{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:02:04Z","timestamp":1760058124790,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Rennova\u00ae"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Lip augmentation using hyaluronic acid (HA) fillers has become one of the most popular non-surgical aesthetic procedures, yet it is not without risks, particularly vascular complications. This study explores a novel vertical injection technique for submucosal placement of HA fillers, designed to enhance safety and achieve natural-looking outcomes. Ten patients underwent lip augmentation using the proposed technique, which involved ultrasound-guided injections at predefined entry points to target intralabial compartments while minimizing the risk of labial artery injury. The results demonstrated high patient satisfaction, with significant improvements in lip volume and contour. The submucosal placement yielded subtle, natural results with fewer visible irregularities compared to superficial injections. No major complications, such as vascular occlusion, were observed, and minor side effects, including transient swelling and redness, resolved within 48 h. The use of ultrasound imaging allowed precise filler placement and reduced the risks associated with traditional horizontal injection paths parallel to the labial arteries. While the findings highlight the technique\u2019s potential in terms of safety and efficacy, limitations include the small sample size, short-term follow-up, and the absence of a control group. Further studies with larger cohorts and comparative analyses are needed to validate long-term outcomes. This innovative approach underscores the importance of anatomical precision and advanced imaging technologies in enhancing safety and aesthetic outcomes in lip augmentation.<\/jats:p>","DOI":"10.3390\/life15040509","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:25:00Z","timestamp":1742541900000},"page":"509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Navigating the Labial Artery: A Safer Approach to Submucosal Lip Filler Techniques"],"prefix":"10.3390","volume":"15","author":[{"given":"Bruna S. F.","family":"Bravo","sequence":"first","affiliation":[{"name":"Department of Dermatology, Bravo Private Clinic, Avenida Ataulfo de Paiva 245 Quinto Andar Leblon, Rio de Janeiro 20440-032, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo G.","family":"Bravo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bravo Private Clinic, Avenida Ataulfo de Paiva 245 Quinto Andar Leblon, Rio de Janeiro 20440-032, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz G.","family":"Cornachini","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bravo Private Clinic, Avenida Ataulfo de Paiva 245 Quinto Andar Leblon, Rio de Janeiro 20440-032, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana C.","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bravo Private Clinic, Avenida Ataulfo de Paiva 245 Quinto Andar Leblon, Rio de Janeiro 20440-032, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel L. T.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bravo Private Clinic, Avenida Ataulfo de Paiva 245 Quinto Andar Leblon, Rio de Janeiro 20440-032, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"ref_1","unstructured":"Plastic Surgery Statistics (2024, July 06). American Society of Plastic Surgeons. Available online: https:\/\/www.plasticsurgery.org\/news\/plastic-surgery-statistics."},{"key":"ref_2","unstructured":"Research, S. (2024, July 06). Lip Augmentation Market Size, Demand and Trends Analysis Report 2031. Available online: https:\/\/straitsresearch.com\/report\/lip-augmentation-market."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/asj\/sjad039","article-title":"Current Status of Early Complications Caused by Hyaluronic Acid Fillers: Insights From a Descriptive, Observational Study of 41,775 Cases","volume":"43","author":"Nishikawa","year":"2023","journal-title":"Aesthetic Surg. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00266-023-03465-1","article-title":"Adverse Events Associated with Hyaluronic Acid Filler Injection for Non-surgical Facial Aesthetics: A Systematic Review of High Level of Evidence Studies","volume":"48","author":"Kyriazidis","year":"2024","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_5","first-page":"E65","article-title":"Vascular Complications after Facial Filler Injection: A Literature Review and Meta-analysis","volume":"12","author":"Sito","year":"2019","journal-title":"J. Clin. 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