{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:12:09Z","timestamp":1760058729411,"version":"build-2065373602"},"reference-count":69,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Subclinical atherosclerosis is a \u201csilent\u201d cardiovascular disease that can be devastating when combined with other illnesses. Its presence may affect therapy responses but can potentially worsen hematological malignancies due to most chemotherapy regimens\u2019 cardiovascular adverse effects. Thus, cardiovascular risk factor (CVRF) assessment is required before chemotherapy. Unfortunately, this rarely happens. Aim: we aim to examine the impact of CVRFs on hemodynamic parameters of acute leukemia (AL) patients before chemotherapy. Methods: Overall, 45 AL patients and 26 controls were included. Intima-media thickness (IMT), ankle brachial index (ABI), pulse wave velocity (PWV), and functional cardiac parameters were used. CVRFs were found in 26 AL patients (36.6%), while 19 AL (26.8%) patients lacked CVRFs. CVRFs were also found in 26 controls (36.6%). Results: Left ventricular ejection fraction (LVEF) significantly decreased for patients with CVRFs (59.26 \u00b1 5.62) compared to those without CVRFs (64.05 \u00b1 7.43, p &lt; 0.05). Hypertensive and diabetic patients had a significantly higher left IMT (mm) of 0.92 \u00b1 0.01 compared to those without them (0.76 \u00b1 0.03, p &lt; 0.05). Patients with acute myeloid leukemia (AML) with CVRFs had a significantly higher PWV (m\/s) of 8.4 \u00b1 0.12 compared to those without CVRFs (6.87 \u00b1 0.66) (p &lt; 0.05). Conclusions: AL and cardiovascular risk factors interacted before chemotherapy. To decrease cardiotoxicity, AL patients need cardiovascular risk assessment. Subclinical atherosclerosis and echocardiography help chemotherapy patients to choose a treatment regimen, predict long-term outcomes, and predict cardiovascular issues.<\/jats:p>","DOI":"10.3390\/life15050704","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:42:37Z","timestamp":1746391357000},"page":"704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predicting Cardiovascular Risk Factors for Acute Leukemia Patients by Assessing Subclinical Atherosclerosis and Left Ventricular Function Before Chemotherapy"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-5341","authenticated-orcid":false,"given":"Anda Gabriela","family":"Militaru","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Medical Semiology I, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Municipal Emergency Hospital Timisoara, Eftimie Murgu Square No 2, 300041 Timisoara, Romania"},{"name":"Center of Advanced Research in Cardiology and Hemostasology, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Florin","family":"Lighezan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Medical Semiology I, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Municipal Emergency Hospital Timisoara, Eftimie Murgu Square No 2, 300041 Timisoara, Romania"},{"name":"Center of Advanced Research in Cardiology and Hemostasology, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9530-022X","authenticated-orcid":false,"given":"Anca Maria","family":"Cimpean","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology\/Histology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No 2, 300041 Timisoara, Romania"},{"name":"Center of Expertise for Rare Vascular Disease in Children, Emergency Hospital for Children Louis Turcanu, 300011 Timisoara, Romania"},{"name":"Center for Genomic Research, GENOMICA, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No 2, 300041 Timisoara, Romania"},{"name":"Research Center for Pharmaco-Toxicological Evaluation, Victor Babe\u0219 University of Medicine and Pharmacy, Eftimie Murgu Square No 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-7449","authenticated-orcid":false,"given":"Elena","family":"Amaricai","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Physical Medicine and Rheumatology, Research Center for Assessment of Human Motion, Functionality and Disability, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-5782","authenticated-orcid":false,"given":"Marius","family":"Militaru","sequence":"additional","affiliation":[{"name":"Center of Advanced Research in Cardiology and Hemostasology, University of Medicine and Pharmacy \u201cVictor Babes\u201d Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania"},{"name":"Department of Neuroscience, Neurology II, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Municipal Emergency Hospital Timisoara, Eftimie Murgu Square No 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jacc.2009.03.095","article-title":"Anthracycline-Induced Cardiomyopathy: Clinical Relevance and Response to Pharmacologic Therapy","volume":"55","author":"Cardinale","year":"2010","journal-title":"J. Am. Coll. 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