{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:56:00Z","timestamp":1760057760487,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Living kidney transplantation yields better outcomes for recipients than deceased donation, though it may present long-term challenges for donors. This study assessed the quality of life (QoL) of living kidney donors in Greece using the SF-36 questionnaire and examined associated sociodemographic and clinical factors. This cross-sectional study included 242 clinically stable kidney donors from Laiko General Hospital\u2019s Kidney Donor Outpatient Clinic in Athens. Data on demographics, comorbidities, laboratory parameters, and QoL were collected. Spearman\u2019s correlation coefficients were used to identify associations between QoL scores and influencing factors. The majority of donors were female (73.55%). Donors reported high QoL, with median PCS and MCS scores of 55.27 (49.08\u201357.73) and 54.17 (46.64\u201359.93), respectively. Male donors had higher PCS and MCS scores than females (p = 0.028 and p = 0.004). Laparoscopic nephrectomy was associated with better mental health and physical outcomes compared to open surgery (p &lt; 0.001). Higher education and eGFR correlated with better PCS scores, while older age negatively affected QoL (p &lt; 0.05). Living kidney donors reported a satisfactory level of overall QoL post-donation. Lower QoL scores were correlated with the female gender, older age, and open nephrectomy. These findings may further reinforce support for our current organ donation policy. Non-modifiable factors appear to influence donor quality of life. These findings reinforce the current organ donation policy while emphasizing the need for careful pre-transplant counseling and ongoing monitoring post-donation.<\/jats:p>","DOI":"10.3390\/life15020325","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:49:27Z","timestamp":1739965767000},"page":"325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of Life of Donors After Living Kidney Transplantation: A Cross-Sectional Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5366-1214","authenticated-orcid":false,"given":"Chrysanthi","family":"Skalioti","sequence":"first","affiliation":[{"name":"Department of Nephrology and Renal Transplantation, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-1232","authenticated-orcid":false,"given":"Maria","family":"Smyrli","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-8320","authenticated-orcid":false,"given":"Chrysoula","family":"Beletsioti","sequence":"additional","affiliation":[{"name":"Department of Quality Control, Research and Continuing Education, General Hospital of Nikaia \u201cAgios Panteleimon\u201d, 18454 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stathis","family":"Tsiakas","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalliopi","family":"Vallianou","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John N.","family":"Boletis","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smaragdi","family":"Marinaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Transplantation, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1111\/ajt.16463","article-title":"Long-term kidney transplant graft survival\u2014Making progress when most needed","volume":"21","author":"Poggio","year":"2021","journal-title":"Am. J. Transplant."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10511","DOI":"10.3389\/ti.2022.10511","article-title":"European Guideline for the Management of Kidney Transplant Patients With HLA Antibodies: By the European Society for Organ Transplantation Working Group","volume":"35","author":"Mamode","year":"2022","journal-title":"Transpl. Int."},{"key":"ref_3","unstructured":"(2025, February 16). Global Observatory on Donation and Transplantation. Available online: https:\/\/www.transplant-observatory.org\/countkidney\/."},{"key":"ref_4","unstructured":"Eurotransplant International Foundation (2025, February 16). Annual Report 2023, Available online: https:\/\/www.eurotransplant.org\/wp-content\/uploads\/2024\/06\/ETP_AR2023_LowRes.pdf."},{"key":"ref_5","unstructured":"Avrami, C., Liossatou, A., and Ho, T.M. (2025, February 16). Strategies for expanding the living donor pool, Current Strategies for Living Donor Kidney Transplantation, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK581483\/."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1001\/jama.2024.14527","article-title":"Thirty-Year Trends in Perioperative Mortality Risk for Living Kidney Donors","volume":"332","author":"Massie","year":"2024","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00345-023-04737-w","article-title":"Trends in kidney transplantation and living donor nephrectomy in Germany: A total population analysis from 2006 to 2021","volume":"42","author":"Zacharis","year":"2024","journal-title":"World J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100855","DOI":"10.1016\/j.trre.2024.100855","article-title":"Experiences of living kidney donors: A synthesis of unsolicited patient narratives","volume":"38","author":"Loban","year":"2024","journal-title":"Transplant. