{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:11:25Z","timestamp":1760058685706,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Eye Institute","doi-asserted-by":"publisher","award":["1P30EY026877-22A1"],"award-info":[{"award-number":["1P30EY026877-22A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>This is the studyto investigate the correlation between macular cone density (MCD) and flicker electroretinogram (ERG) response in healthy eyes. In this exploratory study, 23 eyes from 12 healthy subjects were enrolled in this study. The fixed-luminance flicker full-field electroretinogram (ffERG) responses of the retina and MCDs at 24 locations were measured using the Diopsys\u00ae NOVA\u2122 system and the rtx1 adaptive optics retinal camera, respectively. Regression analysis was employed to evaluate the correlations. The mean age of the subjects was 30 \u00b1 3 years. The average magnitudes of the flicker response and phase response were 13.44 \u00b1 4.88 \u03bcV and 332.63 \u00b1 22.12\u00b0, respectively. The MCDs for all 24 locations were 15,043 \u00b1 3511 cones\/mm\u00b2. Among all locations, regression analysis revealed a significant correlation only at one specific location (0, \u22124\u00b0) between cone density and both the mean magnitude and phase of the flicker response, with p-values of 0.005 and 0.004, respectively.In conclusion, we identified a significant correlation between MCD and ffERG responses at a specific retinal locus (0, \u22124\u00b0). This finding may be attributed to the distribution of different cone types throughout the retina and the possibility that various cone types may contribute differently to ERG. Further studies are required to investigate this finding.<\/jats:p>","DOI":"10.3390\/life15050694","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T08:08:41Z","timestamp":1745482121000},"page":"694","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation Between Fixed-Luminance Flicker Full-Field Electroretinogram Response and Macular Cone Density in Healthy Individuals"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5996-730X","authenticated-orcid":false,"given":"S. Saeed","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2279-2929","authenticated-orcid":false,"given":"Woong-Sun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA"},{"name":"Department of Ophthalmology, College of Medicine, Gyeongsang National University, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negin","family":"Yavari","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9407-5764","authenticated-orcid":false,"given":"Hassan","family":"Khojasteh Jafari","sequence":"additional","affiliation":[{"name":"Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Or","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azadeh","family":"Mobasserian","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, 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Ulaanbaatar 16050, Mongolia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trung Ba","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA"},{"name":"The Department of Ophthalmology, Viet Nam National Children\u2019s Hospital, Hanoi 11512, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0444-224X","authenticated-orcid":false,"given":"Anadi","family":"Khatri","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA"},{"name":"Department of Ophthalmology, Birat Medical College and Teaching Hospital, Kathmandu University, Biratnagar 45200, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng Xian","family":"Thng","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA"},{"name":"National Healthgroup Eye Institute, Tan Tock Seng Hospital, Singapore 308433, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Do","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan Dong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Spencer Center for Vision Research, Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA 94303, 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Express"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/5\/694\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:20:44Z","timestamp":1760030444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/15\/5\/694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["life15050694"],"URL":"https:\/\/doi.org\/10.3390\/life15050694","relation":{},"ISSN":["2075-1729"],"issn-type":[{"type":"electronic","value":"2075-1729"}],"subject":[],"published":{"date-parts":[[2025,4,24]]}}}