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Intriguingly, lunar rocks contain a hundred times less zinc and ten times less potassium than the Earth\u2019s crust; the Moon is also depleted in other moderately volatile elements (MVEs). Current theories of impact formation of the Moon attribute this depletion to the MVEs still being in a gaseous state when the hot post-impact disk contracted and separated from the nascent Moon. The MVEs then fell out onto juvenile Earth\u2019s protocrust; zinc, as the most volatile metal, precipitated last, just after potassium. According to our calculations, the top layer of the protocrust must have contained up to 1019 kg of metallic zinc, a powerful reductant. The venting of hot geothermal fluids through this MVE-fallout layer, rich in metallic zinc and radioactive potassium, both capable of reducing carbon dioxide and dinitrogen, must have yielded a plethora of organic molecules released with the geothermal vapor. In the pools of vapor condensate, the RNA-like molecules may have emerged through a pre-Darwinian selection for low-volatile, associative, mineral-affine, radiation-resistant, nitrogen-rich, and polymerizable molecules.<\/jats:p>","DOI":"10.3390\/life15030399","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T03:26:21Z","timestamp":1741058781000},"page":"399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?"],"prefix":"10.3390","volume":"15","author":[{"given":"Armen Y.","family":"Mulkidjanian","sequence":"first","affiliation":[{"name":"Department of Physics, Osnabrueck University, D-49069 Osnabrueck, Germany"},{"name":"Center of Cellular Nanoanalytics, Osnabrueck University, D-49069 Osnabrueck, Germany"},{"name":"School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119992 Moscow, Russia"},{"name":"Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-6437","authenticated-orcid":false,"given":"Daria V.","family":"Dibrova","sequence":"additional","affiliation":[{"name":"School of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119992 Moscow, Russia"},{"name":"Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey Y.","family":"Bychkov","sequence":"additional","affiliation":[{"name":"School of Geology, Lomonosov Moscow State University, 119992 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"ref_1","unstructured":"Huxley, T.H. 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