{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:53:00Z","timestamp":1787028780768,"version":"build-2736575974"},"reference-count":121,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy in Craiova, Romania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Endometriosis is a multifaceted gynecological disorder defined by endometrium-like tissue outside the uterine cavity. It is mainly localized in the pelvis and creates a local inflammatory environment responsible for its manifestations and complications. In 30\u201350% of cases, endometriosis is associated with infertility. In 17\u201344% of cases, the ovaries are affected in the form of ovarian endometriomas (OEs). The symptoms of OEs are not very pronounced. The development is slow. Diagnosis is difficult because OEs resemble cystic ovarian pathology, which is so diverse. The actual diagnosis is possible through direct visualization or laparoscopy. Surgical treatment by cystectomy is common for OEs. Recently, other therapeutic modalities have emerged that have less impact on ovarian reserves and pregnancy rates. In this context, the review attempts to shed light on the best diagnostic and treatment methods for an insidious pathology with a major impact on fertility.<\/jats:p>","DOI":"10.3390\/life15020161","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T12:24:09Z","timestamp":1737635049000},"page":"161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Narrative Review Regarding Implication of Ovarian Endometriomas in Infertility"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-1756","authenticated-orcid":false,"given":"Constantin-Cristian","family":"V\u0103duva","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, Filantropia Clinical Municipal Hospital Craiova, 200143 Craiova, Romania"},{"name":"Department of Obstetrics, Gynecology and IVF, HitMed Medical Center, 200130 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren\u021biu","family":"D\u00eer\u0103","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, Filantropia Clinical Municipal Hospital Craiova, 200143 Craiova, Romania"},{"name":"Department of Obstetrics, Gynecology and IVF, HitMed Medical Center, 200130 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-1365","authenticated-orcid":false,"given":"Lidia","family":"Boldeanu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Medicine and Pharmacy, County Clinical Emergency Hospital, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea-Sebastian","family":"\u0218erb\u0103nescu","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy, 200349 Craiova, Romania"},{"name":"Department of Pathology, Filantropia Clinical Municipal Hospital Craiova, 200143 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Carp-Veli\u0219cu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and IVF, \u201cCarol Davila\u201d Bucharest Medical University, Prof. Dr. \u201cPanait Sarbu\u201d Clinical Hospital, 060251 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejogrb.2018.09.001","article-title":"Anatomic distribution of endometriosis: A reappraisal based on series of 1101 patients","volume":"230","author":"Audebert","year":"2018","journal-title":"Eur. 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Open, 2017, hox016.","DOI":"10.1093\/hropen\/hox016"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1055\/s-0040-1701622","article-title":"Case Report of Cerebellar Endometriosis","volume":"81","author":"Meggyesy","year":"2020","journal-title":"J. Neurol. Surg. A Cent. Eur. Neurosurg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"Bulun","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"International Working Group of AAGL, ESGE, ESHRE and WES, Tomassetti, C., Johnson, N.P., Petrozza, J., Abrao, M.S., Einarsson, J.I., Horne, A.W., Lee, T.T.M., Missmer, S., and Vermeulen, N. (2021). An International Terminology for Endometriosis, 2021. Facts Views Vis. Obgyn, 13, 295\u2013304.","DOI":"10.52054\/FVVO.13.4.036"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jmig.2017.12.026","article-title":"Isolated Ovarian Endometrioma: A History Between Myth and Reality","volume":"25","author":"Exacoustos","year":"2018","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hwu, Y.M., Wu, F.S., Li, S.H., Sun, F.J., Lin, M.H., and Lee, R.K. (2011). The impact of endometrioma and laparoscopic cystectomy on serum anti-M\u00fcllerian hormone levels. Reprod. Biol. Endocrinol., 9.","DOI":"10.1186\/1477-7827-9-80"},{"key":"ref_9","first-page":"5575","article-title":"Ovarian reserve after treatment of ovarian endometrimas by ethanolic sclerotherapy compared to surgical treatment","volume":"27","author":"Vaduva","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Daniilidis, A., Angioni, S., Di Michele, S., Dinas, K., Gkrozou, F., and D\u2019Alterio, M.N. (2022). Deep Endometriosis and Infertility: What Is the Impact of Surgery?. J. Clin. Med., 11.","DOI":"10.3390\/jcm11226727"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/S0015-0282(02)03112-6","article-title":"Effect of endometriosis on in vitro fertilization","volume":"77","author":"Barnhart","year":"2002","journal-title":"Fertil. Steril."