{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:39:48Z","timestamp":1760146788112,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Semmelweis Science and Innovation Found","award":["STIA-OTKA-2021"],"award-info":[{"award-number":["STIA-OTKA-2021"]}]},{"name":"the Hungarian Hypertension Society","award":["STIA-OTKA-2021"],"award-info":[{"award-number":["STIA-OTKA-2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Our primary objective was to assess the effectiveness of detailed cardiovascular ultrasound screening during the first trimester, which was performed by obstetricians with intermediate experience. We collected first-trimester fetal cardiac screening data from an unselected pregnant population at RMC-Fetal Medicine Center during a study period spanning from 1 January 2010, to 31 January 2015, in order to analyze our learning curve. A pediatric cardiologist performed a follow-up assessment in cases where the examining obstetrician determined that the fetal cardiac screening results were abnormal or high-risk. Overall, 42 (0.88%) congenital heart abnormalities were discovered prenatally out of 4769 fetuses from 4602 pregnant women who had at least one first-trimester cardiac ultrasonography screening. In total, 89.2% of the major congenital heart abnormalities (27 of 28) in the following fetuses were discovered (or at least highly suspected) at the first-trimester screening and subsequent fetal echocardiography by the pediatric cardiology specialist. Of these, 96.4% were diagnosed prenatally. According to our results, the effectiveness of first-trimester fetal cardiovascular ultrasound screening conducted by moderately experienced obstetricians in an unselected (\u2019routine\u2019) pregnant population may reach as high as 90% in terms of major congenital heart defects, provided that equipment, quality assurance, and motivation are appropriate.<\/jats:p>","DOI":"10.3390\/life14121632","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T06:16:14Z","timestamp":1733724974000},"page":"1632","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Learning Curve of First-Trimester Detailed Cardiovascular Ultrasound Screening by Moderately Experienced Obstetricians in 3509 Consecutive Unselected Pregnancies with Fetal Follow-Up"],"prefix":"10.3390","volume":"14","author":[{"given":"Tibor","family":"Elekes","sequence":"first","affiliation":[{"name":"RMC-Fetal Medicine Centre, G\u00e1bor \u00c1ron Street 74-78, H-1026 Budapest, Hungary"},{"name":"Cardiovascular Medicine and Research Division, Semmelweis University, \u00dcll\u0151i Street 26, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyula","family":"Csermely","sequence":"additional","affiliation":[{"name":"RMC-Fetal Medicine Centre, G\u00e1bor \u00c1ron Street 74-78, H-1026 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"K\u00e1d\u00e1r","sequence":"additional","affiliation":[{"name":"RMC-Fetal Medicine Centre, G\u00e1bor \u00c1ron Street 74-78, H-1026 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"RMC-Fetal Medicine Centre, G\u00e1bor \u00c1ron Street 74-78, H-1026 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Keszthelyi","sequence":"additional","affiliation":[{"name":"RMC-Fetal Medicine Centre, G\u00e1bor \u00c1ron Street 74-78, H-1026 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Hozsdora","sequence":"additional","affiliation":[{"name":"RMC-Fetal Medicine Centre, G\u00e1bor \u00c1ron Street 74-78, H-1026 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Vizer","sequence":"additional","affiliation":[{"name":"DaVinci Private Hospital, M\u00e1lics Ott\u00f3 Street 1, H-7635 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2832-0626","authenticated-orcid":false,"given":"Marianna","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Street 78a, H-1082 Budapest, Hungary"},{"name":"Workgroup of Research Management, Doctoral School, Semmelweis University, \u00dcll\u0151i Street 22, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Merkely","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Street 78a, H-1082 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"V\u00e1rb\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Semmelweis University, \u00dcll\u0151i Street 78a, H-1082 Budapest, Hungary"},{"name":"Workgroup of Research Management, Doctoral School, Semmelweis University, \u00dcll\u0151i Street 22, H-1085 Budapest, Hungary"},{"name":"Department of Obstetrics and Gynecology, University of Szeged, Semmelweis Street 1, H-6725 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"Hoffman","year":"2002","journal-title":"J. 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