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However, a growing body of literature explores ANXA2\u2019s involvement in neurodegenerative processes. The evidence suggests a potential contribution of ANXA2 to the pathogenesis of primary and secondary tauopathies, as well as Parkinson\u2019s disease. It is crucial to note that the majority of these findings are correlative and necessitate further experimental validation. This review therefore presents a comprehensive analysis of data pertaining to ANXA2\u2019s involvement in various cellular processes, the disruption of which contributes to neurological pathologies.<\/jats:p>","DOI":"10.3390\/life15030402","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T10:43:31Z","timestamp":1741085011000},"page":"402","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["ANXA2 Protein and Its Role in Neurodegeneration Processes"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7691-7796","authenticated-orcid":false,"given":"Suzanna A.","family":"Partevian","sequence":"first","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr A.","family":"Slominsky","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Shadrina","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-4491","authenticated-orcid":false,"given":"Anelya Kh.","family":"Alieva","sequence":"additional","affiliation":[{"name":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatova Sq., 123182 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic mechanisms of neurodegeneration: A critical update","volume":"14","author":"Jellinger","year":"2010","journal-title":"J. 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