{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:01:31Z","timestamp":1778943691526,"version":"3.51.4"},"reference-count":23,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Provincial Secretariat for Higher Education and Scientific Research, AP Vojvodina","award":["003056005 2024 09418 003 000 000 001"],"award-info":[{"award-number":["003056005 2024 09418 003 000 000 001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Peppers (Capsicum spp.) represent not only a plant with a demonstrated history of diverse medicinal applications but also a species having non-neglectable adverse effects potential. \u201cChili burn\u201d or Hunan hand syndrome represents a type of contact dermatitis rarely appearing after using chili peppers. Here, a case of \u201cchili burn\u201d with no specific treatments or sequelae is presented. A young woman presented with contact dermatitis after first- and second-time dermal exposure to a chili pepper. A strong burning sensation appeared shortly after on the hands and around the mouth after exposure to the plant. The patient applied non-specific measures (hand washing with mild soap and rinsing the affected areas with acidic solutions) with minor improvement; finally, the \u201cchili burn\u201d resolved itself. No other medicines were applied, and no consequences were recorded. Although rare, the use of chili pepper has the potential to cause contact dermatitis. The awareness of medical professionals of this entity should provide adequate diagnosis and treatment for patients.<\/jats:p>","DOI":"10.3390\/life15040539","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T04:17:14Z","timestamp":1742962634000},"page":"539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cChili Burn\u201d\u2014A Case Report of Contact Dermatitis Caused by Capsicum Peppers"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-4785","authenticated-orcid":false,"given":"Maja","family":"Hitl","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Center for Medical and Pharmaceutical Investigations and Quality Control, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-8340","authenticated-orcid":false,"given":"Katarina","family":"Radovanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5781-6412","authenticated-orcid":false,"given":"Neboj\u0161a","family":"Kladar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Center for Medical and Pharmaceutical Investigations and Quality Control, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/10915810601163939","article-title":"Final Report on the Safety Assessment of Capsicum annuum Extract, Capsicum annuum Fruit Extract, Capsicum annuum Resin, Capsicum annuum Fruit Powder, Capsicum frutescens Fruit, Capsicum frutescens Fruit Extract, Capsicum frutescens Resin, and Capsaicin","volume":"26","author":"Johnson","year":"2007","journal-title":"Int. J. Toxicol."},{"key":"ref_2","unstructured":"European Medicines Agency (EMA) (2024, October 07). Capsicum, Capsicum annuum L. var. minimum (Miller) Heiser and Small Fruited Varieties of Capsicum frutescens L., Fructus, EMA\/331421\/2015. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/herbal-summary\/capsicum-summary-public_en.pdf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3390\/molecules16021253","article-title":"Chemical and pharmacological aspects of capsaicin","volume":"16","year":"2011","journal-title":"Molecules"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Basith, S., Cui, M., Hong, S., and Choi, S. (2016). Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases. Molecules, 21.","DOI":"10.3390\/molecules21080966"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejphar.2013.10.053","article-title":"Mechanisms and clinical uses of capsaicin","volume":"720","author":"Sharma","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Siebert, E., Lee, S.Y., and Prescott, M.P. (2022). Chili pepper preference development and its impact on dietary intake: A narrative review. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1039207"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zhang, C., Ma, W., Chen, Z., He, C., Zhang, Y., and Tao, Q. (2022). The Association between Spicy Food Consumption and Psychological Health in Chinese College Students: A Cross-Sectional Study. Nutrients, 14.","DOI":"10.3390\/nu14214508"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e1547","DOI":"10.1002\/wsbm.1547","article-title":"The sense of taste: Development, regeneration, and dysfunction","volume":"14","author":"Barlow","year":"2022","journal-title":"WIREs Mech. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3109\/15563658708992659","article-title":"Capsicum and capsaicin\u2014A review: Case report of the use of hot peppers in child abuse","volume":"25","author":"Tominack","year":"1987","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"ref_10","first-page":"542","article-title":"Clinicopathological effects of pepper (oleoresin capsicum) spray","volume":"21","author":"Yeung","year":"2015","journal-title":"Hong Kong Med. J."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Haar, R.J., Iacopino, V., Ranadive, N., Weiser, S.D., and Dandu, M. (2017). Health impacts of chemical irritants used for crowd control: A systematic review of the injuries and deaths caused by tear gas and pepper spray. BMC Public Health, 17.","DOI":"10.1186\/s12889-017-4814-6"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1056\/NEJM198110223051718","article-title":"Hunan hand","volume":"305","author":"Weinberg","year":"1981","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0196-0644(95)70188-5","article-title":"Contact dermatitis associated with capsaicin: Hunan hand syndrome","volume":"25","author":"Williams","year":"1995","journal-title":"Ann. Emerg. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1533-2500.2012.00567.x","article-title":"Multimodal approach for the management of Hunan hand syndrome: A case report","volume":"13","author":"Saxena","year":"2013","journal-title":"Pain Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/cod.12345","article-title":"Occupational allergic contact dermatitis caused by Capsicum","volume":"72","author":"Lambrecht","year":"2015","journal-title":"Contact Dermat."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Perrier, A., Amazan, E., Habibourahimane, T., and Olivier, N. (2024). Hunan hand syndrome managed in the intensive care unit. Indian J. Dermatol. Venereol. Leprol.","DOI":"10.25259\/IJDVL_427_2024"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-0536.1997.tb00326.x","article-title":"Occupational contact urticaria from paprika","volume":"37","author":"Foti","year":"1997","journal-title":"Contact Dermat."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.aller.2012.12.006","article-title":"Anaphylactic reaction to bell pepper (Capsicum annuum) in a patient with a latex-fruit syndrome","volume":"42","author":"Ledesma","year":"2014","journal-title":"Allergol. Immunopathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1056\/NEJM198201213060321","article-title":"Treatment of Hunan hand","volume":"306","author":"Vogl","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0196-0644(95)70026-9","article-title":"Relief of capsaicin contact dermatitis","volume":"26","author":"Anderson","year":"1995","journal-title":"Ann. Emerg. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1111\/1750-3841.17221","article-title":"Fat, protein, and temperature each contribute to reductions in capsaicin oral burn","volume":"89","author":"Gaiser","year":"2024","journal-title":"J. Food Sci."},{"key":"ref_22","first-page":"1210","article-title":"Effects of Herbal Medicines on the Prevention and Treatment of Contact Dermatitis: A Systematic Review","volume":"51","author":"Rastegar","year":"2022","journal-title":"Iran. J. Public Health"},{"key":"ref_23","first-page":"148","article-title":"Contact dermatitis to botanical extracts","volume":"13","author":"Kiken","year":"2002","journal-title":"Am. J. Contact Dermat."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/4\/539\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:00:20Z","timestamp":1760029220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/4\/539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,26]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["life15040539"],"URL":"https:\/\/doi.org\/10.3390\/life15040539","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,26]]}}}