{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:01:00Z","timestamp":1760058060794,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T00:00:00Z","timestamp":1741478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Ductal carcinoma in situ (DCIS) is a precursor of invasive breast cancer and its early diagnosis and treatment are essential to prevent progression and recurrences. Risk stratification guidelines, such as the Van Nuys Prognostic Index (VNPI) and those by the National Comprehensive Cancer Network (NCCN), help guide appropriate treatment. This study compares VNPI recommendations for DCIS patients treated at Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo (HSPE) with NCCN guidelines, focusing on treatment conducted and recurrence rates. Methods: This retrospective, cross-sectional study reviewed medical records of 145 patients treated for DCIS at HSPE between January 1996 and June 2022, with a mean follow-up of 60.3 months. Results: Based on VNPI, 38.8% were low risk, 53.2% intermediate risk, and 7.8% high risk. NCCN guidelines classified only 12.9% as low risk and 87.1% as high risk. Treatment included breast-conserving surgery (BCS) with radiotherapy (43.1%), BCS alone (38.8%), and mastectomy (18.1%). There were 18 recurrences (15.5%): 5.2% as DCIS and 10.3% as invasive cancer. Of these recurrences, 5.6% occurred in patients who, according to NCCN, would have received BCS with radiotherapy or mastectomy. Conclusion: By integrating the VNPI with NCCN treatment guidelines, the NCCN\u2019s recommendations could potentially reduce local recurrence rates by 5.6%. However, further studies are necessary to evaluate the long-term impact of these guidelines on overall survival outcomes.<\/jats:p>","DOI":"10.3390\/life15030432","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T08:46:41Z","timestamp":1741596401000},"page":"432","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analyses of Van Nuys Prognostic Index and NCCN Guidelines in Ductal Carcinoma In Situ Treatment in a Brazilian Hospital"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1996-7428","authenticated-orcid":false,"given":"Marcelo","family":"Antonini","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Hospital do Servidor P\u00fablico Estadual Francisco Morato de Oliveira, Sao Paulo 04039-000, SP, Brazil"},{"name":"Centro de Desenvolvimento de Ensino e Pesquisa do Instituo de Assist\u00eancia M\u00e9dica ao Servidor P\u00fablico Estadual (CEDEP-IAMSPE), Sao Paulo 04039-000, SP, Brazil"},{"name":"BBREAST\u2014Brazilian Breast Association Team, Sao Paulo 01258-011, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9053-9784","authenticated-orcid":false,"given":"Raissa","family":"Barros Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Hospital do Servidor P\u00fablico Estadual Francisco Morato de Oliveira, Sao Paulo 04039-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5973-623X","authenticated-orcid":false,"given":"Andr\u00e9","family":"Mattar","sequence":"additional","affiliation":[{"name":"BBREAST\u2014Brazilian Breast Association Team, Sao Paulo 01258-011, SP, Brazil"},{"name":"Department of Breast Surgery, Centro de Refer\u00eancia da Sa\u00fade da Mulher\u2014Hospital da Mulher, Sao Paulo 01206-001, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Pollone","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Hospital do Servidor P\u00fablico Estadual Francisco Morato de Oliveira, Sao Paulo 04039-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7516-0215","authenticated-orcid":false,"given":"Marina Di\u00f3genes","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Centro de Refer\u00eancia da Sa\u00fade da Mulher\u2014Hospital da Mulher, Sao Paulo 01206-001, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa Gon\u00e7alves","family":"Amorim","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Centro de Refer\u00eancia da Sa\u00fade da Mulher\u2014Hospital da Mulher, Sao Paulo 01206-001, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odair","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Hospital do Servidor P\u00fablico Estadual Francisco Morato de Oliveira, Sao Paulo 04039-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Chrispim","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Centro de Refer\u00eancia da Sa\u00fade da Mulher\u2014Hospital da Mulher, Sao Paulo 01206-001, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcellus do Nascimento Moreira","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Centro de Refer\u00eancia da Sa\u00fade da Mulher\u2014Hospital da Mulher, Sao Paulo 01206-001, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-2890","authenticated-orcid":false,"given":"Francisco Pimentel","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Hospital Geral de Fortaleza, Fortaleza 60150-160, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1643-727X","authenticated-orcid":false,"given":"Felipe","family":"Zerwes","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Medical School of the Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, RS, Brazil"},{"name":"Department of Breast Surgery, Oncocl\u00ednicas, Porto Alegre 90570-020, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9429-3067","authenticated-orcid":false,"given":"Marcelo","family":"Madeira","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein, Sao Paulo 05653-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-6324","authenticated-orcid":false,"given":"Eduardo de Camargo","family":"Millen","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Americas Oncologia, Rio de Janeiro 22793-080, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Luiz","family":"Frasson","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Hospital Albert Einstein, Sao Paulo 05651-901, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio Palermo","family":"Brenelli","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Universidade Estadual de Campinas (UNICAMP), Campinas 13082-859, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1418-0295","authenticated-orcid":false,"given":"Gil","family":"Facina","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Universidade Federal de Sao Paulo, Sao Paulo 04023-062, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-4461","authenticated-orcid":false,"given":"Henrique Lima","family":"Couto","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, REDIMAMA-REDIMASTO, Belo Horizonte 30110-022, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-9191","authenticated-orcid":false,"given":"Luiz Henrique","family":"Gebrim","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Hospital Beneficiencia Portuguesa, Sao Paulo 01438-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,9]]},"reference":[{"key":"ref_1","unstructured":"Instituto Nacional do C\u00e2ncer (INCA) (2024, November 12). 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Oncol."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/3\/432\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:49:43Z","timestamp":1760028583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/3\/432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,9]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["life15030432"],"URL":"https:\/\/doi.org\/10.3390\/life15030432","relation":{},"ISSN":["2075-1729"],"issn-type":[{"type":"electronic","value":"2075-1729"}],"subject":[],"published":{"date-parts":[[2025,3,9]]}}}