{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T13:03:29Z","timestamp":1771851809750,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Nutritional status is an important prognostic factor in patients with multiple myeloma (MM). The Controlling Nutritional Status (CONUT) score has shown promise in predicting outcomes in various malignancies; however, its role in autologous stem cell transplantation (ASCT) in patients with MM remains unclear. This study aimed to evaluate the significance of pre-transplant CONUT scores in predicting post-transplant engraftment kinetics and early complications in patients with MM undergoing ASCT. This single-center, retrospective study analyzed 59 multiple myeloma patients who underwent ASCT between 1 October 2022, and 1 July 2024. Pre-transplant CONUT scores were calculated, and their associations with various post-transplant outcomes were assessed using statistical analyses. Higher CONUT scores were independently associated with longer neutrophil engraftment times (p = 0.012). Patients who developed oral mucositis (OM) had significantly higher CONUT scores than those without OM (p = 0.028). A CONUT score cut-off of 2.5 demonstrated 100% sensitivity and 57.14% specificity in predicting OM (Area Under the Curve (AUC) 0.792, 95% CI: 0.654\u20130.930, p = 0.033). Our study demonstrates that a higher pre-transplant CONUT score is significantly associated with a delay in neutrophil engraftment and an increased risk of developing oral mucositis. These findings suggest that the CONUT score can serve as a valuable predictive tool for early post-transplant complications, thereby guiding targeted interventions and improving patient management.<\/jats:p>","DOI":"10.3390\/life15020289","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T11:08:51Z","timestamp":1739358531000},"page":"289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optimizing Autologous Stem Cell Transplantation in Multiple Myeloma: The Significance of Pre-Transplant Controlling Nutritional Status Score"],"prefix":"10.3390","volume":"15","author":[{"given":"S\u0131d\u0131ka G\u00fclkan","family":"\u00d6zkan","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bah\u00e7e\u015fehir University, Sahrayi Cedit, Batman Street No:66, Kadikoy, Istanbul 34734, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suna","family":"Avc\u0131","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul 34093, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Kimiaei","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bah\u00e7e\u015fehir University, Sahrayi Cedit, Batman Street No:66, Kadikoy, Istanbul 34734, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedehtina","family":"Safaei","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bah\u00e7e\u015fehir University, Sahrayi Cedit, Batman Street No:66, Kadikoy, Istanbul 34734, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-035X","authenticated-orcid":false,"given":"Y\u00fcksel","family":"Altunta\u015f","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul 34418, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asl\u0131","family":"Y\u00fcksel \u00d6zt\u00fcrkmen","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Sivas Numune Hospital, Sivas 58040, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1004-1169","authenticated-orcid":false,"given":"Zeynep","family":"Asl\u0131 Durak","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bah\u00e7e\u015fehir University, Sahrayi Cedit, Batman Street No:66, Kadikoy, Istanbul 34734, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinem","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Adult Hematology and Bone Marrow Transplantation Unit, Medical Park G\u00f6ztepe Hospital, Istanbul 34730, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1428-8197","authenticated-orcid":false,"given":"Mohammad","family":"Adeeb Abbara","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bah\u00e7e\u015fehir University, Sahrayi Cedit, Batman Street No:66, Kadikoy, Istanbul 34734, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011fba","family":"A\u011fyol","sequence":"additional","affiliation":[{"name":"Adult Hematology and Bone Marrow Transplantation Unit, Medical Park G\u00f6ztepe Hospital, Istanbul 34730, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Serdar Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul 34418, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5590-972X","authenticated-orcid":false,"given":"Hasan Atilla","family":"\u00d6zkan","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Bah\u00e7e\u015fehir University, Sahrayi Cedit, Batman Street No:66, Kadikoy, Istanbul 34734, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00277-019-03702-1","article-title":"Evaluation of the Revised International Staging System (R-ISS) in Japanese patients with multiple myeloma","volume":"98","author":"Ozaki","year":"2019","journal-title":"Ann. 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