{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:56:25Z","timestamp":1760057785207,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: In thermal injuries, enzymatic debridement is a viable option for treating partial- and full-thickness burns, allowing for rapid removal of damaged tissue with minimal bleeding and without sacrificing healthy dermis. Enzymatic debridement using Nexobrid\u00ae combined with negative wound pressure therapy (NWPT) appears to promote healing, as enzymatic debridement helps preserve healthy tissue integrity and epithelial reserves. We explored therapeutic alternatives following enzymatic debridement to assess healing outcomes and reduce reliance on skin grafts. Methods: 24 patients with deep or partially deep thermal burns on 5\u201340% of total body surface area (TBSA) underwent enzymatic debridement; then, half received NWPT and the other half were treated with topicals. Results: Enzymatic debridement effectively removed necrotic tissue and facilitated healing. Only three patients required skin grafts (&lt;10% TBSA). Enzymatic debridement combined with NWPT expedited daily healing, reduced hospitalization days, and eliminated wound secretion, as confirmed by bacteriological examination. This approach was more effective compared to enzymatic debridement followed by topical treatments. Conclusions: Nexobrid\u00ae in combination with NWPT is a promising alternative to surgical treatment, improving healing, reducing the need for skin grafts, and alleviating pain associated with dressing changes. It may be particularly useful in extensive burns, where epithelial reserves are limited.<\/jats:p>","DOI":"10.3390\/life15030352","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T10:04:28Z","timestamp":1740391468000},"page":"352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Benefits of Combined Therapies in Burn Lesions: Enzymatic Debridement and Other Modern Approaches\u2014Our Clinical Experience"],"prefix":"10.3390","volume":"15","author":[{"given":"Angela","family":"Tecuceanu","sequence":"first","affiliation":[{"name":"Department of Morphofunctional Sciences I, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camelia","family":"Tama\u015f","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burn Unit, \u201cSf. Spiridon\u201d Emergency Clinical Hospital, 700111 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca","family":"Sava","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences I, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"},{"name":"Department of Pathology, \u201cProf. Dr. Nicolae Oblu \u201cEmergency Clinical Hospital, 700309 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruxandra","family":"Vatavu","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences I, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea Mioara","family":"Avram","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, \u201cSf. Ioan\u201d Clinical Emergency Hospital for Children, 800487 Gala\u021bi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iulia","family":"Olaru","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, \u201cSf. Ap. Andrei\u201d Emergency Hospital, 800487 Gala\u021bi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan Mihnea","family":"Ciuntu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, \u201cSf. Spiridon\u201d Emergency Clinical Hospital, 700111 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina Mihaela","family":"Abdulan","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences I, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Ciuntu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Corlade","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina Mihaela","family":"Hreniuc Jemnoschi","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences I, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Ludu\u0219anu","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences I, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Bu\u0219il\u0103","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences I, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodor","family":"Stamate","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burn Unit, \u201cSf. Spiridon\u201d Emergency Clinical Hospital, 700111 Ia\u015fi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristinel Ionel","family":"Stan","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences I, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.burns.2013.08.013","article-title":"A novel rapid and selective enzymatic debridement agent for burn wound management: A multi-center RCT","volume":"40","author":"Rosenberg","year":"2014","journal-title":"Burns"},{"key":"ref_2","unstructured":"Herndon, D.N. (2018). Total Burn Care, Elsevier Health Sciences. [5th ed.]."},{"key":"ref_3","unstructured":"Stamate, T. (2002). 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