{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:19:08Z","timestamp":1779164348163,"version":"3.51.4"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background. Skin contact with items containing p-tert-butylphenol-formaldehyde resin (PTBP-FR) may induce sensitization and allergic contact dermatitis (ACD). Methods. This multi-centric cross-sectional study investigated the prevalence of sensitization to PTBP-FR in 30,629 consecutive outpatients patch-tested during 1997\u20132021 in four research centers from Northern Italy: Padua; Pordenone; Trieste; and Trento\/Bolzano\/Rovigo. Patch tests were applied on the upper back of patients with suspected ACD. All patches were removed after 48 h and read at 72 or 96 h. Results. The overall prevalence of PTBP-FR sensitization was 1.11% (=341\/30,629) of cases, with lower prevalence occurring in the Province of Trento\/Bolzano\/Rovigo (0.36%). The body area most frequently affected were the hands (36.32%), followed by face (19.52%) and legs (8.09%). During 1997\u20132004, the prevalence of PTBP-FR positivity was significantly lower in Trento\/Bolzano\/Rovigo (aOR = 0.19; 95%CI: 0.11; 0.35), whereas it was higher among restaurant workers (aOR = 2.44; 95%CI: 1.44; 4.13). During the entire study period (1997\u20132021), excluding Trento\/Bolzano\/Rovigo, PTBP-FR positivity significantly decreased in the period 2011\u20132021 (aOR = 052; 95%CI: 0.39; 0.69) compared to 1997\u20132010 in males (OR = 0.69; 95%CI: 0.52; 0.91). Conclusions. Females were likely to react to PTBP-FR at patch tests. Prevalence of PTBP-FR sensitization significantly decreased over time, possibly reflecting reduced occupational and non-occupational exposure due to replacement of the resin with other adhesive products (acrylates or epoxy agents).<\/jats:p>","DOI":"10.3390\/life15050698","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T08:02:57Z","timestamp":1745568177000},"page":"698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Epidemiological and Occupational Pattern of Patch-Test Reactions to p-Tert-butylphenol-formaldehyde Resin in North-Eastern Italy, 1997\u20132021"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6285-7355","authenticated-orcid":false,"given":"Luca","family":"Cegolon","sequence":"first","affiliation":[{"name":"Department of Medical, Surgical & Health Sciences, University of Trieste, 34128 Trieste, Italy"},{"name":"Public Health Department, University Health Agency Giuliano-Isontina (ASUGI), 34128 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Badalini","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical & Health Sciences, University of Trieste, 34128 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-0417","authenticated-orcid":false,"given":"Francesca","family":"Larese Filon","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical & Health Sciences, University of Trieste, 34128 Trieste, Italy"},{"name":"Occupational Medicine Unit, University Health Agency Giuliano-Isontina (ASUGI), 34128 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"ref_1","unstructured":"Adams, M.D., and Robert, M. 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