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/rmb2.12286","article-title":"The success of various endometrioma treatments in infertility: A systematic review and meta-analysis of prospective studies","volume":"18","author":"Alborzi","year":"2019","journal-title":"Reprod. Med. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/j.1471-0528.2008.01878.x","article-title":"Can symptomatology help in the diagnosis of endometriosis? Findings from a national case-control study\u2014Part 1","volume":"115","author":"Ballard","year":"2008","journal-title":"BJOG"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1097\/01.AOG.0000142714.54857.f8","article-title":"Reproductive history and endometriosis among premenopausal women","volume":"104","author":"Missmer","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1196\/annals.1434.007","article-title":"Endometriosis and infertility: Epidemiology and evidence-based treatments","volume":"1127","author":"Ozkan","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Nouri, K., Ott, J., Krupitz, B., Huber, J.C., and Wenzl, R. (2010). Family incidence of endometriosis in first-, second-, and third-degree relatives: Case-control study. Reprod. Biol. Endocrinol., 8.","DOI":"10.1186\/1477-7827-8-85"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1210\/er.2018-00242","article-title":"Endometriosis","volume":"40","author":"Bulun","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.rbmo.2019.10.007","article-title":"Pathogenesis of endometriosis: Look no further than John Sampson","volume":"40","author":"Yovich","year":"2020","journal-title":"Reprod. Biomed. Online"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/1933719116653677","article-title":"The Presence of Endometrial Cells in Peritoneal Fluid of Women with and Without Endometriosis","volume":"24","author":"Dorien","year":"2017","journal-title":"Reprod. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Armstrong, G.M., Maybin, J.A., Murray, A.A., Nicol, M., Walker, C., Saunders, P.T.K., Rossi, A.G., and Critchley, H.O.D. (2017). Endometrial apoptosis and neutrophil infiltration during menstruation exhibits spatial and temporal dynamics that are recapitulated in a mouse model. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-17565-x"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.fertnstert.2004.04.065","article-title":"In utero exposures and the incidence of endometriosis","volume":"82","author":"Missmer","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Dyson, M.T., Roqueiro, D., Monsivais, D., Ercan, C.M., Pavone, M.E., Brooks, D.C., Kakinuma, T., Ono, M., Jafari, N., and Dai, Y. (2014). Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004158"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e13078","DOI":"10.1111\/aji.13078","article-title":"GATA6 expression promoted by an active enhancer may become a molecular marker in endometriosis lesions","volume":"81","author":"Izawa","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1177\/1933719114532841","article-title":"Altered genome-wide methylation in endometriosis","volume":"21","author":"Naqvi","year":"2014","journal-title":"Reprod. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.fertnstert.2015.04.041","article-title":"Laparoscopic endometrioma resection increases peri-implantation endometrial HOXA-10 and HOXA-11 mRNA expression","volume":"104","author":"Celik","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ogc.2012.10.002","article-title":"Endometriosis and infertility: A review of the pathogenesis and treatment of endometriosis-associated infertility","volume":"39","author":"Macer","year":"2012","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","article-title":"Pathogenesis and pathophysiology of endometriosis","volume":"98","author":"Burney","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.ajpath.2018.06.011","article-title":"IL-1\u03b2 Stimulates Brain-Derived Neurotrophic Factor Production in Eutopic Endometriosis Stromal Cell Cultures: A Model for Cytokine Regulation of Neuroangiogenesis","volume":"188","author":"Yu","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.2741\/220","article-title":"Role of chemokines in the pathogenesis of endometriosis","volume":"3","author":"Nishida","year":"2011","journal-title":"Front. Biosci. (Schol. Ed.)"