{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:02:52Z","timestamp":1772996572151,"version":"3.50.1"},"reference-count":55,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn\u2019s disease (CD), is a chronic, immune-mediated inflammatory disorder of the gastrointestinal tract. Immunosuppressive therapy administration increases the risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) reactivation. This study aimed to investigate the hepatitis screening rate, serological status, and protective antibody levels among the Taiwanese IBD population. This single-center retrospective study included patients with IBD from January 2016 to December 2024. Hepatitis serological markers were analyzed. Patients were categorized into active HBV infection (HBsAg-positive), resolved HBV infection (HBsAg-negative and anti-HBc-positive), and non-HBV-infected groups, with prevalences of 7.5%, 32.5%, and 0.9%, respectively. This study included 347 patients with IBD (UC: 68.3%; CD: 31.7%), with a mean age of 47.1 \u00b1 16.4 years. Patients born after 1984 demonstrated a significantly reduced HBsAg positivity (0.9% vs. 11.0%; p &lt; 0.05) and resolved HBV infection (52.2% vs. 1.0%; p &lt; 0.05). However, among non-HBV-infected individuals, only 42.0% had protective anti-HBs levels (\u226510 mIU\/mL), despite vaccination program initiation. In this study, we found an overall HBsAg positivity rate of 7.5% and an anti-HCV seropositivity rate of 0.9% in our IBD population. Taiwan\u2019s HBV vaccination program has effectively reduced the HBV prevalence. However, a significant proportion of vaccinated individuals lack sufficient protective antibody levels, thereby requiring continued HBV screening and booster vaccinations.<\/jats:p>","DOI":"10.3390\/life15060893","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T03:57:18Z","timestamp":1748923038000},"page":"893","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serological Assessment of Hepatitis in Patients with Inflammatory Bowel Disease in Taiwan: A Retrospective Cohort Analysis"],"prefix":"10.3390","volume":"15","author":[{"given":"Yueh-An","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-2245","authenticated-orcid":false,"given":"Hsu-Heng","family":"Yen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5936-7112","authenticated-orcid":false,"given":"Yang-Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1093\/ecco-jcc\/jjae082","article-title":"Epidemiology of Inflammatory Bowel Disease across the Ages in the Era of Advanced Therapies","volume":"18","author":"Caron","year":"2024","journal-title":"J. Crohns Colitis"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: A systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41575-020-00360-x","article-title":"The four epidemiological stages in the global evolution of inflammatory bowel disease","volume":"18","author":"Kaplan","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1053\/j.gastro.2013.04.007","article-title":"Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn\u2019s and colitis epidemiology study","volume":"145","author":"Ng","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Huang, C.-W., Wei, S.-C., Shieh, M.-J., Chou, J.-W., Chuang, C.-H., Wang, H.-Y., Chang, C.-W., Wu, D.-C., Huang, T.-Y., and Liu, Y.-H. (2025). Epidemiology and temporal trends of adult inflammatory bowel disease in Taiwan: Multicenter study from the TSIBD registration. J. Formos. Med. Assoc., in press.","DOI":"10.1016\/j.jfma.2025.01.018"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: A systematic analysis for the Global Burden of Disease Study 2017","volume":"5","author":"Alatab","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e065186","DOI":"10.1136\/bmjopen-2022-065186","article-title":"Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: A systematic analysis based on the Global Burden of Disease Study 2019","volume":"13","author":"Wang","year":"2023","journal-title":"BMJ Open"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/jgh.14872","article-title":"The epidemiology of inflammatory bowel disease: East meets west","volume":"35","author":"Mak","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000442933","article-title":"IBD and Environment: Are There Differences between East and West","volume":"34","author":"Gearry","year":"2016","journal-title":"Dig. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000446625","article-title":"The Same Intestinal Inflammatory Disease despite Different Genetic Risk Factors in the East and West?","volume":"1","author":"Lui","year":"2016","journal-title":"Inflamm. Intestig. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bpg.2014.04.003","article-title":"Epidemiology of inflammatory bowel disease: Focus on Asia","volume":"28","author":"Ng","year":"2014","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5217\/ir.2018.00096","article-title":"Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: A nationwide populationbased study","volume":"17","author":"Yen","year":"2019","journal-title":"Intest. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1097\/MIB.0000000000000846","article-title":"Epidemiology of Inflammatory Bowel Disease from 1981 to 2014: Results from a Territory-Wide Population-Based Registry in Hong Kong","volume":"22","author":"Ng","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/ibd.20310","article-title":"Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005: A KASID study","volume":"14","author":"Yang","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00384-023-04417-6","article-title":"Trends in the prevalence and incidence of ulcerative colitis in Japan and the US","volume":"38","author":"Yamazaki","year":"2023","journal-title":"Int. J. Color. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100219","DOI":"10.1016\/j.advnut.2024.100219","article-title":"Diet, Food, and Nutritional Exposures and Inflammatory Bowel Disease or Progression of Disease: An Umbrella Review","volume":"15","author":"Christensen","year":"2024","journal-title":"Adv. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7812\/TPP\/18-107","article-title":"Westernized Diet is the Most Ubiquitous Environmental Factor in Inflammatory Bowel Disease","volume":"23","author":"Chiba","year":"2019","journal-title":"Perm. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.5217\/ir.2023.00050","article-title":"Management of ulcerative colitis in Taiwan: Consensus guideline of the Taiwan Society of Inflammatory Bowel Disease updated in 2023","volume":"22","author":"Yen","year":"2024","journal-title":"Intest. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/gut.2010.208413","article-title":"Liver dysfunction related to hepatitis B and C in patients with inflammatory bowel disease treated with immunosuppressive therapy","volume":"59","author":"Loras","year":"2010","journal-title":"Gut"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/ibd.22905","article-title":"Clinical courses of chronic hepatitis B virus infection and inflammatory bowel disease in patients with both diseases","volume":"18","author":"Park","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1053\/j.gastro.2024.11.008","article-title":"AGA Clinical Practice Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation in At-Risk Individuals","volume":"168","author":"Ali","year":"2025","journal-title":"Gastroenterology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1053\/j.gastro.2024.10.001","article-title":"AGA Living Clinical Practice Guideline on Pharmacological Management of Moderate-to-Severe Ulcerative Colitis","volume":"167","author":"Singh","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1093\/ecco-jcc\/jjae091","article-title":"ECCO Guidelines on Therapeutics in Crohn\u2019s Disease: Medical Treatment","volume":"18","author":"Gordon","year":"2024","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/ecco-jcc\/jjab178","article-title":"ECCO Guidelines on Therapeutics in Ulcerative Colitis: Medical Treatment","volume":"16","author":"Raine","year":"2021","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1053\/j.gastro.2021.04.034","article-title":"Canadian Association of Gastroenterology Clinical Practice Guideline for Immunizations in Patients With Inflammatory Bowel Disease (IBD)\u2014Part 2: Inactivated Vaccines","volume":"161","author":"Jones","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"s1","DOI":"10.1136\/gutjnl-2019-318484","article-title":"British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults","volume":"68","author":"Lamb","year":"2019","journal-title":"Gut"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/ecco-jcc\/jjab052","article-title":"ECCO Guidelines on the Prevention, Diagnosis, and Management of Infections in Inflammatory Bowel Disease","volume":"15","author":"Kucharzik","year":"2021","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lin, W.C., Lin, C.C., Hsu, W.H., Chiang, F.F., Chang, C.W., Hsu, T.C., Wu, D.C., Wang, H.Y., Wong, J.M., and Wei, S.C. (2025). Short-term and long-term outcomes of acute severe ulcerative colitis in Taiwan: A multicenter study with pre- and post-biologics comparison. Intest. Res.","DOI":"10.5217\/ir.2024.00112"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/ecco-jcc\/jjx085","article-title":"The 5C Concept and 5S Principles in Inflammatory Bowel Disease Management","volume":"11","author":"Hibi","year":"2017","journal-title":"J. Crohns Colitis"},{"key":"ref_32","unstructured":"World Health Organization (2024). Global Hepatitis Report 2024: Action for Access in Low\u2014and Middle-Income Countries, World Health Organization."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Huang, C.W., Yang, C.T., Su, P.Y., Chen, Y.Y., Huang, S.P., and Yen, H.H. (2023). Long-Term Hepatitis B Surface Antigen Profile and Seroclearance Following Antiviral Treatment: A Single-Center, Real-World Cohort Study. Biomedicines, 11.","DOI":"10.3390\/biomedicines11112966"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s13075-018-1748-z","article-title":"Changes in hepatitis B virus surface antibody titer and risk of hepatitis B reactivation in HBsAg-negative\/HBcAb-positive patients undergoing biologic therapy for rheumatic diseases: A prospective cohort study","volume":"20","author":"Tien","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4175923","DOI":"10.1155\/2019\/4175923","article-title":"Epidemiology and Clinical Outcomes of Inflammatory Bowel Disease: A Hospital-Based Study in Central Taiwan","volume":"2019","author":"Chou","year":"2019","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S1726-4901(09)70195-9","article-title":"Seroprevalence of hepatitis B and C in type 2 diabetic