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/ajt.13687","article-title":"Perioperative Complications After Living Kidney Donation: A National Study","volume":"16","author":"Lentine","year":"2016","journal-title":"Am. J. Transplant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2054358119857718","DOI":"10.1177\/2054358119857718","article-title":"Perioperative Complications During Living Donor Nephrectomy: Results From a Multicenter Cohort Study","volume":"6","author":"Feldman","year":"2019","journal-title":"Can. J. Kidney Health Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e010869","DOI":"10.1136\/bmjopen-2015-010869","article-title":"Investigating kidney donation as a risk factor for hypertension and microalbuminuria: Findings from the Swiss prospective follow-up of living kidney donors","volume":"6","author":"Thiel","year":"2016","journal-title":"BMJ Open"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/jama.2024.8523","article-title":"Hypertension and Kidney Function After Living Kidney Donation","volume":"332","author":"Garg","year":"2024","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1681\/ASN.2015091018","article-title":"Renal Function Profile in White Kidney Donors: The First 4 Decades","volume":"27","author":"Ibrahim","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1111\/ajt.13453","article-title":"The Course and Predictors of Health-Related Quality of Life in Living Kidney Donors: A Systematic Review and Meta-Analysis","volume":"15","author":"Wirken","year":"2015","journal-title":"Am. J. Transplant."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"101649","DOI":"10.1016\/j.trim.2022.101649","article-title":"Psycho-social health and quality of life among kidney donors following transplantation","volume":"74","author":"Kaul","year":"2022","journal-title":"Transpl. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1111\/j.1600-6143.2006.01567.x","article-title":"Psychosocial Health of Living Kidney Donors: A Systematic Review","volume":"6","author":"Clemens","year":"2006","journal-title":"Am. J. Transplant."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Holscher, C.M., Leanza, J., Thomas, A.G., Waldram, M.M., Haugen, C.E., Jackson, K.R., Bae, S., Massie, A.B., and Segev, D.L. (2018). Anxiety, depression, and regret of donation in living kidney donors. BMC Nephrol., 19.","DOI":"10.1186\/s12882-018-1024-0"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.transproceed.2013.02.100","article-title":"Quality of Life Assessment in a Living Donor Kidney Transplantation Program: Evaluation of Recipients and Donors","volume":"45","author":"Lopes","year":"2013","journal-title":"Transplant. Proc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.transproceed.2010.12.028","article-title":"Depression and Anxiety in Living Kidney Donation: Evaluation of Donors and Recipients","volume":"43","author":"Lopes","year":"2011","journal-title":"Transplant. Proc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/appy.12087","article-title":"Anxiety and decreased social support underline poorer quality of life of parent living kidney donors","volume":"7","author":"Chen","year":"2013","journal-title":"Asia Pac. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/tri.12509","article-title":"Psychosocial and physical outcome following kidney donation-a retrospective analysis","volume":"28","author":"Sommerer","year":"2015","journal-title":"Transpl. Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.20471\/dec.2022.58.02.06","article-title":"Female Renal Donors: Impact of Donation on Anxiety, Depressive Symptoms and Quality of Life","volume":"58","author":"Gaur","year":"2022","journal-title":"Arch. Psychiatry Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s11255-023-03542-z","article-title":"Quality of life, anxiety and depression symptoms in living related kidney donors: A cross-sectional study","volume":"55","author":"Shi","year":"2023","journal-title":"Int. Urol. Nephrol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Menjivar, A., Torres, X., Manyalich, M., Fehrman-Ekholm, I., Papachristou, C., de Sousa-Amorim, E., Paredes, D., Hiesse, C., Yucetin, L., and Oppenheimer, F. (2020). Psychosocial risk factors for impaired health-related quality of life in living kidney donors: Results from the ELIPSY prospective study. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-78032-8"},{"key":"ref_25","first-page":"sfae374","article-title":"Health-Related Quality of Life in Living Kidney Donors Participating in Kidney Exchange Programs","volume":"18","author":"Wiltschut","year":"2024","journal-title":"Clin. Kidney J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.transproceed.2017.10.019","article-title":"Multivariate Analysis of Health-related Quality of Life in Donors After Live Kidney Donation","volume":"50","author":"Klop","year":"2018","journal-title":"Transplant. Proc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1111\/ajt.12434","article-title":"Health-Related Quality of Life in Kidney Donors From the Last Five Decades: Results From the RELIVE Study","volume":"13","author":"Gross","year":"2013","journal-title":"Am. J. Transplant."},{"key":"ref_28","first-page":"e52481","article-title":"Quality of Life in Kidney Donors: A Single-Center Experience","volume":"16","author":"Alayoobi","year":"2024","journal-title":"Cureus"},{"key":"ref_29","first-page":"10","article-title":"Newsletter Transplant International figures on donation and transplantation 2021","volume":"27","year":"2022","journal-title":"EDQM"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.chest.2020.03.012","article-title":"Cross-Sectional Studies","volume":"158","author":"Wang","year":"2020","journal-title":"Chest"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s11136-004-6014-y","article-title":"Validating and norming of the Greek SF-36 Health Survey","volume":"14","author":"Pappa","year":"2005","journal-title":"Qual. Life Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Yfantopoulos, J., Chantzaras, A., and Yfantopoulos, P. (2023). The health gap and HRQoL inequalities in Greece before and during the economic crisis. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1138982"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"105","author":"Stevens","year":"2024","journal-title":"Kidney Int."