{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:34:17Z","timestamp":1790026457060,"version":"4.0.1"},"reference-count":20,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Objective: This case series aims to evaluate the efficacy, patient satisfaction, and safety of combined needle radiofrequency (RF) and topical exosome therapy for moderate to severe acne. Methods: This study involved 22 patients (12 females and 10 males, ages 18\u201335) with moderate to severe acne who underwent combined needle RF and topical exosome (Xomage, Zishel Bio Inc., Seoul, Republic of Korea) treatments. Each patient completed between 6 and 10 sessions, conducted weekly over three-week intervals. Acne severity was assessed using the Investigator\u2019s Global Assessment (IGA) scale, while patient satisfaction was measured on a 5-point Likert scale. Clinical photographs were taken at baseline and after the final treatment session. Results: All patients showed improvement in acne severity with a mean decrease in IGA score of 2.5 points from baseline to the final assessment. Patient satisfaction was high, with the majority expressing satisfaction in skin texture and acne reduction. Conclusion: Needle RF combined with topical exosome therapy appears to be an effective treatment for reducing acne lesions and improving skin quality, demonstrating a strong safety profile and high patient satisfaction.<\/jats:p>","DOI":"10.3390\/life15020141","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:47:32Z","timestamp":1737460052000},"page":"141","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Needle Radiofrequency Combined with Topical Exosome Therapy for Moderate to Severe Acne"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2507-4524","authenticated-orcid":false,"given":"Jovian","family":"Wan","sequence":"first","affiliation":[{"name":"Medical Research Inc., Wonju 06010, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Eun","family":"Yoon","sequence":"additional","affiliation":[{"name":"BrandnewAesthetic Surgery Clinic, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4412-7380","authenticated-orcid":false,"given":"Sky","family":"Wong","sequence":"additional","affiliation":[{"name":"Leciel Medical Centre, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inneke Jane","family":"Hidajat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta 1440, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Tanojo","sequence":"additional","affiliation":[{"name":"Melania Clinic, Surabaya 60264, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-7090","authenticated-orcid":false,"given":"Atchima","family":"Suwanchinda","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 73170, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-1364","authenticated-orcid":false,"given":"Kyu-Ho","family":"Yi","sequence":"additional","affiliation":[{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea"},{"name":"Maylin Clinic, Apgujeong, Seoul 06015, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0031-3955(16)38158-5","article-title":"Acne vulgaris. 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