{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T01:38:15Z","timestamp":1772156295125,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>(1) Introduction: Topical dithranol is still commonly used today as an effective treatment for psoriasis. Dithranol treatment is often supplemented with balneotherapy, which has been shown to increase effectiveness and reduce side effects. The inorganic salts (sulfhide, selenium, zinc) are usually thought to be responsible for the effect. The antioxidant effect of the waters is thought to be behind the therapeutic effect, for which inorganic substances (sulfides, selenium, zinc) are thought to be responsible. The organic matter content of medicinal waters is also particularly important, as humic acids, which are often found in medicinal waters, have antioxidant effects. (2) Methods: In this short-term experiment, we aimed to test the possible protective effect of Szigetv\u00e1r medicinal water and its organic matter isolate on HaCaT cells exposed to dithranol. Malondialdehyde levels were measured, and RT-qPCR was used to investigate the gene expression of selected cytokines relevant in the oxidative stress response (IL-6, IL-8, TNF-\u03b1, GM-CSF) and the expression of microRNA-21. (3) Results: Szigetv\u00e1r medicinal water and the organic isolate prevented the increase in malondialdehyde levels caused by dithranol treatment. The cytokine gene expressions elevated by dithranol exposure were reduced by the treatment. (4) Conclusions: Szigetv\u00e1r medicinal water and organic substances alone may have a protective effect on patients\u2019 healthy skin surfaces against dithranol damage. We also demonstrated that the organic compounds are also responsible for the protective effect.<\/jats:p>","DOI":"10.3390\/life14101318","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T03:49:34Z","timestamp":1729136974000},"page":"1318","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Szigetv\u00e1r Medicinal Water on HaCaT Cells Exposed to Dithranol"],"prefix":"10.3390","volume":"14","author":[{"given":"Istv\u00e1n","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"Department of Public Health Medicine, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Szenczi","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5656-089X","authenticated-orcid":false,"given":"Afshin","family":"Zand","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-0669","authenticated-orcid":false,"given":"T\u00edmea","family":"Varjas","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5855-5338","authenticated-orcid":false,"given":"Csaba","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Medical School, University of P\u00e9cs, 7622 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s40272-023-00592-9","article-title":"Topical Management of Pediatric Psoriasis: A Review of New Developments and Existing Therapies","volume":"26","author":"Lie","year":"2024","journal-title":"Pediatr. 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