{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:21:17Z","timestamp":1790266877552,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Accumulating evidence has proposed phase angle (PhA) as a marker for assessing cellular integrity and nutritional status in ulcerative colitis (UC) patients; the aim of the study was to evaluate the efficacy of PhA in assessing nutritional status in patients with UC, investigating its potential as a biomarker of disease activity. Methods: We conducted a cross-sectional study in patients with UC and healthy controls. We determined PhA by electrical bioimpedance and categorized participants through bioelectrical impedance analysis. They were classified as normal PhA &gt; 6.1\u00b0 and low PhA &lt; 6.1\u00b0 in men and normal PhA &gt; 5.6\u00b0 and low PhA &lt; 5.6\u00b0 in women. Results: PhA was significantly lower in UC patients than in controls (5.8 \u00b1 0.8 vs. 6.6 \u00b1 0.7\u00b0; p &lt; 0.001). Among UC patients, participants with low PhA showed a decrease in lean, dry mass (LDM) (p &lt; 0.001), total body water (p = 0.008), and intracellular water (p = 0.005), accompanied by an increase in extracellular water (p = 0.001) compared to UC patients with normal PhA. Conclusions: PhA significantly decreases in UC patients compared to healthy controls and is even more reduced when UC is active. A cut-off point of &lt;6.1 for men and &lt;5.6 for women could be suitable for nutritional diagnosis in patients with UC, but it still needs to be validated.<\/jats:p>","DOI":"10.3390\/life14111511","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T03:57:04Z","timestamp":1732075024000},"page":"1511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Phase Angle (PhA) Is an Easy and Complementary Tool for Assessing Nutritional Status in Ulcerative Colitis (UC) Patients: A Cross-Sectional Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3621-7557","authenticated-orcid":false,"given":"Viridiana Montsserrat","family":"Mendoza-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Directorate, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8539-9595","authenticated-orcid":false,"given":"Roberto","family":"Ba\u00f1os-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Directorate, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-6395","authenticated-orcid":false,"given":"Guillermo","family":"Melendez-Mier","sequence":"additional","affiliation":[{"name":"Faculty of Public Health and Nutrition (FASPyN), Autonomous University of Nuevo Le\u00f3n, Monterrey 66455, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4059-5102","authenticated-orcid":false,"given":"Javier Ivanovychs","family":"Carrillo-Rojas","sequence":"additional","affiliation":[{"name":"Specialty Hospital of the National Medical Center \u201cLa Raza\u201d, Mexico City 02990, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Alison","family":"Santoyo-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Directorate, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarahi","family":"Ontiveros-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Specialty Hospital of the National Medical Center \u201cLa Raza\u201d, Mexico City 02990, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annel","family":"G\u00f3mez-Coello","sequence":"additional","affiliation":[{"name":"Phoniatrics Department, National Institute of Rehabilitation \u201cLuis Guillermo Ibarra Ibarra\u201d, Mexico City 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-7400","authenticated-orcid":false,"given":"Galileo","family":"Escobedo","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Directorate, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Luis","family":"de Le\u00f3n-Rend\u00f3n","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Clinic of the Gastroenterology Service of the General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-0987","authenticated-orcid":false,"given":"Nallely","family":"Bueno-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Proteomics and Metabolomics Laboratory, Research Directorate, General Hospital of Mexico \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"},{"name":"Specialty Hospital of the National Medical Center \u201cLa Raza\u201d, Mexico City 02990, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: Pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.rmclc.2019.06.002","article-title":"Manifestaciones cl\u00ednicas y endosc\u00f3picas en enfermedad inflamatoria intestinal","volume":"30","author":"Gompertz","year":"2019","journal-title":"Rev. M\u00e9dica Cl\u00ednica Las Condes"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.3748\/wjg.v25.i28.3823","article-title":"Systematic review of nutrition screening and assessment in inflammatory bowel disease","volume":"25","author":"Li","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Nishikawa, H., Nakamura, S., Miyazaki, T., Kakimoto, K., Fukunishi, S., Asai, A., Nishiguchi, S., and Higuchi, K. (2021). Inflammatory Bowel Disease and Sarcopenia: Its Mechanism and Clinical Importance. J. Clin. Med., 10.","DOI":"10.3390\/jcm10184214"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.clnu.2022.12.004","article-title":"ESPEN guideline on Clinical Nutrition in inflammatory bowel disease","volume":"42","author":"Bischoff","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Fiorindi, C., Luceri, C., Dragoni, G., Piemonte, G., Scaringi, S., Staderini, F., Nannoni, A., Ficari, F., and Giudici, F. (2020). GLIM Criteria for Malnutrition in Surgical IBD Patients: A Pilot Study. Nutrients, 12.","DOI":"10.3390\/nu12082222"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.clnu.2016.12.027","article-title":"ESPEN guideline: Clinical nutrition in inflammatory bowel disease","volume":"36","author":"Forbes","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_8","first-page":"286","article-title":"Values of the phase angle by bioelectrical impedance; nutritional status and prognostic value","volume":"28","author":"Llames","year":"2013","journal-title":"Nutr. Hosp."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1590\/1806-9282.64.02.133","article-title":"Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients","volume":"64","author":"Urbano","year":"2018","journal-title":"Rev. Assoc. Med. Bras. (1992)"},{"key":"ref_10","first-page":"158","article-title":"Strengthening the reporting of observational studies in epidemiology (STROBE): Explanation and elaboration","volume":"23","author":"Vandenbroucke","year":"2009","journal-title":"Gac. Sanit."