{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:41:42Z","timestamp":1760146902902,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Handong Global University Research Grants","award":["202300770001","2021R1I1A3059820"],"award-info":[{"award-number":["202300770001","2021R1I1A3059820"]}]},{"name":"National Research Foundation of Korea (NRF) through the Ministry of Education","award":["202300770001","2021R1I1A3059820"],"award-info":[{"award-number":["202300770001","2021R1I1A3059820"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Dendritic epidermal T cells (DETCs) are a \u03b3\u03b4 T cell subset residing in the skin epidermis. Although they have been known for decades, the fate of DETCs has largely remained enigmatic. Recent studies have highlighted the relationship between the gut microbiome and \u03b3\u03b4 T cells in various epithelial and non-epithelial tissues, such as the small intestine, lung, liver, gingiva, and testis. While the skin microbiota has been shown to impact skin \u03b3\u03b4 T cells, a direct relationship between the gut microbiota and DETCs remains unexplored. In this study, we investigated whether DETCs are regulated by the gut microbiota in the steady-state skin epidermis. We examined the occurrence of DETCs in Balb\/c mice, which have a skin epidermis barely populated with DETCs, compared to C57BL\/6 mice, under different housing conditions. Our findings reveal that local skin inflammation markedly increases DETC numbers in the ear epidermis of Balb\/c mice and that DETCs are activated by environmental factors. Furthermore, an investigation of the gut microbiota under different housing conditions revealed distinct microbial compositions and functional profiles. Taken together, these results suggest a strong connection between DETCs and gut microbiota.<\/jats:p>","DOI":"10.3390\/life14121695","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T04:33:29Z","timestamp":1734928409000},"page":"1695","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut Microbiota Regulates the Homeostasis of Dendritic Epidermal T Cells"],"prefix":"10.3390","volume":"14","author":[{"given":"Jinwoo","family":"Chung","sequence":"first","affiliation":[{"name":"Laboratory of Inflammation Research, School of Life Science, Handong Global University, Pohang 37554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo-Chan","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation Research, School of Life Science, Handong Global University, Pohang 37554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Oh","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation Research, School of Life Science, Handong Global University, Pohang 37554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesung","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation Research, School of Life Science, Handong Global University, Pohang 37554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suin","family":"Lim","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation Research, School of Life Science, Handong Global University, Pohang 37554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanu","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation Research, School of Life Science, Handong Global University, Pohang 37554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon-Gyu","family":"Shim","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation Research, School of Life Science, Handong Global University, Pohang 37554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Chong","family":"Bang","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation Research, School of Life Science, Handong Global University, Pohang 37554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-5545","authenticated-orcid":false,"given":"Jea-Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Laboratory of Inflammation Research, School of Life Science, Handong Global University, Pohang 37554, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nri.2017.101","article-title":"\u0393\u03b4 T Cells in Homeostasis and Host Defence of Epithelial Barrier Tissues","volume":"17","author":"Nielsen","year":"2017","journal-title":"Nat. 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