{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:10:47Z","timestamp":1788311447662,"version":"build-2803163510"},"reference-count":68,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy of Craiova"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Life"],"abstract":"<jats:p>Early-onset sepsis (EOS) remains a major cause of neonatal morbidity and mortality worldwide, with significant differences in the incidence and outcome of the disease in Europe. Eastern European countries face particular challenges due to differences in access to healthcare, diagnostic facilities, and prevention strategies. This review summarizes the results of recent research to provide insights into maternal risk factors, regional inequalities in access to healthcare, diagnostic biomarkers, pathogen patterns, and treatment protocols for EOS. This review also examines how healthcare infrastructure and socioeconomic factors influence EOS outcomes in Eastern Europe. Introduction: Early-onset sepsis (EOS) presents a significant health challenge for newborns, characterized by sepsis occurring within the first 72 h of life, primarily caused by the vertical transmission of pathogens from mother to child. Despite advancements in medical care, EOS remains particularly burdensome in resource-poor settings, especially in Eastern Europe, where disparities in healthcare access and maternal health are pronounced. This systematic review aims to provide insights into maternal risk factors, regional inequalities in healthcare access, diagnostic biomarkers, pathogen patterns, and treatment protocols for EOS. Background\/Objectives: EOS is increasingly recognized as a public health issue, with outcomes significantly influenced by maternal health, socioeconomic status, and healthcare infrastructure. The review seeks to summarize the existing literature on EOS, particularly focusing on differences between high-income Western and low-resource Eastern European countries. The influence of maternal access to antenatal care, pathogen prevalence, and antibiotic resistance on EOS outcomes across regions will also be examined. Methods: To achieve the review\u2019s objectives, a comprehensive search was conducted across multiple databases including PubMed, Google Scholar, ScienceDirect, and Scopus, adhering to PRISMA guidelines for systematic reviews. The inclusion criteria encompassed studies published within the last 20 years (January 2004\u2013August 2024) that addressed EOS in late preterm or term infants, emphasizing maternal health, risk factors, diagnostic approaches, and treatment protocols pertinent to European populations. Exclusion criteria included non-English publications and studies lacking a focus on maternal and neonatal health. A total of 29 peer-reviewed articles meeting the specified criteria were ultimately included in the analysis. Results: The findings highlight significant regional disparities in EOS management between Western and Eastern Europe. Key issues include maternal risk factors, socioeconomic barriers to healthcare, diagnostic biomarkers, and pathogen resistance trends. Limited access to prenatal screenings and healthcare infrastructure in Eastern European countries, especially in rural regions in Romania, exacerbate the challenges faced by expectant mothers. Financial burdens, such as high out-of-pocket expenses, were shown to further restrict access to necessary maternal care. Conclusions: This systematic review emphasizes the urgent need for targeted investments in maternal healthcare infrastructure in Eastern Europe to mitigate the impacts of EOS. Enhanced screening programs, standardized surveillance systems, and ensuring equitable health policies are essential to improving neonatal outcomes. Additionally, tailored education and awareness campaigns for disadvantaged groups and comprehensive health policy reforms, including universal antenatal care and Group B Streptococcus (GBS), are essential to bridging healthcare gaps.