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Bonavina, G., and Taylor, H.S. (2022). Endometriosis-associated infertility: From pathophysiology to tailored treatment. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1020827"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Istrate-Ofi\u0163eru, A.-M., Mogoant\u0103, C.A., Zoril\u0103, G.-L., Ro\u015fu, G.-C., Dr\u0103gu\u015fin, R.C., Berbecaru, E.-I., Zoril\u0103, M.V., Com\u0103nescu, C.M., Mogoant\u0103, S., and Vaduva, C.-C. (2024). Clinical Characteristics and Local Histopathological Modulators of Endometriosis and Its Progression. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031789"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/humupd\/dmu046","article-title":"Systematic review of endometriosis pain assessment: How to choose a scale?","volume":"21","author":"Bourdel","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/17425247.2021.1829589","article-title":"Novel drug delivery methods for improving efficacy of endometriosis treatments","volume":"18","author":"Garzon","year":"2021","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/GRF.0000000000000292","article-title":"Medical Management of Endometriosis","volume":"60","author":"Rafique","year":"2017","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/1471-0528.13711","article-title":"Endometriosis diagnosis and staging by operating surgeon and expert review using multiple diagnostic tools: An inter-rater agreement study","volume":"124","author":"Schliep","year":"2017","journal-title":"BJOG"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/aogs.13082","article-title":"Endometriosis-associated infertility: Aspects of pathophysiological mechanisms and treatment options","volume":"96","author":"Tanbo","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Trinchant, R., and Garc\u00eda-Velasco, J.A. (2024). Oocyte Quality in Women with Endometriosis. Gynecol. Obstet. Investig., 1\u20139.","DOI":"10.1159\/000541615"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/humupd\/dmv012","article-title":"Risks of conservative management in women with ovarian endometriomas undergoing IVF","volume":"21","author":"Somigliana","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.fertnstert.2009.08.068","article-title":"Oxidative stress status in normal ovarian cortex surrounding ovarian endometriosis","volume":"93","author":"Matsuzaki","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/humupd\/dmt053","article-title":"The distinguishing cellular and molecular features of the endometriotic ovarian cyst: From pathophysiology to the potential endometrioma-mediated damage to the ovary","volume":"20","author":"Sanchez","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1210\/jc.2019-00281","article-title":"Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway","volume":"104","author":"Takeuchi","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jsbmb.2015.07.023","article-title":"Endometriosis as a detrimental condition for granulosa cell steroidogenesis and development: From molecular alterations to clinical impact","volume":"155 Pt A","author":"Sanchez","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1177\/1933719118777637","article-title":"The Gametotoxic Effects of the Endometrioma Content: Insights From a Parthenogenetic Human Model","volume":"26","author":"Paffoni","year":"2019","journal-title":"Reprod. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.fertnstert.2011.06.064","article-title":"Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis","volume":"96","author":"Kitajima","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s13244-017-0591-0","article-title":"Endometriosis: Clinical features, MR imaging findings and pathologic correlation","volume":"9","author":"Foti","year":"2018","journal-title":"Insights Into Imaging"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ejogrb.2014.05.024","article-title":"Visceral syndrome in endometriosis patients","volume":"179","author":"Hansen","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1749-6632.1994.tb21763.x","article-title":"Deeply infiltrating endometriosis is a disease whereas mild endometriosis could be considered a non-disease","volume":"734","author":"Koninckx","year":"1994","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/humupd\/dmi029","article-title":"Endometriosis and pelvic pain: Epidemiological evidence of the relationship and implications","volume":"11","author":"Fauconnier","year":"2005","journal-title":"Hum. Reprod. Update"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/humrep\/17.7.1895","article-title":"Hyperalgesia, nerve infiltration and nerve growth factor expression in deep adenomyotic nodules, peritoneal and ovarian endometriosis","volume":"17","author":"Anaf","year":"2002","journal-title":"Hum. Reprod."