{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:44:10Z","timestamp":1791290650084,"version":"4.3.0"},"reference-count":49,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T00:00:00Z","timestamp":1748044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)\u2014Finance Code 001","award":["APQ-03879\u201323"],"award-info":[{"award-number":["APQ-03879\u201323"]}]},{"name":"the Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)\u2014Finance Code 001","award":["APQ-03316\u201323"],"award-info":[{"award-number":["APQ-03316\u201323"]}]},{"name":"the Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais\u2014Brasil (FAPEMIG)","award":["APQ-03879\u201323"],"award-info":[{"award-number":["APQ-03879\u201323"]}]},{"name":"the Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais\u2014Brasil (FAPEMIG)","award":["APQ-03316\u201323"],"award-info":[{"award-number":["APQ-03316\u201323"]}]},{"name":"the Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014Brasil (CNPq)","award":["APQ-03879\u201323"],"award-info":[{"award-number":["APQ-03879\u201323"]}]},{"name":"the Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014Brasil (CNPq)","award":["APQ-03316\u201323"],"award-info":[{"award-number":["APQ-03316\u201323"]}]},{"name":"the Universidade do Estado de Minas Gerais (UEMG)","award":["APQ-03879\u201323"],"award-info":[{"award-number":["APQ-03879\u201323"]}]},{"name":"the Universidade do Estado de Minas Gerais (UEMG)","award":["APQ-03316\u201323"],"award-info":[{"award-number":["APQ-03316\u201323"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Fibromyalgia is a chronic syndrome characterized by widespread pain and complex pathophysiology, requiring new therapeutic approaches. This study aims to investigate the effects of resistance training (RT) before hyperalgesia induction on pain sensitivity, IL-6 and IL-10 expression in skeletal muscle, and thalamic serotonin levels in a fibromyalgia (FM)-like rat model. Methods: Wistar female rats aged 12 months were divided into four groups: untrained neutral saline (UNS), untrained acid saline (UAS), RT neutral saline (RTN), and RT acid saline (RTA). Both the RTN and RTA groups were subjected to an RT protocol comprising vertical ladder climbing three times a week throughout 14 weeks. The UAS and RTA groups received 100 \u00b5L of neutral, sterile saline (pH 4.0) in the left gastrocnemius muscle, while the UNS and RTN groups received 100 \u00b5L of neutral saline (pH 7.4). Mechanical hyperalgesia was assessed using Von Frey\u2019s electronic esthesiometer. Expression of interleukins 6 (IL-6) and 10 (IL-10) was analyzed in skeletal muscle, and serotonin expression was quantified in the thalamus. Results: After hyperalgesia induction, the RT groups demonstrated higher paw withdrawal thresholds than the UAS group (p &lt; 0.05). Both IL-6 and IL-10 expression was lower in the RTA group compared to the UAS group (p &lt; 0.05). Thalamic serotonin expression was higher (p &lt; 0.05) in the RTA group compared to the UAS group. Conclusion: Previous RT was able to prevent mechanical hyperalgesia experienced by rats after its induction by acid saline by preventing the increase in the IL-6 and IL-10 levels in skeletal muscle and preventing the decrease in thalamic serotonin expression.<\/jats:p>","DOI":"10.3390\/life15060849","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T20:39:36Z","timestamp":1748205576000},"page":"849","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Resistance Training Before Hyperalgesia Induction Promotes Analgesic Effects Through Central and Peripheral Biomarker Modulation in an Experimental Fibromyalgia-like Model"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0266-2636","authenticated-orcid":false,"given":"Andr\u00eas Valente","family":"Chiapeta","sequence":"first","affiliation":[{"name":"Laboratory of Exercise Biology, Department of Physical Education, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-7011","authenticated-orcid":false,"given":"Leandro Licursi","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Structural Biology, Department of General Biology, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3012-1327","authenticated-orcid":false,"given":"Luciano Bernardes","family":"Leite","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Biology, Department of Physical Education, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Aparecida Fonseca","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Biology, Department of Physical Education, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1406-9511","authenticated-orcid":false,"given":"Sebasti\u00e3o Felipe Ferreira","family":"Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Biology, Department of Physical Education, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-1230","authenticated-orcid":false,"given":"Le\u00f4ncio Lopes","family":"Soares","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Biology, Department of Physical Education, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa Alves de","family":"Moraes","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Biology, Department of Physical Education, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Rios","family":"Drummond","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte 30130-100, Brazil"},{"name":"Physical Education Department, State University of Minas Gerais, Divin\u00f3polis 35500-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-6780","authenticated-orcid":false,"given":"Pedro","family":"Forte","sequence":"additional","affiliation":[{"name":"Research Center for Physical Activity and Wellbeing (Livewell), Instituto Polit\u00e9cnico de Bragan\u00e7a, 5301-857 Bragan\u00e7a, Portugal"},{"name":"Department of Sports, Higher Instituto of Educational Sciences of the Douro, 4560-547 Penafiel, Portugal"},{"name":"Department of Sports Sciences, Instituto Polit\u00e9cnico de Bragan\u00e7a, 5301-857 Bragan\u00e7a, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-4024","authenticated-orcid":false,"given":"Ant\u00f4nio","family":"Jos\u00e9 Natali","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Biology, Department of Physical Education, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Araujo","family":"Carneiro-J\u00fanior","sequence":"additional","affiliation":[{"name":"Laboratory of Exercise Biology, Department of Physical Education, Federal University of Vi\u00e7osa, Vi\u00e7osa 36570-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.medcli.2017.06.008","article-title":"Fibromialgia: 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