{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:08:55Z","timestamp":1764688135603,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cDunarea de Jos\u201d University of Galati"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Psoriasis is one of the most frequent immune-mediated chronic inflammatory cutaneous disease that exerts a considerable psychological impact, including low self-esteem, stigmatization, and depression. In recent years, biologic therapies have substantially transformed the therapeutic landscape for individuals with moderate-to-severe psoriasis, shifting treatment towards a more targeted and personalized approach. Seborrheic keratoses (SKs) are common benign skin lesions, and their association with psoriasis and biologic therapy remains poorly understood. Our retrospective study evaluated a small cohort of patients with moderate-to-severe psoriasis undergoing biologic therapy at a tertiary dermatology center in Southeastern Europe to evaluate potential correlations with SK development. Smokers had fewer SKs, whereas postmenopausal women and osteoporosis patients had significantly higher SK counts, implicating hormonal influences. PUVA therapy was linked to an increased SK count, whereas UVB and methotrexate treatments had a lesser effect. These findings suggest that biologic therapy and systemic factors may influence SK development, emphasizing the need for further prospective research.<\/jats:p>","DOI":"10.3390\/life15030485","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T15:24:56Z","timestamp":1742225096000},"page":"485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Psoriasis and Seborrheic Keratoses: Insights from Biologic Therapy and Skin Imaging"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3029-9245","authenticated-orcid":false,"given":"Florin Ciprian","family":"Bujoreanu","sequence":"first","affiliation":[{"name":"Department of Dermatology, \u201cSaint Parascheva\u201d Infectious Disease Clinical Hospital, 800179 Galati, Romania"},{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Sabina","family":"Radaschin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \u201cSaint Parascheva\u201d Infectious Disease Clinical Hospital, 800179 Galati, Romania"},{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-3270","authenticated-orcid":false,"given":"Mihail Alexandru","family":"Badea","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Medicine, Pharmacy, Science and Technology \u201cGeorge Emil Palade\u201d of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Bujoreanu Bezman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Panti\u0219","sequence":"additional","affiliation":[{"name":"Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 1 University Street, 410087 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Tiutiuca","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7602-8435","authenticated-orcid":false,"given":"Liliana","family":"Baroiu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9249-5247","authenticated-orcid":false,"given":"Elena","family":"Nicule\u021b","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-7284","authenticated-orcid":false,"given":"Alina","family":"Ple\u0219ea Condratovici","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-7068","authenticated-orcid":false,"given":"Alin Lauren\u021biu","family":"Tatu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, \u201cSaint Parascheva\u201d Infectious Disease Clinical Hospital, 800179 Galati, Romania"},{"name":"Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"},{"name":"Multidisciplinary Integrated Centre of Dermatological Interface Research (MICDIR), \u201cDunarea de Jos\u201d University of Galati, 800385 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.clindermatol.2007.08.007","article-title":"Psoriasis: Epidemiology","volume":"25","author":"Gudjonsson","year":"2007","journal-title":"Clin. 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