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.fertnstert.2003.11.049","article-title":"Nerve fibers in ovarian dermoid cysts and endometriomas","volume":"82","author":"Bakare","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"8524","DOI":"10.12998\/wjcc.v9.i28.8524","article-title":"Rupture of ovarian endometriotic cyst complicated with endometriosis: A case report","volume":"9","author":"Wang","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2058460118801164","DOI":"10.1177\/2058460118801164","article-title":"CT and MRI findings of bronchopulmonary endometriosis: A case presentation","volume":"7","author":"Sanada","year":"2018","journal-title":"Acta Radiol. Open"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ucl.2007.08.016","article-title":"Female sexual disorders: Assessment, diagnosis, and treatment","volume":"34","author":"Kingsberg","year":"2007","journal-title":"Urol. Clin. N. Am."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1093\/humrep\/dei135","article-title":"ESHRE guideline for the diagnosis and treatment of endometriosis","volume":"20","author":"Kennedy","year":"2005","journal-title":"Hum. Reprod."},{"key":"ref_57","first-page":"594","article-title":"Diagnosis and management of endometriosis","volume":"74","author":"Mounsey","year":"2006","journal-title":"Am. Fam. Physician"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/aogs.13114","article-title":"An update on the diagnosis, surgical management, and fertility outcomes for women with endometrioma","volume":"96","author":"Cranney","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/j.fertnstert.2004.12.034","article-title":"Expression and regulation of CCR1 in peritoneal macrophages from women with and without endometriosis","volume":"83","author":"Wieser","year":"2005","journal-title":"Fertil. Steril."},{"key":"ref_60","first-page":"CD012179","article-title":"Blood Biomarkers for the Non-Invasive Diagnosis of Endometriosis","volume":"2016","author":"Nisenblat","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00404-017-4406-9","article-title":"Patient-Completed or Symptom-Based Screening Tools for Endometriosis: A Scoping Review","volume":"296","author":"Surrey","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_62","first-page":"33","article-title":"GenomeForest: An Ensemble Machine Learning Classifier for Endometriosis","volume":"2020","author":"Akter","year":"2020","journal-title":"AMIA Summits Transl. Sci. Proc."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Bendifallah, S., Suisse, S., Puchar, A., Delbos, L., Poilblanc, M., Descamps, P., Golfier, F., Jornea, L., Bouteiller, D., and Touboul, C. (2022). Salivary MicroRNA Signature for Diagnosis of Endometriosis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030612"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Melinte-Popescu, A.S., Popa, R.F., Harabor, V., Nechita, A., Harabor, A., Adam, A.M., Vasilache, I.A., Melinte-Popescu, M., Vaduva, C., and Socolov, D. (2023). Managing Fetal Ovarian Cysts: Clinical Experience with a Rare Disorder. Medicina, 59.","DOI":"10.3390\/medicina59040715"},{"key":"ref_65","first-page":"893","article-title":"Borderline Brenner tumors associated with ovarian cyst\u2014Case presentation","volume":"57","author":"Albu","year":"2016","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Noventa, M., Scioscia, M., Schincariol, M., Cavallin, F., Pontrelli, G., Virgilio, B., Vitale, S.G., Lagan\u00e0, A.S., Dessole, F., and Cosmi, E. (2019). Imaging Modalities for Diagnosis of Deep Pelvic Endometriosis: Comparison between Trans-Vaginal Sonography, Rectal Endoscopy Sonography and Magnetic Resonance Imaging. A Head-to-Head Meta-Analysis. Diagnostics, 9.","DOI":"10.3390\/diagnostics9040225"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s00261-019-02341-4","article-title":"Sonographer-acquired ultrasound