{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:19:33Z","timestamp":1767374373629,"version":"build-2065373602"},"reference-count":101,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vietnam Ministry of Education and Training","award":["B2023-TNA-25"],"award-info":[{"award-number":["B2023-TNA-25"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Phytochemical investigation of the methanol extract of Embelia parviflora Wall. Ex A. DC. leaves (Primulaceae family) led to the isolation of sixteen compounds including three sterols (1\u20133), one triterpene (4), four flavonoids (5\u20138), four megastigmanes (9\u201312), three phenolic compounds (13\u201315), and one furan derivative (16). Their chemical structures were determined based on ESI-MS and NMR spectral data. This is the first chemical study of E. parviflora. Compounds 3, 8\u201313, and 16 were found in the Embelia genus for the first time. Compounds 9\u201311, 13, and 16 represent the first isolation from the Primulaceae family. In the \u03b1-glucosidase activity assay, MeOH extract, compounds 4 and 5 strongly inhibited enzyme \u03b1-glucosidase activity. A molecular docking study revealed that compounds 4 and 5 showed different interactions with enzyme \u03b1-glucosidase.<\/jats:p>","DOI":"10.3390\/life15050680","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:22:08Z","timestamp":1745295728000},"page":"680","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chemical Constituents and \u03b1-Glucosidase Inhibitory Activities of the Leaves of Embelia parviflora\u2014In Vitro and In Silico Studies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8636-1370","authenticated-orcid":false,"given":"Sy Danh","family":"Thuong","sequence":"first","affiliation":[{"name":"Faculty of Biology, Thai Nguyen University of Education, Thai Nguyen University, Thai Nguyen 250000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai Thi Hoang","family":"Anh","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Thai Nguyen University of Education, Thai Nguyen University, Thai Nguyen 250000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Van","family":"Phuong","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacognosy and Traditional Medicine, Hanoi University of Pharmacy, Hanoi 10000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-6369","authenticated-orcid":false,"given":"Chu Hoang","family":"Mau","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Thai Nguyen University of Education, Thai Nguyen University, Thai Nguyen 250000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-746X","authenticated-orcid":false,"given":"Nguyen Huu","family":"Quan","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Thai Nguyen University of Education, Thai Nguyen University, Thai Nguyen 250000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7552-6469","authenticated-orcid":false,"given":"Nguyen Thanh","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Dai Nam University, Hanoi 10000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8375-4187","authenticated-orcid":false,"given":"Le Nguyen","family":"Thanh","sequence":"additional","affiliation":[{"name":"National Institute of Medicinal Materials, Ministry of Health, Hanoi 10000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12225-015-9570-0","article-title":"A synopsis of the genus Embelia in peninsular Malaysia and Singapore. 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