<\/jats:p>","DOI":"10.3390\/life15020292","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T04:03:35Z","timestamp":1739419415000},"page":"292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Systematic Review: Maternal Risk Factors, Socioeconomic Influences, Neonatal Biomarkers and Management of Early-Onset Sepsis in Late Preterm and Term Newborns\u2014A Focus on European and Eastern European Contexts"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1875-6987","authenticated-orcid":false,"given":"Anca","family":"Vulc\u0103nescu","sequence":"first","affiliation":[{"name":"\u201cFilantropia\u201d Clinical Municipal Hospital, 200143 Craiova, Romania"},{"name":"University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1835-2551","authenticated-orcid":false,"given":"Mirela-Ani\u0219oara","family":"Siminel","sequence":"additional","affiliation":[{"name":"\u201cFilantropia\u201d Clinical Municipal Hospital, 200143 Craiova, Romania"},{"name":"Department of Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin-Nicolae","family":"Dinescu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"Clinical Emergency County Hospital, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2481-6138","authenticated-orcid":false,"given":"Mihail-Virgil","family":"Boldeanu","sequence":"additional","affiliation":[{"name":"\u201cFilantropia\u201d Clinical Municipal Hospital, 200143 Craiova, Romania"},{"name":"Department of Immunology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anda-Lorena","family":"Dijm\u0103rescu","sequence":"additional","affiliation":[{"name":"\u201cFilantropia\u201d Clinical Municipal Hospital, 200143 Craiova, Romania"},{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Magdalena","family":"Manolea","sequence":"additional","affiliation":[{"name":"\u201cFilantropia\u201d Clinical Municipal Hospital, 200143 Craiova, Romania"},{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-1756","authenticated-orcid":false,"given":"Constantin-Cristian","family":"V\u0103duva","sequence":"additional","affiliation":[{"name":"\u201cFilantropia\u201d Clinical Municipal Hospital, 200143 Craiova, Romania"},{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref_1","first-page":"1008","article-title":"Epidemiology of Group B Streptococcus in Europe","volume":"16","author":"Schrag","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_2","first-page":"65","article-title":"Neonatal Sepsis in Eastern Europe: Current Trends and Challenges","volume":"23","author":"Hincu","year":"2024","journal-title":"Pediatr. Rom."},{"key":"ref_3","first-page":"1243","article-title":"Maternal Care Inequities and Neonatal Health: A Focus on Eastern Europe","volume":"31","author":"Miteniece","year":"2021","journal-title":"Eur. Public Health J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jpeds.2018.05.048","article-title":"Neonatal Sepsis of Early Onset, and Hospital-Acquired and Community-Acquired Late Onset: A Prospective Population-Based Cohort Study","volume":"201","author":"Giannoni","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_5","first-page":"79","article-title":"Epidemiology and Prevention of Neonatal Sepsis and Meningitis in Europe","volume":"15","author":"Berardi","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_6","unstructured":"WHO, and UNICEF (2020). A Decade of Action for Child Health, UNICEF."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1080\/00016340801908759","article-title":"Prevalence of Maternal Group B Streptococcal Colonisation in European Countries","volume":"87","author":"Barcaite","year":"2008","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_8","first-page":"157","article-title":"Aetiology of Community-Acquired Neonatal Sepsis in Low and Middle Income Countries","volume":"1","author":"Waters","year":"2011","journal-title":"J. Glob. Health"},{"key":"ref_9","unstructured":"Chanturidze, T. (2012). Technical Assistance for Project Management Unit APL 2, Within the Ministry of Health of Romania, in Order to Develop a Strategy for Primary Health Care in Underserved Areas and the Related Action Plan, FNPMF Romania."},{"key":"ref_10","unstructured":"Flidel-Rimon, O., Cohen, A., Barak, M., Yagupsky, P., Nir-Paz, R., Dagan, R., Greenberg, D., Engelhard, D., Borer, A., and Shapiro, M. (2022). Antibiotic Resistance in Neonatal Units. Clin. Microbiol. Rev., 35."},{"key":"ref_11","first-page":"301","article-title":"Maternal Risk Factors for EOS: A European Perspective","volume":"118","author":"Oikonomou","year":"2020","journal-title":"Neonatology"},{"key":"ref_12","first-page":"31","article-title":"EOS Risk Calculator: Implementation Challenges in Europe","volume":"5","author":"Mukhopadhyay","year":"2019","journal-title":"Neonatal Res."