{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:52:47Z","timestamp":1792111967207,"version":"4.4.0"},"reference-count":168,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Genipin is a non-glycosidic iridoid isolated mainly from the fruits of Gardenia jasminoides and Genipa americana. It is the active ingredient in extracts from these plants, responsible for their anti-inflammatory and hepatoprotective effects. In several in vitro tests, its anti-proliferative activity against tumour cell lines has been demonstrated, and due to its ability to specifically inhibit the UCP2 protein and inhibit STAT3 activation, a significant increase in the cytotoxicity of several anticancer drugs was observed in co-treatment with genipin. In recent years, the importance of genipin has increased due to the possibility of using this iridoid as a biocompatible and low cytotoxicity potent crosslinking agent in the manufacture of dressings, in tissue engineering, as a component of a drug carrier system and in the production of food packaging. Genipin is also a substrate in the production of a blue pigment used as a food additive and fabric pigment, and other applications. Due to documented cases of hepatotoxicity, genipin and the blue pigment derived from it are being investigated for effective and safe therapeutic and non-drug use. The current paper discusses selected aspects of chemistry, activity and use of this interesting compound.<\/jats:p>","DOI":"10.3390\/life15020159","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T12:24:09Z","timestamp":1737635049000},"page":"159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Genipin\u2014Simple but Significant Bioactive Iridoid for Therapeutical Application and Beyond: A Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-5133","authenticated-orcid":false,"given":"Danuta","family":"Sobolewska","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Medical College, Jagiellonian University, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-8646","authenticated-orcid":false,"given":"Agnieszka","family":"Galanty","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Medical College, Jagiellonian University, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-2218","authenticated-orcid":false,"given":"Karolina","family":"Grabowska","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Medical College, Jagiellonian University, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Makowska-W\u0105s","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Medical College, Jagiellonian University, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-7192","authenticated-orcid":false,"given":"Irma","family":"Podolak","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Medical College, Jagiellonian University, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9780-7924","authenticated-orcid":false,"given":"Dagmara","family":"Wr\u00f3bel-Biedrawa","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Medical College, Jagiellonian University, 30-688 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1021\/np50012a001","article-title":"Iridoids. 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