{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:55:04Z","timestamp":1767084904089,"version":"build-2065373602"},"reference-count":61,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>This study aims to investigate the potential impact of commercial low-vision filters on intrinsically photosensitive retinal ganglion cells (ipRGCs), which have significantly advanced our understanding of non-image-forming visual functions. A comprehensive analysis by modeling the potential responses of ipRGCs to commercially available low-vision filters was conducted, focusing on how the spectral properties of these filters could alter ipRGC function. Additionally, the influence of aging on the crystalline lens was considered. Colorimetric changes in the transmitted light by these filters were also analyzed, highlighting variations based on the manufacturer. The study uncovered the diverse responses of ipRGCs to fifty low-vision filters, shedding light on the potential modifications in ipRGC stimulation and visual function. Notably, the consideration of aging in the crystalline lens revealed significant alterations in ipRGC response. Furthermore, the analysis of colorimetric changes demonstrated substantial differences in the light transmitted by these filters, with variations dependent on the manufacturer. This research underscores the nuanced relationship between low-vision filters and ipRGCs, providing insights into their potential impact on visual function. The varying responses observed, coupled with the influence of aging on the crystalline lens, emphasize the complexity of this interaction. Additionally, the distinct colorimetric changes based on filter manufacturer suggest the need for tailored approaches in enhancing visual perception for individuals with visual impairments.<\/jats:p>","DOI":"10.3390\/life15020261","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T06:43:07Z","timestamp":1739169787000},"page":"261","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Colorimetric and Photobiological Properties of Light Transmitted Through Low-Vision Filters: Simulated Potential Impact on ipRGCs Responses Considering Crystalline Lens Aging"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5621-1937","authenticated-orcid":false,"given":"Ana","family":"Sanchez-Cano","sequence":"first","affiliation":[{"name":"Department of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2710-1875","authenticated-orcid":false,"given":"Elvira","family":"Orduna-Hospital","sequence":"additional","affiliation":[{"name":"Department of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justiniano","family":"Aporta","sequence":"additional","affiliation":[{"name":"Department of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/opo.12648","article-title":"Visual and Non-Visual Properties of Filters Manipulating Short-Wavelength Light","volume":"39","author":"Spitschan","year":"2019","journal-title":"Ophthalmic Physiol. 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