{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:16:42Z","timestamp":1790572602966,"version":"4.1.0"},"reference-count":57,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Introduction: Recombinant human collagen, developed through advanced recombinant DNA technology, has emerged as a cutting-edge biomaterial with diverse applications in medicine. It addresses significant limitations of animal-derived collagens, such as immunogenicity and the risk of zoonotic diseases. Objective: This review evaluates the clinical applications, benefits, and challenges associated with recombinant human collagen, focusing on its potential to transform medical and surgical practices. Methods: A comprehensive search was conducted in MEDLINE, PubMed, and Ovid databases using keywords such as \u201cRecombinant Human Collagen\u201d, \u201cCollagen-Based Biomaterials\u201d, \u201cClinical Applications\u201d, \u201cTissue Repair\u201d, and \u201cWound Healing\u201d. Relevant studies, including clinical trials and diagnostic applications, were analyzed and classified according to the Oxford Centre for Evidence-Based Medicine evidence hierarchy. Findings: Recombinant human collagen demonstrates superior mechanical properties and controlled degradation rates compared to traditional collagen sources. Clinical studies highlight its effectiveness in accelerating wound closure, promoting dermal regeneration, and minimizing scarring, making it particularly valuable in chronic wound management and surgical interventions. In tissue engineering, recombinant human collagen scaffolds have shown potential for regenerating cartilage, bone, and cardiovascular tissues by supporting cell proliferation, differentiation, and matrix deposition. Additionally, its adaptability for forming hydrogels and matrices enhances its suitability for drug delivery systems, enabling controlled and sustained release of therapeutic agents. Conclusion: Recombinant human collagen represents a transformative advancement in clinical practice, providing a safer and more effective alternative to traditional collagen sources. Its demonstrated success in wound healing, tissue engineering, and drug delivery highlights its potential to significantly improve patient outcomes. However, challenges such as high production costs, regulatory complexities, and long-term biocompatibility remain barriers to widespread clinical adoption. Further research and collaboration between biotechnology developers and regulatory authorities are essential to fully realize its clinical potential.<\/jats:p>","DOI":"10.3390\/life15040582","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T07:47:44Z","timestamp":1743580064000},"page":"582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7916-0695","authenticated-orcid":false,"given":"Isaac Wong Kai","family":"Jie","sequence":"first","affiliation":[{"name":"The Artisan Clinic, 435 Orchard Road, #20-03, Singapore 238877, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4082-5395","authenticated-orcid":false,"given":"Kar Wai Alvin","family":"Lee","sequence":"additional","affiliation":[{"name":"EverKeen Medical Centre, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Eun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Brandnew Aesthetic Surgery Clinic, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Keun","family":"Song","sequence":"additional","affiliation":[{"name":"Pixelab Plastic Surgery Clinic, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Kwin Wah","family":"Chan","sequence":"additional","affiliation":[{"name":"EverKeen Medical Centre, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk Hung","family":"Lee","sequence":"additional","affiliation":[{"name":"EverKeen Medical Centre, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunji","family":"Jeong","sequence":"additional","affiliation":[{"name":"College of Medicine, Central Michigan University, Saginaw, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"You & I Clinic, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-1364","authenticated-orcid":false,"given":"Kyu-Ho","family":"Yi","sequence":"additional","affiliation":[{"name":"You & I Clinic, Seoul, Republic of Korea"},{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","article-title":"Collagen structure and stability","volume":"78","author":"Shoulders","year":"2009","journal-title":"Annu. 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