, Q.T., Nguyen, P.H., Le, H.X., Ngo, L.T., Trinh, N.-T., Tran, M.T.-T., Nguyen, H.T., Vu, N.T., Nguyen, A.T., and Suda, K. (2022). Automatic Acne Object Detection and Acne Severity Grading Using Smartphone Images and Artificial Intelligence. Diagnostics, 12.","DOI":"10.20944\/preprints202206.0384.v1"},{"key":"ref_189","unstructured":"(2024, September 03). The International Skin Collaboration. Available online: https:\/\/www.isic-archive.com\/."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"180161","DOI":"10.1038\/sdata.2018.161","article-title":"The HAM10000 Dataset, a Large Collection of Multi-Source Dermatoscopic Images of Common Pigmented Skin Lesions","volume":"5","author":"Tschandl","year":"2018","journal-title":"Sci. Data"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1016\/j.eswa.2015.04.034","article-title":"MED-NODE: A Computer-Assisted Melanoma Diagnosis System Using Non-Dermoscopic Images","volume":"42","author":"Giotis","year":"2015","journal-title":"Expert Syst. 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