{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:35:11Z","timestamp":1783038911479,"version":"3.54.6"},"reference-count":24,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Acute limb ischemia is a limb-threatening condition that is associated with a high degree of mortality and morbidity, with the latter related to acute kidney injury and rhabdomyolysis that can rapidly lead to multiple organ failure. The aim of this study was to assess the efficacy and safety of catheter-directed arterial thrombolysis in acute lower limb ischemia in the Department of Vascular Surgery, Timi\u0219oara, Romania. A total of 158 patients (114 males\u201472.15% and 44 females\u201427.85%) with symptoms of acute lower limb ischemia were admitted and treated with catheter-directed arterial thrombolysis following our protocol. The amputation-free survival rate at 1 month after the thrombolysis was 82.3%, and at 6 months it was 77.85%. The performance of additional procedures to obtain distal perfusion was predictive of an improved outcome at 30 days. The estimated survival rate at 6 months was 84.81% (SE 0.02). The mean survival time was 158.74 days. We recommend the usage of a thrombolytic regimen in patients with a life expectancy of more than 6 months, even in Rutherford stage IIb patients, if there is no major impairment in the sensorial and mobility function of the ischemic leg.<\/jats:p>","DOI":"10.3390\/life14111516","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T07:02:58Z","timestamp":1732086178000},"page":"1516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Catheter-Directed Arterial Thrombolysis with a Low-Dose Recombinant Tissue Plasminogen Activator Regimen for Acute Lower Limb Ischemia\u2014Results of the First Regional Registry of Acute Limb Ischemia in Romania"],"prefix":"10.3390","volume":"14","author":[{"given":"Sorin","family":"Barac","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"\u201cPius Br\u00eenzeu\u201d Clincal County Emergency Hospital, 300723 Timi\u0219oara, Romania"},{"name":"Romanian Society for Vascular Pathology, 300633 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-7523","authenticated-orcid":false,"given":"Roxana Ramona","family":"Onofrei","sequence":"additional","affiliation":[{"name":"\u201cPius Br\u00eenzeu\u201d Clincal County Emergency Hospital, 300723 Timi\u0219oara, Romania"},{"name":"Romanian Society for Vascular Pathology, 300633 Timi\u0219oara, Romania"},{"name":"Department of Rehabilitation, Physical Medicine and Rheumatology, Research Centre for Assessment of Human Motion, Functionality and Disability, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian","family":"Barbu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"\u201cPius Br\u00eenzeu\u201d Clincal County Emergency Hospital, 300723 Timi\u0219oara, Romania"},{"name":"Romanian Society for Vascular Pathology, 300633 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-6909","authenticated-orcid":false,"given":"Stelian","family":"Pantea","sequence":"additional","affiliation":[{"name":"\u201cPius Br\u00eenzeu\u201d Clincal County Emergency Hospital, 300723 Timi\u0219oara, Romania"},{"name":"Romanian Society for Vascular Pathology, 300633 Timi\u0219oara, Romania"},{"name":"Surgical Emergencies Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ple\u0219oianu","sequence":"additional","affiliation":[{"name":"The Academy of Economic Studies, 010552 Bucharest, Romania"},{"name":"Romanian Academy of Medical Sciences, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"G\u00eendac","sequence":"additional","affiliation":[{"name":"\u201cPius Br\u00eenzeu\u201d Clincal County Emergency Hospital, 300723 Timi\u0219oara, Romania"},{"name":"Romanian Society for Vascular Pathology, 300633 Timi\u0219oara, Romania"},{"name":"Anesthesiology and Intensive Care Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-6206","authenticated-orcid":false,"given":"Bogdan","family":"Timar","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4009-2248","authenticated-orcid":false,"given":"Andreea Luciana","family":"Ra\u021b\u0103","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"\u201cPius Br\u00eenzeu\u201d Clincal County Emergency Hospital, 300723 Timi\u0219oara, Romania"},{"name":"Romanian Society for Vascular Pathology, 300633 Timi\u0219oara, Romania"},{"name":"Surgical Emergencies Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"ref_1","first-page":"241","article-title":"A method for extraction of arterial emboli and thrombi","volume":"116","author":"Fogarty","year":"1963","journal-title":"Surg. 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