},{"key":"ref_34","unstructured":"Ware, J.E., Snow, K.K., Kosinski, M., and Gandek, B. (2003). New England Medical Center Hospital Health Institute. SF-36 Health Survey: Manual and Interpretation Guide, Quality Metric Inc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.transproceed.2008.03.132","article-title":"Quality of Life of Living Kidney Donors: A Single-Center Experience","volume":"40","author":"Shrestha","year":"2008","journal-title":"Transplant. Proc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1007\/s11136-015-1027-2","article-title":"Long-term health-related quality of life of living kidney donors: A single-center experience","volume":"24","author":"Benzing","year":"2015","journal-title":"Qual. Life Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.transproceed.2009.02.102","article-title":"Quality of Life, Coping, and Mental Health Status After Living Kidney Donation","volume":"41","author":"Wiedebusch","year":"2009","journal-title":"Transplant. Proc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"684","DOI":"10.2340\/16501977-1814","article-title":"Self-reported fatigue and physical function in late mid-life","volume":"46","author":"Boter","year":"2014","journal-title":"J. Rehabil. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/geront\/gnr110","article-title":"Grief, Depressive Symptoms, and Physical Health Among Recently Bereaved Spouses","volume":"52","author":"Utz","year":"2011","journal-title":"Gerontologist"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Faba, O.R., Boissier, R., Budde, K., Figueiredo, A., Hevia, V., Garc\u00eda, E.L., Regele, H., Zakri, R.H., Olsburgh, J., and Bezuidenhout, C. (Eur. Urol. Focus, 2024). European Association of Urology Guidelines on Renal Transplantation: Update 2024, Eur. Urol. Focus, online ahead of print.","DOI":"10.1016\/j.euf.2024.10.010"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wilson, C.H., Sanni, A., Rix, D.A., and Soomro, N.A. (2024, December 15). Laparoscopic Versus Open Nephrectomy for Live Kidney Donors. Cochrane Kidney and Transplant Group, Editor. Cochrane Database of Systematic Reviews. Available online: https:\/\/doi.wiley.com\/10.1002\/14651858.CD006124.pub2.","DOI":"10.1002\/14651858.CD006124.pub3"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3390\/jcm10061195","article-title":"The Evolution of Living Donor Nephrectomy Program at A Hellenic Transplant Center. Laparoscopic vs. Open Donor Nephrectomy: Single-Center Experience","volume":"10","author":"Vernadakis","year":"2021","journal-title":"J. Clin. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/TP.0b013e31817789dd","article-title":"Older Living Kidney Donors: Surgical Outcome and Quality of Life","volume":"86","author":"Minnee","year":"2008","journal-title":"Transplantation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e38068","DOI":"10.1097\/MD.0000000000038068","article-title":"Factors associated with the quality of life of living kidney donors in Korea: A cross-sectional study","volume":"103","author":"Min","year":"2024","journal-title":"Medicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.53590\/japt.02.1053","article-title":"Untreated, unaware hypertensive patients, in Greece; A persistent phenomenon that significantly burdens public health","volume":"14","author":"Panagiotakos","year":"2023","journal-title":"J. Atheroscler. Prev. Treat."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/ckj\/sfac216","article-title":"Donor obesity and weight gain after transplantation: Two still overlooked threats to long-term graft survival","volume":"16","author":"Kanbay","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.surg.2018.07.015","article-title":"Implications of excess weight on kidney donation: Long-term consequences of donor nephrectomy in obese donors","volume":"164","author":"Serrano","year":"2018","journal-title":"Surgery"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/tri.13263","article-title":"The impact of donor body mass index on outcomes after deceased kidney transplantation\u2014A national population-cohort study","volume":"31","author":"Arshad","year":"2018","journal-title":"Transpl. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1016\/j.transproceed.2021.08.030","article-title":"Body Mass Index and Kidney Donor Profile Index as Prognostic Markers of the Outcome of Renal Transplantation","volume":"53","author":"Smyrli","year":"2021","journal-title":"Transplant. Proc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1097\/TP.0b013e31820dd2bd","article-title":"Altruistic Kidney Donation to a Stranger: Psychosocial and Functional Outcomes at Two US Transplant Centers","volume":"91","author":"Rodrigue","year":"2011","journal-title":"Transplantation"},{"key":"ref_51","first-page":"12417","article-title":"Assessing Health-Related Quality of Life in Non-Directed Versus Directed Kidney Donors: Implications for the Promotion of Non-Directed Donation","volume":"37","author":"Vital","year":"2024","journal-title":"Transpl. Int. Off. J. Eur. Soc. Organ Transplant."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-San-Gregorio, M.\u00c1., Mart\u00edn-Rodr\u00edguez, A., Luque-Budia, A., and Conrad, R. (2017). Concerns, Mental Health, and Quality of Life in Living Kidney Donation\u2013Parent Donor Candidates Worry Less about Themselves. Front. Psychol., 8, Available online: http:\/\/journal.frontiersin.org\/article\/10.3389\/fpsyg.2017.00564\/full.","DOI":"10.3389\/fpsyg.2017.00564"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/2\/325\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:38:16Z","timestamp":1760027896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/2\/325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["life15020325"],"URL":"https:\/\/doi.org\/10.3390\/life15020325","relation":{},"ISSN":["2075-1729"],"issn-type":[{"type":"electronic","value":"2075-1729"}],"subject":[],"published":{"date-parts":[[2025,2,19]]}}}