},{"key":"ref_13","first-page":"399","article-title":"Procalcitonin in Early-Onset Sepsis","volume":"49","author":"Gkentzi","year":"2021","journal-title":"J. Perinat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1016\/j.jinf.2016.04.026","article-title":"Recognising Early Onset Neonatal Sepsis: An Essential Step in Appropriate Antimicrobial Use","volume":"72","author":"Stocker","year":"2016","journal-title":"J. Infect."},{"key":"ref_15","first-page":"84","article-title":"Neonatal Sepsis: A Continuing Disease Burden","volume":"55","author":"Odabasi","year":"2020","journal-title":"Turk Pediatri Ars."},{"key":"ref_16","first-page":"698","article-title":"Prevention of Early-Onset Neonatal Group B Streptococcal Infection: Is Universal Screening by Culture Universally Applicable?","volume":"8","author":"Eisenberg","year":"2006","journal-title":"Isr. Med. Assoc. J. IMAJ"},{"key":"ref_17","first-page":"345","article-title":"Socioeconomic Barriers and Neonatal Outcomes: An Observational Study","volume":"38","author":"Barcaite","year":"2008","journal-title":"Int. J. Pediatr."},{"key":"ref_18","first-page":"34","article-title":"Risk Factors for Neonatal Sepsis: A Study in Rural Romania","volume":"20","author":"Panaitescu","year":"2020","journal-title":"Ginecol. \u0218i Perinatol. Pract."},{"key":"ref_19","unstructured":"WHO (2004). World Health Organization Maternal Health and Neonatal Outcomes in Rural Populations, World Health Organization."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ciulpan, A., Lacatu\u0219u, A., Pop, L.L., Paul, C., Lungeanu, D., Iacob, D., Bernad, B.-C., Lascu, A., Maghet, E., and Arnautu, D.-A. (2024). Incidence and Antenatal Detection of Congenital Heart Malformations\u2014Data from a Tertiary Obstetric Romanian Center. Diagnostics, 14.","DOI":"10.3390\/diagnostics14151659"},{"key":"ref_21","first-page":"25","article-title":"Neonatal Outcomes in Rural Romania: Challenges and Solutions","volume":"17","author":"Cobzeanu","year":"2022","journal-title":"Rom. Pediatr. Soc. J."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hincu, M.-A., Zonda, G.-I., Vicoveanu, P., Harabor, V., Harabor, A., Carauleanu, A., Melinte-Popescu, A.-S., Melinte-Popescu, M., Mihalceanu, E., and Stuparu-Cretu, M. (2024). Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children, 11.","DOI":"10.3390\/children11010124"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/S1473-3099(16)30055-X","article-title":"Prevalence of Maternal Colonisation with Group B Streptococcus: A Systematic Review and Meta-Analysis","volume":"16","author":"Kwatra","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1111\/j.1469-0691.2011.03576.x","article-title":"Neonatal Group B Streptococcal Disease: From Pathogenesis to Preventive Strategies","volume":"17","author":"Melin","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gudj\u00f3nsd\u00f3ttir, M.J., Elfvin, A., Hentz, E., Adlerberth, I., Tessin, I., and Trollfors, B. (2019). Changes in Incidence and Etiology of Early-Onset Neonatal Infections 1997\u20132017\u2014A Retrospective Cohort Study in Western Sweden. BMC Pediatr., 19.","DOI":"10.1186\/s12887-019-1866-z"},{"key":"ref_26","first-page":"26","article-title":"Cost Barriers to Prenatal Care in Eastern Europe","volume":"28","author":"Almeida","year":"2019","journal-title":"Health Econ."},{"key":"ref_27","unstructured":"Berardi, A. (2017). GBS Screening and IAP: European Guidelines. BMC Pregnancy Childbirth, 17."},{"key":"ref_28","first-page":"e128","article-title":"National Differences in EOS Rates and Protocols in Europe","volume":"4","author":"Hansen","year":"2016","journal-title":"Lancet Glob. Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"F76","DOI":"10.1136\/archdischild-2013-303984","article-title":"Value of a Single C-Reactive Protein Measurement at 18 h of Age","volume":"99","author":"Rosychuk","year":"2014","journal-title":"Arch. Dis. Child.\u2014Fetal Neonatal Ed."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/archdischild-2020-320217","article-title":"Global Incidence and Mortality of Neonatal Sepsis: A Systematic Review and Meta-Analysis","volume":"106","author":"Fleischmann","year":"2021","journal-title":"Arch. Dis. Child."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Murthy, S., Godinho, M.A., Guddattu, V., Lewis, L.E., and Nair, N.S. (2019). Risk Factors of Neonatal Sepsis in India: A Systematic Review and Meta-Analysis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0215683"},{"key":"ref_32","unstructured":"Miteniece, E. (2021). Access to Adequate Maternal Care in Eastern Europe. [Doctoral Thesis, Maastricht University]."