patients","volume":"69","author":"Chen","year":"2006","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"396","DOI":"10.5009\/gnl210081","article-title":"Clinical Course of Hepatitis B Viral Infection in Patients Undergoing Anti-Tumor Necrosis Factor alpha Therapy for Inflammatory Bowel Disease","volume":"16","author":"Lee","year":"2022","journal-title":"Gut Liver"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"15358","DOI":"10.3748\/wjg.v20.i41.15358","article-title":"Hepatitis B vaccination in patients with inflammatory bowel disease","volume":"20","author":"Gampa","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s10620-018-5042-3","article-title":"Hepatitis B Virus Screening and Reactivation in a National VA Cohort of Patients with Inflammatory Bowel Disease Treated with Tumor Necrosis Factor Antagonists","volume":"63","author":"Shah","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.dld.2014.07.006","article-title":"Screening prior to biological therapy in Crohn\u2019s disease: Adherence to guidelines and prevalence of infections. Results from a multicentre retrospective study","volume":"46","author":"Belderbos","year":"2014","journal-title":"Dig. Liver Dis."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Yen, H.H., Su, P.Y., Liu, I., Zeng, Y.H., Huang, S.P., Hsu, Y.C., Hsu, P.K., and Chen, Y.Y. (2021). Retrieval of lost patients in the system for hepatitis C microelimination: A single-center retrospective study. BMC Gastroenterol., 21.","DOI":"10.1186\/s12876-021-01792-8"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/aid2.13383","article-title":"Attitudes to medication and effects of IBD nursing service among patients with inflammatory bowel disease in Taiwan","volume":"11","author":"Yang","year":"2024","journal-title":"Adv. Dig. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"392","DOI":"10.5217\/ir.2022.00094","article-title":"Prevalence of hepatitis B virus and hepatitis C virus infection in patients with inflammatory bowel disease: A systematic review and meta-analysis","volume":"21","author":"Giri","year":"2023","journal-title":"Intestig. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1001\/jama.1987.03390190075023","article-title":"A Mass Vaccination Program in Taiwan Against Hepatitis B Virus Infection in Infants of Hepatitis B Surface Antigen\u2014Carrier Mothers","volume":"257","author":"Chen","year":"1987","journal-title":"JAMA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/epirev\/mxj010","article-title":"Nationwide hepatitis B vaccination program in Taiwan: Effectiveness in the 20 years after it was launched","volume":"28","author":"Chien","year":"2006","journal-title":"Epidemiol. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1093\/jnci\/djp288","article-title":"Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: A 20-year follow-up study","volume":"101","author":"Chang","year":"2009","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1016\/j.vaccine.2010.06.029","article-title":"Stable seroepidemiology of hepatitis B after universal immunization in Taiwan: A 3-year study of national surveillance of primary school students","volume":"28","author":"Chen","year":"2010","journal-title":"Vaccine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/cid\/ciu867","article-title":"Durability of antibody response against hepatitis B virus in healthcare workers vaccinated as adults","volume":"60","author":"Gara","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Mahmood, S., Shah, K.U., and Khan, T.M. (2018). Immune Persistence After Infant Hepatitis-B Vaccination: A Systematic Review and Meta-Analysis. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-30512-8"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1016\/j.cgh.2023.03.025","article-title":"Effectiveness of Hepatitis B Vaccination for Patients With Inflammatory Bowel and Celiac Disease","volume":"21","author":"Ulrich","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/gene.2010.1","article-title":"New genetic associations detected in a host response study to hepatitis B vaccine","volume":"11","author":"Davila","year":"2010","journal-title":"Genes. Immun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/21645515.2019.1666612","article-title":"Long-term persistence of anti-HBs after hepatitis B vaccination among adults: 8-year results","volume":"16","author":"Ren","year":"2020","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Schell, T.L., and Caldera, F. (2025). Optimizing Hepatitis B Vaccination Strategies for Patients With Inflammatory Bowel Disease. Inflamm. Bowel Dis., izaf042.","DOI":"10.1093\/ibd\/izaf042"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1365-2893.2007.00890.x","article-title":"Waning-off effect of serum hepatitis B surface antibody amongst Taiwanese university students: 18 years post-implementation of Taiwan\u2019s national hepatitis B vaccination programme","volume":"15","author":"Su","year":"2008","journal-title":"J. Viral Hepat."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Yen, H.H., Su, P.Y., Huang, S.P., Wu, L., Hsu, T.C., Zeng, Y.H., and Chen, Y.Y. (2021). Evaluation of non-alcoholic fatty liver disease in patients with inflammatory bowel disease using controlled attenuation parameter technology: A Taiwanese retrospective cohort study. 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