{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:43:17Z","timestamp":1790818997343,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH Funding","award":["R43NS113737"],"award-info":[{"award-number":["R43NS113737"]}]},{"name":"NIH Funding","award":["R44NS080632"],"award-info":[{"award-number":["R44NS080632"]}]},{"name":"NIH Funding","award":["R44NS110237"],"award-info":[{"award-number":["R44NS110237"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: This study aimed to explore the potential associations between voice metrics of patients with PD and their motor symptoms. Methods: Motor and vocal data including the Unified Parkinson\u2019s Disease Rating Scale part III (UPDRS-III), Harmonic\u2013Noise Ratio (HNR), jitter, shimmer, and smoothed cepstral peak prominence (CPPS) were analyzed through exploratory correlations followed by univariate linear regression analyses. We employed these four voice metrics as independent variables and the total and sub-scores of the UPDRS-III as dependent variables. Results: Thirteen subjects were included, 76% males and 24% females, with a mean age of 62.9 \u00b1 10.1 years, and a median Hoehn and Yahr stage of 2.3 \u00b1 0.7. The regression analysis showed that CPPS is associated with posture (UPDRS-III posture scores: \u03b2 = \u22120.196; F = 10.0; p = 0.01; R2 = 0.50) and UPDRS-III postural stability scores (\u03b2 = \u22120.130; F = 5.57; p = 0.04; R2 = 0.35). Additionally, the associations between CPPS and rapid alternating movement (\u03b2 = \u22120.297; p = 0.07), rigidity (\u03b2= \u22120.36; p = 0.11), and body bradykinesia (\u03b2 = \u22120.16; p = 0.13) showed a trend towards significance. Conclusion: These findings highlight the potential role of CPPS as a predictor of postural impairments secondary to PD, emphasizing the need for further investigation.<\/jats:p>","DOI":"10.3390\/life15010027","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T10:17:40Z","timestamp":1735640260000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations of Voice Metrics with Postural Function in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7334-3835","authenticated-orcid":false,"given":"Anna Carolyna","family":"Gianloren\u00e7o","sequence":"first","affiliation":[{"name":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA"},{"name":"Laboratory of Neuroscience and Neurological Rehabilitation, Physical Therapy Department, Federal University of Sao Carlos, Rodovia Washington Luis, km 235, Sao Carlos 13565-905, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-7523","authenticated-orcid":false,"given":"Valton","family":"Costa","sequence":"additional","affiliation":[{"name":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA"},{"name":"Laboratory of Neuroscience and Neurological Rehabilitation, Physical Therapy Department, Federal University of Sao Carlos, Rodovia Washington Luis, km 235, Sao Carlos 13565-905, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Fabris-Moraes","sequence":"additional","affiliation":[{"name":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA"},{"name":"Faculty of Medicine, University of Sao Paulo, Avenida Doutor Arnaldo, 455, Sao Paulo 05508-220, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Eduardo Portes","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Highland Instruments, Inc., Cambridge, MA 02238, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Pacheco-Barrios","sequence":"additional","affiliation":[{"name":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA"},{"name":"Unidad de Investigaci\u00f3n para la Generaci\u00f3n y S\u00edntesis de Evidencias en Salud, Vicerrectorado de Investigaci\u00f3n, Universidad San Ignacio de Loyola, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6737-5374","authenticated-orcid":false,"given":"Ciro","family":"Ramos-Estebanez","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rehabilitation, University of Illinois at Chicago, 912 S Wood St., MC 796, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5510-3814","authenticated-orcid":false,"given":"Arianna","family":"Di Stadio","sequence":"additional","affiliation":[{"name":"Otolaryngology Unit, GF Ingrassia Department, University of Catania, 95121 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirret M.","family":"El-Hagrassy","sequence":"additional","affiliation":[{"name":"Neurology Department, UMass Memorial, UMass Chan Medical School, Suite #301, 67 Belmont St., Worcester, MA 01605, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz Durok","family":"Camsari","sequence":"additional","affiliation":[{"name":"Mayo Clinic, 200 1st St SW, Rochester, MN 55901, USA"},{"name":"Mindpath College Health, 948 Embarcadero del Norte #102, Isla Vista, CA 93117, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Wagner","sequence":"additional","affiliation":[{"name":"Highland Instruments, Inc., Cambridge, MA 02238, USA"},{"name":"Harvard\/MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dipietro","sequence":"additional","affiliation":[{"name":"Highland Instruments, Inc., Cambridge, MA 02238, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1703-7526","authenticated-orcid":false,"given":"Felipe","family":"Fregni","sequence":"additional","affiliation":[{"name":"Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Harvard Medical School, 1575 Cambridge Street, Cambridge, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/978-94-007-5416-4_16","article-title":"Parkinson\u2019s disease","volume":"65","author":"Mhyre","year":"2012","journal-title":"Subcell 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