protocol for deep endometriosis","volume":"45","author":"Young","year":"2020","journal-title":"Abdom. Radiol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Cohen Ben-Meir, L., Mashiach, R., and Eisenberg, V.H. (2021). External Validation of the IOTA Classification in Women with Ovarian Masses Suspected to Be Endometrioma. J. Clin. Med., 10.","DOI":"10.3390\/jcm10132971"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1093\/humrep\/dem187","article-title":"Comparison between clinical examination, transvaginal sonography and magnetic resonance imaging for the diagnosis of deep endometriosis","volume":"22","author":"Abrao","year":"2007","journal-title":"Hum. Reprod."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1093\/humrep\/den293","article-title":"Diagnostic value of transvaginal \u2019tenderness-guided\u2019 ultrasonography for the prediction of location of deep endometriosis","volume":"23","author":"Guerriero","year":"2008","journal-title":"Hum. Reprod."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1074-3804(05)60543-9","article-title":"Retrocervical, retrovaginal pouch, and rectovaginal septum endometriosis","volume":"8","author":"Martin","year":"2001","journal-title":"J. Am. Assoc. Gynecol. Laparosc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/uog.14731","article-title":"High sliding sign: A new soft marker of uterine fundus compromise in deep infiltrating endometriosis","volume":"45","author":"Leon","year":"2015","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.7863\/jum.2009.28.8.1061","article-title":"Three-dimensional sonographic characteristics of deep endometriosis","volume":"28","author":"Guerriero","year":"2009","journal-title":"J. Ultrasound Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"F1000 Faculty Rev-529","DOI":"10.12688\/f1000research.14817.1","article-title":"Endometriosis: Advances and controversies in classification, pathogenesis, diagnosis, and treatment","volume":"8","author":"Rolla","year":"2019","journal-title":"F1000Research"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1074-3804(05)60190-9","article-title":"Deep endometriosis: Definition, pathogenesis, and clinical management","volume":"11","author":"Vercellini","year":"2004","journal-title":"J. Am. Assoc. Gynecol. Laparosc."},{"key":"ref_76","first-page":"CD011031","article-title":"Laparoscopic surgery for endometriosis","volume":"4","author":"Duffy","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_77","unstructured":"Mobeen, S., and Apostol, R. (2025). Ovarian Cyst. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"607","DOI":"10.7863\/jum.2005.24.5.607","article-title":"The likelihood ratio of sonographic findings for the diagnosis of hemorrhagic ovarian cysts","volume":"24","author":"Patel","year":"2005","journal-title":"J. Ultrasound Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"162","DOI":"10.22543\/7674.91.P162167","article-title":"Pain Managemnent in the Right Iliac Fossa During the COVID-19 Pandemic","volume":"9","author":"Costea","year":"2022","journal-title":"J. Mind Med. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/humrep\/dep202","article-title":"The rate of spontaneous ovulation is negatively affected by endometriotic ovarian cysts","volume":"24","author":"Benaglia","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5653\/cerm.2019.02971","article-title":"Treatment options and considerations for infertility due to endometriosis","volume":"47","author":"Kim","year":"2020","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejogrb.2014.07.036","article-title":"IVF outcomes in women with accidental contamination of follicular fluid with endometrioma contents","volume":"181","author":"Benaglia","year":"2014","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.tjog.2010.05.002","article-title":"Long-term follow-up of patients surgically treated for ruptured ovarian endometriotic cysts","volume":"50","author":"Huang","year":"2011","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/humupd\/dmv045","article-title":"A systematic review on endometriosis during pregnancy: Diagnosis, misdiagnosis, complications and outcomes","volume":"22","author":"Ferrero","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1089\/jwh.2009.1914","article-title":"Does controlled ovarian hyperstimulation in women with a history of endometriosis influence recurrence rate?","volume":"19","author":"Coccia","year":"2010","journal-title":"J Womens Health"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.fertnstert.2009.02.092","article-title":"A