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3855\/jidc.11202","article-title":"Endocan\u2014A Potential Diagnostic Marker for Early Onset Sepsis in Neonates","volume":"13","author":"Zonda","year":"2019","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"222","DOI":"10.37897\/RJID.2016.4.2","article-title":"Infections and prematurity, important risk factors for neonatal morbidity and mortality","volume":"19","author":"Tarca","year":"2016","journal-title":"Rom. J. Infect. Dis."},{"key":"ref_35","unstructured":"UNICEF (2021). Maternal Mortality: A Global Challenge, UNICEF."},{"key":"ref_36","unstructured":"Weltgesundheitsorganisation (2004). Abortion and Contraception in Romania: A Strategic Assessment of Policy, Programme and Research Issues, Report of a Strategic Assessment, World Health Organization."},{"key":"ref_37","unstructured":"UNICEF (2020). Romania: Vulnerable Children and Families, UNICEF."},{"key":"ref_38","unstructured":"UNICEF (2023). Romania Country Data Profile, UNICEF."},{"key":"ref_39","unstructured":"UNICEF (2022). Roma Children in Romania: A Study on Poverty and Health, UNICEF."},{"key":"ref_40","first-page":"142","article-title":"Neonatal Sepsis","volume":"54","author":"Bulbul","year":"2020","journal-title":"SiSli Etfal Hastan. Tip Bul. Med. Bull. Sisli Hosp."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/10641955.2020.1801718","article-title":"Incidence of Hypertensive Disorders of Pregnancy in Romania","volume":"39","author":"Panaitescu","year":"2020","journal-title":"Hypertens. Pregnancy"},{"key":"ref_42","first-page":"5575","article-title":"Ovarian Reserve after Treatment of Ovarian Endometriomas by Ethanolic Sclerotherapy Compared to Surgical Treatment","volume":"27","author":"Vaduva","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"162","DOI":"10.22543\/7674.91.P162167","article-title":"Pain Management in the Right Iliac Fossa during the COVID-19 Pandemic","volume":"9","author":"Costea","year":"2022","journal-title":"J. Mind Med. Sci."},{"key":"ref_44","first-page":"281","article-title":"Maternal and Neonatal Health in the Transition Economies of Eastern Europe","volume":"15","author":"Chanturidze","year":"2021","journal-title":"Healthc. Policy J."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Baizat, M.I., Iancu, M., Zaharie, G., Hasmasanu, M., Matyas, M., Rotar, I.C., and Procopciuc, L.M. (2023). Effects of TLR-2, TLR-4, Interleukin-6 and -10 Gene Polymorphisms on Preterm Neonates with Early-Onset Sepsis: An Exploratory, Single-Center Study. Preprints, 2023082107.","DOI":"10.20944\/preprints202308.2107.v1"},{"key":"ref_46","first-page":"e65213","article-title":"D-Dimer as a Useful Biomarker in Early Diagnosis of Neonatal Sepsis: A Single-Center Study From Romania","volume":"16","author":"Lungu","year":"2024","journal-title":"Cureus"},{"key":"ref_47","first-page":"486","article-title":"Maternal Risk Factors Associated with Neonatal Group B Streptococcus Disease","volume":"16","author":"Kwatra","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/OGX.0000000000001223","article-title":"Prevention of Early-Onset Neonatal Group B Streptococcal Disease: A Comprehensive Review of Major Guidelines","volume":"78","author":"Boureka","year":"2023","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_49","first-page":"123","article-title":"Risk Factors for Early-Onset Sepsis in Neonates: Insights from Romania","volume":"9","author":"Berardi","year":"2022","journal-title":"PMC"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"D43","DOI":"10.1016\/j.vaccine.2013.05.094","article-title":"Epidemiology of Group B Streptococcus in Developing Countries","volume":"31","author":"Johri","year":"2013","journal-title":"Vaccine"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Lungu, N., Popescu, D.-E., Manea, A.M., Jura, A.M.C., Doandes, F.M., Popa, Z.L., Gorun, F., Citu, C., Gruber, D., and Ciurescu, S. (2024). Hemoglobin, Ferritin, and Lactate Dehydrogenase as Predictive Markers for Neonatal Sepsis. J. Pers. Med., 14.","DOI":"10.3390\/jpm14050476"},{"key":"ref_52","unstructured":"UNICEF Romania (2022). Universal Language of Motherhood: Refugees and Maternal Care in Romania, UNICEF Romania."},{"key":"ref_53","first-page":"647","article-title":"Roma Migration and Maternal Health Care Access","volume":"37","author":"Nacu","year":"2011","journal-title":"J. Ethn. Migr. Stud."