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1475-2891-6-18","article-title":"Body fat measurement by bioelectrical impedance and air displacement plethysmography: A cross-validation study to design bioelectrical impedance equations in Mexican adults","volume":"6","author":"Macias","year":"2007","journal-title":"Nutr. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/jappl.2000.89.2.465","article-title":"Estimation of skeletal muscle mass by bioelectrical impedance analysis","volume":"89","author":"Janssen","year":"2000","journal-title":"J. Appl. Physiol. (1985)"},{"key":"ref_13","first-page":"CC01","article-title":"Anthropometric Predictors of Bio-Impedance Analysis (BIA) Phase Angle in Healthy Adults","volume":"10","author":"Siddiqui","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_14","unstructured":"Rojas, M.C., and Vargas, R.V. (2004). La medici\u00f3n de la talla y el peso. gu\u00eda para el personal de la salud del primer nivel de atenci\u00f3n, Instituto Nacional de Salud."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Peng, Z., Xu, D., Li, Y., Peng, Y., and Liu, X. (2022). Phase Angle as a Comprehensive Tool for Nutritional Monitoring and Management in Patients with Crohn\u2019s Disease. Nutrients, 14.","DOI":"10.3390\/nu14112260"},{"key":"ref_16","first-page":"587","article-title":"Sobre el uso adecuado del coeficiente de correlaci\u00f3n de Pearson: Definici\u00f3n, propiedades y suposiciones","volume":"37","author":"Lalinde","year":"2018","journal-title":"Arch. Venez. De Farmacol. Ter."},{"key":"ref_17","first-page":"1","article-title":"Physical status: The use and interpretation of anthropometry. Report of a WHO Expert Committee","volume":"854","author":"Sellen","year":"1995","journal-title":"World Health Organ Tech. Rep. Ser."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.clnu.2019.06.023","article-title":"Assessment of bioelectrical phase angle as a predictor of nutritional status in patients with Crohn\u2019s disease: A cross sectional study","volume":"39","author":"Cioffi","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wiech, P., Dabrowski, M., Bazalinski, D., Salacinska, I., Korczowski, B., and Binkowska-Bury, M. (2018). Bioelectrical Impedance Phase Angle as an Indicator of Malnutrition in Hospitalized Children with Diagnosed Inflammatory Bowel Diseases\u2014A Case Control Study. Nutrients, 10.","DOI":"10.3390\/nu10040499"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.clnu.2012.05.008","article-title":"Bioelectrical phase angle and impedance vector analysis\u2014Clinical relevance and applicability of impedance parameters","volume":"31","author":"Norman","year":"2012","journal-title":"Clin. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Mentella, M.C., Scaldaferri, F., Pizzoferrato, M., Gasbarrini, A., and Miggiano, G.A.D. (2019). The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD. Nutrients, 11.","DOI":"10.3390\/nu11112583"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s11154-022-09775-0","article-title":"Phase angle and cellular health: Inflammation and oxidative damage","volume":"24","author":"Orsso","year":"2023","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jablonska, B., and Mrowiec, S. (2023). Nutritional Status and Its Detection in Patients with Inflammatory Bowel Diseases. Nutrients, 15.","DOI":"10.3390\/nu15081991"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e23095","DOI":"10.1590\/s0004-2803.246102023-95","article-title":"Phase Angle as a Predictor of Muscle Mass in Patients with Inflammatory Bowel Disease","volume":"61","author":"Bongiolo","year":"2024","journal-title":"Arq. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s11154-023-09785-6","article-title":"The use of phase angle in patients with digestive and liver diseases","volume":"24","author":"Casirati","year":"2023","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/ibd\/izy212","article-title":"Sarcopenia and Inflammatory Bowel Disease: A Systematic Review","volume":"25","author":"Ryan","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_27","first-page":"236","article-title":"Inflammatory bowel disease and the risk of cardiovascular diseases","volume":"44","author":"Nunez","year":"2021","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e11639","DOI":"10.1097\/MD.0000000000011639","article-title":"Waist-hip ratio as a predictor of myocardial infarction risk: A systematic review and meta-analysis","volume":"97","author":"Cao","year":"2018","journal-title":"Medicine"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.clnesp.2021.10.009","article-title":"Extracellular water to total body water ratio may mediate the association between phase angle and mortality in patients with cancer cachexia: A single-center, retrospective study","volume":"46","author":"Katsura","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/apt.13218","article-title":"Systematic review: Body composition in children with inflammatory bowel disease","volume":"42","author":"Thangarajah","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cger.2016.08.002","article-title":"Pathogenesis and Management of Sarcopenia","volume":"33","author":"Dhillon","year":"2017","journal-title":"Clin. Geriatr. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s11154-023-09803-7","article-title":"Future lines of research on phase angle: Strengths and limitations","volume":"24","author":"Bellido","year":"2023","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1053\/j.gastro.2015.07.003","article-title":"Biomarkers of Inflammation in Inflammatory Bowel Disease","volume":"149","author":"Sands","year":"2015","journal-title":"Gastroenterology"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/11\/1511\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:35:35Z","timestamp":1760114135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/14\/11\/1511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["life14111511"],"URL":"https:\/\/doi.org\/10.3390\/life14111511","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]}}}