{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:03:28Z","timestamp":1760058208590,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Introduction: The management of sedation during percutaneous endoscopic gastrojejunostomy (PEG-J) placement in patients with advanced Parkinson\u2019s disease (PD) is challenging due to the complex interactions between PD treatment, anesthetic agents, and the disease\u2019s motor and non-motor symptoms. This study evaluates the effectiveness and safety of a target-controlled infusion (TCI) propofol protocol in the context of PEG-J placement in advanced PD patients. Materials and Methods: This prospective study included 169 patients diagnosed with advanced Parkinson\u2019s disease (Hoehn and Yahr stages 4 and 5) who underwent PEG-J placement at T\u00e2rgu Mure\u0219 County Emergency Clinical Hospital, Romania. Sedation was induced and maintained using TCI propofol, with additional benzodiazepines and short-acting opioids, while muscle relaxants were not used. Procedural success rates and adverse outcomes were assessed for 30 days post-procedure. Results: The sedation protocol demonstrated a high procedural success rate. No deaths were reported within 30 days post-procedure. Conclusion: This study highlights the feasibility and clinical applicability of a TCI propofol protocol for PEG-J placement in patients with advanced PD (stages 4 and 5). While no deaths were recorded within the 30-day follow-up, the sample size is insufficient to draw definitive conclusions regarding long-term safety.<\/jats:p>","DOI":"10.3390\/life15030492","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T07:20:00Z","timestamp":1742282400000},"page":"492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Target-Controlled Sedation with Propofol Infusion for PEG-J Placement in Advanced Parkinson\u2019s Disease: A Prospective Observational Study on Safety and Feasibility"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9359-6058","authenticated-orcid":false,"given":"Janos","family":"Szederjesi","sequence":"first","affiliation":[{"name":"Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-3644","authenticated-orcid":false,"given":"Irina","family":"S\u0103pl\u0103can","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Laz\u0103r","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matild","family":"Keresztes","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8078-2177","authenticated-orcid":false,"given":"Georgiana-Mihaela","family":"Muller-\u0218erban","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-036X","authenticated-orcid":false,"given":"Jozsef Attila","family":"Szasz","sequence":"additional","affiliation":[{"name":"2nd Clinic of Neurology, T\u00e2rgu Mures, County Emergency Clinical Hospital, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Liana","family":"Grigorescu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, George Emil Palade University of Medicine, Pharmacy, Science and Technology of T\u00e2rgu-Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.14108","article-title":"Parkinson disease","volume":"27","author":"Balestrino","year":"2020","journal-title":"Eur. 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