{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:30:48Z","timestamp":1782858648142,"version":"3.54.5"},"reference-count":64,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Regional Health Management of Castilla y Le\u00f3n","award":["GRS 2753\/C\/2023"],"award-info":[{"award-number":["GRS 2753\/C\/2023"]}]},{"name":"Regional Health Management of Castilla y Le\u00f3n","award":["K23 DA052041-03"],"award-info":[{"award-number":["K23 DA052041-03"]}]},{"name":"NIH NIDA","award":["GRS 2753\/C\/2023"],"award-info":[{"award-number":["GRS 2753\/C\/2023"]}]},{"name":"NIH NIDA","award":["K23 DA052041-03"],"award-info":[{"award-number":["K23 DA052041-03"]}]},{"name":"Scott Schoen and Nancy Adams Discovery Center for Recovery","award":["GRS 2753\/C\/2023"],"award-info":[{"award-number":["GRS 2753\/C\/2023"]}]},{"name":"Scott Schoen and Nancy Adams Discovery Center for Recovery","award":["K23 DA052041-03"],"award-info":[{"award-number":["K23 DA052041-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Chronic non-cancer pain (CNCP) is one of the leading causes of disability. The use of strong opioids (SOs) in the management of CNCP is increasing, although evidence supporting their use remains limited. Primary care (PC) plays a key role in this context. Objectives: Our objectives were to determine the prevalence and profile of patients using SOs for CNCP in PC consultations in Valladolid in 2022, and to describe the consumption of SO prescribed for CNCP from 2020 to 2023. Methods: We conducted a descriptive and retrospective study using data extracted from the Pharmaceutical Consumption Information System of Castilla y Le\u00f3n. Patients in Valladolid with SO use for more than three months due to CNCP were analyzed. Sociodemographic and clinical characteristics of these patients in 2022 were described. The number of defined daily doses (n\u00ba DDDs) and costs from 2020 to 2023 were analyzed. Results: A total of 3642 patients were included (0.7% of the population of Valladolid), 71.8% of whom were women. Of the patients, 62.4% were aged 70 or older, 39.8% lived in rural areas, and 9.9% resided in nursing homes. The most frequently prescribed SOs in n\u00ba DDDs were fentanyl and tapentadol. The highest consumption in n\u00ba DDDs was in patients who lived in nursing homes, were over 70 years old and were resident in rural areas. The number of DDDs from 2020 to 2023 for SOs in DCNO increased by 41%. Conclusions: In total, 0.7% of the population of Valladolid consumes SOs for CNCP, mostly women and people over 70 years old. The consumption of strong opioids in DDDs grew by 41% from 2020 to 2023.<\/jats:p>","DOI":"10.3390\/life15010114","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T12:27:54Z","timestamp":1737030474000},"page":"114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prescription of Strong Opioids in Chronic Non-Cancer Pain in the Province of Valladolid (Spain)"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2933-6598","authenticated-orcid":false,"given":"Rodrigo","family":"Enr\u00edquez de Salamanca Gambara","sequence":"first","affiliation":[{"name":"Primary Care Management of Valladolid Oeste, 47012 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Sierra Santos","sequence":"additional","affiliation":[{"name":"Primary Care Management of Valladolid Oeste, 47012 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-7998","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Ruiz San Pedro","sequence":"additional","affiliation":[{"name":"Primary Care Management of Valladolid Este, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Montero Cuadrado","sequence":"additional","affiliation":[{"name":"Active Pain Coping Strategies Unit of Primary Care in Castile and Le\u00f3n, 47011 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Mu\u00f1oz Le\u00f3n","sequence":"additional","affiliation":[{"name":"Rio Hortega University Hospital, 47012 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-427X","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Castro Villamor","sequence":"additional","affiliation":[{"name":"Advanced Clinical Simulation Center, Faculty of Medicine, Universidad de Valladolid, 47002 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"C\u00f3rdoba Romero","sequence":"additional","affiliation":[{"name":"Medical Team Coordination Unit, Primary Care Management of Valladolid Oeste, 47012 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Del Olmo Tornero","sequence":"additional","affiliation":[{"name":"Medical Team Coordination Unit, Primary Care Management of Valladolid Este, 47005 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-6619","authenticated-orcid":false,"given":"Luc\u00eda","family":"P\u00e9rez P\u00e9rez","sequence":"additional","affiliation":[{"name":"Primary Care Management of Valladolid Oeste, 47012 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u00f3n","family":"Morales-Quezada","sequence":"additional","affiliation":[{"name":"Spaulding Rehabilitation Hospital, Department of Physical Medicine & Rehabilitation, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref_1","unstructured":"International Association for the Study of Pain (IASP) (2024, November 24). 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