{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T18:33:17Z","timestamp":1771785197409,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Introduction: Chronic osteomyelitis is a persistent infection of the bone that poses significant challenges, particularly when associated with pathological fractures and extensive bone defects. This case report highlights the application of Masquelet\u2019s induced membrane technique (MIMT) in managing a complex distal femur defect in a 50-year-old male with a long-standing history of chronic osteomyelitis. The patient presented with a non-union fracture, severe osseous destruction, and infection, requiring a multidisciplinary approach. Case report: The first stage involved radical debridement of necrotic tissue and stabilization with a titanium plate and an antibiotic-impregnated polymethylmethacrylate spacer to induce a bioactive membrane. The second stage, performed 30 days later, after infection resolution, entailed removing the spacer, harvesting an autologous iliac crest bone graft, and filling the defect within the preserved membrane. Postoperative care included a tailored antibiotic regimen and gradual weight-bearing, leading to favorable clinical and radiological outcomes. Conclusions: This case demonstrates the utility of MIMT in reconstructing extensive bone defects while addressing infection. The technique provides a reliable and effective alternative to amputation, offering high success rates and functional restoration in complex cases.<\/jats:p>","DOI":"10.3390\/life15040537","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T12:18:52Z","timestamp":1742905132000},"page":"537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of the Masquelet Technique in the Treatment of Pathological Distal Third Femoral Fracture Secondary to Chronic Osteomyelitis"],"prefix":"10.3390","volume":"15","author":[{"given":"Razvan Cosmin","family":"Tudor","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"\u201cDr. Iacob Czihac\u201d Military Emergency Clinical Hospital, 700483 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-874X","authenticated-orcid":false,"given":"Daniel Vasile","family":"Timofte","sequence":"additional","affiliation":[{"name":"Department of Surgery, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"\u201cSfantul Spiridon\u201d Emergency County Clinical Hospital, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5637-2095","authenticated-orcid":false,"given":"Norin","family":"Forna","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Medical Rehabilitation, 700661 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7050-8430","authenticated-orcid":false,"given":"Oana Viola","family":"Badulescu","sequence":"additional","affiliation":[{"name":"\u201cSfantul Spiridon\u201d Emergency County Clinical Hospital, 700111 Iasi, Romania"},{"name":"Department of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Savin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Medical Rehabilitation, 700661 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7664-0918","authenticated-orcid":false,"given":"Tudor","family":"Pinteala","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Medical Rehabilitation, 700661 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Mihailescu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tudor","family":"Ciobotariu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alin","family":"Ciobica","sequence":"additional","affiliation":[{"name":"\u201cIoan Haulica\u201d Institute, Apollonia University, 700511 Iasi, Romania"},{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania"},{"name":"Center of Biomedical Research, Romanian Academy, 700506 Iasi, Romania"},{"name":"Academy of Romanian Scientists, 050094 Bucuresti, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihnea Theodor","family":"Sirbu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"\u201cSfantul Spiridon\u201d Emergency County Clinical Hospital, 700111 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-0649","authenticated-orcid":false,"given":"Paul Dan","family":"Sirbu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Surgical Science (II), Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Clinical Hospital of Medical Rehabilitation, 700661 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-1684","authenticated-orcid":false,"given":"Serban","family":"Dragosloveanu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, The \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Orthopaedics, \u201cFoisor\u201d Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan Sorin","family":"Capitanu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, \u201cFoisor\u201d Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romica","family":"Cergan","sequence":"additional","affiliation":[{"name":"Department of Anatomy, The \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Radiology and Medical Imaging, \u201cFoisor\u201d Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-6393","authenticated-orcid":false,"given":"Cristian","family":"Scheau","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, \u201cFoisor\u201d Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania"},{"name":"Department of Physiology, The \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1302\/2058-5241.1.000017","article-title":"Chronic osteomyelitis: What the surgeon needs to know","volume":"1","author":"Panteli","year":"2016","journal-title":"EFORT Open Rev."},{"key":"ref_2","unstructured":"Momodu, I.I., and Savaliya, V. 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