retrospective analysis of ovarian endometriosis during pregnancy","volume":"94","author":"Ueda","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3109\/09513590.2013.813476","article-title":"The disappearing endometrioma: The intriguing effect of pregnancy on small endometriotic ovarian cysts","volume":"29","author":"Benaglia","year":"2013","journal-title":"Gynecol. Endocrinol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jmig.2013.09.010","article-title":"Adnexal torsion: Review of the literature","volume":"21","author":"Sasaki","year":"2014","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Centini, G., Schettini, G., Pieri, E., Giorgi, M., Lazzeri, L., Martire, F.G., Mancini, V., Raimondo, D., Seracchioli, R., and Habib, N. (2024). Endometriosis-Related Ovarian Cancer: Where Are We Now? A Narrative Review towards a Pragmatic Approach. J. Clin. Med., 13.","DOI":"10.3390\/jcm13071933"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1470-2045(11)70404-1","article-title":"Association between endometriosis and risk of histological subtypes of ovarian cancer: A pooled analysis of case-control studies","volume":"13","author":"Pearce","year":"2012","journal-title":"Lancet Oncol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/AOG.0000000000002624","article-title":"Risk of Gynecologic Cancer According to the Type of Endometriosis","volume":"131","author":"Saavalainen","year":"2018","journal-title":"Obstet. Gynecol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"18824","DOI":"10.3390\/ijms140918824","article-title":"ARID1A mutations and PI3K\/AKT pathway alterations in endometriosis and endometriosis-associated ovarian carcinOEs","volume":"14","author":"Samartzis","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/humrep\/det457","article-title":"ESHRE guideline: Management of women with endometriosis","volume":"29","author":"Dunselman","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Mansouri, G., Safinataj, M., Shahesmaeili, A., Allahqoli, L., Salehiniya, H., and Alkatout, I. (2022). Effect of laparoscopic cystectomy on ovarian reserve in patients with ovarian cyst. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.964229"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.fertnstert.2012.08.009","article-title":"Surgical excision of endometriomas and ovarian reserve: A systematic review on serum antim\u00fcllerian hormone level modifications","volume":"98","author":"Somigliana","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Pais, A.S., Flagothier, C., Tebache, L., Almeida Santos, T., and Nisolle, M. (2021). Impact of Surgical Management of Endometrioma on AMH Levels and Pregnancy Rates: A Review of Recent Literature. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030414"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.fertnstert.2009.01.138","article-title":"The impact on ovarian reserve after laparoscopic ovarian cystectomy versus three-stage management in patients with endometriomas: A prospective randomized study","volume":"94","author":"Tsolakidis","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2009.02.065","article-title":"Laparoscopic management of endometrioms using a combined technique of excisional (cystectomy) and ablative surgery","volume":"94","author":"Donnez","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Daniilidis, A., Grigoriadis, G., Kalaitzopoulos, D.R., Angioni, S., Kalkan, \u00dc., Crestani, A., Merlot, B., and Roman, H. (2023). Surgical Management of Ovarian Endometrioma: Impact on Ovarian Reserve Parameters and Reproductive Outcomes. J. Clin. Med., 12.","DOI":"10.20944\/preprints202307.1698.v1"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.fertnstert.2022.08.860","article-title":"Impact of cystectomy versus ablation for endometrioma on ovarian reserve: A systematic review and meta-analysis","volume":"118","author":"Zhang","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_101","first-page":"339","article-title":"Comparison between the stripping technique and the combined excisional\/ablative technique for the treatment of bilateral ovarian endometriomas: A multicentre RCT","volume":"31","author":"Muzii","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmig.2016.12.010","article-title":"Impact of Cystectomy on Ovarian Reserve: Review of the Literature","volume":"24","author":"Alammari","year":"2017","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"E137","DOI":"10.1111\/ans.15916","article-title":"Endometriosis as a rare cause of small bowel obstruction","volume":"90","author":"Lam","year":"2020","journal-title":"ANZ J. Surg."