{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:11:54Z","timestamp":1760058714299,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016386","name":"Conselleria de Innovaci\u00f3n, Universidades, Ciencia y Sociedad Digital de la Generalitat Valenciana, within the Program ACIF (Subvenciones para la contrataci\u00f3n de personal investigador predoctoral)","doi-asserted-by":"publisher","award":["CIACIF\/2022\/073"],"award-info":[{"award-number":["CIACIF\/2022\/073"]}],"id":[{"id":"10.13039\/501100016386","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Social Fund","award":["CIACIF\/2022\/073"],"award-info":[{"award-number":["CIACIF\/2022\/073"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: The objective was to preliminarily evaluate the short-term clinical outcomes obtained in presbyopic patients with a novel, multifocal, customized corneo-scleral contact lens (CSCL). Methods: A total of 11 presbyopic subjects (age 45\u201380 years, corrected-distance visual acuity \u2264 0.1 LogMAR, near addition \u2265 +1.00 D) were recruited and fitted with a multifocal corneo-scleral contact lens in this pilot study. Pre-fitting evaluations included stereopsis, contrast sensitivity (CS), and ocular aberrometry, with follow-up assessments conducted at 20 min and 1-month post-fitting. The defocus curve was also measured to assess visual performance across varying distances. Results: Twenty-two eyes from 11 participants (53.9 \u00b1 4.7 years, 10 female) were included in this study. Significant changes were observed post-fitting for primary and secondary spherical aberration, coma, and stereopsis (p \u2264 0.033). No significant changes in Strehl ratio and total root mean square were detected (p \u2265 0.182). Binocular contrast sensitivity was better with spectacles than with the fitted CSCL at all frequencies (p \u2264 0.048), but the change in monocular did not reach statistical significance for 18 cycles per degree (p = 0.109). All patients and 90.9% of patients achieved a visual acuity of 0.0 LogMAR or better at distance and at intermediate, respectively, and 91.8% achieved 0.3 LogMAR or better for near vision. Conclusions: The customized CSCL evaluated provided functional recovery of visual quality across distances, with acceptable reductions of CS and stereopsis that are comparable to those reported for other multifocal contact lenses.<\/jats:p>","DOI":"10.3390\/life15050700","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:42:09Z","timestamp":1745577729000},"page":"700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pilot Study Evaluating the Early Clinical Outcomes Obtained with a Novel, Customized, Multifocal Corneo-Scleral Contact Lens for Presbyopia Correction"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2995-4970","authenticated-orcid":false,"given":"Laura","family":"Barber\u00e1n-Bernardos","sequence":"first","affiliation":[{"name":"Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1987-4867","authenticated-orcid":false,"given":"Daniel","family":"Soriano Salcedo","sequence":"additional","affiliation":[{"name":"Centro Oftalmol\u00f3gico Integral Bilbao Berri SL, Miranza COI Bilbao, 48008 Bilbao, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4413-9701","authenticated-orcid":false,"given":"Sergio","family":"D\u00edaz-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Centro Oftalmol\u00f3gico Integral Bilbao Berri SL, Miranza COI Bilbao, 48008 Bilbao, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1546-4807","authenticated-orcid":false,"given":"David P.","family":"Pi\u00f1ero","sequence":"additional","affiliation":[{"name":"Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain"},{"name":"Department of Ophthalmology (IMQO-Oftalmar), Vithas Medimar International Hospital, 03016 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.ophtha.2018.04.013","article-title":"Global prevalence of presbyopia and vision impairment from uncorrected presbyopia: Systematic review, meta-analysis, and modelling","volume":"125","author":"Fricke","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_2","first-page":"78","article-title":"Presbyopia corrected with single vision spectacles or corneal lenses in preference to bifocal corneal lenses","volume":"25","author":"Fonda","year":"1966","journal-title":"Trans. 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