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0749-3797(01)00315-4","article-title":"Barriers to Prenatal Care in Europe","volume":"21","author":"Delvaux","year":"2001","journal-title":"Am. J. Prev. Med."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ilyes, S.-G., Chiriac, V.D., Gluhovschi, A., Mihaela, V., Dahma, G., Mocanu, A.G., Neamtu, R., Silaghi, C., Radu, D., and Bernad, E. (2022). The Influence of Maternal Factors on Neonatal Intensive Care Unit Admission and In-Hospital Mortality in Premature Newborns from Western Romania: A Population-Based Study. Medicina, 58.","DOI":"10.3390\/medicina58060709"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"F72","DOI":"10.1136\/adc.2005.074963","article-title":"Unnatural Selection: Reducing Antibiotic Resistance in Neonatal Units","volume":"91","author":"Isaacs","year":"2005","journal-title":"Arch. Dis. Child.\u2014Fetal Neonatal Ed."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"114153","DOI":"10.1016\/j.jpeds.2024.114153","article-title":"Trends in C-Reactive Protein Use in Early-Onset Sepsis Evaluations and Associated Antibiotic Use","volume":"273","author":"Barboza","year":"2024","journal-title":"J. Pediatr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.7754\/Clin.Lab.2019.190105","article-title":"Potential Clinical Predictors of Suspected Early and Late Onset Sepsis (EOS and LOS) in Preterm Newborns: A Single Tertiary Center Retrospective Study","volume":"65","author":"Baizat","year":"2019","journal-title":"Clin. Lab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e20170266","DOI":"10.1542\/peds.2017-0266","article-title":"Health Services Use by Late Preterm and Term Infants From Infancy to Adulthood: A Meta-Analysis","volume":"140","author":"Isayama","year":"2017","journal-title":"Pediatrics"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.30574\/wjarr.2024.21.1.0151","article-title":"Sofia Al Farizi Maternal Risk Factors for Low Birth Weight Infants: A Systematic Review Study","volume":"21","author":"Lutfia","year":"2024","journal-title":"World J. Adv. Res. Rev."},{"key":"ref_61","unstructured":"UNICEF Romania (2022). Better Healthcare for Every Mother and Child, UNICEF Romania."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijgo.2004.04.001","article-title":"Safe Abortion: WHO Technical and Policy Guidance","volume":"86","author":"Horga","year":"2004","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_63","first-page":"231","article-title":"Early-Onset Sepsis in Newborns: Epidemiology and Clinical Implications","volume":"63","year":"2020","journal-title":"Neonatologia"},{"key":"ref_64","unstructured":"Russell, N.J. (2017). Maternal and Neonatal Factors in EOS Risk Stratification. PLoS ONE, 12."},{"key":"ref_65","first-page":"361","article-title":"Driving Assessment Scores with Effective Calculator Implementation","volume":"3","author":"Lutsic","year":"2023","journal-title":"Int. J. Soc. Learn. IJSL"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1203\/00006450-199904020-01583","article-title":"Maternal and Infant Risk Factors for Neonatal Sepsis: A Comparison between an Inner-City County Hospital and a Health Maintenance Organization","volume":"45","author":"Martinez","year":"1999","journal-title":"Pediatr. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"163","DOI":"10.37897\/RJID.2023.4.2","article-title":"Early-Onset Neonatal Sepsis with Haemophilus Influenzae in a Premature Low Birth Weight Newborn\u2014Case Report","volume":"26","author":"Toth","year":"2023","journal-title":"Rom. J. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"dlac133.023","DOI":"10.1093\/jacamr\/dlac133.023","article-title":"P19 Antibacterial Susceptibility Patterns and Resistance Genes from Bacterial Isolates of Neonatal Sepsis","volume":"5","author":"Aziegbemhin","year":"2023","journal-title":"JAC-Antimicrob. Resist."}],"updated-by":[{"DOI":"10.3390\/life15040616","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000}}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/2\/292\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T14:50:49Z","timestamp":1754232649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/2\/292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":68,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["life15020292"],"URL":"https:\/\/doi.org\/10.3390\/life15020292","relation":{"correction":[{"id-type":"doi","id":"10.3390\/life15040616","asserted-by":"object"}]},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]}}}