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1159\/000503795","article-title":"Efficacy of Laparoscopic Partial Cystectomy with a Transurethral Resectoscope in Patients with Bladder Endometriosis: See-Through Technique","volume":"104","author":"Endo","year":"2020","journal-title":"Urol. Int."},{"key":"ref_105","unstructured":"Hoffman, B.L., Schorge, J.O., Halvorson, L.M., Hamid, C.A., Corton, M.M., and Schaffer, J.I. (2020). Williams Gynecology, McGraw-Hill Education. [4th ed.]."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Kalaitzopoulos, D.R., Samartzis, N., Kolovos, G.N., Mareti, E., Samartzis, E.P., Eberhard, M., Dinas, K., and Daniilidis, A. (2021). Treatment of endometriosis: A review with comparison of 8 guidelines. BMC Women\u2019s Health, 21.","DOI":"10.1186\/s12905-021-01545-5"},{"key":"ref_107","first-page":"CD003678","article-title":"Pre- and postsurgical medical therapy for endometriosis surgery","volume":"11","author":"Chen","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1093\/humrep\/dep259","article-title":"Post-operative use of oral contraceptive pills for prevention of anatomical relapse or symptom-recurrence after conservative surgery for endometriosis","volume":"24","author":"Seracchioli","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1089\/can.2021.0162","article-title":"Endometriosis and Cannabis Consumption During the COVID-19 Pandemic: An International Cross-Sectional Survey","volume":"7","author":"Armour","year":"2022","journal-title":"Cannabis Cannabinoid Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/GCO.0000000000000983","article-title":"Medical management of endometriosis","volume":"36","author":"Alonso","year":"2024","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.fertnstert.2017.05.015","article-title":"Sclerotherapy in the management of ovarian endometrioma: Systematic review and meta-analysis","volume":"108","author":"Cohen","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0020-7292(00)00307-6","article-title":"Efficacy of ethanol sclerotherapy for ovarian endometriomas","volume":"72","author":"Noma","year":"2001","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.tjog.2021.03.021","article-title":"Changes in anti-m\u00fcllerian hormone after ultrasound guided aspiration and ethanol sclerotic therapy of ovarian cyst","volume":"60","author":"Huang","year":"2021","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00330-020-07111-1","article-title":"Comparison of the therapeutic efficacy and ovarian reserve between catheter-directed sclerotherapy and surgical excision for ovarian endometrioma","volume":"31","author":"Koo","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.jmig.2019.08.036","article-title":"Ethanol Sclerotherapy versus Laparoscopic Surgery for Endometrioma Treatment: A Prospective, Multicenter, Cohort Pilot Study","volume":"27","author":"Candas","year":"2020","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"102528","DOI":"10.1016\/j.bpobgyn.2024.102528","article-title":"Endometrioma surgery: Hit with your best shot (But know when to stop)","volume":"96","author":"Perrone","year":"2024","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Practice Committee of the American Society for Reproductive Medicine (2012). Endometriosis and infertility: A committee opinion. Fertil. Steril., 98, 591\u2013598.","DOI":"10.1016\/j.fertnstert.2012.05.031"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5653\/cerm.2019.02971","article-title":"Management of endometriosis-related infertility: Considerations and treatment options","volume":"47","author":"Lee","year":"2020","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000339630","article-title":"Endometrioma \u22643 cm in diameter per se does not affect ovarian reserve in intracytoplasmic sperm injection cycles","volume":"74","author":"Esinler","year":"2012","journal-title":"Gynecol. Obstet. Investig."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/humupd\/dmv035","article-title":"The impact of endometrioma on IVF\/ICSI outcomes: A systematic review and metaanalysis","volume":"21","author":"Hamdan","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"ref_121","first-page":"139","article-title":"Oocyte, embryo and blastocyst cryopreservation in ART: Systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance","volume":"23","author":"Rienzi","year":"2017","journal-title":"Hum. Reprod. 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