{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:58:49Z","timestamp":1789657129142,"version":"4.0.1"},"reference-count":65,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lympha Press"},{"name":"Carolina Vein Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Lipedema is a painful disease of subcutaneous adipose tissue (SAT) in women. This study determined whether an advanced pneumatic compression device (APCD) improved lipedema SAT depth, swelling, and pain. Women with lipedema started 20\u201330 mm Hg compression leggings then were randomized to an APCD (Lympha Press Optimal Plus) group for 30 days (treatment; n = 22) or a no APCD (Control; n = 24) group. APCD treatment significantly reduced left leg volume (3D imaging, LymphaTech; p &lt; 0.043) and fluid in the left (p = 0.0018) and right legs (p = 0.0476; SOZO, bioimpedance spectroscopy); controls showed no change. Treatment significantly decreased extracellular fluid (ECF) and intracellular fluid (ICF) in left (p = 0.0077; p = 0.0060) and right legs (p = 0.0476; p \u2264 0.025), respectively. Only ECF decreased significantly in the left (p &lt; 0.0183) and right legs (p = 0.0009) in controls. SAT depth decreased significantly by ultrasound after treatment at the anterior (p \u2264 0.0234) and medial thigh (p \u2264 0.0052), medial knee (p \u2264 0.0002) and posterior calf (p \u2264 0.0118) but not in controls. All signs and symptoms of lipedema improved in the treatment group including swelling (p = 0.0005) and tenderness (pain) of right (p = 0.0003) and left legs (p &lt; 0.0001); only swelling improved in controls (p = 0.0377). In total, 87.5% of RAND SF-36 quality of life improved after treatment (p \u2264 0.0351) compared to 37.5% in controls (p \u2264 0.0475). APCDs are effective treatment for lipedema.<\/jats:p>","DOI":"10.3390\/life15050725","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:42:37Z","timestamp":1746391357000},"page":"725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["An Advanced Pneumatic Compression Therapy System Improves Leg Volume and Fluid, Adipose Tissue Thickness, Symptoms, and Quality of Life and Reduces Risk of Lymphedema in Women with Lipedema"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9079-9754","authenticated-orcid":false,"given":"Karen L.","family":"Herbst","sequence":"first","affiliation":[{"name":"The Roxbury Institute, Tucson, AZ 85715, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Zelaya","sequence":"additional","affiliation":[{"name":"Carolina Vein Center, Durham, NC 27713, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Sommerville","sequence":"additional","affiliation":[{"name":"Carolina Vein Center, Durham, NC 27713, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Carolina Vein Center, Durham, NC 27713, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindy","family":"McHutchison","sequence":"additional","affiliation":[{"name":"Carolina Vein Center, Durham, NC 27713, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"ref_1","first-page":"315","article-title":"Measurements of skin elasticity in patients with lipedema of the Moncorps \u201crusticanus\u201d type","volume":"37","author":"Jagtman","year":"1984","journal-title":"Phlebologie"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/02683555211015887","article-title":"Standard of care for lipedema in the United States","volume":"36","author":"Herbst","year":"2021","journal-title":"Phlebology"},{"key":"ref_3","first-page":"1","article-title":"Lipedema Fat and Signs and Symptoms of Illness, Increase with Advancing Stage","volume":"7","author":"Herbst","year":"2015","journal-title":"Arch. 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